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22 条记录 (耗时 0.04 秒)

    Production of Polyketides and Other Natural Products
    12.
    发明申请
    Production of Polyketides and Other Natural Products 有权
    聚酮化合物及其他天然产物的生产

    公开(公告)号：US20110165633A1

    公开(公告)日：2011-07-07

    申请号：US13046304

    申请日：2011-03-11

    申请人： Matthew Alan Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    发明人： Matthew Alan Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    IPC分类号： C12P17/18

    CPC分类号： C07D498/18 ,  C07D405/12 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07K14/36 ,  C12N15/52 ,  C12N15/70 ,  C12N15/76 ,  C12P17/188

    摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

    摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。

    Production of polyketides and other natural products
    13.
    发明授权
    Production of polyketides and other natural products 有权
    生产聚酮化合物等天然产物

    公开(公告)号：US07390895B2

    公开(公告)日：2008-06-24

    申请号：US11778264

    申请日：2007-07-16

    申请人： Matthew Alan Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    发明人： Matthew Alan Gregory ,  Sabine Gaisser ,  Hrvoje Petkovic ,  Steven Moss

    IPC分类号： C07D498/18

    CPC分类号： C07D498/18 ,  C07D405/12 ,  C07D471/18 ,  C07D487/18 ,  C07D493/18 ,  C07K14/36 ,  C12N15/52 ,  C12N15/70 ,  C12N15/76 ,  C12P17/188

    摘要： The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

    摘要翻译： 本发明涉及聚酮化合物和其它天然产物的生产以及化合物和单个新化合物的文库。 一个重要的领域是产生这些化合物的新型FKBP-配体类似物和宿主细胞的分离和潜在的使用。 本发明特别涉及有效转化产生FKBP类似物的菌株和重组细胞的方法，其中克隆的基因或基因盒被表达以产生新的化合物，例如聚酮化合物（特别是雷帕霉素）FKBP-配体类似物， 制备和其中使用的手段（例如核酸，载体，基因盒和遗传修饰的菌株）。

    Combination toilet seat and bidet apparatus
    16.
    发明申请
    Combination toilet seat and bidet apparatus 审中-公开
    组合马桶座和坐浴盆装置

    公开(公告)号：US20060162058A1

    公开(公告)日：2006-07-27

    申请号：US11040938

    申请日：2005-01-21

    申请人： Steven Moss ,  Mart Betts ,  Keith Lindsey

    发明人： Steven Moss ,  Mart Betts ,  Keith Lindsey

    IPC分类号： E03D9/08

    CPC分类号： E03D9/08

    摘要： A combination toilet seat and bidet apparatus includes a toilet seat member formed with a top wall, a continuous arcuate outer sidewall extending between opposite ends of a back wall and an inner sidewall defining, in part, a seat opening. An arcuate nozzle support arm is mounted on the seat member for rotation about an axis generally normal to the longitudinal axis of the seat member. An operating handle is connected to the arm at one side of the seat and a water flow control valve and operating handle are mounted on the seat opposite the arm operating handle for controlling water flow to a water jet nozzle mounted on the arm. The arm is adapted to be moved to selected working positions by the arm operating handle, and water flow may be selectively varied at will.

    摘要翻译： 组合马桶座圈和坐浴盆装置包括形成有顶壁的马桶座圈构件，在后壁的相对端部之间延伸的连续弧形外侧壁和部分地限定座椅开口的内侧壁。 弧形喷嘴支撑臂安装在座椅构件上，用于围绕基本上垂直于座椅构件的纵向轴线的轴线旋转。 操作手柄在座椅的一侧连接到臂上，并且水流控制阀和操作手柄安装在与臂操作手柄相对的座上，用于控制到安装在臂上的水喷嘴的水流。 手臂适于通过手臂操作手柄移动到所选择的工作位置，并且水流可以随意选择性地变化。

    C21-Deoxy Ansamycin Derivatives as Antitumor Agents
    20.
    发明申请
    C21-Deoxy Ansamycin Derivatives as Antitumor Agents 审中-公开
    C21-Deoxy Ansamycin衍生物作为抗肿瘤剂

    公开(公告)号：US20100210597A1

    公开(公告)日：2010-08-19

    申请号：US12526605

    申请日：2008-03-03

    申请人： Steven Moss ,  Christine Martin ,  Ming Zhang

    发明人： Steven Moss ,  Christine Martin ,  Ming Zhang

    IPC分类号： A61K31/675 ,  C07D225/06 ,  A61K31/33 ,  A61P35/00 ,  A61P31/00 ,  A61P25/00 ,  A61P37/06 ,  A61P9/00

    CPC分类号： C07D225/06

    摘要： According to the invention there are provided derivatives of a C21-deoxy ansamycin or salt thereof which contain a 1-hydroxyphenyl moiety bearing at position 3 an aminocarboxy substituent, in which position 5 and the aminocarboxy substituent at position 3 are connected by an aliphatic chain of varying length characterised in that the 1-hydroxy position of the phenyl ring is derivatised by an aminoalkyleneaminocarbonyl group, which alkylene group (which may optionally be substituted by alkyl groups) has a chain length of 2 or 3 carbon atoms, a phosphoric acid, or a phosphoric acid ester (such as an alkyl ester) group, or a salt thereof, and which derivatising group increases the water solubility and/or the bioavailability of the parent molecule. Such compounds are useful in therapy eg in the treatment of cancer and B-cell malignancies.

    摘要翻译： 根据本发明，提供了一种C21-脱氧安莎霉素或其盐的衍生物，其含有在位置3具有氨基羧基取代基的1-羟基苯基部分，其中位置5和位置3上的氨基羧基取代基通过脂族链连接 变化的长度，其特征在于苯环的1-羟基位置被氨基亚烷基氨基羰基衍生，该亚烷基（其可以任选被烷基取代）具有2或3个碳原子的链长，磷酸或 磷酸酯（例如烷基酯）或其盐，并且该衍生基增加了母体分子的水溶性和/或生物利用度。 这样的化合物可用于治疗，例如治疗癌症和B细胞恶性肿瘤。