公开(公告)号：US11155542B2

公开(公告)日：2021-10-26

申请号：US16335384

申请日：2017-09-21

Applicant: Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie E.V. Hans-Knöll Institut (HKI) ,  Klinikum der Universität München ,  University of Notre Dame du Lac, Office of Technology Transfer

Inventor： Florian Kloss ,  Sebastian Schieferdecker ,  Axel Brakhage ,  Julia Dreisbach ,  Marvin J. Miller ,  Ute Mollmann ,  Kamil Philip Wojtas

IPC: C07D513/04 ,  A61P31/04 ,  A61P31/06 ,  C07D417/04

Abstract: The present invention relates to the general field of treatment of infectious diseases of mammals (humans and animals) caused by bacteria, in particular to the treatment of diseases like tuberculosis (TB), Buruli ulcer and leprosy caused by mycobacteria. The invention aims at the generation of a new series of benzothiazinone compounds having the potential to overcome the above mentioned problems. In a preferred embodiment the invention is concerned with compounds of the general formula (I) wherein R1 represents NO2, R2 represents CF3, at least one of the substituents R3 and R4 is OH, SR14, NHR15, CN, N3, a saturated or unsaturated, optionally halogenated, linear or branched aliphatic radical having 1-4 carbon atoms, linear or branched C1-C4 alkoxy, C1-C4 acyl, and the other of R3 and R4 may in addition be hydrogen, R6 represents a 2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl or a 4-(cyclo-hexylmethyl)piperazin-1-yl group and R14 and R15 independently of each other are hydrogen or a C1-C4 alkyl group and/or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210031055A1

公开(公告)日：2021-02-04

申请号：US17045978

申请日：2019-04-11

Applicant: Board of Regents of the University of Texas System ,  Rensselaer Polytechnic Institute Office Of Technology Transfer

Inventor： Steve Bin Jiang ,  Xun Jia ,  Ge Wang ,  Hak Choy ,  Nima Hassan-Rezaeian ,  Chenyang Shen

IPC: A61N5/10 ,  G01R33/3815 ,  A61B6/04 ,  A61B5/055 ,  G01R33/38 ,  G01R33/385 ,  G01R33/48 ,  G01R33/3875

Abstract: Various examples of methods, systems, apparatus and devices are provided for MRI adaptation for radiotherapy machines. In one example, a system for MRI-guided radiotherapy can include a mounting ring and superconducting magnets. The mounting ring can be installed on a gantry of a LINAC to rotate about an isocenter of the LINAC moving with the gantry. The first and second superconducting magnet can be positioned substantially parallel to each other at a separation distance with the centers substantially aligned. The first and second superconducting magnets can provide a main magnetic field within a region of interest located between the first and second superconducting magnets. The superconducting magnets can have an aperture positioned at the center of each magnet and can allow a radiotherapy beam emitting from the gantry head to pass through the apertures. In another example, superconducting magnets can be installed at opposite ends of a LINAC gantry.

公开(公告)号：US20200181566A1

公开(公告)日：2020-06-11

申请号：US16789231

申请日：2020-02-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, OFFICE OF TECHNOLOGY TRANSFER

Inventor： Koh Meng AW YONG ,  Jianping FU

IPC: C12N5/00 ,  C12M1/12 ,  C12M3/06 ,  C12M1/00

Abstract: Described herein are various embodiments directed to microfluidic cell culture devices, systems, and methods. Embodiments of devices and systems disclosed herein may be used to grow and characterize one or more phenotypes of a cell sample. An apparatus may include an apparatus including a substrate defining a cavity, and further include a scaffold disposed within the cavity. The substrate and the scaffold may collectively define a set of channels including a first channel and a second channel. The first channel may be configured to receive and culture a cell sample during use. The second channel may be configured to receive a fluid during use. The scaffold may be configured to permit diffusion of the fluid through the scaffold and into the first channel.

公开(公告)号：US20190119346A1

公开(公告)日：2019-04-25

申请号：US16175709

申请日：2018-10-30

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  United States Department of Health and Human Services, Office of Technology Transfer, National

Inventor： Christopher K. Garcia ,  Suman Mitra ,  Warren J. Leonard ,  Aaron M. Ring

IPC: C07K14/55 ,  A61K38/00

Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2Rβ receptor and a decreased binding capacity for IL-2Rγc receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

公开(公告)号：US10001483B2

公开(公告)日：2018-06-19

申请号：US15192819

申请日：2016-06-24

Applicant: Celgene Corporation ,  The United States of America, as represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health

Inventor： Robert Yarchoan ,  Jerome B. Zeldis ,  Mark N. Polizzotto ,  David A. Davis ,  Irini Sereti ,  Thomas S. Uldrick ,  Denise Whitby ,  Vikram Khetani

IPC: A61K31/40 ,  G01N33/574 ,  A61K31/454 ,  A61K45/06 ,  A61K31/704 ,  A61K31/4035

CPC classification number: G01N33/57407 ,  A61K31/4035 ,  A61K31/454 ,  A61K31/704 ,  A61K45/06 ,  A61P35/00 ,  G01N2333/70539 ,  G01N2800/52 ,  A61K2300/00

Abstract: Provided herein are uses of gene and protein biomarkers as a predictor of clinical sensitivity of Kaposi's sarcoma (KS) or Kaposi's sarcoma-associated herpesvirus (KSHV) induced lymphoma and patient response to treatment with an immunomodulatory compound. Further provided herein are methods for the treatment or management of Kaposi's sarcoma or KSHV-induced lymphoma with an immunomodulatory compound, alone or in combination with doxorubicin.

公开(公告)号：US09874622B2

公开(公告)日：2018-01-23

申请号：US14038948

申请日：2013-09-27

Applicant: General Electric Company ,  The United States of America, As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health

Inventor： Timothy William Skloss ,  Jonathan Alan Murray ,  Jan Henrik Ardenkjaer-Larsen ,  Murali K. Cherukuri ,  Marcelino Bernardo ,  Nallathamby Devasahayam

IPC: G01R33/28 ,  G01R33/56 ,  A61B5/055

CPC classification number: G01R33/5601 ,  A61B5/055 ,  A61B2560/06 ,  G01R33/282

Abstract: A system and method for transporting a hyperpolarized substance is disclosed. A transport vessel for transporting such a hyperpolarized substance includes a vessel housing, a chamber formed within the vessel housing that is configured to receive a container holding a hyperpolarized substance, and an electromagnet configured to generate a magnetic containment field about the chamber when a current is supplied thereto, the magnetic containment field comprising a homogeneous magnetic field. The transport vessel also includes a non-magnetic power source to supply the current to the electromagnet and a control circuit configured to selectively interrupt the supply of current to the electromagnet so as to control generation of the magnetic containment field, with the transport vessel being magnetically inert when the supply of current to the electromagnet is interrupted by the control circuit.

公开(公告)号：US09696534B2

公开(公告)日：2017-07-04

申请号：US14380392

申请日：2013-02-22

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INTITUTES OF HEALTH ,  Hari Shroff ,  Andrew York

Inventor： Hari Shroff ,  Andrew York

IPC: G01N21/64 ,  G02B21/00

CPC classification number: G02B21/0072 ,  G01N21/6458 ,  G01N2021/6478 ,  G01N2201/0633 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/004 ,  G02B21/0076

Abstract: A multi-focal selective illumination microscopy (SIM) system for generating multi-focal patterns of a sample is disclosed. The multi-focal SIM system performs a focusing, scaling and summing operation on each multi-focal pattern in a sequence of multi-focal patterns that completely scan the sample to produce a high resolution composite image.

公开(公告)号：US20150361386A1

公开(公告)日：2015-12-17

申请号：US14737809

申请日：2015-06-12

Applicant: Lehigh University, Office of Technology Transfer

Inventor： Yaling Liu ,  Antony Thomas

IPC: C12M3/06 ,  C12M1/12

CPC classification number: C12M23/16 ,  C12M23/20 ,  C12M25/02

Abstract: Described herein are apparatus comprising: a first layer comprising a first microfluidic channel; a second layer comprising a second microfluidic channel; and a membrane for culturing cells; along with methods of making and using same.

Abstract translation: 本文描述的装置包括：包含第一微流体通道的第一层; 第二层，包括第二微流体通道; 和用于培养细胞的膜; 以及制作和使用方法。

公开(公告)号：US20150349283A1

公开(公告)日：2015-12-03

申请号：US14646154

申请日：2013-11-22

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN Office Of Technology Transfer

Inventor： Stephen R. FORREST ,  Jeramy, D. ZIMMERMAN, ,  Xin XIAO

IPC: H01L51/42 ,  H01L51/00

CPC classification number: H01L51/4253 ,  B82Y10/00 ,  H01L51/0046 ,  H01L51/0056 ,  H01L51/0072 ,  H01L2251/552 ,  Y02E10/549

Abstract: Disclosed herein are organic photosensitive optoelectronic devices comprising two electrodes in superposed relation; a mixed photoactive layer located between the two electrodes, wherein the mixed photoactive layer comprises at least one donor material having a HOMO energy and at least one acceptor material having a LUMO energy, wherein the at least one donor material and the at least one acceptor material form a mixed donor-acceptor heterojunction; a photoactive layer adjacent to and interfacing with the mixed photoactive layer, wherein the photoactive layer comprises a material having a LUMO energy within 0.3 eV of the LUMO energy of the at least one acceptor material or a HOMO energy within 0.3 eV of the HOMO energy of the at least one donor material; and a buffer layer adjacent to and interfacing with the mixed photoactive layer.

Abstract translation: 本文公开了包括两个重叠关系的电极的有机光敏光电器件; 位于所述两个电极之间的混合光敏层，其中所述混合光活性层包含至少一种具有HOMO能量的供体材料和至少一种具有LUMO能量的受主材料，其中所述至少一种供体材料和所述至少一种受体材料 形成混合的供体 - 受体异质结; 邻近并与混合光活性层接合的光活性层，其中光活性层包括具有在至少一种受体材料的LUMO能量的0.3eV以内的LUMO能量的材料的HUMO能量或在0.3EV以内的HOMO能量的材料， 所述至少一种供体材料; 以及与混合光活性层相邻并与其接合的缓冲层。

公开(公告)号：US20140024042A1

公开(公告)日：2014-01-23

申请号：US14034916

申请日：2013-09-24

Applicant: University of Miami, Office of Technology Transfer

Inventor： Elizabeth J. Franzmann ,  Vinata B. Lokeshwar

IPC: G01N33/574

CPC classification number: G01N33/57407 ,  G01N33/573 ,  G01N33/57488 ,  G01N2333/70585 ,  G01N2333/924 ,  G01N2333/926 ,  G01N2400/40 ,  G01N2800/52

Abstract: Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.

Abstract translation: 提供了一种用于诊断和监测头颈鳞状细胞癌（HNSCC）的新型敏感和特异性标记物和方法。 描述了使用透明质酸，透明质酸酶和CD44来诊断HNSCC的试剂盒和方法。