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    Reducing flow through a tubular structure
    12.
    发明授权
    Reducing flow through a tubular structure 有权
    减少通过管状结构的流动

    公开(公告)号：US09017351B2

    公开(公告)日：2015-04-28

    申请号：US12826593

    申请日：2010-06-29

    申请人： Leon Rudakov ,  Phillipe Gailloud

    发明人： Leon Rudakov ,  Phillipe Gailloud

    IPC分类号： A61B17/08 ,  A61B17/12 ,  A61B17/00 ,  A61B17/22

    CPC分类号： A61B17/12145 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/1215 ,  A61B2017/00469 ,  A61B2017/00809 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/1209 ,  A61B2017/22035

    摘要： In some embodiments, an apparatus, for reducing or stopping flow through a tubular structure of a patient, includes an elongate member arranged to form a frame having a distal and proximal opening and configured to be positioned within a lumen of the tubular structure. The frame includes a proximal, distal, and middle portion. The distal portion is tapered such that an outer cross sectional dimension (OCSD) of the distal opening is less than an OCSD of the middle portion. The frame is configured to be inverted such that the distal portion moves within and toward the middle portion for removing the frame from within the lumen. The apparatus also comprises a flow reducing member coupled to the frame such that when the frame is positioned within the lumen, the flow reducing member substantially reduces or totally obstructs flow of at least one of emboli and fluid flowing through the lumen.

    摘要翻译： 在一些实施例中，用于减少或阻止穿过患者的管状结构的流动的装置包括细长构件，该细长构件布置成形成具有远端和近侧开口并被配置为定位在管状结构的内腔内的框架。 框架包括近端，远端和中间部分。 远侧部分是锥形的，使得远端开口的外横截面尺寸（OCSD）小于中间部分的OCSD。 框架被构造成倒置，使得远端部分在中间部分内移动并朝向中间部分移动，以从框架内移除框架。 该装置还包括联接到框架的流动减少构件，使得当框架定位在内腔内时，减流构件基本上减少或完全阻碍栓塞和流过管腔的流体中的至少一个的流动。

    Endovascular device with membrane having permanently attached agents
    14.
    发明申请
    Endovascular device with membrane having permanently attached agents 审中-公开
    具有膜的血管内装置具有永久附着的药剂

    公开(公告)号：US20070203573A1

    公开(公告)日：2007-08-30

    申请号：US11637188

    申请日：2006-12-12

    申请人： Leon Rudakov ,  Tsui Ying Hong ,  Peir Sung

    发明人： Leon Rudakov ,  Tsui Ying Hong ,  Peir Sung

    IPC分类号： A61F2/06

    CPC分类号： A61F2/07 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/40 ,  A61L2400/18

    摘要： An endovascular device (10) for treatment of a bodily vessel (5) of a patient at a surgical site, the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (15) secured to a portion of the circumferential surface of said mechanically expandable device (11); wherein at least one capture agent (20, 21) is permanently attached to the lumenal surface of the membrane (15) to capture a predetermined target component from blood passing through the fluid pathway; and at least one signal agent (22) is permanently attached to the lumenal surface of the membrane (15) to signal the captured target component to up regulate or down regulate a cell function of the captured target component to enhance endothelialization and healing.

    摘要翻译： 一种用于在外科手术部位处理患者的身体血管（5）的血管内装置（10），所述血管内装置（10）包括：机械可扩张装置（11），其可从第一位置扩展到第二位置，所述机械 可膨胀装置（11）径向向外扩张到第二位置，使得所述机械可扩张装置（11）的圆周表面与容器（5）的内表面接合，以便保持通过所述容器（5）的流体通道， ; 以及固定到所述机械可扩张装置（11）的所述圆周表面的一部分上的膜（15）; 其中至少一个捕获剂（20,21）永久地附着到膜（15）的内腔表面，以从穿过流体通路的血液中捕获预定的目标成分; 并且至少一个信号剂（22）永久地附着到膜（15）的内腔表面上，以通知所捕获的靶组分以调节或下调所捕获的靶组分的细胞功能以增强内皮化和愈合。

    Expandable device delivery
    15.
    发明授权
    Expandable device delivery 有权
    可扩展设备交付

    公开(公告)号：US09149277B2

    公开(公告)日：2015-10-06

    申请号：US12906993

    申请日：2010-10-18

    申请人： Leon Rudakov ,  Andrew R. Leopold ,  Kelly L. Jensen ,  Philippe Gailloud

    发明人： Leon Rudakov ,  Andrew R. Leopold ,  Kelly L. Jensen ,  Philippe Gailloud

    IPC分类号： A61F2/95 ,  A61B17/12

    CPC分类号： A61B17/12031 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/1215 ,  A61B2017/1205 ,  A61B2017/12054

    摘要： A device for delivering an expandable member to a luminal structure in a patient is described. In some embodiments, the device has a carrier member, with a carrier lumen extending at least partially therethrough. The device can have an elongate member that extends through the carrier lumen across a first notch in the carrier member. The device can have an expandable member that expands within and engages the luminal structure, can be carried by the carrier member, and has a first portion that fits within the first notch. When the elongate member extends through the carrier lumen and across the first notch, the elongate member secures the first portion to the carrier member. The elongate member is configured to move axially through the carrier lumen such that the elongate member permits release of the first portion from the carrier member and expansion of at least part of the expandable member.

    摘要翻译： 描述了用于将可扩张构件递送到患者体内的腔体结构的装置。 在一些实施例中，该装置具有载体构件，其中载体腔至少部分延伸穿过其中。 该装置可以具有延伸穿过载体内腔的细长构件跨越载体构件中的第一凹口。 该装置可以具有在腔体结构内扩张并与腔体结构接合的可扩张构件，其可以由承载构件承载，并且具有装配在第一凹口内的第一部分。 当细长构件延伸穿过载体内腔并穿过第一凹口时，细长构件将第一部分固定到载体构件。 细长构件被构造成轴向地移动穿过载体腔，使得细长构件允许第一部分从承载构件释放并且至少部分可扩张构件的膨胀。

    Medical device
    16.
    发明授权
    Medical device 有权
    医疗装置

    公开(公告)号：US08500751B2

    公开(公告)日：2013-08-06

    申请号：US11586899

    申请日：2006-10-25

    申请人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    发明人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    IPC分类号： A61F2/06 ,  A61F11/00

    CPC分类号： A61F2/07 ,  A61B17/12118 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2002/91541 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016

    摘要： A method for treating a bifurcation or trifurcation aneurysm (201) occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising: inserting a medical device (202) such that it is at least partially located in the first artery and is at least partially located in the third artery; expanding the medical device (202) from a first position to a second position, said medical device (202) is expanded radially outwardly to the second position such that the exterior surface of said medical device (202) engages with the inner surface of the first and third arteries so as to maintain a fluid pathway through said arteries; and positioning the medical device (202) such that a membrane (203) of the medical device (202) is located against an aneurysm neck of the aneurysm (201) to obstruct blood circulation to the aneurysm (201) when the medical device (202) is expanded to the second position, and at least a portion of the membrane (203) is secured to the medical device (202) to maintain the position of the membrane (203) relative to the medical device (202) when expanded to the second position; wherein the membrane (203) is permeable and porous, the size of the pores of the membrane (203) and the ratio of the material surface area of the membrane (203) being such that blood supply to perforators and/or microscopic branches of main brain arteries is permitted to improve healing of the first artery but blood supply to the aneurysm (201) is prevented.

    摘要翻译： 一种用于治疗在第一动脉上发生的分叉或三叉神经动脉瘤（201）的方法，所述第一动脉和连接到第三动脉的第二动脉，所述方法包括：插入医疗装置（202），使得其至少部分位于 在第一动脉中并且至少部分地位于第三动脉中; 将医疗设备（202）从第一位置扩展到第二位置，所述医疗设备（202）径向向外扩展到第二位置，使得所述医疗设备（202）的外表面与第一位置 和第三动脉，以便保持通过所述动脉的流体通道; 以及医疗装置（202）的定位，使得医疗装置（202）的膜（203）抵靠动脉瘤（201）的动脉瘤颈部定位，以在医疗装置（202）处阻止血液循环至动脉瘤 ）扩张到第二位置，并且膜（203）的至少一部分固定到医疗装置（202），以在将膜（203）扩大到第二位置时保持膜（203）相对于医疗装置（202）的位置 第二位 其中所述膜（203）是可渗透和多孔的，所述膜（203）的孔的尺寸和所述膜（203）的材料表面积的比率使得向主要的穿孔器和/或微观分支提供血液供应 允许脑动脉改善第一动脉的愈合，但是防止了对动脉瘤（201）的供血。

    ENDOVASCULAR DEVICE
    17.
    发明申请
    ENDOVASCULAR DEVICE 有权
    内镜装置

    公开(公告)号：US20100063582A1

    公开(公告)日：2010-03-11

    申请号：US12205827

    申请日：2008-09-05

    申请人： Leon RUDAKOV

    发明人： Leon RUDAKOV

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/12136 ,  A61B17/12172 ,  A61F2/90 ,  A61F2002/823 ,  A61F2002/828 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2250/0068

    摘要： Embodiments of an endovascular device and of methods for treating an aneurysm therewith are described. In certain embodiments, an endovascular device includes a distal assembly coupled to a flow reducing member. In some embodiments, the distal assembly is composed of multiple engagement members that, when deployed within an aneurysm, engage an inner surface of the aneurysm. In certain embodiments, the engagements members are substantially parallel to a central axis of the distal assembly in a first position and shift away from the central axis to a second position, and the distal ends of some engagement members are substantially curled when in the second position. In certain embodiments, the flow-reducing member reduces blood flow from a blood vessel into the aneurysm. In certain embodiments the flow reducing member includes a membrane, which can include a porous section.

    摘要翻译： 描述了血管内装置的实施方案和用于治疗动脉瘤的方法。 在某些实施例中，血管内装置包括联接到减流构件的远端组件。 在一些实施例中，远侧组件由多个接合构件构成，当部署在动脉瘤内时，多个接合构件接合动脉瘤的内表面。 在某些实施例中，接合构件在远离组件的中心轴线基本上平行于第一位置并且从中心轴线移开到第二位置，并且当处于第二位置时，一些接合构件的远端基本上卷曲 。 在某些实施例中，减流部件减少从血管到动脉瘤的血流量。 在某些实施例中，减流构件包括膜，其可以包括多孔区段。

    Medical device
    19.
    发明申请
    Medical device 有权
    医疗装置

    公开(公告)号：US20070100430A1

    公开(公告)日：2007-05-03

    申请号：US10580139

    申请日：2004-12-13

    申请人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    发明人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    IPC分类号： A61F2/06

    CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12186 ,  A61F2/07 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/075 ,  A61F2002/3008 ,  A61F2002/823 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0037 ,  A61F2250/0098

    摘要： A medical device for insertion into a bodily vessel to treat an aneurysm (201), the device comprising: a mechanically expandable device (202) expandable from a first position to a second position, said mechanically expandable device (202) is expanded radially outwardly to the second position such that the exterior surface of said mechanically expandable (202) engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and a membrane (203) expandable from a first position to a second position in response to expansion of said mechanically expandable device (202), said membrane (203) obstructing blood circulation to the aneurysm (201) when expanded to the second position, and at least a portion of the membrane (203) is secured to the mechanically expandable device (202) to maintain the position of the membrane (203) relative to the mechanically expandable device (202) when expanded to the second position.

    摘要翻译： 一种用于插入身体血管以治疗动脉瘤（201）的医疗装置，所述装置包括：可从第一位置扩展到第二位置的机械可扩张装置（202），所述机械可扩张装置（202）径向向外扩张 所述第二位置使得所述机械可膨胀（202）的外表面与所述容器的内表面接合，以便保持通过所述容器的流体通路; 以及响应于所述机械可扩张装置（202）的膨胀而从第一位置扩展到第二位置的膜（203），所述膜（203）在膨胀到第二位置时阻碍血液循环到动脉瘤（201），并且 当膨胀到第二位置时，膜（203）的至少一部分被固定到机械可扩张装置（202）以保持膜（203）相对于机械可扩张装置（202）的位置。