公开(公告)号：US5847148A

公开(公告)日：1998-12-08

申请号：US835599

申请日：1997-04-10

Applicant: Eric J. Jacobsen ,  Mark A. Mitchell ,  Heinrich J. Schostarez ,  Donald E. Harper

Inventor： Eric J. Jacobsen ,  Mark A. Mitchell ,  Heinrich J. Schostarez ,  Donald E. Harper

IPC: C07D285/12 ,  C07D285/135 ,  C07D417/12 ,  C07F7/18 ,  C07D285/125 ,  C07D209/08 ,  C07D241/04 ,  A01N43/82

CPC classification number: C07D285/135 ,  C07D417/12 ,  C07F7/1856

Abstract: The present invention provides novel thiadiazole derivatives represented by formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.

Abstract translation: 本发明提供由式I表示的新型噻二唑衍生物或其药学上可接受的盐，其中本发明的化合物抑制基质金属蛋白酶家族的各种酶，主要是基质溶素，因此可用于治疗基质金属 骨关节炎，类风湿性关节炎，脓毒性关节炎，骨质疏松症，骨质疏松症，肿瘤转移（侵袭和生长），牙周炎，牙龈炎，角膜溃疡，皮肤溃疡，胃溃疡等与结缔组织降解相关的疾病。

公开(公告)号：US5150694A

公开(公告)日：1992-09-29

申请号：US796140

申请日：1991-11-22

Applicant: James H. Currie ,  Richard A. Peden ,  David P. Sczomak ,  Mark A. Mitchell ,  Michael J. Brown

Inventor： James H. Currie ,  Richard A. Peden ,  David P. Sczomak ,  Mark A. Mitchell ,  Michael J. Brown

IPC: F02D41/14 ,  F02B3/06 ,  F02D21/08 ,  F02D41/00 ,  F02M25/07

CPC classification number: F02D41/0052 ,  F02B3/06 ,  F02M26/57 ,  Y02T10/47

Abstract: The air/fuel ratio of the combustion mixture in the cylinders of an engine is sensed and the sensed air/fuel ratio is controlled to a predetermined scheduled air/fuel ratio by controlling the amount of exhaust gases recirculated. When the exhaust gas recirculated is substantially zero, the air/fuel ratio is thereafter closed loop adjusted to a predetermined scheduled minimum air/fuel ratio when the sensed air/fuel ratio is less than the minimum and when the sensed air/fuel ratio is greater than the minimum while the operator command is at a maximum to thereby provide precise fuel limiting at a predetermined fuel limit schedule.

公开(公告)号：US20130068104A1

公开(公告)日：2013-03-21

申请号：US13612655

申请日：2012-09-12

Applicant: Erik P. Brown ,  Mark A. Mitchell ,  Ronald A. Beaulieu

Inventor： Erik P. Brown ,  Mark A. Mitchell ,  Ronald A. Beaulieu

IPC: B01D46/00 ,  F16J15/02

CPC classification number: B01D46/0084 ,  B01D46/0093 ,  F16J15/02 ,  F16J15/065 ,  F16J15/14

Abstract: An equipment component system including an equipment component structure having a first unit and a second unit and an intumescent paint or sealant on said equipment component structure. The intumescent paint or sealant provides sealing or prevents warpage or deformation or separation of a equipment component or sub-component in a fire or at high temperatures. The intumescent paint can shut a gap in a fire or at high temperatures. The intumescent paint can also pen a gap in a fire or at high temperatures so that fluid flow is preferentially directed one route versus another.

Abstract translation: 一种设备部件系统，包括在所述设备部件结构上具有第一单元和第二单元以及膨胀型涂料或密封剂的设备部件结构。 膨胀型涂料或密封剂提供密封或防止设备​​部件或副部件在火灾或高温下的翘曲或变形或分离。 膨胀型油漆可以在火中或高温下封闭间隙。 膨胀型涂料还可以在火中或高温下冲出间隙，使得流体流优先通过一条路线相对于另一条路线。

公开(公告)号：US20130048579A1

公开(公告)日：2013-02-28

申请号：US13598125

申请日：2012-08-29

Applicant: Jeffery J. Haslam ,  Mark A. Mitchell

Inventor： Jeffery J. Haslam ,  Mark A. Mitchell

IPC: B01D29/00 ,  B01D37/00 ,  B82Y30/00

CPC classification number: B01D39/2068 ,  B01D2239/025 ,  B01D2239/0654 ,  B82Y30/00

Abstract: A filter system for filtering a fluid containing particles includes a porous substrate. The porous substrate is made of a porous ceramic material. A filtering material is connected to the porous ceramic substrate. The filtering material includes nanofibers. The fluid travels through the porous ceramic substrate and travels through the filtering material wherein the particles are captured in the porous ceramic substrate and in the filtering material.

Abstract translation: 用于过滤含有颗粒的流体的过滤系统包括多孔基材。 多孔基材由多孔陶瓷材料制成。 过滤材料连接到多孔陶瓷基板。 过滤材料包括纳米纤维。 流体穿过多孔陶瓷基体并且通过过滤材料，其中颗粒被捕获在多孔陶瓷基底和过滤材料中。

公开(公告)号：US5012785A

公开(公告)日：1991-05-07

申请号：US372596

申请日：1989-06-28

Applicant: David L. Long ,  Mark A. Mitchell ,  David P. Sczomak

Inventor： David L. Long ,  Mark A. Mitchell ,  David P. Sczomak

IPC: F02M41/12 ,  F02M41/14 ,  F02M55/00 ,  F02M59/02 ,  F02M59/46

CPC classification number: F02M59/462 ,  F02M41/1405 ,  F02M55/007 ,  Y10T137/2544

Abstract: Fuel delivery valving operatively mounted in an axially extending center bore of a high pressure pump rotor. The valve axially shifts between an open position in which a charge of fuel generated by the pump is transmitted as a pressure wave to a fuel injector nozzle and a closed position in which the pump charging chamber is sealed from the injection line and the injection line is vented to low pressure so that secondary pressure waves reflecting from the injector nozzle will be routed to the low pressure line for dissipation therein rather than rebounding from the delivery valve. This improves engine operation efficiency and eliminates seocndary injection of fuel by the injector nozzle and high hydrocarbon and smoke emissions. One embodiment has a fuel delivery valve operatively mounted in each discharge fitting of a hydraulic head assembly of the fuel injection pump.