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    Polyisobutylene-Based Polyurethanes
    4.
    发明申请
    Polyisobutylene-Based Polyurethanes 有权
    聚异丁烯基聚氨酯

    公开(公告)号：US20100179298A1

    公开(公告)日：2010-07-15

    申请号：US12685858

    申请日：2010-01-12

    Applicant: Rudolf Faust ,  Umaprasana Ojha

    Inventor： Rudolf Faust ,  Umaprasana Ojha

    IPC: C08G18/67

    CPC classification number: C08G18/6204 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L29/049 ,  A61L29/06 ,  A61L29/085 ,  A61L31/06 ,  A61L31/10 ,  C08G18/32 ,  C08G18/3206 ,  C08G18/4063 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/7671 ,  C08L75/04

    Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.

    Abstract translation: 一种弹性体聚合物，其包含（1）所述弹性体聚合物的10至60重量％的硬链段，其中所述硬链段包括氨基甲酸酯，脲或氨基脲; 和（2）弹性体聚合物的40重量％至90重量％的软链段。 软链段包含（a）至少2重量％的至少一个聚醚大分子二醇的软链段和/或至少一个聚碳酸酯大分子二醇; 和（b）至少2重量％的至少一种聚异丁烯大分子二醇和/或二胺的软链段。

    POLYISOBUTYLENE-BASED POLYURETHANES
    7.
    发明申请
    POLYISOBUTYLENE-BASED POLYURETHANES 有权
    聚异丁烯基聚氨酯

    公开(公告)号：US20130079487A1

    公开(公告)日：2013-03-28

    申请号：US13681811

    申请日：2012-11-20

    Applicant: Rudolf Faust ,  Umaprasana Ojha

    Inventor： Rudolf Faust ,  Umaprasana Ojha

    IPC: C08G18/32

    CPC classification number: C08G18/6204 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L29/049 ,  A61L29/06 ,  A61L29/085 ,  A61L31/06 ,  A61L31/10 ,  C08G18/32 ,  C08G18/3206 ,  C08G18/4063 ,  C08G18/4854 ,  C08G18/6511 ,  C08G18/7671 ,  C08L75/04

    Abstract: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.

    Abstract translation: 一种弹性体聚合物，其包含（1）所述弹性体聚合物的10至60重量％的硬链段，其中所述硬链段包括氨基甲酸酯，脲或氨基脲; 和（2）弹性体聚合物的40重量％至90重量％的软链段。 软链段包含（a）至少2重量％的至少一个聚醚大分子二醇的软链段和/或至少一个聚碳酸酯大分子二醇; 和（b）至少2重量％的至少一种聚异丁烯大分子二醇和/或二胺的软链段。

    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
    9.
    发明申请
    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权

    公开(公告)号：US20060171985A1

    公开(公告)日：2006-08-03

    申请号：US11048616

    申请日：2005-02-01

    Applicant: Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

    Inventor： Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

    IPC: A61F2/00

    CPC classification number: A61L31/129 ,  A61L27/48 ,  A61N1/05

    Abstract: The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    End-capped polymer chains and products thereof
    10.
    发明授权
    End-capped polymer chains and products thereof 失效
    封端聚合物链及其制品

    公开(公告)号：US07056985B2

    公开(公告)日：2006-06-06

    申请号：US10776681

    申请日：2004-02-11

    Applicant: Rudolf Faust ,  Jae Cheol Cho

    Inventor： Rudolf Faust ,  Jae Cheol Cho

    IPC: C08F293/00

    CPC classification number: C08F297/026 ,  C08F8/00 ,  C08F110/10 ,  C08F295/00 ,  C08F297/00 ,  C08F297/02 ,  C08F10/10 ,  C08F4/00 ,  C08F2/38 ,  C08F2500/03 ,  C08F2500/01

    Abstract: According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions. According to another aspect of the present invention, a novel polymer is provided that comprises a polymer chain, which chain further comprises the following: (a) a plurality of constitutional units that correspond to cationically polymerizable monomer species and (b) an end-cap comprising a group or a group, where R is a branched or unbranched alkyl group containing from 1 to 20 carbons and R1 is a branched, unbranched, or cyclic alkyl group or an aryl group, containing from 1 to 20 carbons. Other aspects of the present invention relate to novel copolymers that comprise: (a) a first polymer block that comprises a plurality of constitutional units that correspond to isobutylene; and (b) a second polymer block that comprises a plurality of constitutional units that correspond to hydroxyethyl methacrylate.

    Abstract translation: 根据本发明的一个方面，提供了一种方法，其中双二苯基乙烯化合物与含有碳阳离子末端链的聚合物反应，从而提供1,1-二亚苯基端官能化链。 随后，使烷基化剂与1,1-二亚苯基末端官能化链反应，从而提供烷基化的1,1-二亚苯基端官能化链。 在一些实施方案中，该方法还包括（a）任选地将1,1-二苯基有机锂化合物与烷基化的1,1-二亚苯基端官能化聚合物组合，然后（b）使有机锂化合物与烷基化的1,1-二亚苯基末端 官能化聚合物。 这提供了阴离子封端的聚合物，其可以用于例如随后的阴离子聚合和偶联反应。 根据本发明的另一方面，提供了一种包含聚合物链的新型聚合物，该链还包含以下物质：（a）多个与阳离子可聚合单体物质相对应的结构单元和（b）端帽 包括基团或基团，其中R是含有1至20个碳的支链或非支链烷基，R 1是支链，非支链或环状烷基或芳基，其含有1个 至20个碳。 本发明的其它方面涉及包含以下的新型共聚物：（a）包含对应于异丁烯的多个结构单元的第一聚合物嵌段; 和（b）包含对应于甲基丙烯酸羟乙酯的多个结构单元的第二聚合物嵌段。

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