公开(公告)号：US08932524B2

公开(公告)日：2015-01-13

申请号：US13199601

申请日：2011-09-02

Applicant: Stuart Farquharson ,  Paul Maksymiuk ,  Chetan S. Shende

Inventor： Stuart Farquharson ,  Paul Maksymiuk ,  Chetan S. Shende

IPC: G01N21/00 ,  G01N21/65 ,  G01N1/40 ,  G01N30/74 ,  B01L3/00 ,  G01N30/60 ,  G01N30/78

CPC classification number: G01N21/658 ,  B01L3/5027 ,  G01N1/40 ,  G01N30/6082 ,  G01N30/6095 ,  G01N30/74 ,  G01N30/78 ,  G01N21/63

Abstract: A stationary medium is employed both to separate chemicals from a sample solution and also to generate surface-enhanced Raman scattering, so that spectral analysis of the separated analyte chemical can be performed. Applied driving force causes the sample to flow into the stationary medium and to distribute therethrough, thereby causing rapid separation of the analyte chemical, and surface-enhanced Raman scattered radiation is quickly detected, at a plurality of locations along a flow path defined by the stationary medium, for ultimate analysis.

Abstract translation: 既采用固定介质将样品溶液中的化学物质分开，也可产生表面增强的拉曼散射，从而可以进行分离的分析物化学品的光谱分析。 施加的驱动力使得样品流入固定介质并分布在其中，从而导致分析物化学物质的快速分离，并且在沿着由静止物定义的流动路径的多个位置处快速检测到表面增强的拉曼散射辐射 中等，用于最终分析。

公开(公告)号：US08781757B2

公开(公告)日：2014-07-15

申请号：US12734091

申请日：2008-10-10

Applicant: Stuart Farquharson ,  Wayne W. Smith

Inventor： Stuart Farquharson ,  Wayne W. Smith

IPC: G06F19/00

CPC classification number: G01N21/359 ,  G01N21/3577 ,  G01N21/65 ,  G01N21/84 ,  G01N2021/6421 ,  G01N2021/8411 ,  G01N2201/1293

Abstract: The method and apparatus are used to determine class, grade and properties of fuel samples, regardless of ambient, instrument, or sample temperature, using mathematical correlations between fuel class, grade and properties and their spectra developed from a database of samples with measured properties and spectra. The ability to measure a fuel sample using the present method and apparatus is useful in identifying unknown fuel samples, determining suitability in equipment, and monitoring and controlling fuel processes, such as blending operations, distillation, and synthesis.

Abstract translation: 该方法和设备用于确定燃料样品的等级，等级和性能，无论环境，仪器或样品温度如何，使用燃料类别，等级和性质之间的数学相关性以及从具有测量性质的样品数据库开发的光谱，以及 光谱。 使用本方法和装置测量燃料样品的能力可用于识别未知燃料样品，确定设备的适用性，以及监测和控制燃料过程，例如混合操作，蒸馏和合成。

公开(公告)号：US20110317159A1

公开(公告)日：2011-12-29

申请号：US13199601

申请日：2011-09-02

Applicant: Chetan S. Shende ,  Stuart Farquharson ,  Paul Maksymiuk

Inventor： Chetan S. Shende ,  Stuart Farquharson ,  Paul Maksymiuk

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B01L3/5027 ,  G01N1/40 ,  G01N30/6082 ,  G01N30/6095 ,  G01N30/74 ,  G01N30/78 ,  G01N21/63

Abstract: A stationary medium is employed both to separate chemicals from a sample solution and also to generate surface-enhanced Raman scattering, so that spectral analysis of the separated analyte chemical can be performed. Applied driving force causes the sample to flow into the stationary medium and to distribute therethrough, thereby causing rapid separation of the analyte chemical, and surface-enhanced Raman scattered radiation is quickly detected, at a plurality of locations along a flow path defined by the stationary medium, for ultimate analysis.

Abstract translation: 既采用固定介质将样品溶液中的化学物质分开，也可产生表面增强的拉曼散射，从而可以进行分离的分析物化学品的光谱分析。 施加的驱动力使得样品流入固定介质并分布在其中，从而导致分析物化学物质的快速分离，并且在沿着由静止物定义的流动路径的多个位置处快速检测到表面增强的拉曼散射辐射 中等，用于最终分析。

公开(公告)号：US07713914B2

公开(公告)日：2010-05-11

申请号：US11355782

申请日：2006-02-16

Applicant: Stuart Farquharson ,  Frank E. Inscore ,  Alan D. Gift ,  Chetan Shrikant Shende

Inventor： Stuart Farquharson ,  Frank E. Inscore ,  Alan D. Gift ,  Chetan Shrikant Shende

IPC: C40B30/00

CPC classification number: C12Q1/04 ,  G01N2333/32 ,  G01N2333/33 ,  Y02A50/451

Abstract: A weak organic acid is used to effect the release of CaDPA from Bacillus or Clostridium endospores, rapidly and at room temperature, to enable detection and measurement of DPA and thereby the assessment of risk associated with exposure to Bacillus anthracis, Clostridium botulinum, and like spores. The method can be applied to airborne, food-borne, and water-borne spores, as well as to spores collected from surfaces or contained in body fluids, and analysis is advantageously carried out using surface-enhanced Raman spectroscopy.

Abstract translation: 使用弱有机酸快速和室温下从芽孢杆菌或梭状芽孢杆菌内孢子中释放CaDPA，以便能够检测和测量DPA，从而评估与接触炭疽芽孢杆菌，肉毒梭菌和类似孢子相关的风险 。 该方法可以应用于空气传播，食源性和水性孢子，以及从表面收集的或包含在体液中的孢子，并且有利地使用表面增强拉曼光谱进行分析。

公开(公告)号：US20050282288A1

公开(公告)日：2005-12-22

申请号：US11193895

申请日：2005-07-29

Applicant: Stuart Farquharson ,  Paul Maksymiuk

Inventor： Stuart Farquharson ,  Paul Maksymiuk

IPC: B01J20/02 ,  B01J20/286 ,  B01J20/291 ,  B01L3/00 ,  B01L3/02 ,  G01N1/40 ,  G01N21/65 ,  G01N30/60 ,  G01N30/74 ,  G01N21/62

CPC classification number: G01N21/658 ,  B01J20/02 ,  B01J20/28047 ,  B01J20/286 ,  B01J20/291 ,  B01J2220/54 ,  B01L3/0275 ,  B01L3/5023 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/087 ,  B01L2400/0457 ,  G01N1/40 ,  G01N30/6082 ,  G01N30/74 ,  G01N21/63

Abstract: Sol-gel beds and deposits are utilized for SERS analysis of liquid analytes. The use of the same medium to both separate the chemicals and also for SERS greatly reduces the complexity of such apparatus and enhances the efficiency of the method.

Abstract translation: 溶胶凝胶床和沉积物用于液体分析物的SERS分析。 使用相同的介质来分离化学品，也为SERS分离，大大降低了这种设备的复杂性，并提高了该方法的效率。

公开(公告)号：US20050266584A1

公开(公告)日：2005-12-01

申请号：US10902511

申请日：2004-07-29

Applicant: Stuart Farquharson

Inventor： Stuart Farquharson

IPC: G01N21/27 ,  G01N21/47 ,  G01N21/62 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01N21/278

Abstract: Apparatus for use in effecting surface-enhanced Raman spectroscopy comprises first and second containment means, the first containment means containing a known quantity of a reference chemical having an effective surface-enhanced Raman factor, and the second containment means containing a surface-enhanced Raman-active medium and being sufficiently transparent, at least at one optical access location, to permit both the excitation irradiation of, and also the collection of surface-enhanced Raman scattered radiation from, a common field of view of the surface-enhanced Raman-active medium. The apparatus is constructed for carrying out the method of the invention; i.e., for effecting intimate mixing, substantially prior to introduction to the surface-enhanced Raman-active medium contained in the second containment means, of the reference chemical with an analyte chemical-containing solution introduced through an entrance into the first containment means. The homogeneous test solution so formed permeates the SER-active material in the second containment means, which is irradiated at the common field of view so as to produce SER scattered radiation for collection and quantitative analysis.

Abstract translation: 用于实现表面增强拉曼光谱的装置包括第一和第二容纳装置，第一容纳装置含有已知量的具有有效表面增强拉曼因子的参考化学品，第二容纳装置含有表面增强拉曼光谱， 至少在一个光学接近位置处，至少在一个光学接近位置处具有足够的透明度，以允许来自表面增强拉曼活性介质的共同视野的激发照射和表面增强拉曼散射辐射的收集 。 该装置被构造用于实施本发明的方法; 即在进入第二容纳装置中的表面增强拉曼活性介质引入参考化学品之前，通过入口进入第一容纳装置，进行紧密混合。 如此形成的均匀试验溶液渗透到第二容纳装置中的SER活性物质，其在公共视野下照射，以产生用于收集和定量分析的SER散射辐射。

公开(公告)号：US5604581A

公开(公告)日：1997-02-18

申请号：US319749

申请日：1994-10-07

Applicant: Shaohua Liu ,  Peter R. Solomon ,  Peter A. Rosenthal ,  Stuart Farquharson

Inventor： Shaohua Liu ,  Peter R. Solomon ,  Peter A. Rosenthal ,  Stuart Farquharson

IPC: G01B11/06 ,  G01N21/41

CPC classification number: G01B11/0625

Abstract: The method determines the thickness and the free carrier concentration of at least one layer of a structure. An exposed surface of the structure is irradiated using spectral radiation, and the measured reflectance spectrum is compared to a calculated spectrum. Using algorithms that include terms representative of complex refractive indices, layer thickness, dielectric constants, and free carrier concentrations, values are iteratively assigned to the thickness and free carrier concentration parameters so as to produce a best fit relationship between the compared spectra, and to thereby determine those parameters.

Abstract translation: 该方法确定至少一层结构的厚度和自由载流子浓度。 使用光谱辐射照射结构的暴露表面，并将测量的反射光谱与计算的光谱进行比较。 使用包括代表复折射率，层厚度，介电常数和自由载流子浓度的术语的算法被迭代地分配给厚度和自由载流子浓度参数，以便产生比较光谱之间的最佳拟合关系，从而 确定这些参数。

公开(公告)号：US5062713A

公开(公告)日：1991-11-05

申请号：US608066

申请日：1990-11-01

Applicant: Stuart Farquharson ,  Peter T. Keillor, III

Inventor： Stuart Farquharson ,  Peter T. Keillor, III

IPC: B29C47/92 ,  G01N21/31 ,  G01N21/85

CPC classification number: B29C47/92 ,  G01N21/85 ,  B29C2947/92057 ,  B29C2947/92409 ,  B29C2947/92485 ,  B29C47/0014 ,  B29C47/0026 ,  G01N2021/1746 ,  G01N2021/3137 ,  G01N21/314

Abstract: A method for the on-line determination of the residence time distribution of a polymer extruder by injecting a quantity of dye, such as Mobay Red 5B, into the feed throat of the extruder and then photometrically monitoring the polymer flowing from the extruder for the dye. The advance of the present invention is to direct a single beam of polychromatic light through the polymer flowing from the extruder, e.g., by using a quartz-halogen light source and an optical fiber, and then to split this single beam of light that has passed through the polymer into two beams, e.g., by the use of a bifurcated optical fiber, each of which resulting beams are then passed through a separate filter to a separate photodetector. The wavelength of maximum transmission of one of the filters is selected to be near the wavelength of maximum light absorption of the dye so that the signal from the photodetector associated with this filter is a function of the concentration of the dye in the polymer flowing from the extruder. The wavelength of maximum transmission of the other filter is selected to be near the wavelength of minimum light adsorption of the dye and the polymer so that the signal from the photodetector associated with this filter is a function of the background light absorption of the polymer flowing from the extruder. The noise level of the dye concentration signal can be a problem due to bubbles and inclusions in the polymer flowing from the extruder and this noise level is substantially reduced by correcting the dye concentration signal with the background signal.

Abstract translation: 通过将一定量的染料（例如Mobay Red 5B）注射到挤出机的进料喉中，然后对从染料的挤出机流出的聚合物进行光度监测来在线测定聚合物挤出机的停留时间分布的方法 。 本发明的进步是通过例如通过使用石英卤素光源和光纤从挤出机流出的聚合物引导单个多色光束，然后将已经通过的单光束 通过聚合物分成两个光束，例如通过使用分叉光纤，然后将所得到的光束中的每一个通过单独的滤光器到单独的光电检测器。 选择一个滤光器的最大透射波长接近于染料的最大光吸收波长，使得与该滤光片相关的来自光电检测器的信号是从聚合物流中的染料浓度的函数 挤出机。 选择另一个滤光器的最大透射波长接近于染料和聚合物的最小光吸收波长，使得来自与该滤光片相关联的光电检测器的信号是从该滤光片流出的聚合物的背景光吸收的函数 挤出机。 染料浓度信号的噪声水平可能是由于挤出机中流出的聚合物中的气泡和夹杂物引起的问题，并且通过用背景信号校正染料浓度信号，该噪声水平被显着降低。

公开(公告)号：US5046854A

公开(公告)日：1991-09-10

申请号：US647179

申请日：1991-01-24

Applicant: Joseph P. Weller ,  David P. Denton ,  Sandra V. Lange ,  Chester R. Norman ,  Mary A. Leugers ,  Stuart Farquharson ,  Jean P. Chauvel, Jr.

Inventor： Joseph P. Weller ,  David P. Denton ,  Sandra V. Lange ,  Chester R. Norman ,  Mary A. Leugers ,  Stuart Farquharson ,  Jean P. Chauvel, Jr.

IPC: G01N21/03 ,  G01N21/85

CPC classification number: G01N21/03 ,  G01N21/8507 ,  G01N21/0317

Abstract: A photometric probe or a photometric cell having separate windows and a metallic probe body or cell body. The window(s) are sealed to the probe or cell body by brazed or frit seals which are less likely to leak after extended use in high temperature and/or high pressure industrial applications than probes and cells having gasket sealed windows. The windows can be made of sapphire, cubic zirconia, diamond, ruby, glass or quartz and, in the case of the probe, can be in the shape of an Attenuated Total Reflectance prism. The probe or cell body can be Kovar alloy or stainless steel.

Abstract translation: 具有独立窗口和金属探针体或细胞体的光度探测器或光度测定单元。 窗口通过钎焊或玻璃料密封件密封到探针或电池体上，这些密封件在长期使用高温和/或高压工业应用后不太可能泄漏，而不是具有垫圈密封窗口的探针和电池。 窗户可以由蓝宝石，立方氧化锆，金刚石，红宝石，玻璃或石英制成，而在探针的情况下，可以是衰减总反射棱镜的形状。 探头或电池体可以是科瓦合金或不锈钢。

公开(公告)号：US20160003747A1

公开(公告)日：2016-01-07

申请号：US14756502

申请日：2015-09-11

Applicant: Stuart Farquharson ,  Chetan Shende

Inventor： Stuart Farquharson ,  Chetan Shende

IPC: G01N21/65 ,  G01N33/543

CPC classification number: G01N21/658 ,  G01N33/54373 ,  G01N33/58 ,  G01N33/587

Abstract: A kit of components is used in the detection, identification, analysis, and quantitation, by SERS, of a designated target analyte in a sample, comprising: packaging means normally containing a SER-active device component providing a support structure including a SER-active material, a collection component, a container component containing a liquid reagent comprised of a SER-active material, and a component for introducing the liquid reagent into the SER-active device. At least one of the SER-active materials is functionalized with an agent having the specific capability of binding the designated target analyte, and is accessible for the deposit thereon of liquid analyte samples. The SER-active device is constructed for receiving the liquid reagent and for enabling irradiation and collection of Raman-scattered radiation, by and from a Raman spectrometer, cooperatively generated by SER-active metals of the SER-active materials.

Abstract translation: SERS在样品中的指定目标分析物的检测，鉴定，分析和定量中使用一组成分，包括：通常包含提供包含SER活性的支持结构的SER活性器件组分的包装装置 材料，收集成分，含有由SER活性物质构成的液体试剂的容器成分，以及将液体试剂引入SER活性器件的成分。 至少一种SER活性材料用具有与指定靶标分析物结合的特异性能的试剂进行官能化，并可用于在其上沉积液体分析物样品。 SER活性器件被构造为用于接收液体试剂并且用于通过由SER活性材料的SER活性金属协同产生的拉曼光谱仪的拉曼散射辐射的照射和收集。