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公开(公告)号:US10213948B2
公开(公告)日:2019-02-26
申请号:US15920133
申请日:2018-03-13
IPC分类号: A61K9/16 , A61K9/20 , B29C47/00 , B29C47/40 , B29C47/60 , B29C47/80 , B29K91/00 , B29K105/00
摘要: A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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公开(公告)号:US20180360737A1
公开(公告)日:2018-12-20
申请号:US15781090
申请日:2016-12-12
发明人: Indu BHUSHAN , Vijay KULKARNI , Rakshith SHETTY
IPC分类号: A61K9/46 , A61K31/155 , A61P3/10
摘要: The present invention relates to effervescent compositions of Metformin and optionally other anti-diabetic agents and processes for preparation thereof. More particularly provides an effervescent composition comprising Metformin, an acid and a base such that the composition is free of affirmatively added binders and granulating solvents. The effervescent composition of the present invention has retained carbon dioxide content of at least 90% of the input blend.
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公开(公告)号:US20180214835A1
公开(公告)日:2018-08-02
申请号:US15747021
申请日:2016-08-01
发明人: Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
摘要: The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also discl
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公开(公告)号:US11247380B2
公开(公告)日:2022-02-15
申请号:US16373187
申请日:2019-04-02
发明人: Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号: B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要: Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号:US11247379B2
公开(公告)日:2022-02-15
申请号:US16373178
申请日:2019-04-02
发明人: Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
IPC分类号: B29C48/405 , B29C48/57 , B29C48/64 , B29B9/16 , B29B7/48 , B29B9/06 , B29B7/94 , B29B9/08 , B29C48/04 , B29C48/625 , B29C48/80
摘要: Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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公开(公告)号:US20210046439A1
公开(公告)日:2021-02-18
申请号:US17007641
申请日:2020-08-31
发明人: Radhika Ghike , Vijay Kulkarni , Indu Bhushan , Himadri Sen , Babu Padmanabhan , Vinay Rao
摘要: The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.
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公开(公告)号:US20190263043A1
公开(公告)日:2019-08-29
申请号:US16373187
申请日:2019-04-02
发明人: Indu Bhushan , Babu Padmanabhan , Vinay Rao , Vijay Kulkarni , Chetan Chincholi , Radhika Ghike , Raja Ganeshan
摘要: Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.
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18.
公开(公告)号:US20190060242A1
公开(公告)日:2019-02-28
申请号:US15766729
申请日:2016-10-07
发明人: Babu PADMANABHAN , Himadri SEN , Indu BHUSHAN , Vijay KULKARNI , Rakshith SHETTY , Aravind Kumar GURRAM
IPC分类号: A61K9/20 , A61K31/403 , A61J3/10 , A61K31/4985
摘要: A rapidly disintegrating tablet comprising a therapeutically effective amount of a DPP-IV inhibitor and an acid-base couple having mineral content below the daily intake limits is disclosed. The rapidly disintegrating tablet has a sodium content less than 10 mg and a potassium content less than 15 mg. A process for preparation of the rapidly disintegrating tablet comprising the DPP-IV inhibitor is also disclosed.
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公开(公告)号:US09956709B2
公开(公告)日:2018-05-01
申请号:US14888916
申请日:2014-05-27
IPC分类号: B29C47/00 , B29C47/40 , B29C47/60 , B29C47/80 , A61K9/16 , A61K9/20 , B29K91/00 , B29K105/00
CPC分类号: B29C47/0011 , A61K9/1617 , A61K9/1694 , A61K9/2095 , B29C47/00 , B29C47/402 , B29C47/6075 , B29C47/805 , B29C47/807 , B29K2091/00 , B29K2105/0035
摘要: A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder.
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公开(公告)号:US11219594B2
公开(公告)日:2022-01-11
申请号:US15781090
申请日:2016-12-12
发明人: Indu Bhushan , Vijay Kulkarni , Rakshith Shetty
摘要: The present invention relates to effervescent compositions of Metformin and optionally other anti-diabetic agents and processes for preparation thereof. More particularly provides an effervescent composition comprising Metformin, an acid and a base such that the composition is free of affirmatively added binders and granulating solvents. The effervescent composition of the present invention has retained carbon dioxide content of at least 90% of the input blend.
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