公开(公告)号：US06334947B1

公开(公告)日：2002-01-01

申请号：US08793438

申请日：1997-05-06

Applicant: Mark De Boer ,  Eelco Titus Carel Vogt ,  Robertus Gerardus Leliveld ,  John Wilhelm Geus ,  Roland Jacobus Martinus Josephus Vogels

Inventor： Mark De Boer ,  Eelco Titus Carel Vogt ,  Robertus Gerardus Leliveld ,  John Wilhelm Geus ,  Roland Jacobus Martinus Josephus Vogels

IPC: C10G4712

CPC classification number: B01J21/16 ,  B01J23/40 ,  B01J23/85

Abstract: The invention pertains to a catalyst at least comprising a hydrogenation metal component and a swelling synthetic clay consisting of elemental clay platelets, with the average diameter of the clay platelets not exceeding 1 micron and the average degree of stacking of the clay platelets not exceeding 20 platelets per stack. The catalyst is especially suitable for the hydroprocessing of hydrocarbon feeds, the term “hydroprocessing” encompassing all processes in which a hydrocarbon feed is treated with hydrogen. The clays which are suitable for use in the catalyst according to the invention may be prepared as described in Netherlands patent application No. 9401433.

Abstract translation: 本发明涉及至少包含氢化金属组分和由元素粘土片晶组成的溶胀合成粘土的催化剂，粘土片的平均直径不超过1微米，粘土片状物的平均层叠度不超过20个血小板 每堆 催化剂特别适用于烃进料的加氢处理，术语“加氢处理”包括用氢气处理烃进料的所有方法。 适用于根据本发明的催化剂的粘土可按照荷兰专利申请号9401433中所述制备。

公开(公告)号：US6030915A

公开(公告)日：2000-02-29

申请号：US814145

申请日：1997-03-10

Applicant: Mark de Boer

Inventor： Mark de Boer

IPC: B01J23/94 ,  B01J37/00 ,  B01J38/00 ,  B01J38/12 ,  B01J20/34 ,  B01J23/16

CPC classification number: C10G45/08 ,  B01J23/94 ,  B01J37/0036 ,  B01J38/00 ,  B01J38/12 ,  C10G49/02 ,  C10G49/16

Abstract: The present invention relates to a process for preparing a hydroprocessing catalyst comprising the steps of subjecting a spent hydroprocessing catalyst comprising carbonaceous and sulphurous deposits to a thermal treatment to remove at least part of said deposits, grinding the thus obtained spent catalyst, mixing the ground hydroprocessing catalyst with at least one additive, and shaping the mixture of additive and ground hydroprocessing catalyst to form particles of a new hydroprocessing catalyst, with the spent hydroprocessing catalyst being subjected to a high-temperature calcination step carried out at a temperature in the range of 550-1000.degree. C. for a period sufficient to increase the MPD of the spent catalyst by at least 0.5 nm.The process according to the invention is particularly suitable for preparing ebullated bed catalysts from spent hydroprocessing catalysts.

Abstract translation: 本发明涉及一种制备加氢处理催化剂的方法，包括以下步骤：将含有碳质和硫酸沉积物的废加氢处理催化剂进行热处理以除去至少部分所述沉积物，研磨由此获得的废催化剂，混合地下加氢处理 具有至少一种添加剂的催化剂，并且对添加剂和研磨加氢处理催化剂的混合物进行成型以形成新的加氢处理催化剂的颗粒，将废加氢处理催化剂进行在550℃范围内的温度下进行的高温煅烧步骤 -1000℃，足以使废催化剂的MPD增加至少0.5nm的时间。 根据本发明的方法特别适用于从废加氢处理催化剂制备沸腾床催化剂。

公开(公告)号：US5874082A

公开(公告)日：1999-02-23

申请号：US606293

申请日：1996-02-23

Applicant: Mark de Boer

Inventor： Mark de Boer

IPC: A61K38/00 ,  A61K39/395 ,  A61P37/06 ,  A61P37/08 ,  C07K14/705 ,  C07K16/28

CPC classification number: A61K39/395 ,  C07K14/705 ,  C07K14/70532 ,  C07K14/70578 ,  C07K16/2827 ,  C07K16/2878 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K38/00 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

Abstract: Methods for preventing or treating an antibody-mediated disease in patient are presented, the methods comprising administration of a humanized monoclonal antibody or fragment thereof that is capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Humanized monoclonal antibodies and fragments useful in these methods are also presented.

Abstract translation: 提供了用于预防或治疗患者抗体介导的疾病的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的人源化单克隆抗体或其片段，其中所述结合 的CD40抗原的抗体阻止B细胞的生长或分化。 还提出了在这些方法中有用的人源化单克隆抗体和片段。

公开(公告)号：US5869050A

公开(公告)日：1999-02-09

申请号：US15147

申请日：1993-02-09

Applicant: Mark de Boer ,  Leah B. Conroy

Inventor： Mark de Boer ,  Leah B. Conroy

IPC: C12N15/02 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/573 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P1/16 ,  A61P7/06 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/06 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531

CPC classification number: C07K16/2878 ,  A61K39/395 ,  C07K14/705 ,  C07K14/70532 ,  C07K14/70578 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

Abstract: Methods for causing T cell anergy, treating allograft transplant rejection, treating graft versus host disease, and preventing or treating rheumatoid arthritis are presented, the methods comprising co-administration of a molecule that binds to the B7 antigen and an immunosuppressive agent.

Abstract translation: 提出了引起T细胞无反应性的方法，治疗同种异体移植排斥反应，治疗移植物抗宿主病以及预防或治疗类风湿性关节炎的方法，所述方法包括共同施用结合B7抗原的分子和免疫抑制剂。

公开(公告)号：US5677165A

公开(公告)日：1997-10-14

申请号：US70158

申请日：1993-05-28

Applicant: Mark de Boer ,  Leah B. Conroy

Inventor： Mark de Boer ,  Leah B. Conroy

IPC: C12N15/02 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/573 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P1/16 ,  A61P7/06 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/06 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  C12N5/12

CPC classification number: C07K16/2878 ,  A61K39/395 ,  C07K14/705 ,  C07K14/70532 ,  C07K14/70578 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

Abstract: Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.

Abstract translation: 提供了用于预防或治疗患者中抗体介导的死亡酶的方法，所述方法包括施用能够结合位于人B细胞表面上的人CD40抗原的单克隆抗体，其中所述抗体与 CD40抗原阻止B细胞的生长或分化。 还提出了可用于这些方法的单克隆抗体和与这种单克隆抗体免疫反应的表位。

公开(公告)号：US5397703A

公开(公告)日：1995-03-14

申请号：US910222

申请日：1992-07-09

Applicant: Mark De Boer ,  Leah B. Conroy

Inventor： Mark De Boer ,  Leah B. Conroy

IPC: C12N15/02 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/573 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P1/16 ,  A61P7/06 ,  A61P29/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/06 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/395 ,  C07K14/705 ,  C07K14/70532 ,  C07K14/70578 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

Abstract: The present invention relates to a method of generating antibodies directed against cell surface antigens. The method uses as immunogen recombinant insect cells into which have been transfected coding regions for a molecule containing a cell surface antigen. Host animals are immunized with these transfected insect cells to generate antibodies directed against the cell surface antigen. Antibody-producing cells from the host animal are used to generate monoclonal antibody-producing hybridoma cells. Sera and hybridoma supernatants can be tested for the presence of antibodies against the surface antigen, using the transfected cells in a screening assay.

Abstract translation: 本发明涉及产生针对细胞表面抗原的抗体的方法。 该方法用作已经转染了含有细胞表面抗原的分子的编码区的免疫原重组昆虫细胞。 宿主动物用这些转染的昆虫细胞免疫以产生针对细胞表面抗原的抗体。 使用来自宿主动物的产生抗体的细胞产生产生产生单克隆抗体的杂交瘤细胞。 可以使用筛选测定中的转染细胞，测试血清和杂交瘤上清液中抗表面抗原的抗体的存在。

公开(公告)号：US07547438B2

公开(公告)日：2009-06-16

申请号：US11613409

申请日：2006-12-20

Applicant: David Thomas ,  Mark De Boer ,  Pieter C. J. M. Res ,  Peter J. Simone

Inventor： David Thomas ,  Mark De Boer ,  Pieter C. J. M. Res ,  Peter J. Simone

IPC: A61K39/395 ,  C07K16/28 ,  C12N5/12

CPC classification number: A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

Abstract translation: 公开了可以结合并刺激专业和非专业人抗原呈递细胞（“APC”）的激动剂抗CD40分子，包括单克隆抗体，增强CD40L对CD40阳性细胞的刺激作用和/或诱导表型成熟 的单核细胞来源的树突状细胞。 提供了几种这样的单克隆抗体，并且生产它们的细胞系已经保藏在美国典型培养物保藏中心。

公开(公告)号：US20070009517A1

公开(公告)日：2007-01-11

申请号：US10569390

申请日：2004-08-25

Applicant: Mark De Boer ,  Louis Boon

Inventor： Mark De Boer ,  Louis Boon

IPC: A61K39/395 ,  A61K38/13 ,  A61K31/573 ,  A61K31/5377 ,  A61K31/522 ,  A61K31/4745

CPC classification number: C07K16/2878 ,  A61K31/00 ,  A61K38/00 ,  A61K38/13 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/2827 ,  C07K2317/24 ,  A61K2300/00

Abstract: Methods for inducing tolerance to a transplant in a subject are disclosed. The methods comprise administering multiple doses of a therapeutically effective amount of a CD40 antagonist alone or in combination with a CD86 antagonist, wherein the first dose of the antagonist is given before or at the time of transplantation; and administering multiple doses of a therapeutically effective amount of an immunosuppressive drug, wherein the first dose of the immunosuppressive drug is given at least several days after transplantation.

Abstract translation: 公开了诱导受试者移植耐受性的方法。 所述方法包括单独施用多个剂量的治疗有效量的CD40拮抗剂或与CD86拮抗剂组合施用，其中所述拮抗剂的第一剂量在移植前或移植时给予; 以及施用多剂量的治疗有效量的免疫抑制药物，其中在移植后至少几天给予免疫抑制药物的第一剂量。

公开(公告)号：US06127299A

公开(公告)日：2000-10-03

申请号：US734986

申请日：1996-10-22

Applicant: Mark de Boer ,  Johannes Wilhelmus Maria Sonnemans ,  Pankaj Himatlal Desai ,  Jaap Enters

Inventor： Mark de Boer ,  Johannes Wilhelmus Maria Sonnemans ,  Pankaj Himatlal Desai ,  Jaap Enters

IPC: B01J23/652 ,  B01J23/85 ,  B01J23/88 ,  B01J23/94 ,  B01J27/186 ,  B01J35/10 ,  B01J37/00 ,  B01J38/00 ,  B01J38/02 ,  B01J38/04 ,  B01J38/12 ,  C10G45/08 ,  C10G49/02 ,  C10G49/04 ,  B01J23/92

CPC classification number: C10G49/04 ,  B01J23/85 ,  B01J35/023 ,  B01J35/026 ,  B01J35/1038 ,  B01J35/1047 ,  B01J35/1061 ,  B01J35/1085 ,  B01J35/109 ,  B01J37/0009 ,  B01J37/0036 ,  B01J38/00 ,  B01J38/04 ,  B01J38/12 ,  C10G49/02

Abstract: The present invention relates to a process for preparing a catalyst suitable for the hydroprocessing of heavy hydrocarbon feeds, which process comprises the steps of(i) if necessary removing carbonaceous and sulphurous deposits from waste catalyst by subjecting the waste catalyst to a thermal treatment,(ii) grinding the waste catalyst obtained in step (i),(iii) mixing the ground material obtained in step (ii) with a binder and, optionally, additives, and(iv) shaping the mixture to form a new catalyst,wherein the loss on ignition of the catalyst composition mixture at any point in the steps (ii), (iii), and (iv) is not higher than 70%.The process according to the invention is suitable, int. al., for the production of ebullated bed catalysts. In that case, it is envisaged to incorporate a macroporous additive into the catalyst composition. Spent hydroprocessing catalyst which has been used for hydroprocessing light hydrocarbon feedstocks is particularly suitable for use in the process according to the invention.

Abstract translation: 本发明涉及一种制备适用于重烃进料加氢处理的催化剂的方法，该方法包括以下步骤：（i）如果需要，通过对废催化剂进行热处理从废催化剂中除去碳质和硫化物沉积物（ ii）研磨步骤（i）中获得的废催化剂，（iii）将步骤（ii）中获得的研磨材料与粘合剂和任选的添加剂混合，和（iv）使混合物成形以形成新的催化剂，其中 在步骤（ii），（iii）和（iv）中的任何一点，催化剂组合物混合物的灼烧失重不高于70％。 根据本发明的方法是合适的， 用于生产沸腾床催化剂。 在这种情况下，设想在催化剂组合物中加入大孔添加剂。 已经用于加氢处理轻烃原料的废加氢处理催化剂特别适用于本发明的方法。

公开(公告)号：US20090311268A1

公开(公告)日：2009-12-17

申请号：US12420481

申请日：2009-04-08

Applicant: David Thomas ,  Mark de Boer ,  Pieter C.J.M. Res ,  Peter J. Simons

Inventor： David Thomas ,  Mark de Boer ,  Pieter C.J.M. Res ,  Peter J. Simons

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07H21/04 ,  C12N5/10

CPC classification number: A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

Abstract: Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

Abstract translation: 公开了可以结合并刺激专业和非专业人抗原呈递细胞（“APC”）的激动剂抗CD40分子，包括单克隆抗体，增强CD40L对CD40阳性细胞的刺激作用和/或诱导表型成熟 的单核细胞来源的树突状细胞。 提供了几种这样的单克隆抗体，并且生产它们的细胞系已经保藏在美国典型培养物保藏中心。