公开(公告)号：US20060264395A1

公开(公告)日：2006-11-23

申请号：US10553722

申请日：2004-04-15

Applicant: Rosanne Crooke ,  Mark Graham ,  Kristina Tarbet ,  Kenneth Dobie

Inventor： Rosanne Crooke ,  Mark Graham ,  Kristina Tarbet ,  Kenneth Dobie

IPC: A61K48/00 ,  C07H21/02

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/30 ,  C12N2330/31 ,  C12N2310/3521

Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.

Abstract translation: 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。

公开(公告)号：US20060009410A1

公开(公告)日：2006-01-12

申请号：US11123656

申请日：2005-05-05

Applicant: Rosanne Crooke ,  Mark Graham

Inventor： Rosanne Crooke ,  Mark Graham

IPC: A61K48/00

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/13 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.

Abstract translation: 提供了用于调节参与脂质代谢的基因的表达的方法，其可用于治疗与心血管风险相关的病症。 靶向载脂蛋白B的反义寡核苷酸降低载脂蛋白B mRNA的水平，降低血清胆固醇，并将肥胖动物的肝脏基因表达谱从精子动物转移到肝脏基因表达谱。 还提供了通过载脂蛋白B的反义抑制来改善受试者的心血管风险的方法。还提供了使用靶向载脂蛋白B的反义寡核苷酸调节细胞途径或代谢过程的方法。

公开(公告)号：US20050181376A1

公开(公告)日：2005-08-18

申请号：US10759618

申请日：2004-01-16

Applicant: Rosanne Crooke ,  Mark Graham

Inventor： Rosanne Crooke ,  Mark Graham

IPC: A61K38/00 ,  C12N15/113 ,  A61K48/00 ,  C07H21/02 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of microsomal triglyceride transfer protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding microsomal triglyceride transfer protein. Methods of using these compounds for modulation of microsomal triglyceride transfer protein expression and for treatment of diseases associated with expression of microsomal triglyceride transfer protein are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节微粒体甘油三酯转运蛋白的表达。 组合物包含靶向编码微粒体甘油三酸转移蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节微粒体甘油三酯转移蛋白表达和治疗与微粒体甘油三酯转运蛋白表达有关的疾病的方法。

公开(公告)号：US20050014257A1

公开(公告)日：2005-01-20

申请号：US10858500

申请日：2004-06-01

Applicant: Rosanne Crooke ,  Mark Graham

Inventor： Rosanne Crooke ,  Mark Graham

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N20060101 ,  C12N15/113 ,  C12Q1/68

CPC classification number: C07H21/04 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.

Abstract translation: 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。

公开(公告)号：US06792719B2

公开(公告)日：2004-09-21

申请号：US10024436

申请日：2001-12-18

Applicant: Mark Graham Lawrie ,  Yann Le Gallo ,  Pascal de Vries ,  Klaus B. Wilhelm Blume ,  Charles Berry Hopson ,  Herve Laurandel ,  Simon Blair Dobson ,  Damien Cabanne

Inventor： Mark Graham Lawrie ,  Yann Le Gallo ,  Pascal de Vries ,  Klaus B. Wilhelm Blume ,  Charles Berry Hopson ,  Herve Laurandel ,  Simon Blair Dobson ,  Damien Cabanne

IPC: B60J504

CPC classification number: B60R11/02 ,  B60R13/06 ,  B60R2011/0021 ,  B60R2011/0043

Abstract: A vehicle door includes a window regulator motor and an inner panel. The window regulator motor further includes a connector housing which houses electrical connector terminals. The connector housing is sealed against the inner panel of the vehicle door via a diaphragm seal.

Abstract translation: 车门包括窗调节器马达和内板。 窗户调节器电动机还包括容纳电连接器端子的连接器壳体。 连接器壳体通过隔膜密封件与车门的内板密封。

公开(公告)号：US06465064B1

公开(公告)日：2002-10-15

申请号：US08849582

申请日：1997-08-04

Applicant: Mark Graham Branch

Inventor： Mark Graham Branch

IPC: B29D2320

CPC classification number: C08K7/00 ,  C08K2201/016 ,  Y10T428/1341 ,  Y10T428/1372 ,  Y10T428/1379 ,  Y10T428/1383 ,  Y10T428/139 ,  Y10T428/25 ,  Y10T428/259

Abstract: Compositions having improved gas/vapor barrier qualities are described. The compositions are composed of a substantially non-polar resin and a lamellar filler, the lamellar filler delaminating under high shear, to increase its aspect ratio. Also described are compositions composed of a non-polar thermoplastic resin filled with platelets of talc having an aspect ratio of at least 5; the platelets have an average aspect ratio of between 16-30 and a CIE whiteness index of at least 40.

Abstract translation: 描述了具有改善的气体/蒸汽阻挡性质的组合物。 组合物由基本上非极性的树脂和层状填料组成，层状填料在高剪切下分层，以增加其纵横比。 还描述了由填充有纵横比为至少为5的滑石粉的非极性热塑性树脂组成的组合物; 血小板的平均纵横比在16-30和CIE白度指数之间至少为40。

公开(公告)号：US06300443B1

公开(公告)日：2001-10-09

申请号：US09341583

申请日：1999-09-07

Applicant: David Henry Solomon ,  Simmi Abrol ,  Peter Agapitos Kambouris ,  Mark Graham Looney

Inventor： David Henry Solomon ,  Simmi Abrol ,  Peter Agapitos Kambouris ,  Mark Graham Looney

IPC: C08F200

CPC classification number: A61K47/32 ,  A61K9/06 ,  C08F4/00 ,  C08F112/12 ,  C08F293/005 ,  C08L47/00 ,  C09D7/65

Abstract: A process for preparation of a microgel comprising reacting an alkoxyamine with an unsaturated monomer composition comprising a cross-linking agent comprising at least two double bonds and optionally one or more further monomers selected from monounsaturated monomers and conjugated diene monomers.

Abstract translation: 一种制备微凝胶的方法，包括使烷氧基胺与包含交联剂的不饱和单体组合物反应，所述交联剂包含至少两个双键和任选的一种或多种选自单不饱和单体和共轭二烯单体的其它单体。

公开(公告)号：US09145238B2

公开(公告)日：2015-09-29

申请号：US13491765

申请日：2012-06-08

Applicant: Aldo J. Barreto ,  David K. Mackenzie ,  John Dugan ,  Mark Graham ,  Bryan Keller ,  Thomas B. Remm

Inventor： Aldo J. Barreto ,  David K. Mackenzie ,  John Dugan ,  Mark Graham ,  Bryan Keller ,  Thomas B. Remm

IPC: B65D51/18 ,  A47G19/22 ,  B65D43/12 ,  B65D43/02 ,  B65D47/28 ,  B65D47/32 ,  B65D81/38

CPC classification number: B65D43/12 ,  A47G19/2205 ,  A47G19/2272 ,  B65D43/022 ,  B65D47/286 ,  B65D47/32 ,  B65D81/3869 ,  B65D2205/02 ,  B65D2543/00046 ,  B65D2543/00092 ,  B65D2543/00296 ,  B65D2543/00314 ,  B65D2543/00518 ,  B65D2543/00546 ,  B65D2543/00564

Abstract: A beverage container having a slidably openable lid assembly is disclosed. The lid assembly basically comprises a base member and a cover member. The base member includes a wall portion releasably securing the lid assembly to the container and an opening in fluid communication with a beverage holding chamber in the container. The cover member is slidably coupled to the base member to slide from a closed position to an open position and vice versa. When the cover member is in the closed position it isolates the opening and the contiguous portions of the base member from the ambient surroundings. When the cover member is in the open position it exposes the opening to enable a user to drink the beverage via the opening. The cover includes an elastomeric member arranged to engage and seal the opening in the base member when the cover member is in the closed position.

Abstract translation: 公开了一种具有可滑动打开的盖组件的饮料容器。 盖组件基本上包括基部构件和盖构件。 底座部件包括壁部分，该壁部分将盖组件可释放地固定到容器上，开口与容器中的饮料容纳室流体连通。 盖构件可滑动地联接到基座构件以从关闭位置滑动到打开位置，反之亦然。 当盖构件处于关闭位置时，其将基部构件的开口和邻接部分与周围环境隔离。 当盖构件处于打开位置时，它暴露开口以使使用者能够经由开口饮用饮料。 所述盖包括弹性体构件，所述弹性构件布置成当所述盖构件处于所述关闭位置时接合并密封所述基座构件中的所述开口。

公开(公告)号：US08951123B2

公开(公告)日：2015-02-10

申请号：US12528920

申请日：2008-03-03

Applicant: Scott Christopher Waugaman ,  Ronald Jonas Festejo ,  Mitchell Robert Jay Goodwin ,  Mark Anderson ,  Mark Graham Swinhoe

Inventor： Scott Christopher Waugaman ,  Ronald Jonas Festejo ,  Mitchell Robert Jay Goodwin ,  Mark Anderson ,  Mark Graham Swinhoe

IPC: A63F13/12 ,  A63F13/30 ,  A63F13/00

CPC classification number: A63F13/31 ,  A63F13/005 ,  A63F13/12 ,  A63F13/335 ,  A63F13/35 ,  A63F13/5375 ,  A63F2300/407 ,  A63F2300/408 ,  A63F2300/50 ,  A63F2300/534 ,  A63F2300/8082

Abstract: An entertainment device comprises a display generator arranged to generate for display a representation of an on-line virtual environment, that on-line virtual environment being able to host interactions between a user of the entertainment device and other users of one or more remote entertainment devices, a network communications arrangement operable to receive data representative of the actions of the other users within the on-line virtual environment and to receive data indicative of any supplementary data files interoperable with the on-line virtual environment that are associated with one or more remote entertainment devices of one or more of the other users, a data file searcher operable to search the entertainment device for any supplementary data files indicated by the received data, a data file acquisition arrangement operable to acquire, from a networked device, a copy of a supplementary data file indicated by the received data that was not found on the entertainment device, and a data file integrator operable to incorporate relevant elements of the or each supplementary data file into the representation of the on-line virtual environment.

Abstract translation: 一种娱乐设备包括：显示器，其被布置为生成用于显示在线虚拟环境的表示，所述在线虚拟环境能够承载娱乐设备的用户与一个或多个远程娱乐设备的其他用户之间的交互 网络通信装置，其可操作以接收表示在线虚拟环境中的其他用户的动作的数据，并且接收指示与在线虚拟环境可互操作的任何补充数据文件的数据，所述补充数据文件与一个或多个远程 一个或多个其他用户的娱乐设备，数据文件搜索器，可操作以搜索娱乐设备以获得由接收到的数据指示的任何补充数据文件;数据文件获取装置，可操作以从联网设备获取一个 在娱乐设备上没有找到的接收到的数据指示的辅助数据文件， 以及数据文件集成器，其可操作以将该或每个补充数据文件的相关元素合并到在线虚拟环境的表示中。

公开(公告)号：US08784163B2

公开(公告)日：2014-07-22

申请号：US13061619

申请日：2009-08-20

Applicant: Mark Graham Rogers

Inventor： Mark Graham Rogers

IPC: B24B23/00

CPC classification number: B24D9/04

Abstract: Sanding apparatus comprises a rigid non-expanding cylindrical sanding drum (1) formed with splines on its outer surface (4) and a separate cylindrical cover (2) formed of elastomeric material fitted removably onto the drum and formed with splines on its inner surface (8) adapted to engage with the outer surface of the drum so as to be driven in rotation therewith. An abrasive tube (3) fits over the cover (2) and is gripped by the cover which expands radially when the apparatus is in operation.

Abstract translation: 打磨装置包括在其外表面（4）上形成有花键的刚性非扩展圆柱形砂磨鼓（1）和由可拆卸地装配到滚筒上并由其内表面上的花键形成的弹性体材料形成的单独的圆柱形盖（2） 8）适于与滚筒的外表面接合以便与其一起旋转驱动。 研磨管（3）装配在盖（2）上方，并且在装置运行时被盖子径向扩张。