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公开(公告)号：US11951307B2
公开(公告)日：2024-04-09
申请号：US17306314
申请日：2021-05-03
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. Pakhomov , Olga N. Pakhomova , Shu Xiao
CPC classification number: A61N1/323 , A61N1/327 , C12N13/00 , A61N1/0412 , A61N1/0476 , A61N1/36
Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
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公开(公告)号：US20230277241A1
公开(公告)日：2023-09-07
申请号：US18307051
申请日：2023-04-26
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
IPC: A61B18/14
CPC classification number: A61B18/1492 , A61B2018/00357
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
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公开(公告)号：US20180200510A1
公开(公告)日：2018-07-19
申请号：US15922758
申请日：2018-03-15
Inventor： Richard NUCCITELLI , Stephen J. BEEBE , Karl H. SCHOENBACH
Abstract: Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin.
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公开(公告)号：US20180168725A1
公开(公告)日：2018-06-21
申请号：US15885930
申请日：2018-02-01
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
CPC classification number: A61B18/1492 , A61B18/1477 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00613
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
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公开(公告)号：US20180153609A1
公开(公告)日：2018-06-07
申请号：US15827875
申请日：2017-11-30
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Karl SCHOENBACH , Richard HELLER
CPC classification number: A61B18/14 , A61B18/1206 , A61B2018/0016 , A61B2018/124 , A61B2018/143 , A61B2018/1467
Abstract: Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.
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Patent Agency Ranking
公开(公告)号：US09918790B2
公开(公告)日：2018-03-20
申请号：US14604400
申请日：2015-01-23
Applicant: Old Dominion University Research Foundation
Inventor： Christian W. Zemlin
CPC classification number: A61B18/1492 , A61B18/1477 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00613
Abstract: An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.
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公开(公告)号：US20170072193A1
公开(公告)日：2017-03-16
申请号：US15311130
申请日：2015-03-24
Applicant: Old Dominion University Research Foundation
Inventor： Richard Heller , Chen Yeong-Jer
Abstract: Catheter devices can include an elongate housing extending along a major axis, the elongate housing comprising a first end an opening. The catheter devices can also include an electrode assembly disposed in the elongate housing and including deformable electrodes with respective electrode distal ends, where the electrode distal ends each consist of respective member portions and respective tip portions. The electrode assembly is slidably movable within the housing along the major axis to allow the electrode distal end portions to transition between a first retracted position and a second extended position. The catheter device is configured such that an average distance between the tip portions in the second position is configured to be greater than an average distance between the tip portions in the first position the tip portions are positioned substantially in a same plane when the electrode assembly is in the second position.
Abstract translation: 导管装置可以包括沿着长轴延伸的细长壳体，细长壳体包括第一端部的开口。 导管装置还可以包括设置在细长壳体中的电极组件，并且包括具有相应电极远端的可变形电极，其中电极远端各自由相应的构件部分和相应的尖端部分组成。 电极组件可在壳体内沿着长轴线可滑动地移动，以允许电极远端部分在第一缩回位置和第二延伸位置之间转变。 导管装置构造成使得在第二位置的末端部分之间的平均距离被构造成大于当电极组件为电极组件时，尖端部分基本上位于同一平面中的第一位置的尖端部分之间的平均距离 处于第二位置。
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公开(公告)号：US20130189345A1
公开(公告)日：2013-07-25
申请号：US13737565
申请日：2013-01-09
Applicant: Old Dominion University Research Foundation
Inventor： Helmut BAUMGART , Diefeng GU
CPC classification number: A01N25/34 , A61F13/00 , A61F2013/0091 , A61K33/24 , A61K45/06 , A61L2/10 , A61L9/205 , A61L15/20 , A61L15/42 , A61L29/126 , A61L29/14 , A61L31/128 , A61L31/14 , A61L2202/16 , A61L2202/24 , A61L2209/12 , C23C16/405 , C23C16/45555 , Y10T428/265 , Y10T428/31504 , Y10T428/31678 , Y10T428/31971 , A61K2300/00
Abstract: A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO2, and the light may be UV or visible light. A variety of methods including ALD may be used to coat the first material.
Abstract translation: 公开了包括伤口护理系统，制造伤口护理系统的方法，杀菌剂以及使用这些系统来治疗伤口的方法的各种制品和系统。 伤口护理系统可以包括包含一种或多种纤维或多孔介质的第一材料。 一种或多种纤维或多孔介质可以涂覆有能够抑制细菌生长并杀死细菌以使伤口护理系统无菌的第二种材料，增加第一种材料的吸收性或在暴露于光时两者 。 第一种材料可以是棉花或任何合适的纤维材料，第二种材料可以是TiO 2，并且光可以是UV或可见光。 可以使用包括ALD的各种方法来涂覆第一材料。
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公开(公告)号：US20210268274A1
公开(公告)日：2021-09-02
申请号：US17306314
申请日：2021-05-03
Applicant: Old Dominion University Research Foundation
Inventor： Andrei G. PAKHOMOV , Olga N. PAKHOMOVA , Shu XIAO
Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
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公开(公告)号：US20210214712A1
公开(公告)日：2021-07-15
申请号：US17215773
申请日：2021-03-29
Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
Inventor： Olga Pakhomova , Andrei G. Pakhomov
Abstract: Systems and methods of enhancing membrane permeabilization in a cell are provided. An example method includes disposing the cell between a first electrode and a second electrode and applying a plurality of electrical pulses between the first electrode and the second electrode. In the systems and methods, the plurality of electrical pulses include at least two trains of pulses separated by an interval greater than about 10 s. Further, the amplitude of the electrical pulses is selected to be greater than about 0.2 kV/cm.
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