公开(公告)号：US06847454B2

公开(公告)日：2005-01-25

申请号：US10020040

申请日：2001-10-18

Applicant: Robert J. Crowley ,  Louis J. Barbato ,  Isaac Ostrovsky ,  Mark D. Modell

Inventor： Robert J. Crowley ,  Louis J. Barbato ,  Isaac Ostrovsky ,  Mark D. Modell

IPC: G01N21/17 ,  A61B5/00 ,  A61B8/00 ,  A61B8/12 ,  G01B9/02 ,  G01N29/06 ,  G01N29/22

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/0095 ,  A61B5/02007 ,  A61B8/12 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02028 ,  G01B9/0203 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N29/06 ,  G01N29/223 ,  G01N2291/02416 ,  G01N2291/02466

Abstract: An imaging system comprises an interferometer and an ultrasound console that processes signals from the interferometer into an image for display. The interferometer may include one or more multi-element photo detectors with a plurality of parallel outputs. A parallel to serial converter is provided between the parallel output of the interferometer and the input of the ultrasound console, to convert the signals provided on the parallel outputs into a serial signal for analysis by the ultrasound console. The interferometer may be selectively coupled to the ultrasound console and the system may further comprise an ultrasound device that may also be selectively coupled to the console, offering a user the option of using either the interferometer or the ultrasound device. The ultrasound console may also include two inputs, one for the interferometer and the other for the ultrasound device. The interferometer and the ultrasound device may both be carried by catheters for insertion into internal body cavities, such as blood vessels. Imaging methods are also disclosed.

Abstract translation: 成像系统包括干涉仪和超声控制台，其将来自干涉仪的信号处理成用于显示的图像。 干涉仪可以包括具有多个并行输出的一个或多个多元素光电检测器。 在干涉仪的并行输出和超声控制台的输入之间提供并行到串行转换器，以将并行输出上提供的信号转换为串行信号，以便由超声控制台进行分析。 所述干涉仪可选择性地耦合到所述超声控制台，并且所述系统还可包括超声装置，所述超声装置还可以选择性地耦合到所述控制台，为使用者提供使用所述干涉仪或所述超声装置的选项。 超声控制台还可以包括两个输入，一个用于干涉仪，另一个用于超声装置。 干涉仪和超声波装置都可以由导管承载以插入诸如血管的内部体腔中。 还公开了成像方法。

公开(公告)号：US20100280321A1

公开(公告)日：2010-11-04

申请号：US12661829

申请日：2010-03-24

Applicant: Mark D. Modell

Inventor： Mark D. Modell

IPC: A61B1/06

CPC classification number: G01B9/02097 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02091 ,  G01J3/45

Abstract: Light is collected from a sample that is to be imaged, such as tissue or the like, and made to undergo self-interference, e.g., on a detector. An imaging system may include a low coherence light source arranged for illuminating the sample, and an interferometer arranged to receive the light collected from the sample and to pass it to a detector. The interferometer includes a beam divider that directs the radiation collected from the sample along two paths, phase-delaying one beam relative to another and then recombining the beams on a detector. A processor may be coordinated with the phase delay and in some embodiments with spatial scanning or detector array addresses, and operates on the signal from the detector to form a tomographic image of the sample illuminated tissue. By constructing an image based upon interference the interferometric signal from of the split and then recombined radiation collected from the sample signal, rather than interference of a source reference and a return signal, the invention is able to image with light naturally emitted by the sample. , or with wavelength-shifted, delayed or induced light signals of different types, allowing new modalities of diagnostic and other imaging of the sample and its structure. A processor generates one or more images of the structure being viewed, and may create images in registry from different (for example, close but separable) wavelengths. Some systems may operate without an illumination source or may apply other stimuli to evoke emission from the sample.

Abstract translation: 从要成像的样品（例如组织等）收集光，并使其经受自干扰，例如在检测器上。 成像系统可以包括布置成照亮样本的低相干光源和布置成接收从样品收集的光并将其传递到检测器的干涉仪。 该干涉仪包括一个光束分离器，其引导从两个路径收集的样本的辐射，相对于另一个相位延迟一个光束，然后在检测器上重新组合光束。 处理器可以与相位延迟协调，并且在一些实施例中与空间扫描或检测器阵列地址协调，并且对来自检测器的信号进行操作以形成样本照射的组织的断层图像。 通过基于干扰构建来自采样信号收集的分离干扰信号的干涉信号，而不是源参考和返回信号的干扰，本发明能够利用样品自然发射的光进行成像。 ，或具有不同类型的波长偏移，延迟或感应光信号，允许样本的诊断和其他成像的新形式及其结构。 处理器生成正在观看的结构的一个或多个图像，并且可以从不同的（例如，接近但可分离的）波长创建注册表中的图像。 一些系统可以在没有照明源的情况下操作，或者可以应用其他刺激来引起来自样品的发射。