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公开(公告)号：US20090099136A1
公开(公告)日：2009-04-16
申请号：US12251574
申请日：2008-10-15
IPC分类号： C07F9/6509 , A61K31/675 , A61P31/18
CPC分类号： C07F9/65586
摘要： Disclosed are dioxolane thymine phosphoramidate compounds, compositions, and methods for using dioxolane thymine phosphoramidate compounds and compositions to treat viral infections, such as HIV infections.
摘要翻译： 公开了二氧杂环戊烷胸腺嘧啶氨基磷酸酯化合物，组合物和使用二氧戊环胸腺嘧啶氨基磷酸化合物和组合物治疗病毒感染如HIV感染的方法。
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公开(公告)号：US20150344473A1
公开(公告)日：2015-12-03
申请号：US14728562
申请日：2015-06-02
申请人： Zhimin Du , Juan Arnaldo Guerrero , Joshua Aaron Kaplan , John Edward Knox, JR. , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jeff Zablocki
发明人： Zhimin Du , Juan Arnaldo Guerrero , Joshua Aaron Kaplan , John Edward Knox, JR. , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jeff Zablocki
IPC分类号： C07D471/04 , C07D487/04 , C07D473/00 , C07D519/00
CPC分类号： C07D471/04 , C07D473/00 , C07D487/04
摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:
摘要翻译： 公开了具有下式（I）的化合物及其使用和制备方法：
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公开(公告)号：US08618076B2
公开(公告)日：2013-12-31
申请号：US13076552
申请日：2011-03-31
申请人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
发明人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
CPC分类号： A61K31/7072 , A61K9/20 , A61K45/06 , C07B2200/13 , C07F9/2479 , C07H19/06 , C07H19/10 , C07H23/00
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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15.发明申请PREPARATION OF ALKYL-SUBSTITUTED 2-DEOXY-2-FLUORO-D-RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES 有权烷基取代的2-脱氧-2-氟-D-呋喃糖基吡啶并吡啶及其衍生物的制备公开(公告)号：US20100234585A1
公开(公告)日：2010-09-16
申请号：US12786459
申请日：2010-05-25
申请人： Peiyuan Wang , Wojciech Stec , Byoung-Kwon Chun , Junxing Shi , Jinfa Du
发明人： Peiyuan Wang , Wojciech Stec , Byoung-Kwon Chun , Junxing Shi , Jinfa Du
IPC分类号： C07H19/067
CPC分类号： C07D307/33 , C07D307/62 , C07D405/04 , C07D473/34 , C07H19/12 , C07H19/16
摘要： The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
摘要翻译： 本发明提供（i）2-脱氧-2-氟-2-甲基-D-核糖内酯衍生物的制备方法，（ii）将内酯转化为具有有效抗HCV活性的核苷及其类似物，以及 （iii）从预先形成的，优选天然存在的核苷制备含有2-脱氧-2-氟-2-C-甲基-β-呋喃核糖核苷的抗HCV核苷的方法。
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公开(公告)号：US20100016251A1
公开(公告)日：2010-01-21
申请号：US12053015
申请日：2008-03-21
IPC分类号： A61K31/7076 , C07H19/073 , A61K31/706 , A61P31/12 , A61K31/7072 , C07H19/173
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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公开(公告)号：US08716262B2
公开(公告)日：2014-05-06
申请号：US12645765
申请日：2009-12-23
CPC分类号： C07H19/20
摘要： A nucleoside compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的核苷化合物。
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公开(公告)号：US08481713B2
公开(公告)日：2013-07-09
申请号：US12786459
申请日：2010-05-25
申请人： Peiyuan Wang , Wojciech Stec , Byoung Kwon Chun , Junxing Shi , Jinfa Du
发明人： Peiyuan Wang , Wojciech Stec , Byoung Kwon Chun , Junxing Shi , Jinfa Du
CPC分类号： C07D307/33 , C07D307/62 , C07D405/04 , C07D473/34 , C07H19/12 , C07H19/16
摘要： The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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公开(公告)号：US20130029929A1
公开(公告)日：2013-01-31
申请号：US13609614
申请日：2012-09-11
IPC分类号： C07H19/06 , A61P31/16 , A61P31/14 , A61K31/7072 , C07H1/00
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
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公开(公告)号：US20110251152A1
公开(公告)日：2011-10-13
申请号：US13076552
申请日：2011-03-31
申请人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
发明人： Bruce S. Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
IPC分类号： A61K31/7072 , A61P31/14 , C07H19/10
CPC分类号： A61K31/7072 , A61K9/20 , A61K45/06 , C07B2200/13 , C07F9/2479 , C07H19/06 , C07H19/10 , C07H23/00
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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