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    15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies
    4.
    发明申请
    15-O-Desmethylmacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies 审中-公开
    15-O-去甲基衍生物及其在治疗癌症或B细胞恶性肿瘤中的应用

    公开(公告)号：US20090209507A1

    公开(公告)日：2009-08-20

    申请号：US12294253

    申请日：2007-03-30

    申请人： Sabine Gaisser ,  Christine Martin ,  Ming Zhang ,  Barrie Wilkinson ,  Nigel Coates ,  Mohammed Nur-E-Alam ,  William Vousden

    发明人： Sabine Gaisser ,  Christine Martin ,  Ming Zhang ,  Barrie Wilkinson ,  Nigel Coates ,  Mohammed Nur-E-Alam ,  William Vousden

    IPC分类号： A61K31/395 ,  C07D225/06 ,  A61P35/00 ,  C12P17/10 ,  C12N5/10

    CPC分类号： C07D225/06

    摘要： The present invention relates to 15-O-desmethylmacbecin analogues according to the formula (IA) or (IB) herein, or a pharmaceutically acceptable salt thereof: wherein: R1 and R2 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R3 represents H or CONH2 that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.

    摘要翻译： 本发明涉及根据本文的式（IA）或（IB）的15-O-去甲基蒿酸类似物或其药学上可接受的盐：其中：R 1和R 2都表示H或一起表示一个键（即C 4至 C5是双键）; 并且R 3表示可用的H或CONH 2，例如。 在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

    NOVEL COMPOUNDS
    5.
    发明申请
    NOVEL COMPOUNDS 审中-公开
    新型化合物

    公开(公告)号：US20090312316A1

    公开(公告)日：2009-12-17

    申请号：US12296482

    申请日：2007-05-17

    申请人： Barrie Wilkinson ,  Steven Moss ,  Ming Zhang

    发明人： Barrie Wilkinson ,  Steven Moss ,  Ming Zhang

    IPC分类号： A61K31/365 ,  C07D313/00 ,  C07D405/02 ,  C07D413/02 ,  A61P35/00 ,  A61P27/02 ,  A61K31/5377 ,  A61K31/4427

    CPC分类号： C07D405/12

    摘要： The present invention relates to derivatives of borrelidin that are useful in medicine, e.g. in the treatment of cancer or B-cell malignancies, or other diseases in which angiogenesis contributes to the pathology including ophthalmic disorders such as diabetic retinopathy as well as age related macular degeneration (AMD), corneal neovascularisation and retinopathy or prematurity. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies and other diseases in which angiogenesis is implicated in the pathogenic process.

    摘要翻译： 本发明涉及可用于医药的例如硼砂灵兰衍生物。 在治疗癌症或B细胞恶性肿瘤或其它血管发生有助于包括眼部疾病如糖尿病性视网膜病变以及年龄相关性黄斑变性（AMD），角膜新生血管形成和视网膜病变或早产的病理学的疾病中。 本发明还提供了这些化合物的制备方法及其在药物中的用途，特别是在治疗和/或预防癌细胞或B细胞恶性肿瘤以及血管生成涉及致病过程的其它疾病中的用途。