公开(公告)号：US10561161B2

公开(公告)日：2020-02-18

申请号：US15694015

申请日：2017-09-01

Applicant: PepsiCo, Inc. ,  Massey University

Inventor： Yuan Fang ,  Breda Kennedy ,  Teodoro Rivera ,  Kyoung-Sik Han ,  Anil Kumar Anal ,  Harjinder Singh

IPC: A23L1/00 ,  A23L2/52 ,  A23P10/30 ,  A23L29/256 ,  A23L27/30 ,  A23L33/135 ,  A23L33/155 ,  A23L33/16 ,  A23L33/19 ,  A23L2/02 ,  A23L2/60 ,  A23L2/66 ,  A23L2/68 ,  A61K35/745 ,  A61K35/747 ,  C12N1/04 ,  C12N11/04 ,  C12N11/10 ,  B01J13/04 ,  B01J13/20

Abstract: Comestible products, for example beverage products, are disclosed containing encapsulated probiotic bacteria having resistance to subjection to at least thermal and acidic conditions. Beverage products include at least one aqueous liquid and capsules comprising a gelled mixture of alginate and denatured protein, and probiotic bacteria entrapped within the gelled mixture. The average particle size of the capsules is optionally less than 1000 microns (μm) in diameter, such as less than 500 μm in diameter. Methods are provided for making such encapsulated probiotics by providing a mixture comprising sodium alginate, denatured protein and active probiotic cells, and combining the mixture with a divalent cation to initiate cold gelation of the sodium alginate and denatured protein to form a second mixture. The second mixture is passed through an opening having a diameter of less than 1000 μm to form capsules. The weight ratio of protein to alginate is from 1:1 to 9:1.

公开(公告)号：US20180344650A1

公开(公告)日：2018-12-06

申请号：US15771399

申请日：2016-10-26

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  MASSEY UNIVERSITY ,  AGRESEARCH

Inventor： Harjinder SINGH ,  Brendan HAIGH ,  Nicole ROY ,  Maxim KIRYUKHIN ,  Maria ANTIPINA ,  Marina NOVOSELOVA ,  Gleb SUKHORUKOV

IPC: A61K9/48 ,  A61K47/38 ,  A61K47/42 ,  A61K47/34

CPC classification number: A61K9/4825 ,  A61K9/19 ,  A61K9/4833 ,  A61K9/4891 ,  A61K9/5073 ,  A61K47/34 ,  A61K47/38 ,  A61K47/42

Abstract: Disclosed herein is a core-shell composite material comprising: a core optionally comprising an active ingredient compound; a shell structure comprising at least two alternating layers; the alternating layers being a protein layer and a polyphenol layer; and optionally a polyelectrolyte layer interfacing said core and said shell structure, said polyelectrolyte layer being disposed adjacent to said protein layer or said polyphenol layer, wherein said shell structure is selected to be resistant to degradation under gastric conditions but is degradable by one or more intestinal enzymes. In a preferred embodiment the protein is bovine serum albumin (BSA) or pepsin, the polyphenol layer is tannin or tannic acid, and the shell structure is degradable by pepsin.

公开(公告)号：US20170339996A1

公开(公告)日：2017-11-30

申请号：US15679909

申请日：2017-08-17

Applicant: MASSEY UNIVERSITY

Inventor： Vikas Ashok Mittal ,  Ashling Ellis ,  Shantanu Das ,  Aiqian Ye ,  Harjinder Singh

IPC: A23L33/165 ,  A23C9/146 ,  A23L33/19 ,  A23C9/152 ,  A23J3/10

CPC classification number: A23L33/165 ,  A23C9/146 ,  A23C9/1522 ,  A23C9/1526 ,  A23J3/10 ,  A23L33/19 ,  A23V2002/00 ,  A23V2250/1592 ,  A23V2250/1618 ,  A23V2250/5424

Abstract: A non-micellar mineral-protein complex including an exogenously added mineral and a protein, where the mineral-protein complex is soluble in a solution at a physiological pH between 6.6 to 6.9 and the complex includes exogenous phosphorus.

公开(公告)号：US20240140983A1

公开(公告)日：2024-05-02

申请号：US18262896

申请日：2022-01-26

Applicant: MASSEY UNIVERSITY

Inventor： Fareeda Maged Yahya BARZAK ,  Vyacheslav Vladimirovich FILICHEV ,  Elena HARJES ,  Stefan HARJES ,  Geoffrey Brind JAMESON ,  Harikrishnan Mohana KURUP ,  Maksim V. KVACH ,  Yongdong SU

IPC: C07H21/04

CPC classification number: C07H21/04

Abstract: The invention relates to single stranded DNA inhibitors of APOBEC3 enzymes and uses thereof. The compounds of the invention comprise β-D-5-O-phosphato-2-deoxyribofuranosyl analogues of nucleoside-like inhibitors of cytidine deaminase, flanked by oligonucleotide sequences which may be cross-linked. The compounds of the invention may have therapeutic application against diseases and conditions in which inhibition of a human cytidine deaminase of the APOBEC3 family would be beneficial.

公开(公告)号：US20220002785A1

公开(公告)日：2022-01-06

申请号：US17292341

申请日：2019-11-08

Applicant: MASSEY UNIVERSITY

Inventor： Peter LOCKHART ,  Richard WINKWORTH ,  Patricia MCLENACHAN ,  Nicole GRÜNHEIT ,  Richard FONG

IPC: C12Q1/689

Abstract: Disclosed herein are methods and compositions for specific detection of Mycobacterium spp. in a sample and for profiling multiple gene loci within Mycobacterium spp. that are linked to or that are directly involved in antibiotic resistance. In particular the method employs a unique set of nucleic acid amplification primers that enable the whole genome sequence-based approach disclosed herein, allowing for the full characterization of the antibiotic resistance profile of Mycobacterium spp.

公开(公告)号：US20210330645A1

公开(公告)日：2021-10-28

申请号：US17274115

申请日：2019-09-06

Applicant: MASSEY UNIVERSITY

Inventor： Jasna Rakonjac ,  Van Hung Vuong Le ,  Catrina Olivera ,  Raveen Weerasinghe ,  Julian Spagnuolo

IPC: A61K31/4178 ,  A61K31/575 ,  A61K31/345 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/422 ,  A61K38/14 ,  A61K8/49 ,  A61K8/64 ,  A61K8/63 ,  A61Q17/00 ,  A01N47/34 ,  A01N45/00 ,  A01N43/76 ,  A01N43/84 ,  A01N43/08 ,  A01N43/50 ,  A01P1/00 ,  A61P31/04

Abstract: Disclosed herein are antibacterial combinations and compositions that are effective against Gram-negative bacteria. Also disclosed are uses of such combinations and compositions for inhibiting the growth and proliferation of Gram-negative bacteria and/or for killing Gram-negative bacteria and/or for treating a Gram-negative bacterial infection.

公开(公告)号：US10241099B2

公开(公告)日：2019-03-26

申请号：US15125405

申请日：2015-03-19

Applicant: Agency for Science, Technology and Research ,  Massey University

Inventor： Maxim Kiryukhin ,  Anton Sadovoy ,  Vladimir Korzh ,  Cathleen Teh ,  Harjinder Singh ,  Mita Lad

IPC: G01N33/12 ,  G01N21/64 ,  G01N21/80 ,  G01N21/77 ,  G01N31/22

Abstract: The present disclosure relates to a sensor for indicating food quality comprising a semi-permeable film layer, the semi-permeable film layer comprising at least one integrally formed well having at least one sensing element disposed therein; wherein the well is sealed by a second film layer, the semi-permeable film layer being impermeable to said sensing element but is permeable to at least one analyte detectable by said sensing element.

公开(公告)号：US20160231242A1

公开(公告)日：2016-08-11

申请号：US15026866

申请日：2014-10-03

Applicant: MASSEY UNIVERSITY

Inventor： Mack Saraswat ,  John Andrew Harrison ,  Ralph Stefan Grand ,  Frazer Kingsley Noble ,  Lutz Robert Gehlen ,  Matthew Alan Woods ,  Sam Bartho

IPC: G01N21/51

CPC classification number: G01N21/51 ,  G01N21/49 ,  G01N21/5907 ,  G01N2201/0212 ,  G01N2201/0227

Abstract: The present invention relates to optical measurement devices and systems, and methods of using these systems and devices, and more particularly but not exclusively it relates to a system and apparatus adapted to measure optical properties in-situ.

Abstract translation: 本发明涉及光学测量装置和系统以及使用这些系统和装置的方法，更具体地但并非排他地涉及适于原位测量光学特性的系统和装置。