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公开(公告)号：US20250034621A1
公开(公告)日：2025-01-30
申请号：US18782100
申请日：2024-07-24
Applicant: The Texas A&M University System
Inventor： Sayantan TRIPATHY , Samuel MABBOTT , Gerard L. COTE
IPC: C12Q1/682 , G01N33/543 , G01N33/68
Abstract: In one aspect, the disclosure relates to a universal method for biomarker extraction and detection from clinical samples using magnetic nanoparticles (MNPs) coupled with a locked aptamer-initiator approach. The MNP bound locked aptamer undergoes a conformational change in the presence of the target biomarker and the unfolded initiator triggers a hybridization chain reaction with a structurally stabilized catalytic trimeric triplex DNAzyme hairpin. Amplicons from the hybridization chain reaction can be incubated with hemin to obtain a stable triplex structure that has horseradish peroxidase-like activity in the presence of H2O2 and a substrate molecule. The intensity of the signal is directly proportional to the amount of biomarker present. Binding one or more reagents on a nanoparticle can be coupled with this approach for use in a microfluidic or paper fluidic platform. In any of these aspects, the assay can detect as low as femtogram amounts of biomarker from the clinical sample.
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公开(公告)号：US12209159B2
公开(公告)日：2025-01-28
申请号：US18189277
申请日：2023-03-24
Inventor： Keith Hearon , Landon D. Nash , Thomas Wilson , Duncan J. Maitland , Mark A. Wierzbicki
Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.
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公开(公告)号：US12208377B2
公开(公告)日：2025-01-28
申请号：US17263536
申请日：2019-07-30
Applicant: The Texas A&M University System
Inventor： David E. Bergbreiter , Thomas J. Malinski
Abstract: A solution consisting of: a poly(a-olefin) (PAO) selected from the group consisting of PAO283, PAO432, and PAO687; and a reactive organometallic reagent selected from the group consisting of n-butyllithium, sec-butyllithium, tert-butyllithium, n-butyllithium in hexane, sec-butyllithium in cyclohexane, and tert-butyllithium in pentane.
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公开(公告)号：US20250014730A1
公开(公告)日：2025-01-09
申请号：US18765535
申请日：2024-07-08
Applicant: The Texas A&M University System
Inventor： Mark Benden , Les Jebson , Kaysey Aguilar
IPC: G16H40/20 , G06F3/0487 , G06Q30/01 , G06V40/16
Abstract: The digital human workplace solution is deployed in a customer service setting and involves a computer programmed with a digital human that is displayed to interact with the customer and adapt to inputs providing information about the user or the environment. The digital human workforce solution is also programmed to interface with one or more databases of information that can be used during the customer service interaction.
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公开(公告)号：US20250011781A1
公开(公告)日：2025-01-09
申请号：US18712539
申请日：2022-11-22
Inventor： Jianxun SONG , Jin-Ming YANG
IPC: C12N15/113 , A61K31/165 , A61P35/00 , C07K16/18 , C12N9/22 , C12N15/11
Abstract: Provided herein are methods of for enhancing or inducing an anti-tumor response or treating an autoimmune disorder by administering a therapeutically effective amount of an inhibitor of NAC 1. Also, provided herein are methods of enhancing effectiveness of a vaccine in a subject by administering to the subject a therapeutically effective amount of an inhibitor of NAC 1. Inhibitors of NAC1 can include a chemical agent, such as a composition containing NIC3, or a biological agent that inhibit the function of NAC1 protein, such as an isolated antibody or its binding fragment thereof that binds to NAC1. Inhibitors of NAC 1 can include a biological agent that reduces the expression of NAC1 gene, such as a NAC 1-targeted siRNA administered as a nanoliposome or a CRISPR/Cas-based genome editing composition targeting the NAC1 Gene.
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Patent Agency Ranking
公开(公告)号：US20250009934A1
公开(公告)日：2025-01-09
申请号：US18709960
申请日：2022-11-11
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Abstract: The present disclosure provides a vascular graft comprising i) one or more extracellular matrix compositions and ii) one or more hydrogels. In particular, the vascular grafts of the present disclosure can be functionalized and/or be completely biologic. The disclosure also provides methods of administering the vascular grafts as well as methods for forming the vascular grafts.
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公开(公告)号：US20250002646A1
公开(公告)日：2025-01-02
申请号：US18749963
申请日：2024-06-21
Inventor： Karen L. Wooley , Stephen John Clifford Taylor , Senthil Kumar Boopathi , Ashlee A. Jahnke , Guorong Sun , Hai Wang
Abstract: The present invention provides a polymer, preferably a degradable polymer, derived from monomers (A) and (B) and/or comprising a repeat unit of formula (Ii) and at least one terminal group of formula (II).
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公开(公告)号：US20250002492A1
公开(公告)日：2025-01-02
申请号：US18752069
申请日：2024-06-24
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Michael POLYMENIS
IPC: C07D471/04 , A61K31/365 , A61K31/366 , A61K31/404 , A61K31/409 , A61K31/437 , A61K31/4433 , A61K31/506 , A61K31/5513 , C07D307/33 , C07D471/14 , C07D487/04 , C07D487/20 , C07D491/147 , C07D493/04 , C07D519/00
Abstract: The present disclosure relates to folate inhibitor compounds, pharmaceutical compositions containing folate inhibitor compounds, and methods of using folate inhibitor compounds to promote healthy aging.
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公开(公告)号：US20240369657A1
公开(公告)日：2024-11-07
申请号：US18651795
申请日：2024-05-01
Applicant: The Texas A&M University System
Inventor： Edith Touchet-Valle , Seelay Tasmim , Mary P. McDougall , Taylor Ware
Abstract: The present provides for a stimuli-responsive switches, circuits including a stimuli-responsive switch, systems include the circuit, method of switching frequencies in a nuclear magnetic resonance system, and the like. The stimuli-responsive switch can be made of a stimuli-responsive material, where a conductive material can be moved and brought in contact with disconnected conductive paths by the stimuli-responsive material so that upon stimulation a conductive path can be achieved.
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公开(公告)号：US20240368225A1
公开(公告)日：2024-11-07
申请号：US18566143
申请日：2022-06-01
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Kevin BURGESS
Abstract: The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as diseases of the eye.
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