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    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
    1.
    发明申请
    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权

    公开(公告)号：US20060171985A1

    公开(公告)日：2006-08-03

    申请号：US11048616

    申请日：2005-02-01

    申请人： Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

    发明人： Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

    IPC分类号： A61F2/00

    CPC分类号： A61L31/129 ,  A61L27/48 ,  A61N1/05

    摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    Polymers having covalently bound therapeutic agents
    2.
    发明申请
    Polymers having covalently bound therapeutic agents 有权
    具有共价结合治疗剂的聚合物

    公开(公告)号：US20070020308A1

    公开(公告)日：2007-01-25

    申请号：US11184223

    申请日：2005-07-19

    申请人： Robert Richard ,  Rudolf Faust

    发明人： Robert Richard ,  Rudolf Faust

    IPC分类号： A61K31/74

    CPC分类号： A61K47/58

    摘要： Therapeutic polymers are described, which contain at least one polymeric portion and at least one therapeutic agent. The therapeutic agent and the polymeric portion are covalently linked via one or more linkages which hydrolyze in an aqueous environment, for example, one or more linkages selected from an Si—N linkage, an Si—O linkage, and a combination of the same. Other aspects the invention are directed to methods of making the above therapeutic polymers.

    摘要翻译： 描述了含有至少一个聚合物部分和至少一种治疗剂的治疗性聚合物。 治疗剂和聚合物部分通过在水性环境中水解的一种或多种键共价连接，例如一种或多种选自Si-N键，Si-O键及其组合的键。 本发明的其它方面涉及制备上述治疗性聚合物的方法。

    Medical devices and materials containing isobutylene copolymer
    4.
    发明申请
    Medical devices and materials containing isobutylene copolymer 失效
    包含异丁烯共聚物的医疗器械和材料

    公开(公告)号：US20060013867A1

    公开(公告)日：2006-01-19

    申请号：US10894394

    申请日：2004-07-19

    申请人： Robert Richard ,  Rudolf Faust

    发明人： Robert Richard ,  Rudolf Faust

    IPC分类号： A61K9/70

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L53/02

    摘要： The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.

    摘要翻译： 本发明涉及包含异丁烯共聚物的医疗装置。 本发明还涉及用于治疗剂递送的生物相容性共聚物材料，其包含负载治疗剂的异丁烯共聚物。 根据本发明的一个方面，提供了一种医疗装置，其包括：（a）基底和（b）至少一个包含共聚物的聚合物层，其设置在基底的全部或一部分上。 共聚物含有一个或多个聚合物链，其中异丁烯和升高的T单体（和任选地，其它单体）以无规，周期，统计或梯度分布结合。

    End-capped polymer chains and products thereof
    6.
    发明授权
    End-capped polymer chains and products thereof 失效
    封端聚合物链及其制品

    公开(公告)号：US07056985B2

    公开(公告)日：2006-06-06

    申请号：US10776681

    申请日：2004-02-11

    申请人： Rudolf Faust ,  Jae Cheol Cho

    发明人： Rudolf Faust ,  Jae Cheol Cho

    IPC分类号： C08F293/00

    CPC分类号： C08F297/026 ,  C08F8/00 ,  C08F110/10 ,  C08F295/00 ,  C08F297/00 ,  C08F297/02 ,  C08F10/10 ,  C08F4/00 ,  C08F2/38 ,  C08F2500/03 ,  C08F2500/01

    摘要： According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently, an alkylating agent is reacted with the 1,1-diphenylene end-functionalized chain, thereby providing an alkylated 1,1-diphenylene end-functionalized chain. In some embodiments, the method further comprises (a) optionally combining a 1,1-diphenylorganolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer followed by (b) reacting an organolithium compound with the alkylated 1,1-diphenylene end-functionalized polymer. This provides an anionically terminated polymer, which can be used, for example, in subsequent anionic polymerization and coupling reactions. According to another aspect of the present invention, a novel polymer is provided that comprises a polymer chain, which chain further comprises the following: (a) a plurality of constitutional units that correspond to cationically polymerizable monomer species and (b) an end-cap comprising a group or a group, where R is a branched or unbranched alkyl group containing from 1 to 20 carbons and R1 is a branched, unbranched, or cyclic alkyl group or an aryl group, containing from 1 to 20 carbons. Other aspects of the present invention relate to novel copolymers that comprise: (a) a first polymer block that comprises a plurality of constitutional units that correspond to isobutylene; and (b) a second polymer block that comprises a plurality of constitutional units that correspond to hydroxyethyl methacrylate.

    摘要翻译： 根据本发明的一个方面，提供了一种方法，其中双二苯基乙烯化合物与含有碳阳离子末端链的聚合物反应，从而提供1,1-二亚苯基端官能化链。 随后，使烷基化剂与1,1-二亚苯基末端官能化链反应，从而提供烷基化的1,1-二亚苯基端官能化链。 在一些实施方案中，该方法还包括（a）任选地将1,1-二苯基有机锂化合物与烷基化的1,1-二亚苯基端官能化聚合物组合，然后（b）使有机锂化合物与烷基化的1,1-二亚苯基末端 官能化聚合物。 这提供了阴离子封端的聚合物，其可以用于例如随后的阴离子聚合和偶联反应。 根据本发明的另一方面，提供了一种包含聚合物链的新型聚合物，该链还包含以下物质：（a）多个与阳离子可聚合单体物质相对应的结构单元和（b）端帽 包括基团或基团，其中R是含有1至20个碳的支链或非支链烷基，R 1是支链，非支链或环状烷基或芳基，其含有1个 至20个碳。 本发明的其它方面涉及包含以下的新型共聚物：（a）包含对应于异丁烯的多个结构单元的第一聚合物嵌段; 和（b）包含对应于甲基丙烯酸羟乙酯的多个结构单元的第二聚合物嵌段。

    Living catalysts, complexes and polymers therefrom
    8.
    发明授权
    Living catalysts, complexes and polymers therefrom 失效
    活性催化剂，络合物和聚合物

    公开(公告)号：US5122572A

    公开(公告)日：1992-06-16

    申请号：US443468

    申请日：1989-11-29

    申请人： Joseph P. Kennedy ,  Rudolf Faust

    发明人： Joseph P. Kennedy ,  Rudolf Faust

    IPC分类号： C08F10/00

    CPC分类号： C08F10/00

    摘要： This invention provides a novel catalyst composed of a complex of an organic acid or its ester and a Lewis acid, preferably boron trichloride that can add olefin monomers to increase the molecular weight of the complex from as low as 200 to in excess of a million, with the complex being active viz., living, until the complex dies, viz., is decomposed or destroyed so that polymers in the liquid or easily liquefiable range of 300 to about 10,000 can be made of those more difficult to be liquefied or unliquefiable, viz., those of over 10,000 up to 100,000 or in some cases 500,000 and then those in the range of the elastomers, or moldable or extrudable plastics range having very high molecular weights, generally in excess of 100,000 up to in excess of 500,000 and having useful end groups such as the halogens and specifically chloride, allyl, acryl or methacryl, acetate or formate to name some of the more useful ones.

    摘要翻译： 本发明提供一种由有机酸或其酯的络合物和路易斯酸（优选三氯化硼）组成的新型催化剂，其可以加入烯烃单体以将络合物的分子量从低至200升至超过百万分之一， 复合物是活性的，即生活，直到复合物死亡，即分解或破坏，使得液体中容易或可容易液化的范围为300至约10,000的聚合物可以由难以液化或不易液化的聚合物制成， 即超过10,000至100,000或在某些情况下为500,000的那些，然后在弹性体或可塑或可挤压塑料范围内的那些具有非常高的分子量，通常超过100,000至超过500,000，并具有 有用的端基，如卤素，特别是氯离子，烯丙基，丙烯基或甲基丙烯酰基，乙酸酯或甲酸酯，以命名一些更有用的。

    Medical devices and materials containing isobutylene copolymer
    9.
    发明授权
    Medical devices and materials containing isobutylene copolymer 失效
    包含异丁烯共聚物的医疗器械和材料

    公开(公告)号：US08697119B2

    公开(公告)日：2014-04-15

    申请号：US10894394

    申请日：2004-07-19

    申请人： Robert E. Richard ,  Rudolf Faust

    发明人： Robert E. Richard ,  Rudolf Faust

    IPC分类号： A61K9/70

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/00 ,  C08L53/02

    摘要： The present invention relates to medical devices which contain isobutylene copolymers. The present invention also relates to biocompatible copolymer materials for therapeutic agent delivery comprising a therapeutic-agent-loaded isobutylene copolymer. According to an aspect of the present invention, a medical device is provided, which includes: (a) a substrate and (b) at least one polymeric layer, which contains a copolymer, disposed over all or a portion of the substrate. The copolymer contains one or more polymer chains, within which isobutylene and elevated Tg monomers (and, optionally, other monomers) are incorporated in a random, periodic, statistical or gradient distribution.

    摘要翻译： 本发明涉及包含异丁烯共聚物的医疗装置。 本发明还涉及用于治疗剂递送的生物相容性共聚物材料，其包含负载治疗剂的异丁烯共聚物。 根据本发明的一个方面，提供了一种医疗装置，其包括：（a）基底和（b）至少一个包含共聚物的聚合物层，其设置在基底的全部或一部分上。 共聚物含有一个或多个聚合物链，其中异丁烯和升高的Tg单体（和任选地，其它单体）以随机，周期，统计或梯度分布引入。