公开(公告)号：US20130331372A1

公开(公告)日：2013-12-12

申请号：US13881896

申请日：2011-10-25

Applicant: Zhijian Lu ,  Yi-Heng Chen ,  Cameron Smith ,  Hong Li ,  Christopher F. Thompson ,  Julianne Hunt ,  Florida Kallashi ,  Ramzi Sweis ,  Peter Sinclair ,  Samantha E. Adamson ,  Guizhen Dong ,  Debra L. Ondeyka ,  Xiaoxia Qian ,  Wanying Sun ,  Petr Vachal ,  Kake Zhao

Inventor： Zhijian Lu ,  Yi-Heng Chen ,  Cameron Smith ,  Hong Li ,  Christopher F. Thompson ,  Julianne Hunt ,  Florida Kallashi ,  Ramzi Sweis ,  Peter Sinclair ,  Samantha E. Adamson ,  Guizhen Dong ,  Debra L. Ondeyka ,  Xiaoxia Qian ,  Wanying Sun ,  Petr Vachal ,  Kake Zhao

IPC: C07D491/08 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/444 ,  A61K31/497 ,  C07D417/14 ,  C07D413/14 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/506

CPC classification number: C07D491/08 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).

Abstract translation: 具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。 在式I的化合物中，A3是取代的苯基或茚满基。 式（I）。

公开(公告)号：US07888350B2

公开(公告)日：2011-02-15

申请号：US12294599

申请日：2007-03-28

Applicant: Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: C07D279/18 ,  A61K31/5415

CPC classification number: A61K31/5415 ,  C07D279/20 ,  C07D279/22 ,  C09B21/00 ,  Y02A50/393 ,  Y02A50/411

Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).

Abstract translation: 本发明一般涉及吩噻嗪化合物领域，更具体地涉及某些稳定还原的吩噻嗪化合物，具体地，下列通式的某些3,7-二氨基-10H-吩噻嗪（DAPTZ）化合物其中：R 1和R 9各自独立地选自 从：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R3NA和R3NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; HX1和HX2各自独立地是质子酸; 及其药学上可接受的盐，溶剂化物和水合物。 这些化合物可用作药物，例如用于治疗tau蛋白病如阿尔茨海默氏病，以及作为相应的氧化硫堇药物（例如氯化甲硫氨酸，MTC）的前药。

公开(公告)号：US20080033505A1

公开(公告)日：2008-02-07

申请号：US11828513

申请日：2007-07-26

Applicant: Glen Davis ,  Peter Sinclair ,  Che Fornusek

Inventor： Glen Davis ,  Peter Sinclair ,  Che Fornusek

IPC: A61N1/04

CPC classification number: A61N1/36003 ,  A61H1/02 ,  A61H2230/08

Abstract: A control system for controlled exercise controls a functional electrical stimulation (FES) system which applies electrical signals to muscle groups of a user such as a user having a disability; the user exercises on a motor driven exercise machine such that substantially isokinetic exercise during a movement is obtained as the user's body part moves with a motor driven displaceable element of the machine. This element provides resistance to applied displacement load from the user's stimulated muscles. A feedback control system receives signals indicative of the user's performance and a control arrangement controls electrical stimulation to the user's muscles to achieve a desired exercise regime.

Abstract translation: 用于受控运动的控制系统控制将电信号施加到诸如具有残疾的用户的用户的肌肉组的功能性电刺激（FES）系统; 用户在马达驱动的运动器械上进行锻炼，使得当用户的身体部分随着机器的马达驱动的可移动元件移动时，获得运动期间的基本上等速运动。 该元件提供对来自使用者的被刺激的肌肉的施加的位移负荷的抵抗力。 反馈控制系统接收指示用户的性能的信号，并且控制装置控制对用户肌肉的电刺激以实现期望的运动方式。

公开(公告)号：US20070225365A1

公开(公告)日：2007-09-27

申请号：US11578694

申请日：2005-04-08

Applicant: Amjad Ali ,  Joann Bohn ,  Qiaolin Deng ,  Zhijian Lu ,  Peter Sinclair ,  Gayle Taylor ,  Christopher Thompson ,  Nazia Quraishi

Inventor： Amjad Ali ,  Joann Bohn ,  Qiaolin Deng ,  Zhijian Lu ,  Peter Sinclair ,  Gayle Taylor ,  Christopher Thompson ,  Nazia Quraishi

IPC: A61K31/216 ,  C07C69/612

CPC classification number: C07C271/20 ,  C07C233/18 ,  C07C271/16 ,  C07C271/22 ,  C07C279/08 ,  C07C311/04 ,  C07C311/08 ,  C07C317/32 ,  C07D209/08 ,  C07D213/40 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D213/89 ,  C07D215/12 ,  C07D215/26 ,  C07D217/02 ,  C07D217/14 ,  C07D261/08 ,  C07D271/06 ,  C07D307/52 ,  C07D307/79 ,  C07D333/20 ,  C07D333/22 ,  C07D333/28

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.

Abstract translation: 式I化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及治疗或预防动脉粥样硬化。 在式1化合物中，A 1和A 2各自为芳环，5-6元杂环，稠合至杂环的芳环， 与杂环稠合的苯环或环烷基环。

公开(公告)号：US20070138339A1

公开(公告)日：2007-06-21

申请号：US10561379

申请日：2004-06-18

Applicant: Peter Sinclair

Inventor： Peter Sinclair

IPC: B64C33/02

CPC classification number: A63H27/008

Abstract: A apparatus for assisting in flying, walking or swimming having wings, legs or fins attached to a drive mechanism in which the end of the wings, legs or fins are simultaneously oscillated and moved linearly generating lift or walk and swim movement.

Abstract translation: 一种用于辅助飞行，行走或游泳的装置，其具有附接到驱动机构的翼，腿或翅片，其中翼，腿或翅片的端部同时振动并且线性地移动产生升降或步行和游泳运动。

公开(公告)号：US5807621A

公开(公告)日：1998-09-15

申请号：US733921

申请日：1996-10-18

Applicant: Nicholas John Kite ,  Peter Sinclair ,  Roger Anthony Allen ,  Neil Harvey Clifford

Inventor： Nicholas John Kite ,  Peter Sinclair ,  Roger Anthony Allen ,  Neil Harvey Clifford

IPC: D21H19/36 ,  D21H19/20 ,  D21H19/22 ,  D21H19/66 ,  D21H19/84 ,  D21H25/14 ,  B05D3/12 ,  B05D3/02 ,  B05D5/02

CPC classification number: D21H19/66 ,  D21H19/84 ,  D21H25/14 ,  D21H19/20 ,  D21H19/22 ,  Y10T428/24438 ,  Y10T428/24455 ,  Y10T428/31993

Abstract: Casting paper of a desired surface texture or finish for use in the manufacture of artificial leather is produced by heating the polymer coating 1 of a polymer-coated paper 2 to a temperature sufficient to melt the polymer and then cooling the polymer coating from its molten state to a solid state as it passes through a nip between an embossing roll 3 having a surface configuration corresponding to said desired surface texture or finish and a backing roll 4, thereby to impart the surface configuration of the embossing roll to the polymer-coated paper. The polymer is preferably polyolefinic, for example poly (4-methyl-1-pentene) or a polypropylene/polyethylene blend. An anti-curl back-coat, for example of polyvinyl alcohol, can be applied after the embossing operation.

Abstract translation: 通过将聚合物涂布纸2的聚合物涂层1加热至足以熔化聚合物的温度，然后将聚合物涂层从其熔融状态冷却而制造出用于制造人造皮革的所需表面纹理或表面处理用的铸造纸 当其通过具有对应于所需的表面纹理或表面的表面形状的压花辊3和背衬辊4之间的辊隙时，从而赋予压花辊的表面构造到聚合物涂布的纸上。 聚合物优选为聚烯烃，例如聚（4-甲基-1-戊烯）或聚丙烯/聚乙烯共混物。 可以在压花操作之后施加抗卷曲背胶，例如聚乙烯醇。

公开(公告)号：US09454677B1

公开(公告)日：2016-09-27

申请号：US14542380

申请日：2014-11-14

Applicant: Peter Sinclair ,  James Lloyd ,  Michael Eynon

Inventor： Peter Sinclair ,  James Lloyd ,  Michael Eynon

IPC: G06F21/00 ,  G06F21/83 ,  F01P7/16 ,  G06F21/60 ,  H04L9/32 ,  H04L29/06

CPC classification number: G06F21/83 ,  F01P7/16 ,  G06F21/554 ,  G06F21/602 ,  G06F21/6272 ,  G06F21/64 ,  G06F21/84 ,  G06F2221/2115 ,  H04L9/3247 ,  H04L9/3263 ,  H04L63/0823 ,  H04L63/10 ,  H04L63/105

Abstract: Secure communication of user inputs is achieved by isolating part of an endpoint device such that certificates and encryption keys are protected from corruption by malware. Further, the communication is passed through a trusted data relay that is configured to decrypt and/or certify the user inputs encrypted by the isolated part of the endpoint device. The trusted data relay can determine that the user inputs were encrypted or certified by the protected certificates and encryption keys, thus authenticating their origin within the endpoint device. The trusted data relay then forwards the inputs to an intended destination. In some embodiments, the isolated part of the endpoint device is configured to detect input created by auto-completion logic and/or spell checking logic.

Abstract translation: 通过隔离端点设备的一部分来实现用户输入的安全通信，从而保护证书和加密密钥免受恶意软件的破坏。 此外，通信被传递通过被配置为解密和/或认证由端点设备的隔离部分加密的用户输入的可信数据中继。 可信数据中继器可以确定用户输入被受保护的证书和加密密钥加密或认证，从而在端点设备内对其来源进行认证。 然后，可信数据中继器将输入转发到预定的目的地。 在一些实施例中，端点设备的隔离部分被配置为检测由自动完成逻辑和/或拼写检查逻辑创建的输入。

公开(公告)号：US20140108821A1

公开(公告)日：2014-04-17

申请号：US14055861

申请日：2013-10-16

Applicant: James Lloyd ,  Michael Eynon ,  Peter Sinclair

Inventor： James Lloyd ,  Michael Eynon ,  Peter Sinclair

IPC: G06F21/83

CPC classification number: G06F21/83 ,  G06F21/554 ,  G06F21/602 ,  G06F21/84 ,  H04L9/3247 ,  H04L63/0823 ,  H04L63/10 ,  H04L63/105

Abstract: Secure communication of user inputs is achieved by isolating part of an endpoint device such that certificates and encryption keys are protected from corruption by malware. Further, the communication is passed through a trusted data relay that is configured to decrypt and/or certify the user inputs encrypted by the isolated part of the endpoint device. The trusted data relay can determine that the user inputs were encrypted or certified by the protected certificates and encryption keys, thus authenticating their origin within the endpoint device. The trusted data relay then forwards the inputs to an intended destination. In some embodiments, the isolated part of the endpoint device is configured to detect input created by auto-completion logic and/or spell checking logic.

Abstract translation: 通过隔离端点设备的一部分来实现用户输入的安全通信，从而保护证书和加密密钥免受恶意软件的破坏。 此外，通信被传递通过被配置为解密和/或认证由端点设备的隔离部分加密的用户输入的可信数据中继。 可信数据中继器可以确定用户输入被受保护的证书和加密密钥加密或认证，从而在端点设备内对其来源进行认证。 然后，可信数据中继器将输入转发到预定的目的地。 在一些实施例中，端点设备的隔离部分被配置为检测由自动完成逻辑和/或拼写检查逻辑创建的输入。

公开(公告)号：US20140108790A1

公开(公告)日：2014-04-17

申请号：US14055868

申请日：2013-10-16

Applicant: Michael Eynon ,  Peter Sinclair ,  James Lloyd

Inventor： Michael Eynon ,  Peter Sinclair ,  James Lloyd

IPC: H04L9/32

CPC classification number: G06F21/83 ,  G06F21/554 ,  G06F21/602 ,  G06F21/84 ,  H04L9/3247 ,  H04L63/0823 ,  H04L63/10 ,  H04L63/105

Abstract: Secure communication of user inputs is achieved by isolating part of an endpoint device such that certificates and encryption keys are protected from corruption by malware. Further, the communication is passed through a trusted data relay that is configured to decrypt and/or certify the user inputs encrypted by the isolated part of the endpoint device. The trusted data relay can determine that the user inputs were encrypted or certified by the protected certificates and encryption keys, thus authenticating their origin within the endpoint device. The trusted data relay then forwards the inputs to an intended destination. In some embodiments, the isolated part of the endpoint device is configured to detect input created by auto-completion logic and/or spell checking logic.

Abstract translation: 通过隔离端点设备的一部分来实现用户输入的安全通信，从而保护证书和加密密钥免受恶意软件的破坏。 此外，通信被传递通过被配置为解密和/或认证由端点设备的隔离部分加密的用户输入的可信数据中继。 可信数据中继器可以确定用户输入被受保护的证书和加密密钥加密或认证，从而在端点设备内对其来源进行认证。 然后，可信数据中继器将输入转发到预定的目的地。 在一些实施例中，端点设备的隔离部分被配置为检测由自动完成逻辑和/或拼写检查逻辑创建的输入。

公开(公告)号：US20110294795A1

公开(公告)日：2011-12-01

申请号：US13149164

申请日：2011-05-31

Applicant: Claude Michel WISCHIK ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel WISCHIK ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: A61K31/5415 ,  A61P25/28 ,  A61P25/16 ,  A61P35/00 ,  A61P31/12 ,  A01P1/00 ,  A61P33/02 ,  A61P33/00 ,  A61P33/06 ,  A61P31/14 ,  A61P31/18 ,  A01N43/84 ,  C07D279/20 ,  A61P31/04

CPC classification number: A61K31/5415 ,  C07D279/18 ,  C07D279/20

Abstract: Described are compositions and methods of making high purity diaminophenothiazinium compounds of the following formula which are characterised by: a purity of greater than 98%; less than 1% Azure B as impurity; less than 0.15% Azure A as impurity; less than 0.15% Azure C as impurity; and less than 0.05% Methylene Violet Bernthsen (MVB) as impurity. Examples include methylthioninium chloride (MTC), also known as Methylene Blue (MB).

Abstract translation: 描述了制备下式的高纯度二氨基吩噻嗪鎓化合物的组合物和方法，其特征在于：纯度大于98％; 少于1％的Azure B作为杂质; 小于0.15％的Azure A为杂质; 小于0.15％的Azure C为杂质; 和少于0.05％的亚甲基紫伯氏（MVB）杂质。 实例包括甲基硫堇（MTC），也称为亚甲蓝（MB）。