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    B7-DC BINDING ANTIBODY
    11.
    发明申请
    B7-DC BINDING ANTIBODY 审中-公开
    B7-DC结合抗体

    公开(公告)号：US20160122431A1

    公开(公告)日：2016-05-05

    申请号：US14988938

    申请日：2016-01-06

    申请人： Larry R. Pease ,  Virginia Van Keulen ,  Bogolub Ciric

    发明人： Larry R. Pease ,  Virginia Van Keulen ,  Bogolub Ciric

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/75

    摘要： An antibody capable of potentiating immune responses and modifying existing states of immune responsiveness is described, as is the sequence of the antibody. Also described are compositions containing the antibody, as well as methods for using the antibody and the compositions to enhance immune responses, to enhance DC function, to modify an existing state of immune responsiveness, to immunize individuals, or to treat or inhibit conditions such as allergic asthma.

    摘要翻译： 描述了能够增强免疫应答并改变现有的免疫应答状态的抗体，抗体的序列也是如此。 还描述了含有抗体的组合物，以及使用抗体和组合物来增强免疫应答，增强DC功能，改变现有的免疫应答状态，免疫个体或治疗或抑制诸如 过敏性哮喘

    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
    12.
    发明授权
    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system 有权

    公开(公告)号：US08420795B2

    公开(公告)日：2013-04-16

    申请号：US12845977

    申请日：2010-07-29

    申请人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    发明人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    IPC分类号： C12N15/13 ,  C12P21/04

    CPC分类号： A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/77 ,  C12Q1/6876 ,  Y02A50/473

    摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes.

    IgM-MEDIATED RECEPTOR CLUSTERING AND CELL MODULATION
    13.
    发明申请
    IgM-MEDIATED RECEPTOR CLUSTERING AND CELL MODULATION 审中-公开
    IgM介导的受体聚集和细胞调节

    公开(公告)号：US20100291675A1

    公开(公告)日：2010-11-18

    申请号：US12738774

    申请日：2008-10-17

    申请人： Larry R. Pease ,  Moses Rodriguez

    发明人： Larry R. Pease ,  Moses Rodriguez

    IPC分类号： C12N5/071 ,  C07K2/00 ,  C07K7/06

    CPC分类号： C07K14/4726

    摘要： Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker on the cell surface.

    摘要翻译： 使用多价分子（例如抗体）调节细胞功能的材料和方法。 分子可以通过直接结合细胞表面上的表位或通过识别细胞表面上的多价分子和标记物的接头来靶向特定类型的细胞。

    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
    14.
    发明授权
    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system 有权
    人IgM抗体及其诊断和治疗用途，特别是在中枢神经系统中

    公开(公告)号：US07473423B2

    公开(公告)日：2009-01-06

    申请号：US10010729

    申请日：2001-11-13

    申请人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    发明人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    IPC分类号： A61K39/395 ,  C07K16/06

    CPC分类号： A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/77 ,  C12Q1/6876 ,  Y02A50/473

    摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes.

    摘要翻译： 公开了抗体，特别是人抗体，其表现出治疗脱髓鞘疾病以及中枢神经系统的病毒，细菌或特发性起源的其它疾病，包括由脊髓损伤引起的神经功能障碍的活性。 阐述神经调节剂，其包括并且包含选自能够结合中枢神经系统结构或细胞的抗体，肽类似物，半抗原，其活性片段，其激动剂，其模拟物，其单体 及其组合。 神经调节剂具有以下一个或多个特征：它能够诱导髓鞘再生; 结合神经组织; 用少突胶质细胞促进Ca ++信号传导; 并促进神经胶质细胞的细胞增殖。 公开了示例性抗体的氨基酸和DNA序列。 描述了使用多克隆IgM抗体和人单克隆抗体sHIgm22（LYM22），sHIgm46（LYM46）ebvHIgM MSI19D10，CB2bG8，AKJR4，CB2iE12，CB2iE7等治疗脱髓鞘疾病和人和家畜的中枢神经系统疾病的方法， MSI19E5和MSI10E10，其活性片段等。 本发明还延伸到使用人类抗体，片段，肽衍生物和类似材料，以及它们在诊断和治疗应用中的用途，包括用于发现结合神经系统细胞，特别是少突胶质细胞的其它抗体的筛选测定。

    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
    15.
    发明授权
    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system 有权

    公开(公告)号：US10351620B2

    公开(公告)日：2019-07-16

    申请号：US15629123

    申请日：2017-06-21

    申请人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    发明人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    IPC分类号： C07K14/705 ,  C07K16/18 ,  C12Q1/6876 ,  A61K38/00 ,  A61K39/00

    摘要： Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more of the following characteristics: capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, and active fragments thereof. The invention extends to the use of antibodies and fragments in diagnostic and therapeutic applications, including screening assays.

    METHODS AND MOLECULES FOR MODULATING AN IMMUNE RESPONSE
    18.
    发明申请
    METHODS AND MOLECULES FOR MODULATING AN IMMUNE RESPONSE 审中-公开
    用于调节免疫应答的方法和分子

    公开(公告)号：US20100260779A1

    公开(公告)日：2010-10-14

    申请号：US12362007

    申请日：2009-01-29

    申请人： Suresh Radhakrishnan ,  Larry R. Pease ,  Hirohito Kita ,  Koji Iijima

    发明人： Suresh Radhakrishnan ,  Larry R. Pease ,  Hirohito Kita ,  Koji Iijima

    IPC分类号： A61K39/395 ,  A61P11/06

    CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K2317/22

    摘要： A molecule capable of potentiating immune responses and modifying existing states of immune responsiveness is described. Also described are compositions containing the molecule, as well as methods for using the molecule and the compositions to enhance immune responses, to enhance DC function, to modify an existing state of immune responsiveness, to immunize individuals, or to treat or inhibit conditions such as allergic asthma.

    摘要翻译： 描述了能够增强免疫应答并改变现有的免疫应答状态的分子。 还描述了含有该分子的组合物，以及使用该分子和组合物来增强免疫应答，增强DC功能，改变现有的免疫应答状态，免疫个体或治疗或抑制诸如 过敏性哮喘

    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
    19.
    发明申请
    Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system 有权
    人IgM抗体及其诊断和治疗用途，特别是在中枢神经系统中

    公开(公告)号：US20090274690A1

    公开(公告)日：2009-11-05

    申请号：US12313515

    申请日：2008-11-20

    申请人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    发明人： Moses Rodriguez ,  David J. Miller ,  Larry R. Pease

    IPC分类号： A61K39/395 ,  A61P25/00

    CPC分类号： A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/77 ,  C12Q1/6876 ,  Y02A50/473

    摘要： Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca−− signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system of humans and domestic animals, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, active fragments thereof and the like. The invention also extends to the use of human antibodies, fragments, peptide derivatives and like materials, and their use in diagnostic and therapeutic applications, including screening assays for the discovery of additional antibodies that bind to cells of the nervous system, particularly oligodendrocytes.

    摘要翻译： 公开了抗体，特别是人抗体，其表现出治疗脱髓鞘疾病以及中枢神经系统的病毒，细菌或特发性起源的其它疾病，包括由脊髓损伤引起的神经功能障碍的活性。 阐述神经调节剂，其包括并且包含选自能够结合中枢神经系统结构或细胞的抗体，肽类似物，半抗原，其活性片段，其激动剂，其模拟物，其单体 及其组合。 神经调节剂具有以下一个或多个特征：它能够诱导髓鞘再生; 结合神经组织; 促进少突胶质细胞的Ca-信号传导; 并促进神经胶质细胞的细胞增殖。 公开了示例性抗体的氨基酸和DNA序列。 描述了使用多克隆IgM抗体和人单克隆抗体sHIgm22（LYM22），sHIgm46（LYM46）ebvHIgM MSI19D10，CB2bG8，AKJR4，CB2iE12，CB2iE7等治疗脱髓鞘疾病和人和家畜的中枢神经系统疾病的方法， MSI19E5和MSI10E10，其活性片段等。 本发明还延伸到使用人类抗体，片段，肽衍生物和类似材料，以及它们在诊断和治疗应用中的用途，包括用于发现结合神经系统细胞，特别是少突胶质细胞的其它抗体的筛选测定。

    Methods and molecules for modulating an immune response
    20.
    发明授权
    Methods and molecules for modulating an immune response 失效
    用于调节免疫应答的方法和分子

    公开(公告)号：US07501119B2

    公开(公告)日：2009-03-10

    申请号：US10881661

    申请日：2004-06-30

    申请人： Suresh Radhakrishnan ,  Larry R. Pease ,  Hirohito Kita ,  Koji Iijima

    发明人： Suresh Radhakrishnan ,  Larry R. Pease ,  Hirohito Kita ,  Koji Iijima

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K2317/22

    摘要： A molecule capable of potentiating immune responses and modifying existing states of immune responsiveness is described. Also described are compositions containing the molecule, as well as methods for using the molecule and the compositions to enhance immune responses, to enhance DC function, to modify an existing state of immune responsiveness, to immunize individuals, or to treat or inhibit conditions such as allergic asthma.

    摘要翻译： 描述了能够增强免疫应答并改变现有的免疫应答状态的分子。 还描述了含有该分子的组合物，以及使用该分子和组合物来增强免疫应答，增强DC功能，改变现有的免疫应答状态，免疫个体或治疗或抑制诸如 过敏性哮喘