利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.046 秒)

    Novel Polypeptide and the Use Thereof
    12.
    发明申请
    Novel Polypeptide and the Use Thereof 有权
    新型多肽及其用途

    公开(公告)号：US20080124335A1

    公开(公告)日：2008-05-29

    申请号：US11793760

    申请日：2005-12-22

    申请人： Kenji Kangawa ,  Kenji Mori ,  Mikiya Miyazato ,  Masayasu Kojima

    发明人： Kenji Kangawa ,  Kenji Mori ,  Mikiya Miyazato ,  Masayasu Kojima

    IPC分类号： A61K39/395 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07H21/00 ,  A61P1/00 ,  A01K67/00 ,  G01N33/00 ,  A61K38/00 ,  A61K31/70 ,  C07K16/18

    CPC分类号： G01N33/9406 ,  A01K2217/05 ,  A01K2227/10 ,  A61K38/17 ,  C07K14/47 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/046 ,  G01N2800/306 ,  G01N2800/362 ,  G01N2800/367

    摘要： The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, its amide, or a salt thereof can be used as an agent for preventing/treating hypotension; an agent for preventing/treating obesity, hyperphagia, etc.; an agent for preventing/treating lethargy, time-zone change syndrome (jet lag), etc.; an agent for preventing/treating sterility, etc. A compound or its salt that promotes the activity of a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, its partial peptide, or a salt thereof is useful as an agent for preventing/treating, e.g., menopausal symptoms or hyperthyroidism. A compound or its salt that inhibits the activity of said polypeptide is useful as an agent for preventing/treating, e.g., sterility or hypothyroidism.

    摘要翻译： 本发明提供了多种有用的多肽。 特别地，可以使用包含与SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽，其酰胺或其盐 作为预防/治疗低血压的药剂; 用于预防/治疗肥胖症，食欲过多等的药剂; 预防/治疗嗜睡，时区变化综合征（时差）等的药剂; 用于预防/治疗不育症的药剂等。一种促进包含与SEQ ID NO：7至12和37中任一项所示的氨基酸序列相同或基本上相同的氨基酸序列的多肽的活性的化合物或其盐 至42，其部分肽或其盐可用作预防/治疗例如绝经症状或甲状腺功能亢进的药剂。 抑制所述多肽的活性的化合物或其盐可用作预防/治疗例如不育或甲状腺功能减退的药剂。

    Method of Hydraulic bulging and shaft pressing profile element pipe to make hydraulically bulged product
    13.
    发明申请
    Method of Hydraulic bulging and shaft pressing profile element pipe to make hydraulically bulged product 审中-公开
    液压膨胀方法和轴压型材元件管制作液压膨胀产品

    公开(公告)号：US20070234771A1

    公开(公告)日：2007-10-11

    申请号：US11806531

    申请日：2007-06-01

    申请人： Atsushi Tomizawa ,  Masayasu Kojima

    发明人： Atsushi Tomizawa ,  Masayasu Kojima

    IPC分类号： B21D22/00

    CPC分类号： B21D26/033 ,  B21D26/045

    摘要： A profile element pipe for hydraulic bulging of the present invention has a peripheral length with an outer diameter gradually increasing or decreasing from one axial side toward the other thereof and has a parallel part formed on at least one end thereof. According to a bulging device and a bulging method using this profile element pipe, for example, even when a profile steel pipe having a cross sectional shape varying in the axial direction as in a tapered pipe is hydraulically bulged, a bulging in which an internal pressure loading and an shaft pressing are combined with each other can be performed to provide a larger expansion ratio than a conventional case and a joining and socket connection thereof to the other part can also be easily performed.

    摘要翻译： 本发明的液压膨胀用轮廓元件管具有从一个轴向侧朝向另一个的外径逐渐增大或减小的圆周长度，并且在其至少一端形成有平行部。 根据使用该型材元件管的凸起装置和膨胀方法，例如即使在锥形管中具有沿轴向方向变化的截面形状的型材钢管是液压膨胀的，也可以是膨胀，其中内压 可以进行加载和轴压相结合以提供比常规壳体更大的膨胀比，并且也可以容易地进行与另一部分的接合和插座连接。

    Method and apparatus for hydroforming metallic tube
    14.
    发明授权
    Method and apparatus for hydroforming metallic tube 有权
    液压金属管的方法和装置

    公开(公告)号：US06237382B1

    公开(公告)日：2001-05-29

    申请号：US09542292

    申请日：2000-04-04

    申请人： Masayasu Kojima ,  Saburo Inoue

    发明人： Masayasu Kojima ,  Saburo Inoue

    IPC分类号： B21D3908

    CPC分类号： B21D22/025 ,  B21D26/033 ,  B21D26/047 ,  Y10T29/49805

    摘要： A method for hydroforming a metallic tube comprising primary hydroforming and secondary hydroforming, wherein in the primary hydroforming step, the metallic tube is formed such that a circumferential length of an expanded portion of the primary-hydroformed tube as measured at a wall center region of the expanded portion becomes substantially equal to or slightly shorter than a circumferential length of an expanded portion of a product as measured at a wall center region of the expanded portion, and in the secondary hydroforming step, movable forming plates incorporated in the dies press the expanded portion formed through primary hydroforming so as to finish the cross-sectional profile of the expanded portion into that of the expanded portion of the product, and said primary hydroforming and secondary hydroforming are continuously performed within the dies. Also disclosed is an apparatus for performing the hydroformation method. According to the method of the present invention, high liquid pressure is not required, and reduction in wall thickness and shape defects can be prevented.

    摘要翻译： 一种用于液压成形金属管的方法，所述金属管包括主液压成形和二次液压成形，其中在所述主液压成形步骤中，所述金属管形成为使得在所述主液压成形步骤的壁中心区域处测量的所述主液压成型管的扩展部分的周长 膨胀部分变得基本上等于或稍短于在膨胀部分的壁中心区域测量的产品的膨胀部分的周向长度，并且在次级液压成形步骤中，结合到模具中的可移动成形板将膨胀部分 通过主液压成型形成，以便将膨胀部分的横截面轮廓完成到产品的膨胀部分的横截面轮廓，并且在模具内连续执行所述主液压成形和二次液压成形。 还公开了一种用于执行加氢信息方法的装置。 根据本发明的方法，不需要高液压，可以防止壁厚和形状缺陷的减少。

    IC package heat sink fin
    15.
    发明授权
    IC package heat sink fin 失效
    IC封装散热片

    公开(公告)号：US5455382A

    公开(公告)日：1995-10-03

    申请号：US335952

    申请日：1994-11-03

    申请人： Masayasu Kojima ,  Chihiro Hayashi

    发明人： Masayasu Kojima ,  Chihiro Hayashi

    IPC分类号： H01L21/48 ,  H01L23/367 ,  H01L23/373

    CPC分类号： H01L21/4878 ,  H01L23/3677 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2924/16152

    摘要： A fin assembly for use as a heat sink and production thereof are disclosed. The fin assembly comprises a plurality of heat dissipating plates formed by means of a multi-wire saw, and the heat dissipating plates each has a thickness t of no more than 1 mm and being spaced apart by a gap g of no more than 1.5 mm the heat dissipating plates or pins having a height h, wherein the ratio h/t is not less than 20 and the ratio h/g is not less than 15 in one embodiment and 19 in another embodiment of the invention.

    摘要翻译： 公开了一种用作散热器的翅片组件及其制造方法。 翅片组件包括通过多线锯形成的多个散热板，并且散热板各自具有不大于1mm的厚度t并且间隔开不大于1.5mm的间隙g 具有高度h的散热板或销，其中在一个实施例中，比率h / t不小于20，比率h / g不小于15，在本发明的另一个实施例中为19。

    Method and apparatus for hydroforming metallic tube
    19.
    发明授权
    Method and apparatus for hydroforming metallic tube 失效
    液压金属管的方法和装置

    公开(公告)号：US6105409A

    公开(公告)日：2000-08-22

    申请号：US119963

    申请日：1998-07-21

    申请人： Masayasu Kojima ,  Saburo Inoue

    发明人： Masayasu Kojima ,  Saburo Inoue

    IPC分类号： B21D26/033 ,  B21D26/041 ,  B21D26/043 ,  B21D26/047 ,  B21D39/08 ,  B21D26/02

    CPC分类号： B21D37/02 ,  B21D26/047 ,  Y10T29/49805

    摘要： A method for hydroforming a metallic tube comprising primary hydroforming and secondary hydroforming, wherein in the primary hydroforming step, the metallic tube is formed such that a circumferential length of an expanded portion of the primary-hydroformed tube as measured at a wall center region of the expanded portion becomes substantially equal to or slightly shorter than a circumferential length of an expanded portion of a product as measured at a wall center region of the expanded portion, and in the secondary hydroforming step, movable pads incorporated in the dies press the expanded portion formed through primary hydroforming so as to finish the cross-sectional profile of the expanded portion into that of the expanded portion of the product, and said primary hydroforming and secondary hydroforming are continuously performed within the dies. Also disclosed is an apparatus for performing the hydroformation method. According to the method of the present invention, high liquid pressure is not required, and reduction in wall thickness and shape defects can be revented.

    摘要翻译： 一种用于液压成形金属管的方法，所述金属管包括主液压成形和二次液压成形，其中在所述主液压成形步骤中，所述金属管形成为使得在所述主液压成形步骤的壁中心区域处测量的所述主液压成型管的扩展部分的周长 膨胀部分变得基本上等于或略短于在膨胀部分的壁中心区域测量的产品的膨胀部分的周向长度，并且在次级液压成形步骤中，结合到模具中的可移动垫压制形成的膨胀部分 通过主液压成形，以将扩展部分的横截面轮廓完成到产品的膨胀部分的横截面轮廓，并且在模具内连续执行所述主液压成形和二次液压成形。 还公开了一种用于执行加氢信息方法的装置。 根据本发明的方法，不需要高液体压力，可以减少壁厚和形状缺陷。

    C-terminal .alpha.-amidating enzyme and process for production thereof
    20.
    发明授权
    C-terminal .alpha.-amidating enzyme and process for production thereof 失效
    C-末端α-酰胺化酶及其制备方法

    公开(公告)号：US5360727A

    公开(公告)日：1994-11-01

    申请号：US921600

    申请日：1992-08-03

    申请人： Hisayuki Matsuo ,  Kensaku Mizuno ,  Masayasu Kojima

    发明人： Hisayuki Matsuo ,  Kensaku Mizuno ,  Masayasu Kojima

    IPC分类号： C12N9/80 ,  C12N9/02 ,  C12N9/00 ,  C12P21/00

    CPC分类号： C12N9/0071 ,  C12Y114/17003

    摘要： The invention relates to a C-terminal .alpha.-amidating enzyme of porcine origin having the following properties: (1) the action is on a peptide or protein represented by the formula:X-R-Gly,wherein Gly represents a C-terminal glycine residue, R represents an amino acid residue to be .alpha.-amidated, and X represents a remaining portion of the peptide or protein to convert it to a peptide or protein represented by the formula:X-R-NH.sub.2,wherein R-NH.sub.2 represents a C-terminal .alpha.-amidated amino acid residue and X represents a remaining portion of the peptide or protein; (2) the optimal pH is 6.5 to 8.5; (3) the molecular weight is about 92,000 as determined by SDS-polyacrylamide gel electrophoresis; and (4) it contains the following peptide fragment:. . . Glu-Ala-Pro-Leu-Leu-Ile-Leu-Gly . . . .Further, the invention relates to a process for the production of the C-terminal .alpha.-amidating enzyme comprising the steps of extracting and purifying the enzyme from porcine atrium cordis exhibiting the enzyme activity.

    摘要翻译： 本发明涉及具有以下性质的猪来源的C-末端α-酰胺化酶：（1）作用是由下式表示的肽或蛋白：XR-Gly，其中Gly表示C-末端甘氨酸残基， R表示待酰胺化的氨基酸残基，X表示肽或蛋白质的剩余部分，以将其转化为由式XR-NH 2表示的肽或蛋白质，其中R-NH 2表示C末端α 酰胺化氨基酸残基，X表示肽或蛋白质的剩余部分; （2）最适pH为6.5〜8.5; （3）通过SDS-聚丙烯酰胺凝胶电泳测定分子量约为92,000; 和（4）它含有以下肽片段：。 。 。 Glu-Ala-Pro-Leu-Leu-Ile-Leu-Gly。 。 。 。 此外，本发明涉及一种生产C-末端α-酰胺化酶的方法，其包括从显示酶活性的猪心室提取和纯化酶的步骤。