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    Apparatus, Method and System for Measuring the Influence of Ophthalmic Lens Design
    12.
    发明申请
    Apparatus, Method and System for Measuring the Influence of Ophthalmic Lens Design 审中-公开

    公开(公告)号：US20200081269A1

    公开(公告)日：2020-03-12

    申请号：US16493948

    申请日：2018-03-15

    Applicant: Queensland University of Technology

    Inventor： Michael John Collins ,  Brett Ashley Davis ,  Fan Yi

    IPC: G02C7/02 ,  G01M11/02

    Abstract: A method for measuring an influence of an ophthalmic lens design is disclosed. The method comprises splitting an optical light beam into a wavefront measurement light path and a wavefront modulation light path; implementing the ophthalmic lens design in an adaptive optics device positioned in the wavefront modulation light path; and obtaining ocular biometric data in the ocular biometric and wavefront measurement light path to measure the influence of the ophthalmic lens design. Also disclosed are an apparatus and a system for measuring an influence of an ophthalmic lens design along with a method for assembling the device and system. The ocular biometric device may be an interferometer and the adaptive optics device may comprise one or more wavefront shapers.

    KITS AND METHODS FOR DIAGNOSIS, SCREENING, TREATMENT AND DISEASE MONITORING
    13.
    发明申请
    KITS AND METHODS FOR DIAGNOSIS, SCREENING, TREATMENT AND DISEASE MONITORING 审中-公开
    用于诊断，筛查，治疗和疾病监测的检查和方法

    公开(公告)号：US20160298197A1

    公开(公告)日：2016-10-13

    申请号：US15026960

    申请日：2014-10-01

    Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

    Inventor： Chamindie PUNYADEERA ,  Dmitry OVCHINNIKOV

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154

    Abstract: Disclosed are methods for detecting the presence of a carcinoma or an increased likelihood that a carcinoma is present in a subject. More particularly, the present invention discloses methods for diagnosis, screening, treatment and monitoring of carcinomas associated with aberrant DNA methylation of the MED15 promoter region.

    Abstract translation: 公开了用于检测癌症的存在或癌症存在于受试者中的可能性增加的方法。 更具体地，本发明公开了用于诊断，筛选，治疗和监测与MED15启动子区域的异常DNA甲基化有关的癌症的方法。

    JOHNSON GRASS ALLERGENIC POLLEN PROTEINS, ENCODING NUCLEIC ACIDS AND METHODS OF USE
    14.
    发明申请
    JOHNSON GRASS ALLERGENIC POLLEN PROTEINS, ENCODING NUCLEIC ACIDS AND METHODS OF USE 审中-公开
    约翰逊草过敏性蛋白质，编码核酸和使用方法

    公开(公告)号：US20160144020A1

    公开(公告)日：2016-05-26

    申请号：US14899538

    申请日：2014-06-18

    Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

    Inventor： Janet Davies ,  Bradley Campbell

    IPC: A61K39/36 ,  G01N33/68

    CPC classification number: A61K39/36 ,  C07K14/415 ,  C07K16/16 ,  G01N33/6893 ,  G01N2333/415 ,  G01N2800/24

    Abstract: Allergenic Johnson Grass proteins, antibodies thereto and encoding nucleic acids are provided, which may be used for the diagnosis and/or therapy of sensitivity to these allergenic proteins or to immunologically cross-reactive allergenic proteins. In particular, the allergenic Johnson grass proteins and nucleic acids may be used for environmental testing for airborne allergens and/or for batch standardization of diagnostic and therapeutic compositions.

    Abstract translation: 提供过敏性约翰逊草蛋白，其抗体和编码核酸，其可用于诊断和/或治疗对这些变应原蛋白或免疫交叉反应性变应原蛋白的敏感性。 特别地，过敏性约翰逊草蛋白和核酸可用于空气传播过敏原的环境测试和/或用于诊断和治疗组合物的批量标准化。

    FUTURE EVENT PREDICTION USING AUGMENTED CONDITIONAL RANDOM FIELD
    15.
    发明申请
    FUTURE EVENT PREDICTION USING AUGMENTED CONDITIONAL RANDOM FIELD 审中-公开
    使用有条件的随机场的未来事件预测

    公开(公告)号：US20150347918A1

    公开(公告)日：2015-12-03

    申请号：US14294000

    申请日：2014-06-02

    Applicant: Disney Enterprises, Inc. ,  Queensland University of Technology

    Inventor： Patrick LUCEY ,  Xinyu WEI

    IPC: G06N5/04 ,  G06N99/00

    CPC classification number: G06N5/048 ,  G06N7/005 ,  G06N20/00

    Abstract: Systems and methods are disclosed for a future event prediction. Embodiments include capturing spatiotemporal data pertaining to activities, wherein the activities include a plurality of events, and employing an augmented-hidden-conditional-random-field (a-HCRF) predictor to generate a future event prediction based on a parameter-vector input, hidden states, and the spatiotemporal data. Methods therein utilize a graph including a first node associated with random variables corresponding to a future event state, a second node associated with random variables corresponding to spatiotemporal input data, a first group of nodes, each node therein associated with random variables corresponding to a subset of the spatiotemporal input data, a second group of nodes, each node therein associated with random variables corresponding to a hidden-state; wherein the edges connect the first node with the second node, the first node with the second group of nodes, and the first group of nodes with the second group of nodes.

    Abstract translation: 公开了用于未来事件预测的系统和方法。 实施例包括捕获与活动相关的时空数据，其中活动包括多个事件，并且采用增强隐藏条件随机场（a-HCRF）预测器，以基于参数向量输入生成未来事件预测， 隐藏状态和时空数据。 其中的方法使用包括与对应于未来事件状态的随机变量相关联的第一节点的图形，与对应于时空输入数据的随机变量相关联的第二节点，第一组节点，其中每个节点与对应于子集的随机变量相关联 的时空输入数据，第二组节点，其中的每个节点与对应于隐藏状态的随机变量相关联; 其中所述边缘将所述第一节点与所述第二节点，所述第一节点与所述第二组节点连接，所述第一节点与所述第二组节点连接。

    COMPLEX-FORMATION-MODULATING AGENTS AND USES THEREFOR
    16.
    发明申请
    COMPLEX-FORMATION-MODULATING AGENTS AND USES THEREFOR 审中-公开
    复合形成调节剂及其用途

    公开(公告)号：US20150299263A1

    公开(公告)日：2015-10-22

    申请号：US14646860

    申请日：2013-11-21

    Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

    Inventor： Abhishek Kashyap ,  Gary Keith Shooter ,  David Leavesley ,  Brett Hollier ,  Adrian Charles Herington ,  Zee Upton

    IPC: C07K9/00 ,  A61K45/06 ,  A61K38/14

    CPC classification number: C07K9/00 ,  A61K38/00 ,  A61K38/14 ,  A61K45/06 ,  C07K14/72

    Abstract: Disclosed are methods and agents for modulating proliferation, migration and/or survival of cells. More particularly, the present invention discloses molecules that have any one or more activities selected from: inhibiting binding of vitronectin to at least one vitronectin-binding partner selected from an IGF and IGFBP, inhibiting formation of a complex comprising vitronectin and at least one vitronectin-binding partner selected from an IGF and IGFBP, or inhibiting proliferation or survival of a hyperproliferative cell (e.g., a neoplastic cell or non-neoplastic cell), or inhibiting migration or invasion of a hyperproliferative cell (e.g., a neoplastic cell or a non-neoplastic cell). Additionally, the present invention discloses the use of these molecules in methods and compositions for treating or preventing hyperproliferative cell disorders including neoplastic (e.g., cancers such as epithelial cancers) and non-neoplastic disorders.

    Abstract translation: 公开了用于调节细胞增殖，迁移和/或存活的方法和试剂。 更具体地，本发明公开了具有任何一种或多种活性的分子，所述活性选自：抑制玻连蛋白与选自IGF和IGFBP的至少一种玻连蛋白结合配偶体的结合，抑制形成包含玻连蛋白和至少一种玻连蛋白 - 选自IGF和IGFBP的结合配偶体，或抑制过度增殖细胞（例如，肿瘤细胞或非肿瘤细胞）的增殖或存活，或抑制过度增殖细胞（例如肿瘤细胞或非肿瘤细胞）的迁移或侵袭， 肿瘤细胞）。 此外，本发明公开了这些分子在用于治疗或预防过度增殖性细胞病症（包括肿瘤（例如癌症如上皮癌））和非肿瘤性疾病的方法和组合物中的用途。

    GROWTH FACTOR COMPLEX
    17.
    发明申请
    GROWTH FACTOR COMPLEX 有权
    生长因子复合体

    公开(公告)号：US20140045749A1

    公开(公告)日：2014-02-13

    申请号：US14032848

    申请日：2013-09-20

    Applicant: Queensland University of Technology

    Inventor： Zee Upton ,  Jennifer Ann Kricker

    IPC: A61K47/48

    CPC classification number: A61K47/48246 ,  A61K38/1709 ,  A61K38/30 ,  A61K38/39 ,  C07K14/71 ,  C07K14/78 ,  A61K2300/00

    Abstract: A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor I (IGF-I); an insulin-like growth factor binding protein (IGFBP) selected from IGFBP-3 and IGFBP-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal. The agent is selected from the group consisting a polypeptide that is distinguished from IGF-II by substitution of at least one amino acid residue, wherein the polypeptide disrupts the isolated protein complex.

    Abstract translation: 提供了一种治疗以异常上皮细胞增殖和/或迁移为特征的疾病或病症的方法。 该方法的一个步骤可以包括向哺乳动物施用破坏分离的蛋白质复合物的试剂，包括：胰岛素样生长因子I（IGF-I）; 选自IGFBP-3和IGFBP-5的胰岛素样生长因子结合蛋白（IGFBP）; 和玻连蛋白; 或其防止分离的蛋白质复合物的形成，从而治疗哺乳动物的疾病或病症。 所述试剂选自通过至少一个氨基酸残基的取代与IGF-II区分的多肽，其中多肽破坏分离的蛋白质复合物。

    Surgical training device
    19.
    发明授权
    Surgical training device 有权

    公开(公告)号：US11830377B2

    公开(公告)日：2023-11-28

    申请号：US16765239

    申请日：2018-11-30

    Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

    Inventor： Dietmar Hutmacher ,  Nathan Castro ,  Onur Bas

    IPC: G09B23/28 ,  A61B17/04 ,  A61B17/00

    CPC classification number: G09B23/28 ,  A61B17/0401 ,  A61B2017/00716

    Abstract: Disclosed is a suturing training device and a method of using the device. The device comprises a base having a first side and a second side, the base defining a plane. The device also comprises a first anchor and a second anchor positioned on the first side of the base. The first and second anchors are each connectable to a segment of tissue so that the tissue is suspended therebetween in use of the device. An actuator is associated with one or both of the first anchor and the second anchor. The actuator is actuatable to cause relative movement of the first and second anchors along the plane. A force gauge is configured to measure a force applied to the tissue when the first and second anchors are moved relative one another by the actuator.

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