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    Antibodies to human ErbB4
    17.
    发明授权
    Antibodies to human ErbB4 有权
    人ErbB4抗体

    公开(公告)号：US07332579B2

    公开(公告)日：2008-02-19

    申请号：US10362380

    申请日：2001-08-29

    申请人： Mary E. Gerritsen ,  Mark X. Sliwkowski

    发明人： Mary E. Gerritsen ,  Mark X. Sliwkowski

    IPC分类号： C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C12P21/08

    CPC分类号： C07K14/82 ,  A61K38/00 ,  C07K14/4756 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/5061

    摘要： The present invention concerns isolated antibodies that specifically bind to the human ErbB4 of SEQ ID NO:2, as well as humanized antibodies, human antibodies and antibody fragments, as well as bispecific antibodies capable of binding both the human ErbB4 of SEQ ID NO:2 and ErbB3. The invention further concerns antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 with a Kd less than 100 nM, antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 and which reduces heregulin binding thereto, and antibodies which specifically bind to human ErbB4 of SEQ ID NO: 2 and which reduce heregulin-induced tyrosine phosphorylation thereof.

    摘要翻译： 本发明涉及与SEQ ID NO：2的人ErbB4以及人源化抗体，人抗体和抗体片段特异性结合的分离的抗体，以及能够结合SEQ ID NO：2的人ErbB4两者的双特异性抗体 和ErbB3。 本发明还涉及以小于100nM的Kd特异性结合SEQ ID NO：2的人ErbB4的抗体，特异性结合SEQ ID NO：2的人ErbB4的抗体，并且其特异性结合的抗体 与SEQ ID NO：2的人ErbB4结合，并且其降低其胰腺素诱导的酪氨酸磷酸化。