公开(公告)号：US20060120964A1

公开(公告)日：2006-06-08

申请号：US11336347

申请日：2006-01-20

Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC: A61K49/16 ,  A61K49/08

CPC classification number: B82Y5/00 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/183 ,  Y10S977/777 ,  Y10S977/904 ,  Y10S977/915 ,  Y10T428/2982

Abstract: Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles are represented as (FewGdx)Zy, wherein w is from 99.9% to 97.5%, x is from 0.1% to 2.5%, Z is an element of the group VIa, and v, y are positive numbers.

Abstract translation: 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒表示为（Fe x Gd x Z z）Z y y，其中w为99.9％至97.5％，x为0.1 ％至2.5％，Z为VIa族的元素，v，y为正数。

公开(公告)号：US20060111638A1

公开(公告)日：2006-05-25

申请号：US11126612

申请日：2005-05-11

Applicant: Hen-Hong Chang ,  Kang-Ping Lin ,  Wen-Chen Lin

Inventor： Hen-Hong Chang ,  Kang-Ping Lin ,  Wen-Chen Lin

IPC: A61B5/02

CPC classification number: A61B5/022 ,  A61B5/7242

Abstract: The invention is related to a noninvasive pulse measurement system with constant pressure for extremities of a human, and the constant pressure is modulated among 30 to 120 mmHg. There are an auto-mode and a manual mode for measurement algorithm. The auto-mode completes measurement and recording processes automatically during 2 minutes and pressurizes the system from low pressure (30 mmHg) to high pressure (120 mmHg) with 10 mmHg gradient every 5 seconds while the manual mode completes measurement and recording processes during a long time under a user's setting. Moreover, by a post-treatment of the system, the system is able to obtain continuous pulse signals, continuous pulse differential signals, and continuous pulse integral signals that are useful for Chinese medicine to evaluate and monitor the user's cardio-physiology and circulatory system.

Abstract translation: 本发明涉及一种具有恒定压力的无创脉冲测量系统，用于人的四肢，并且将恒压调制在30至120mmHg之间。 有自动模式和手动模式的测量算法。 自动模式在2分钟内自动完成测量和记录过程，并将系统从低压（30 mmHg）压缩至高压（120 mmHg），每5秒钟以10mmHg的梯度加压，而手动模式在长时间内完成测量和记录过程 在用户设置下的时间。 此外，通过对系统进行后处理，该系统能够获得连续脉冲信号，连续脉冲差分信号和连续脉冲积分信号，这些信号对于中医药评估和监测用户的心脏生理和循环系统是有用的。

公开(公告)号：US20050274629A1

公开(公告)日：2005-12-15

申请号：US10854369

申请日：2004-05-27

Applicant: Kang-Ping Lin

Inventor： Kang-Ping Lin

IPC: G01N27/26 ,  G01N33/543

CPC classification number: G01N33/5438

Abstract: The present invention relates to offer an apparatus and a method for an integral electrochemical biosensor combining designs of blood sampling, continuous and multiply testing, multi-channel detecting and adjustable working voltage; furthermore several physiologic parameters can be obtained simultaneously in an identical testing. The invention provides convenience for users and improves the practicability. Said integral electrochemical biosensor comprises: at least a sampling device configured to supply a sample carrying room, which is in vacuum or a state of relative negative pressure by an applied force with a pressure difference to make inactive humor at a relative high pressure injecting into said sample carrying room; a plurality of electrode sets comprising a compared electrode, an assisting electrode and an operating electrode, on which chemical and/or physical reactions between said inactive humor and chemicals bring out after said inactive humor injecting into said sample carrying room; a multi-channel electrochemical detector configured to provide several choices of operating voltage for said operating electrodes; a logic and data device configured to grab and calculate data of result from said physical or/and chemical reactions; a signal displaying device configured to explicitly show physiological parameter values of said inactive humor and corresponding concentration of said physiological parameters.

Abstract translation: 本发明涉及提供一种集成电化学生物传感器的装置和方法，其结合了血液采样，连续和多次测试，多通道检测和可调工作电压的设计; 此外，可以在相同的测试中同时获得几个生理参数。 本发明为用户提供便利，提高了实用性。 所述一体式电化学生物传感器包括：至少一个采样装置，其被配置为通过施加的压力差提供处于真空状态或相对负压状态的样品携带室，以使相对高压注入所述 样品携带室; 多个电极组，包括比较电极，辅助电极和操作电极，所述无活性幽默和化学物质在所述无活性幽默注射入所述样品携带室之后引起化学和/或物理反应; 多通道电化学检测器，被配置为为所述操作电极提供几种工作电压选择; 逻辑和数据设备被配置为从所述物理或/和化学反应中获取和计算结果的数据; 信号显示装置，被配置为明确地显示所述无效幽默的生理参数值和所述生理参数的对应浓度。

公开(公告)号：US20050025971A1

公开(公告)日：2005-02-03

申请号：US10741238

申请日：2003-12-19

Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC: A61K47/48 ,  A61K49/18 ,  B32B5/16 ,  B32B15/02 ,  B32B23/02 ,  B32B27/02

CPC classification number: B82Y5/00 ,  A61K47/6923 ,  A61K49/1818 ,  A61K49/183 ,  Y10T428/2991

Abstract: A magnetic nanoparticle applicable in imaging, diagnosis, therapy and biomaterial separation. The magnetic nanoparticle is characterized as comprising at least an inner-transition element, represented as FexMavZy, wherein Ma is an inner-transition element, Z is an element of the group VIa, x is greater or equal to 0, and both v and y are positive numbers. The magnetic nanoparticle may further comprise a shell to form a core-shell structure, wherein the shell is an inner-transition element Mb or the compound thereof.

Abstract translation: 适用于成像，诊断，治疗和生物材料分离的磁性纳米颗粒。 磁性纳米颗粒的特征在于至少包含内部过渡元素，表示为FexMaAvZy，其中M是>内部过渡元素，Z是VIa的元素，x大于或等于 0，v和y均为正数。 磁性纳米颗粒还可以包含壳形成核 - 壳结构，其中壳是内部过渡元素M或其化合物。

公开(公告)号：US20130138196A1

公开(公告)日：2013-05-30

申请号：US13306844

申请日：2011-11-29

Applicant: Cheng-Lun TSAI ,  Kang Ping Lin ,  Yi-Rou Lin ,  Yu-Ju Chiang ,  Shih-Wei Liu

Inventor： Cheng-Lun TSAI ,  Kang Ping Lin ,  Yi-Rou Lin ,  Yu-Ju Chiang ,  Shih-Wei Liu

IPC: A61N1/04

CPC classification number: A61N1/046 ,  A61N1/0492

Abstract: An electrode pad set comprises a left electrode pad, a right electrode pad, a first indication figure on the left electrode pad, a second indication figure on the right electrode pad. The left electrode pad and the right electrode pad respectively have a first warning sign with a first shape and a second warning sign with a second shape corresponding to the first shape. The perimeter of the first warning sign has a first coating with a first color. The perimeter of the second warning sign has a second coating with a second color. A left electrode pad symbol of the first indication figure has a color identical to the first color. A right electrode pad symbol of the second indication figure has a color identical to the second color. The present invention uses colors, shapes and indication figures to promote the success rate of attaching the electrode pads.

Abstract translation: 电极焊盘组包括左电极焊盘，右电极焊盘，左电极焊盘上的第一指示图，右电极焊盘上的第二指示图。 左电极焊盘和右电极焊盘分别具有第一形状的第一警告标志和与第一形状对应的第二形状的第二警告标志。 第一个警告标志的周边有第一个涂层，第一个颜色。 第二警告标志的周边具有第二涂层，其具有第二颜色。 第一指示图形的左电极垫符号具有与第一颜色相同的颜色。 第二指示图的右电极焊盘符号具有与第二颜色相同的颜色。 本发明使用颜色，形状和指示图来提高连接电极焊盘的成功率。

公开(公告)号：US20130046192A1

公开(公告)日：2013-02-21

申请号：US13307883

申请日：2011-11-30

Applicant: Yue-Der LIN ,  Ching Che TSAI ,  Hu Ying HO ,  Shih Fan WANG ,  Kang Ping LIN ,  Hen Hong CHANG ,  Yung Ching CHANG

Inventor： Yue-Der LIN ,  Ching Che TSAI ,  Hu Ying HO ,  Shih Fan WANG ,  Kang Ping LIN ,  Hen Hong CHANG ,  Yung Ching CHANG

IPC: A61B5/02

CPC classification number: A61B5/02007 ,  A61B5/02416 ,  A61B5/0285

Abstract: An image-based PWV measurement device and method are provided. The measurement device comprises at least two light emitting units respectively projecting light beams to at least two detected regions on body surface; at least two light transmitting units respectively receiving and transmitting light signals measured at the different detected regions; an image sensing unit converting the light signals measured at the detected regions into image signals; a length measurement unit used to measure the distance between the detected regions; and an image analysis unit analyzing the image signals to obtain PPG signals for the detected regions. According to the PPG signals, the image analysis unit calculates the physiological parameters, including the perfusion index, respiration rate, pulse rate, stiffness index, reflection index, and PWV between the detected regions, which is derived according to the distance and the pulse transit time from the PPG signals of the two detected regions.

Abstract translation: 提供了基于图像的PWV测量装置和方法。 测量装置包括至少两个发光单元，其分别将光束投射到身体表面上的至少两个检测区域; 至少两个光发送单元分别接收和发送在不同的检测区域测量的光信号; 图像感测单元，将在检测到的区域测量的光信号转换为图像信号; 用于测量检测到的区域之间的距离的长度测量单元; 以及图像分析单元，分析图像信号以获得用于检测到的区域的PPG信号。 根据PPG信号，图像分析单元计算检测区域之间的生理参数，包括灌注指数，呼吸率，脉搏率，刚度指数，反射指数和PWV，根据距离和脉冲传递 时间来自两个检测区域的PPG信号。

公开(公告)号：US07471976B2

公开(公告)日：2008-12-30

申请号：US10753388

申请日：2004-01-09

Applicant: Kang-Ping Lin ,  Chih-Hui Hsieh

Inventor： Kang-Ping Lin ,  Chih-Hui Hsieh

IPC: A61B5/0404

CPC classification number: A61B5/0404 ,  A61B5/04085 ,  A61B5/0464

Abstract: A device for measuring an electrocardiogram with a tapeless format and its method is provided with electrodes having a flat shape that are contacted by root portions between two fingers of a user's hands or by two fingers of each of the user's hands. The electrocardiogram can be measured directly by that contact, without adding any conductive liquid or gel material.

Abstract translation: 用于以无带格式测量心电图的装置及其方法设置有具有平坦形状的电极，其与使用者的手的两个手指的两根手指之间的根部部分或用户的手中的每个手指接触。 心电图可以直接由该接触测量，而不添加任何导电液体或凝胶材料。

公开(公告)号：US07270636B2

公开(公告)日：2007-09-18

申请号：US11163881

申请日：2005-11-02

Applicant: Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen

Inventor： Kang-Ping Lin ,  Hong-Dun Lin ,  Bor-Iuan Jan ,  Mei-Feng Chen

IPC: A61B5/02

CPC classification number: A61B5/02007 ,  A61B5/0225 ,  A61B5/025 ,  A61B5/4854

Abstract: An apparatus and method for pulse detection based on blood pressure measuring stage is disclosed. Both monitoring of blood pressure and blood vessel pulse are integrated and applied to an apparatus. With the components of the blood pressure monitor, such as an inflatable cuff an air pump and a variable flow valve, with a unique sequential pressure control of reduction and regulation of pressure, not only can blood pressure parameters but also pulse signals under various pressures be measured to provide a complete analysis of blood artery/vessel conditions.

Abstract translation: 公开了一种基于血压测量级的脉冲检测装置和方法。 将血压和血管脉搏的监测都集成并应用于装置。 利用血压监测器的组件，例如可充气套管，气泵和可变流量阀，具有减少和调节压力的独特的连续压力控制，不仅血压参数而且在各种压力下的脉搏信号都是 测量以提供血液动脉/血管状况的完整分析。

公开(公告)号：US20070166232A1

公开(公告)日：2007-07-19

申请号：US11687697

申请日：2007-03-19

Applicant: Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

Inventor： Hui-Ju Cho ,  Sheng-Ming Shih ,  Yuh-Jiuan Lin ,  Hong-Dun Lin ,  Kang-Ping Lin

IPC: A61K49/10

CPC classification number: A61K49/183 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/777 ,  Y10S977/904 ,  Y10T428/2991

Abstract: Magnetic nanoparticles are applicable in imaging, diagnosis, therapy, and biomaterial separation. The magnetic nanoparticles comprise a core represented as FexMavZy and a shell of an inner-transition element Mb or the compound thereof, wherein Ma is an inner-transition element, Z is an element of the group Vla, x is greater or equal to 0, and v, y are positive numbers. The surface of the shell is optionally modified by liposome, polymer, aliphatic compound, aromatic compound or combinations thereof.

Abstract translation: 磁性纳米颗粒适用于成像，诊断，治疗和生物材料分离。 磁性纳米颗粒包含一个表示为Fe x Si x Z y的核， 过渡元素M b或其化合物，其中M a是内部过渡元素，Z是基团Vla的元素，x大于或等于0， v，y为正数。 壳的表面任选地被脂质体，聚合物，脂族化合物，芳族化合物或其组合改性。

公开(公告)号：US20070038135A1

公开(公告)日：2007-02-15

申请号：US11438410

申请日：2006-05-22

Applicant: Kang-Ping Lin ,  Bor-Iuan Jan ,  Hao-Yu Jan ,  Geng-Hong Lin

Inventor： Kang-Ping Lin ,  Bor-Iuan Jan ,  Hao-Yu Jan ,  Geng-Hong Lin

IPC: A61B5/02

CPC classification number: A61B5/02438 ,  A61B5/02405 ,  A61B5/02416 ,  A61B5/7445 ,  A61B2560/0418

Abstract: A portable bio parameter detection/display assembly includes an optical sensor for engagement with an operator to acquire a pulse signal, an A/D converter converting the pulse signal into a digital format, a microprocessor for receiving the digital format pulse signal and proceeding with calculation of a pulse rate and at least one heart rate variability parameter, a display to display and a power module to provide necessary electricity to the assembly.

Abstract translation: 便携式生物参数检测/显示组件包括用于与操作者接合以获取脉冲信号的光学传感器，将脉冲信号转换成数字格式的A / D转换器，用于接收数字格式脉冲信号并进行计算的微处理器 脉搏率和至少一个心率变异性参数，显示器和功率模块，以向组件提供必要的电力。