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公开(公告)号:US07229798B2
公开(公告)日:2007-06-12
申请号:US10332834
申请日:2001-07-05
Applicant: Paul R. August , Pamela J. Keagle , Henry Long , Anna Wiencis Montmayeur , Katherine Call , Michael Draper
Inventor: Paul R. August , Pamela J. Keagle , Henry Long , Anna Wiencis Montmayeur , Katherine Call , Michael Draper
CPC classification number: C12Q1/6806 , C12Q1/6869 , C12Q2525/155 , C12Q2537/143 , C12Q2531/113
Abstract: The present invention relates to an automated method of transposon-mediated multiplex sequencing of DNA fragments inserted into a vector. It relates more particularity to an increased efficiency in such automated methods, where the increased efficiency is obtained by screening out before the sequencing those constructs in which the transposon inserted into the vector sequence. This prevents a waste of time and resources in performing reactions sequencing the vector instead of the DNA fragments of interest.
Abstract translation: 本发明涉及插入到载体中的DNA片段的转座子介导的多重测序的自动化方法。 它更具体地涉及这种自动化方法中提高的效率,其中通过在将转座子插入到载体序列中的那些构建体进行测序之前筛选来获得提高的效率。 这样可以避免在进行反应测序时反而对感兴趣的DNA片段进行测序而浪费时间和资源。
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12.
公开(公告)号:US20060194773A1
公开(公告)日:2006-08-31
申请号:US10996119
申请日:2004-11-22
Applicant: Stuart Levy , Michael Draper , Mark Nelson , Graham Jones
Inventor: Stuart Levy , Michael Draper , Mark Nelson , Graham Jones
IPC: A61K31/65
CPC classification number: C07C237/26 , A61K31/65 , A61K45/06 , Y02A50/411
Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
Abstract translation: 描述了用具有目标治疗活性的四环素化合物治疗疾病的方法和化合物。
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公开(公告)号:US20050279478A1
公开(公告)日:2005-12-22
申请号:US11148624
申请日:2005-06-09
Applicant: Michael Draper , John James
Inventor: Michael Draper , John James
IPC: D21G3/00
Abstract: A planar element for use in a papermaking machine comprising a synthetic construction incorporating nanoparticles in a polymeric resin matrix.
Abstract translation: 一种用于造纸机的平面元件,其包括在聚合物树脂基质中掺入纳米颗粒的合成结构。
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公开(公告)号:US06841546B2
公开(公告)日:2005-01-11
申请号:US10097457
申请日:2002-03-14
Applicant: Michael Draper , Mark L. Nelson
Inventor: Michael Draper , Mark L. Nelson
CPC classification number: A61K31/65
Abstract: Methods and compositions for treating fungal associated disorders in subjects are discussed.
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15.PLANAR ELEMENTS INCORPORATING BASALT FIBERS FOR USE IN PAPERMAKING APPARATUS 审中-公开
Title translation: 用于造纸设备中使用的基板纤维的平面元件公开(公告)号:US20070052134A1
公开(公告)日:2007-03-08
申请号:US11469912
申请日:2006-09-05
Applicant: Michael Draper , John James , John Rotherham
Inventor: Michael Draper , John James , John Rotherham
CPC classification number: D21G3/005 , B29C70/12 , B29C70/228 , B29K2709/00
Abstract: A planar element is disclosed for use in a papermaking machine. The planar element includes a composite of multiple layers, with at least some of the layers including resin impregnated fabrics including basalt fibers.
Abstract translation: 公开了一种在造纸机中使用的平面元件。 平面元件包括多层复合材料,其中至少一些层包括包括玄武岩纤维在内的树脂浸渍织物。
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16.Papermaking belts and industrial textiles with enhanced surface properties 失效
Title translation: 造纸带和具有增强表面性能的工业纺织品公开(公告)号:US20050124243A1
公开(公告)日:2005-06-09
申请号:US10887661
申请日:2004-07-09
Applicant: Sanjay Patel , Michael Draper
Inventor: Sanjay Patel , Michael Draper
IPC: B32B5/00 , B32B5/02 , B32B27/04 , B32B27/12 , C08F283/06 , D04H1/64 , D06M14/00 , D06M15/53 , D06M15/568 , D06M15/576 , D21F1/00 , D21F1/30
CPC classification number: D06M14/00 , D06M15/53 , D06M15/568 , D06M15/576 , D21F1/30 , Y10T442/2221 , Y10T442/2238 , Y10T442/2279 , Y10T442/2287 , Y10T442/2311 , Y10T442/232 , Y10T442/2328 , Y10T442/3976 , Y10T442/696
Abstract: An industrial textile including a polymeric substrate and a resin system grafted onto the polymeric substrate by way of a primer. The resin system includes a water-borne thermoplastic, a polyhydroxyether resin and/or an analogue of a polyhydroxyether resin, and at least one co-resin.
Abstract translation: 一种工业织物,其包括聚合物基材和通过底漆接枝到聚合物基材上的树脂体系。 树脂体系包括水性热塑性塑料,聚羟基醚树脂和/或聚羟基醚树脂的类似物,以及至少一种共树脂。
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17.Substituted Tetracycline Compounds as Synergistic Antifungal Agents 审中-公开
Title translation: 取代四环素化合物作为协同抗真菌剂公开(公告)号:US20110245501A1
公开(公告)日:2011-10-06
申请号:US13160027
申请日:2011-06-14
Applicant: Michael Draper , Mark L. Nelson
Inventor: Michael Draper , Mark L. Nelson
IPC: C07D295/155 , C07D307/81 , C07C237/26 , C07D307/54 , C07D277/42 , C07D213/56
CPC classification number: A61K45/06 , A61K31/65 , A61K31/7048 , A61K2300/00
Abstract: The present invention relates to substituted tetracycline compounds and related methods for increasing the antifungal activity of an antifungal agent. The methods include administering to a subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that the subject is treated for the fungal associated disorder.
Abstract translation: 本发明涉及取代的四环素化合物以及提高抗真菌剂抗真菌活性的相关方法。 所述方法包括向受试者施用有效量的取代的四环素化合物与抗真菌剂的组合,使得受试者被治疗用于真菌相关病症。
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18.Substituted tetracycline compounds as synergistic antifungal agents 有权
Title translation: 取代的四环素化合物作为协同抗真菌剂公开(公告)号:US07960366B2
公开(公告)日:2011-06-14
申请号:US10943571
申请日:2004-09-16
Applicant: Michael Draper , Mark L. Nelson
Inventor: Michael Draper , Mark L. Nelson
CPC classification number: A61K45/06 , A61K31/65 , A61K31/7048 , A61K2300/00
Abstract: Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
Abstract translation: 讨论了用于治疗真菌相关疾病的协同治疗的方法和组合物。
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19.Methods for treating spinal muscular atrophy using tetracycline compounds 有权
Title translation: 使用四环素化合物治疗脊髓性肌肉萎缩的方法公开(公告)号:US07935687B2
公开(公告)日:2011-05-03
申请号:US12102623
申请日:2008-04-14
Applicant: Joel Berniac , Todd Bowser , Michael Draper , Stuart B. Levy , Mark L. Nelson
Inventor: Joel Berniac , Todd Bowser , Michael Draper , Stuart B. Levy , Mark L. Nelson
IPC: A61K31/835 , A61K31/16
CPC classification number: A61K31/65
Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
Abstract translation: 描述了使用四环素化合物治疗脊髓性肌萎缩的方法。
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20.Substituted Tetracycline Compounds for Treatment of Inflammatory Skin Disorders 有权
Title translation: 用于治疗炎症性皮肤病的取代四环素化合物公开(公告)号:US20080312193A1
公开(公告)日:2008-12-18
申请号:US11963509
申请日:2007-12-21
Applicant: Haregewein Assefa , Beena Bhatia , Michael Draper , Laura Honeyman , Oak K. Kim , Dennis P. Molnar
Inventor: Haregewein Assefa , Beena Bhatia , Michael Draper , Laura Honeyman , Oak K. Kim , Dennis P. Molnar
IPC: A61K31/65 , A61P29/00 , C07C237/26
CPC classification number: C07C237/48 , A61K31/65 , C07C237/26 , C07C2103/46 , C07C2603/46
Abstract: Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
Abstract translation: 描述了用于治疗皮肤病症(例如痤疮,红斑痤疮)的方法和组合物。
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