-
公开(公告)号：US20130280171A1
公开(公告)日：2013-10-24
申请号：US13997069
申请日：2011-12-22
IPC分类号： A61K49/00 , A61K39/395
CPC分类号： G01N33/6893 , A61K39/3955 , A61K49/00 , C07K16/241 , C07K2317/21 , C07K2317/24 , G01N33/564 , G01N33/6854 , G01N33/9493 , G01N2333/525 , G01N2800/102 , G01N2800/24 , G01N2800/52 , G06F19/325 , G06F19/3468 , G16H20/17 , G16H40/20 , Y02A90/26
摘要： The invention relates to the field of personalized therapy and, in particular, to a method for classifying a patient suffering from rheumatoid arthritis as a responder or as a non-responder patient to a treatment based on a biological drug.
摘要翻译： 本发明涉及个性化治疗领域，特别涉及一种将类风湿性关节炎患者作为应答者或作为无反应者的患者分类为基于生物药物的治疗的方法。
-
公开(公告)号：US07914990B2
公开(公告)日：2011-03-29
申请号：US11813646
申请日：2006-01-12
申请人： Laureano Simon Buela , Antonio Martinez Martinez , Diego Tejedor Hernandez , Elisa Jimenez Uribe , Monica Lopez Martinez , Marta Artieda Osenalde , Lorena Hernandez Garcia
发明人： Laureano Simon Buela , Antonio Martinez Martinez , Diego Tejedor Hernandez , Elisa Jimenez Uribe , Monica Lopez Martinez , Marta Artieda Osenalde , Lorena Hernandez Garcia
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q1/6883 , C12Q1/6888 , C12Q2600/156 , C12Q2600/16 , G06F19/00 , Y02A90/26
摘要： An in vitro method for genotyping genetic variations in a individual, and products for use in the method.
摘要翻译： 用于个体遗传变异的基因分型的体外方法和用于该方法的产品。
-
13.发明申请Non-Invasive in Vitro Method to Detect Transitional Cell Carcinoma of the Bladder 审中-公开非侵入性体外检测膀胱移行细胞癌的方法公开(公告)号：US20090209431A1
公开(公告)日：2009-08-20
申请号：US12083446
申请日：2006-10-10
申请人： Ana Soloaga Villoch , Jose Luis Castrillo Diez , Inma Ramos Rodriguez , Kepa Escuredo Garcia-Galdeano , Antonio Martinez Martinez , Laureano Simon Buela
发明人： Ana Soloaga Villoch , Jose Luis Castrillo Diez , Inma Ramos Rodriguez , Kepa Escuredo Garcia-Galdeano , Antonio Martinez Martinez , Laureano Simon Buela
IPC分类号： C40B30/00 , G01N33/574 , G01N33/53 , C12Q1/02
CPC分类号： G01N33/57407 , G01N2800/52
摘要： The present invention refers to a non-invasive in vitro method to detect a transitional cell carcinoma of the bladder in an individual via urine analysis, to determine the stage or severity of this cancer in an individual or to monitor the effect of treatment administered to an individual suffering from this cancer.
摘要翻译： 本发明涉及通过尿液分析检测个体中膀胱移行细胞癌的非侵入性体外方法，以确定个体中该癌症的阶段或严重程度，或监测施用于患者的治疗效果 个体患有这种癌症。
-
14.发明申请公开(公告)号：US20080113347A1
公开(公告)日：2008-05-15
申请号：US10596857
申请日：2004-12-28
申请人： Ainara Vallejo Illarramendi , Antonio Martinez Martinez , Usue Ariz Lopez de Castro , Lourdes Osaba Ortiz de Mendibil , Corina Junquera Sanchez-Vallejo , Simon Santa Cruz , Pedro Escudero Garcia de Galdeano , Jorge Ochoa Garay , Laureano Simon Buela , Carlos Matute Almau , Elena Alberdi Alfonso , Maria Victoria Sanchez Gomez , Gaskon Ibarretxe Bilbao , Estibaliz Etxebarria Galnares
发明人： Ainara Vallejo Illarramendi , Antonio Martinez Martinez , Usue Ariz Lopez de Castro , Lourdes Osaba Ortiz de Mendibil , Corina Junquera Sanchez-Vallejo , Simon Santa Cruz , Pedro Escudero Garcia de Galdeano , Jorge Ochoa Garay , Laureano Simon Buela , Carlos Matute Almau , Elena Alberdi Alfonso , Maria Victoria Sanchez Gomez , Gaskon Ibarretxe Bilbao , Estibaliz Etxebarria Galnares
CPC分类号： C12N9/16 , C12Q1/42 , G01N33/5088 , G01N33/564 , G01N2800/285
摘要： The present invention refers to an in vitro method for detecting the presence of demyelinating diseases in an individual, for determining the stage or severity of said diseases in the individual, or for monitoring the effect of the therapy administered to an individual suffering said diseases; to the search, identification, development and evaluation of efficacy of compounds for therapy of said diseases for the purpose of developing new drugs; as well as to agents inhibiting DUSP6 protein expression and/or activity, and/or the effects of this expression. The methods and agents of the invention are preferably applied to multiple sclerosis.
摘要翻译： 本发明涉及用于检测个体中脱髓鞘疾病的存在的体外方法，用于确定个体中所述疾病的阶段或严重程度，或用于监测施用于患有所述疾病的个体的治疗效果; 用于研究，鉴定，开发和评估化合物治疗所述疾病以开发新药物的功效; 以及抑制DUSP6蛋白表达和/或活性的药剂，和/或该表达的作用。 本发明的方法和试剂优选应用于多发性硬化。
-
公开(公告)号：US09637788B2
公开(公告)日：2017-05-02
申请号：US14126819
申请日：2012-06-14
申请人： Jorge Ochoa , Monica Lopez , Sergio Escorza , Diego Tejedor , Antonio Martinez , Laureano Simon
发明人： Jorge Ochoa , Monica Lopez , Sergio Escorza , Diego Tejedor , Antonio Martinez , Laureano Simon
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r′s, RHD*DIIIa, RHD*DIVa-2, RHCE*css and RHCE*ce733G. The method comprises genotyping a sample obtained from a human subject at one or more positions in intron 7 of the RHD gene and/or in intron 7 of the RHCE gene. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.
-
16.发明授权Probes and methods for determining the presence or absence of genetic segments 有权用于确定遗传分段的存在或不存在的探针和方法公开(公告)号：US09165108B2
公开(公告)日：2015-10-20
申请号：US13161779
申请日：2011-06-16
申请人： David Garcia , Laureano Simon , Antonio Martinez , Jorge Ochoa , Diego Tejedor , Monica Lopez
发明人： David Garcia , Laureano Simon , Antonio Martinez , Jorge Ochoa , Diego Tejedor , Monica Lopez
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/156 , G06F19/18 , G06F19/20 , G06F19/24
摘要： A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.
摘要翻译： 用于确定在含DNA样品中存在或不存在感兴趣的遗传节段如外显子，内含子或启动子的方法，以及用于此类方法的探针组，包括包含具有核苷酸的寡核苷酸探针的探针组 选自SEQ ID NO：1-101的序列。
-
17.发明申请公开(公告)号：US20130263294A1
公开(公告)日：2013-10-03
申请号：US13824842
申请日：2011-09-19
申请人： Antonio Martinez , Laureano Simon , Diego Tejedor , Marta Artieda , Nerea Bartolome , Jose Escaich , Alfonso Velasco , Miriam Selles , Carlos Chetrit , Daniel Martinez , Armand Sanchez , Olga Francino , Elisenda Sanchez
发明人： Antonio Martinez , Laureano Simon , Diego Tejedor , Marta Artieda , Nerea Bartolome , Jose Escaich , Alfonso Velasco , Miriam Selles , Carlos Chetrit , Daniel Martinez , Armand Sanchez , Olga Francino , Elisenda Sanchez
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要： A method for predicting risk of joint dysplasia, osteoarthritis and/or a condition that is secondary to joint dysplasia in a mammalian subject of the order Carnivora, the method comprising: (a) determining the genotype of said subject in respect of one or more genetic polymorphisms and/or alterations, such as polymorphisms in the CHST3 gene; and (b) providing a prediction of said risk based on said genotype. Products for use in such a method and related methods of determining propensity of a subject to respond to therapy and of selective breeding, are also disclosed.
摘要翻译： 一种用于预测关节发育不良，骨关节炎和/或继发于哺乳动物食肉动物主题的关节发育不良的病症的方法，所述方法包括：（a）确定所述受试者关于一种或多种遗传物质的基因型 多态性和/或改变，如CHST3基因的多态性; 和（b）基于所述基因型提供所述风险的预测。 还公开了用于确定受试者对治疗和选择性育种的倾向的这种方法和相关方法的产品。
-
公开(公告)号：US20120215459A1
公开(公告)日：2012-08-23
申请号：US13394078
申请日：2010-09-02
申请人： Marianne Stef , Diego Tejedor , Antonio Martinez , Laureano Simon
发明人： Marianne Stef , Diego Tejedor , Antonio Martinez , Laureano Simon
CPC分类号： C12Q1/6837 , G16B20/00 , G16B25/00 , G16B40/00 , C12Q2545/113 , C12Q2537/165 , C12Q2537/157
摘要： The invention relates to methods and algorithms for detecting and analysis of copy number variances in a genetic segment. The invention also relates to a computer implemented sequential method of processing and interpreting experimental data generated by genotyping nucleic acid-chips or nucleic acid-beads based on detection of a hybridization signal.
摘要翻译： 本发明涉及用于检测和分析遗传区段中拷贝数变异的方法和算法。 本发明还涉及一种基于检测杂交信号来处理和解释通过基因分型核酸片段或核酸珠产生的实验数据的计算机实现的顺序方法。
-
19.发明申请PROBES AND METHODS FOR DETERMINING THE PRESENCE OR ABSENCE OF GENETIC SEGMENTS 有权确定遗传部分存在或不存在的探索和方法公开(公告)号：US20110313678A1
公开(公告)日：2011-12-22
申请号：US13161779
申请日：2011-06-16
申请人： David Garcia , Laureano Simon , Antonio Martinez , Jorge Ochoa , Diego Tejedor , Monica Lopez
发明人： David Garcia , Laureano Simon , Antonio Martinez , Jorge Ochoa , Diego Tejedor , Monica Lopez
IPC分类号： G06F19/00
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/156 , G06F19/18 , G06F19/20 , G06F19/24
摘要： A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.
摘要翻译： 用于确定在含DNA样品中存在或不存在感兴趣的遗传节段如外显子，内含子或启动子的方法，以及用于此类方法的探针组，包括包含具有核苷酸的寡核苷酸探针的探针组 选自SEQ ID NO：1-101的序列。
-
公开(公告)号：US20110098191A1
公开(公告)日：2011-04-28
申请号：US12877092
申请日：2010-09-07
申请人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
发明人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
IPC分类号： C40B30/04 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： G01N33/57438 , C07K14/4703 , C07K14/705 , C07K14/71 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , Y10T436/143333
摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.
摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.021 秒)
