公开(公告)号：US20130079487A1

公开(公告)日：2013-03-28

申请号：US13681811

申请日：2012-11-20

Applicant: Rudolf Faust ,  Umaprasana Ojha

Inventor： Rudolf Faust ,  Umaprasana Ojha

IPC: C08G18/32

CPC classification number: C08G18/6204 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L29/049 ,  A61L29/06 ,  A61L29/085 ,  A61L31/06 ,  A61L31/10 ,  C08G18/32 ,  C08G18/3206 ,  C08G18/4063 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/7671 ,  C08L75/04

Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.

Abstract translation: 一种弹性体聚合物，其包含（1）所述弹性体聚合物的10至60重量％的硬链段，其中所述硬链段包括氨基甲酸酯，脲或氨基脲; 和（2）弹性体聚合物的40重量％至90重量％的软链段。 软链段包含（a）至少2重量％的至少一个聚醚大分子二醇的软链段和/或至少一个聚碳酸酯大分子二醇; 和（b）至少2重量％的至少一种聚异丁烯大分子二醇和/或二胺的软链段。

公开(公告)号：US07786217B2

公开(公告)日：2010-08-31

申请号：US11734230

申请日：2007-04-11

Applicant: Rudolf Faust ,  Tomoya Higashihara

Inventor： Rudolf Faust ,  Tomoya Higashihara

IPC: C08F30/04

CPC classification number: C08F295/00 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  C08F297/023 ,  C08L53/00

Abstract: The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from the group consisting of monomers of formula (I): wherein R1, R2, R3, R4, n, p, M, X, and L are defined herein. The present invention also provides methods for making and using (e.g., in articles of manufacture such as medical devices) the copolymers of the present invention.

Abstract translation: 本发明提供了共聚物，其包括对应于至少一种可阳离子聚合的异单烯烃种类的多个结构单元和对应于至少一种选自式（I）的单体的阴离子可聚合单体种类的结构单元， ：其中R1，R2，R3，R4，n，p，M，X和L在本文中定义。 本发明还提供了用于制造和使用（例如在诸如医疗器械的制品中）本发明的共聚物的方法。

公开(公告)号：US07671158B2

公开(公告)日：2010-03-02

申请号：US11447403

申请日：2006-06-05

Applicant: Rudolf Faust ,  Jae Cheol Cho

Inventor： Rudolf Faust ,  Jae Cheol Cho

IPC: C08F10/10 ,  C08F110/10 ,  C08F210/10

CPC classification number: C08F297/026 ,  C08F8/00 ,  C08F110/10 ,  C08F295/00 ,  C08F297/00 ,  C08F297/02 ,  C08F10/10 ,  C08F4/00 ,  C08F2/38 ,  C08F2500/03 ,  C08F2500/01

Abstract: According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions. According to another aspect of the present invention, a novel polymer is provided that comprises a polymer chain, which chain further comprises the following: (a) a plurality of constitutional units that correspond to cationically polymerizable monomer species and (b) an end-cap comprising a group or a group, where R is a branched or unbranched alkyl group containing from 1 to 20 carbons and R1 is a branched, unbranched, or cyclic alkyl group or an aryl group, containing from 1 to 20 carbons. Other aspects of the present invention relate to novel copolymers that comprise: (a) a first polymer block that comprises a plurality of constitutional units that correspond to isobutylene; and (b) a second polymer block that comprises a plurality of constitutional units that correspond to hydroxyethyl methacrylate.

Abstract translation: 根据本发明的一个方面，提供了一种方法，其中双二苯基乙烯化合物与含有碳阳离子末端链的聚合物反应，从而提供1,1-二亚苯基端官能化链。 随后，使烷基化剂与1,1-二亚苯基末端官能化链反应，从而提供烷基化的1,1-二亚苯基端官能化链。 在一些实施方案中，该方法还包括（a）任选地将1,1-二苯基有机锂化合物与烷基化的1,1-二亚苯基端官能化聚合物组合，然后（b）使有机锂化合物与烷基化的1,1-二亚苯基末端 官能化聚合物。 这提供了阴离子封端的聚合物，其可以用于例如随后的阴离子聚合和偶联反应。 根据本发明的另一方面，提供了一种包含聚合物链的新型聚合物，该链还包含以下物质：（a）多个与阳离子可聚合单体物质相对应的结构单元和（b）端帽 包括基团或基团，其中R是含有1至20个碳的支链或非支链烷基，R 1是含有1至20个碳的支链，非支链或环状烷基或芳基。 本发明的其它方面涉及包含以下的新型共聚物：（a）包含对应于异丁烯的多个结构单元的第一聚合物嵌段; 和（b）包含对应于甲基丙烯酸羟乙酯的多个结构单元的第二聚合物嵌段。

公开(公告)号：US20080255330A1

公开(公告)日：2008-10-16

申请号：US11734230

申请日：2007-04-11

Applicant: Rudolf Faust ,  Tomoya Higashihara

Inventor： Rudolf Faust ,  Tomoya Higashihara

IPC: C08F4/46 ,  C08F30/04

CPC classification number: C08F295/00 ,  A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  C08F297/023 ,  C08L53/00

Abstract: The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from the group consisting of monomers of formula (I): wherein R1, R2, R3, R4, n, p, M, X, and L are defined herein.The present invention also provides methods for making and using (e.g., in articles of manufacture such as medical devices) the copolymers of the present invention.

Abstract translation: 本发明提供了共聚物，其包括对应于至少一种可阳离子聚合的异单烯烃种类的多个结构单元和对应于至少一种选自式（I）的单体的阴离子可聚合单体种类的结构单元， 其中R 1，R 2，R 3，R 4，n，p，M，X， 和L在本文中定义。 本发明还提供了用于制造和使用（例如在诸如医疗器械的制品中）本发明的共聚物的方法。

公开(公告)号：US07417092B2

公开(公告)日：2008-08-26

申请号：US10872134

申请日：2004-06-18

Applicant: Rudolf Faust ,  Axel H. E. Mueller

Inventor： Rudolf Faust ,  Axel H. E. Mueller

IPC: C08F293/00

CPC classification number: C08F297/00 ,  C08F8/30 ,  C08F110/10 ,  C08F295/00 ,  C08F297/02 ,  C08F297/026 ,  C08F2810/40 ,  C08F8/00 ,  C08F10/10 ,  C08F8/42 ,  C08F4/00 ,  C08F2/38 ,  C08F2500/03 ,  C08F8/34

Abstract: Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiety with a heterocyclic compound of the formula where —X— is selected from —S—, —O—, —NH— and —NR—, and where R is an alkyl group or an aryl group, thereby providing an end-capped polymeric moiety; and (c) reacting the end-capped polymeric moiety with an organolithium compound to yield an anionically terminated polymeric moiety. Also described are block copolymers in which a first polymer block comprising cationically polymerized monomers is linked to a second polymer block comprising anionically polymerized monomers by a group, as well as a polymer in which a polymer block comprising cationically polymerized monomers is linked to a halogenated silane residue or a carbosilane residue by a group.

Abstract translation: 本文描述了将碳阳离子封端的聚合物转化成阴离子封端的聚合物的方法。 这些方法包括：（a）提供碳阳离子封端的聚合物部分; （b）使碳阳离子封端的聚合物部分与下式的杂环化合物反应，其中-X-选自-S-， -​​ O - ， - NH-和-NR-，其中R是烷基或芳基 ，从而提供封端的聚合物部分; 和（c）使封端的聚合物部分与有机锂化合物反应，得到阴离子封端的聚合物部分。 还描述了嵌段共聚物，其中包含阳离子聚合的单体的第一聚合物嵌段与包含阴离子聚合的单体的第二聚合物嵌段连接，其中包含阳离子聚合的单体的聚合物嵌段与卤代硅烷 残基或碳硅烷残基。

公开(公告)号：US20060223946A1

公开(公告)日：2006-10-05

申请号：US11447403

申请日：2006-06-05

Applicant: Rudolf Faust ,  Jae Cho

Inventor： Rudolf Faust ,  Jae Cho

IPC: C08F297/00

CPC classification number: C08F297/026 ,  C08F8/00 ,  C08F110/10 ,  C08F295/00 ,  C08F297/00 ,  C08F297/02 ,  C08F10/10 ,  C08F4/00 ,  C08F2/38 ,  C08F2500/03 ,  C08F2500/01

Abstract: According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions. According to another aspect of the present invention, a novel polymer is provided that comprises a polymer chain, which chain further comprises the following: (a) a plurality of constitutional units that correspond to cationically polymerizable monomer species and (b) an end-cap comprising a group or a group, where R is a branched or unbranched alkyl group containing from 1 to 20 carbons and R1 is a branched, unbranched, or cyclic alkyl group or an aryl group, containing from 1 to 20 carbons. Other aspects of the present invention relate to novel copolymers that comprise: (a) a first polymer block that comprises a plurality of constitutional units that correspond to isobutylene; and (b) a second polymer block that comprises a plurality of constitutional units that correspond to hydroxyethyl methacrylate.

公开(公告)号：US20060013867A1

公开(公告)日：2006-01-19

申请号：US10894394

申请日：2004-07-19

Applicant: Robert Richard ,  Rudolf Faust

Inventor： Robert Richard ,  Rudolf Faust

IPC: A61K9/70

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L53/02

Abstract: The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.

Abstract translation: 本发明涉及包含异丁烯共聚物的医疗装置。 本发明还涉及用于治疗剂递送的生物相容性共聚物材料，其包含负载治疗剂的异丁烯共聚物。 根据本发明的一个方面，提供了一种医疗装置，其包括：（a）基底和（b）至少一个包含共聚物的聚合物层，其设置在基底的全部或一部分上。 共聚物含有一个或多个聚合物链，其中异丁烯和升高的T单体（和任选地，其它单体）以无规，周期，统计或梯度分布结合。

公开(公告)号：US5981785A

公开(公告)日：1999-11-09

申请号：US204900

申请日：1998-12-03

Applicant: Rudolf Faust ,  Savvas E. Hadjikyriacou ,  Toshio Suzuki

Inventor： Rudolf Faust ,  Savvas E. Hadjikyriacou ,  Toshio Suzuki

IPC: C07F7/12

CPC classification number: C07F7/12

Abstract: A novel initiator which may be used to prepare a silyl-functional living cationic polymer is disclosed, said initiator having the formula ##STR1## wherein R is independently selected from the group consisting of alkyl groups having 1 to 10 carbon atoms and aryl groups having 6 to 10 carbon atoms, R' is a divalent aliphatic hydrocarbon group having at least 3 carbon atoms, X is halogen, Y is selected from the group consisting of halogen, alkoxy, acyloxy and hydroxyl groups and a is 1, 2 or 3.

Abstract translation: 公开了可用于制备甲硅烷基官能的活性阳离子聚合物的新型引发剂，所述引发剂具有下式：其中R独立地选自具有1-10个碳原子的烷基和具有6-10个碳原子的芳基 原子，R'是具有至少3个碳原子的二价脂族烃基，X是卤素，Y选自卤素，烷氧基，酰氧基和羟基，a是1,2或3。

公开(公告)号：US5451647A

公开(公告)日：1995-09-19

申请号：US958406

申请日：1992-10-08

Applicant: Rudolf Faust ,  Hsien-Chang Wang ,  Miklos Gyor

Inventor： Rudolf Faust ,  Hsien-Chang Wang ,  Miklos Gyor

IPC: C08F4/16 ,  C08F4/60 ,  C08F4/64 ,  C08F10/00 ,  C08F12/00 ,  C08F12/08 ,  C08F297/00 ,  C08F10/10

CPC classification number: C08F297/00 ,  C08F10/00 ,  Y10S526/912

Abstract: An olefin polymerization process is provided wherein an olefin chargestock is contacted with an organic compound polymerization initiator, a Lewis acid coinitiator and a pyridine compound such as 2,6-di-tert-butylpyridine to produce homopolymers, copolymers or block copolymers having a narrow molecular weight distribution.

Abstract translation: 提供了一种烯烃聚合方法，其中烯烃装料与有机化合物聚合引发剂，路易斯酸共引发剂和吡啶化合物如2,6-二叔丁基吡啶接触以制备具有窄分子量的均聚物，共聚物或嵌段共聚物 体重分布。

公开(公告)号：US4910321A

公开(公告)日：1990-03-20

申请号：US156538

申请日：1988-02-16

Applicant: Joseph P. Kennedy ,  Rudolf Faust

Inventor： Joseph P. Kennedy ,  Rudolf Faust

IPC: C08F10/00

CPC classification number: C08F10/00

Abstract: This invention provides a novel catalyst composed of a complex of an organic acid or its ester and a Lewis acid, preferably boron trichloride that can add olefin monomers to increase the molecular weight of the complex from as low as 200 to in excess of a million, with the complex being active viz., living, until the complex dies, viz., is decomposed or destroyed so that polymers in the liquid or easily liquefiable range of 300 to about 20,000 can be made or those more difficult to be liquefied or unliquefiable, viz., those of over 10,000 up to 100,000 or in some cases 500,000 and then those in the range of the elastomers, or moldable or extrudable plastics range having very high molecular weights, generally in excess of 100,000 up to in excess of 500,000 and having useful end groups such as the halogens and specifically chloride, allyl, acryl or methacryl, acetate or formate to name some of the more useful ones.

Abstract translation: 本发明提供一种由有机酸或其酯的络合物和路易斯酸（优选三氯化硼）组成的新型催化剂，其可以加入烯烃单体以将络合物的分子量从低至200升至超过百万分之一， 复合物是活性的，即生活，直到复合物死亡，即分解或破坏，使得可以制备液体中的聚合物或易于液化的范围为300至约20,000，或者难以液化或不液化的聚合物， 即超过10,000至100,000或在某些情况下为500,000的那些，然后在弹性体或可塑或可挤压塑料范围内的那些具有非常高的分子量，通常超过100,000至超过500,000，并具有 有用的端基，如卤素，特别是氯离子，烯丙基，丙烯基或甲基丙烯酰基，乙酸酯或甲酸酯，以命名一些更有用的。