公开(公告)号：US07448279B2

公开(公告)日：2008-11-11

申请号：US11073103

申请日：2005-03-03

Applicant: Thomas Brinz ,  Jane Lewis ,  Thomas Geiger

Inventor： Thomas Brinz ,  Jane Lewis ,  Thomas Geiger

IPC: G01N3/24

CPC classification number: G01N19/04 ,  G01N3/08 ,  G01N3/24 ,  G01N2203/0266 ,  G01N2203/04

Abstract: A device for testing material properties with regard to combined tensile and shear loads, in particular for testing adhesives, includes a device for applying the force, a measuring device, a test piece receptacle, and a test piece having a bonding surface. The test piece is dimensionally stable within the intended limits of the force to be applied. This measure ensures that the shear forces acting on the joint act approximately at a right angle to the bonding surface over the entire test period, so that realistic conclusions may be drawn with regard to the material properties of the tested adhesive.

Abstract translation: 用于测试关于组合的拉伸和剪切载荷的材料特性的装置，特别是用于测试粘合剂的装置，包括用于施加力的装置，测量装置，试件容器和具有粘合表面的试验片。 试件在要施加的力的预期限度内尺寸稳定。 该措施确保在整个试验期间作用在接头上的剪切力与接合表面大致成直角，从而可以得出关于被测粘合剂的材料特性的现实结论。

公开(公告)号：US07191917B2

公开(公告)日：2007-03-20

申请号：US11159923

申请日：2005-06-22

Applicant: Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger

Inventor： Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger

IPC: A61M37/00 ,  A61M5/00 ,  B67D5/00 ,  B01L3/02

CPC classification number: B01L3/0206 ,  B01F13/005 ,  B01F13/08 ,  B01J2219/00373 ,  B01J2219/00376 ,  B01J2219/00691 ,  B01L3/021 ,  B01L2200/0605 ,  B01L2200/0657

Abstract: A metering device or a metering element, in particular for metering substances in the compiling of combinatory material libraries, described as comprising a metering element having a supply vessel, open on one side, for holding the substances to be metered, and a plunger, which is axially displaceable and reversibly seals the opening of the supply vessel and which has at least one, preferably centered metering orifice for metering the substances provided in the supply vessel, the supply vessel and/or the plunger having an accommodation as contact point for a mechanical gripping device. Moreover, a metering method is described.

Abstract translation: 计量装置或计量元件，特别是用于组合组合材料库的计量物质的描述，所述计量装置或计量元件被描述为包括具有供给容器的计量元件，所述供给容器在一侧开口，用于保持要计量的物质，以及柱塞， 轴向可移动和可逆地密封供应容器的开口，并且具有至少一个优选为中心的计量孔口，用于计量供应容器中设置的物质，供应容器和/或柱塞具有用作机械的接触点 夹紧装置。 此外，描述了计量方法。

公开(公告)号：US5744460A

公开(公告)日：1998-04-28

申请号：US612775

申请日：1996-03-07

Applicant: Marcel Muller ,  Thomas Geiger ,  Karl-Heinz Altmann ,  Doriano Fabbro ,  Nicholas M. Dean ,  Brett Monia ,  Clarence Frank Bennett

Inventor： Marcel Muller ,  Thomas Geiger ,  Karl-Heinz Altmann ,  Doriano Fabbro ,  Nicholas M. Dean ,  Brett Monia ,  Clarence Frank Bennett

IPC: A61K45/06 ,  A61K31/44 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61K31/70 ,  A61K48/00 ,  C07H21/04

CPC classification number: A61K31/70 ,  A61K45/06

Abstract: The invention relates to combinations of PKC-targeted (especially PKC-.alpha.-targeted) deoxyribo- and ribo-oligonucleotides and derivatives thereof with other chemotherapeutic compounds, as well as to pharmaceutical preparations and/or therapies, in relation to disease states which respond to such oligonucleotides or oligonucleotide derivatives, especially to to modulation of the activity of a regulatory protein. In particular, the invention relates to products or combinations comprising antisense oligonucleotides or oligonucleotide derivatives targeted to nucleic acids encoding human PKC and other (preferably standard) chemotherapeutics, either in fixed combination or for chronologically staggered or simultaneous administration, and the combined use of both classes of compounds, either in fixed combination or for chronologically staggered or simultaneous administration, for the treatment of proliferative diseases, especially tumor diseases, that can be treated by inhibition of PKC activity, that is, where the antisense oligonucleotides or oligonucleotide derivatives are targeted to nucleic acids encoding the regulatory protein PKC or active mutated derivatives thereof.

Abstract translation: 本发明涉及PKC靶向（特别是PKC-α靶向的）脱氧核糖核苷酸和核糖寡核苷酸及其衍生物与其它化学治疗化合物的组合，以及关于响应于所述药物的疾病状态的药物制剂和/或治疗 这样的寡核苷酸或寡核苷酸衍生物，特别是调节调节蛋白的活性。 特别地，本发明涉及包含针对编码人PKC的核酸的反义寡核苷酸或寡核苷酸衍生物或其它（优选标准的）化学治疗剂的产品或组合，其以固定组合或按时间顺序交错或同时施用，以及两类的组合使用 的化合物，以固定组合或按时间顺序交错或同时给药，用于治疗可通过抑制PKC活性治疗的增殖性疾病，特别是肿瘤疾病，即反义寡核苷酸或寡核苷酸衍生物靶向核酸 编码调节蛋白PKC的酸或其活性突变衍生物。

公开(公告)号：US08717440B2

公开(公告)日：2014-05-06

申请号：US12447975

申请日：2007-09-11

Applicant: Eva Wagner ,  Thomas Brinz ,  Thomas Geiger ,  Jane Lewis ,  Markus Tiefenbacher ,  Tobias Burk ,  Sebastian Koltzenburg ,  Wolfgang Schrof

Inventor： Eva Wagner ,  Thomas Brinz ,  Thomas Geiger ,  Jane Lewis ,  Markus Tiefenbacher ,  Tobias Burk ,  Sebastian Koltzenburg ,  Wolfgang Schrof

IPC: H04N7/18

CPC classification number: G01N25/72

Abstract: In a method for evaluating mechanical tests of a coating on a substrate, in a first step a mechanical stress is applied onto the coating, in a second step the substrate having the coating is isothermally clamped, in a third step an infrared photograph is generated of the region in which the mechanical stress is applied onto the coating in the first step, and in a fourth step the infrared photograph is evaluated. A device is arranged for carrying out the method.

Abstract translation: 在用于评价基板上的涂层的机械试验的方法中，在第一步骤中，将机械应力施加到涂层上，在第二步骤中，具有涂层的基板被等温夹持，在第三步骤中，产生红外照片 在第一步骤中将机械应力施加到涂层上的区域，在第四步骤中评估红外照片。 布置了用于执行该方法的装置。

公开(公告)号：US20130070325A1

公开(公告)日：2013-03-21

申请号：US13238635

申请日：2011-09-21

Applicant: Carlos G. Maraviglia ,  Michael Michelizzi ,  Kevin Cox ,  Thomas Geiger

Inventor： Carlos G. Maraviglia ,  Michael Michelizzi ,  Kevin Cox ,  Thomas Geiger

IPC: G02B26/10

CPC classification number: G02B27/644

Abstract: An optical scanning system includes a frame having a central axis along which is mounted a first elevation mirror for receiving an incident light and reflecting the incident light along a first optical path, a telescope for receiving the reflected incident light and outputting an output light, a visible linear array imager for receiving the output light from the telescope, and a folding mirror positioned to receive part of the output light from the telescope and directing it to a linear array infrared imager. The optical scanning system scans large areas of sky using multiple linear sensors in order to detect, identify and track low and slow flying manned and unmanned aircraft as well as to surveil large areas of terrain.

Abstract translation: 光学扫描系统包括具有中心轴的框架，沿其安装有用于接收入射光并沿着第一光路反射入射光的第一仰角镜，用于接收反射入射光并输出输出光的望远镜， 用于接收来自望远镜的输出光的可见线性阵列成像器和折射镜，其被定位成接收来自望远镜的一部分输出光并将其引导到线性阵列红外成像器。 光学扫描系统使用多个线性传感器扫描大面积的天空，以便检测，识别和跟踪低速和慢速的载人和无人飞行器以及监视大面积的地形。

公开(公告)号：US08363213B2

公开(公告)日：2013-01-29

申请号：US12444750

申请日：2007-09-11

Applicant: Eva Wagner ,  Thomas Brinz ,  Thomas Geiger ,  Jane Lewis ,  Markus Tiefenbacher ,  Tobias Burk ,  Sebastian Koltzenburg ,  Wolfgang Schrof

Inventor： Eva Wagner ,  Thomas Brinz ,  Thomas Geiger ,  Jane Lewis ,  Markus Tiefenbacher ,  Tobias Burk ,  Sebastian Koltzenburg ,  Wolfgang Schrof

IPC: G01N21/88

CPC classification number: G01N1/04 ,  G01N21/94 ,  G01N2001/028 ,  G01N2001/2833

Abstract: A method is provided for detecting not fully set coatings and liquid or smearing impurities on a surface, in which in a first step a film is pressed onto a surface of a coating using a predefined press-on pressure, the film having a relative motion with respect to the surface of the coating, thereafter the film is pulled off the surface of the coating and finally it is determined whether impurities are adhering to the film. A device is also provided for performing the method, including at least one film, which may be pressed against a surface to be tested, at least one press-on roller having a surface by which the film is pressed against the coating, and at least one device for determining whether there are impurities adhering to the film.

Abstract translation: 提供了一种用于检测表面上未完全固化的涂层和液体或污迹杂质的方法，其中在第一步骤中，使用预定的压力压力将膜压在涂层的表面上，所述膜具有相对运动 相对于涂层的表面，然后将膜从涂层的表面拉出，最后确定杂质是否粘附在膜上。 还提供了一种用于执行该方法的装置，包括至少一个可压在被测试表面上的膜，至少一个压膜辊，其具有将膜压在涂层上的表面，至少 一种用于确定是否存在粘附于薄膜上的杂质的装置。

公开(公告)号：US08235953B2

公开(公告)日：2012-08-07

申请号：US11435431

申请日：2006-05-16

Applicant: Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger

Inventor： Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger

IPC: A61M5/315 ,  A61M37/00

CPC classification number: B01J19/0046 ,  A61J1/2096 ,  A61M5/283 ,  A61M5/284

Abstract: A metering device, a metering element, and a method for operating same, the metering element having a storage container open on one side for receiving the substances to be metered and a plunger which is axially movable and reversibly seals the opening of the storage container and which preferably has at least one centrally located metering opening for metering the substances provided in the storage container, the plunger including a separation device for particles.

Abstract translation: 计量装置，计量元件及其操作方法，所述计量元件具有在一侧开口用于接收要计量的物质的储存容器和可轴向移动和可逆地密封储存容器的开口的柱塞， 其优选地具有至少一个居中定位的计量开口，用于计量设置在储存容器中的物质，柱塞包括用于颗粒的分离装置。

公开(公告)号：US08000515B2

公开(公告)日：2011-08-16

申请号：US11901638

申请日：2007-09-17

Applicant: Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger ,  Tobias Burk

Inventor： Thomas Brinz ,  Jane Lewis ,  Markus Tiefenbacher ,  Thomas Geiger ,  Tobias Burk

IPC: G06K9/00

CPC classification number: B60R16/0231 ,  G01N21/33 ,  G01N21/35 ,  G01N21/8422 ,  G01N21/8806 ,  G01N25/72

Abstract: A method and a device for inspecting surface coatings on workpieces, in particular of lacquer coatings, using an image capture and/or image processing system. The image capture and/or image processing system is designed to measure and/or process electromagnetic radiation from surface coating and/or a layer beneath it which is at least partially outside of the visible wavelength range.

Abstract translation: 使用图像捕获和/或图像处理系统检查工件上的表面涂层，特别是漆涂层的方法和装置。 图像捕获和/或图像处理系统被设计为测量和/或处理来自表面涂层的电磁辐射和/或其下面的至少部分在可见波长范围之外的层。

公开(公告)号：US5862503A

公开(公告)日：1999-01-19

申请号：US977369

申请日：1997-11-24

Applicant: Alfred Eckert ,  Benno Lammen ,  Peter Wanke ,  Karl-Friedrick Worsdorfer ,  Thomas Geiger ,  Johannes Graber ,  Stefan Drumm ,  Thomas Kranz ,  C. Jan Neederkorn

Inventor： Alfred Eckert ,  Benno Lammen ,  Peter Wanke ,  Karl-Friedrick Worsdorfer ,  Thomas Geiger ,  Johannes Graber ,  Stefan Drumm ,  Thomas Kranz ,  C. Jan Neederkorn

IPC: B60T8/1755 ,  B60T8/00 ,  B60K28/16 ,  G01P3/44

CPC classification number: B60W10/184 ,  B60T8/1755 ,  B60W30/02 ,  B60W40/064 ,  B60G2400/1042 ,  B60T2210/12 ,  B60T2230/02 ,  B60T2270/313 ,  B60W2422/95 ,  B60W2520/125 ,  B60W2520/14 ,  B60W2520/20 ,  B60W2720/14 ,  B60W2720/30

Abstract: Apparatus for improving the driving behavior of a vehicle is provided. The vehicle has front and rear axles, each having a plurality of wheels. Each wheel-has a brake. Sensor are provided for measuring the rotational speed of each wheel, the vehicle yaw rate and the vehicle lateral acceleration. An anti-lock braking system provides first preset pressure values for controlling each brake, to prevent the wheels from locking during braking. A traction slip control system provides second preset pressure values for controlling each brake, to prevent the wheels from slipping during acceleration. A brake effort proportioning system provides third preset pressure values for distributing braking pressure between the wheels of the front axle and the wheels of the rear axle. A yawing moment controller provides fourth preset pressure values used to control each brake during cornering, to avoid application to the vehicle of an unbalanced moment which would cause the vehicle to understeer or oversteer. The antilock braking system, traction slip control system, brake effort proportioning means and yawing moment control system all operate independently of one another. A prioritizing mechanism applies criteria to determine a desired brake pressure that is applied to each wheel, based on the outputs of the antilack braking, traction slip control, brake effort proportioning, and yawing moment control systems.

Abstract translation: 提供了用于改善车辆的驾驶行为的装置。 车辆具有前轮和后轴，每个轴具有多个车轮。 每个车轮都有制动器。 传感器用于测量每个车轮的转速，车辆横摆角速度和车辆横向加速度。 防抱死制动系统提供用于控制每个制动器的第一预设压力值，以防止在制动期间车轮被锁定。 牵引滑动控制系统提供用于控制每个制动器的第二预设压力值，以防止车轮在加速期间滑倒。 制动力配比系统提供第三预设压力值，用于在前轴的车轮和后桥的车轮之间分配制动压力。 偏转力矩控制器提供用于在转弯过程中控制每个制动器的第四预设压力值，以避免车辆向车辆施加不平衡力矩，这将导致车辆转向不足或过度转向。 防抱死制动系统，牵引滑动控制系统，制动力比例装置和偏航力矩控制系统都彼此独立运行。 优先排序机构基于反铲制动，牵引滑动控制，制动器制动比例和偏航力矩控制系统的输出，应用标准来确定施加到每个车轮的期望的制动压力。

公开(公告)号：US5362624A

公开(公告)日：1994-11-08

申请号：US925300

申请日：1992-08-05

Applicant: Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg ,  Thomas Geiger ,  Wolf D. Engel

Inventor： Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg ,  Thomas Geiger ,  Wolf D. Engel

IPC: G01N33/531 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574 ,  G01N33/58 ,  C01N33/576 ,  C01N33/547

CPC classification number: G01N33/57473 ,  G01N33/531 ,  G01N33/54366 ,  G01N33/56988 ,  G01N33/58 ,  Y10S435/82 ,  Y10S436/811

Abstract: For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inner surface of which streptavidin or avidin is bound in such an amount that 0.1 to 2.5 .mu.g are present per ml reaction volume.A suitable reaction vessel for this has optically transparent wall areas which face one another and has avidin or streptavidin coated walls which are at least partially within the inner wall region intended as a receptacle for liquid, wherein the inner space of the container intended as a receptacle for liquid and the respective streptavidin or avidin content of the coating are so matched that 0.1 to 2.5 .mu.g streptavidin or avidin are present per ml reaction volume.

Abstract translation: 为了通过使用其上结合有免疫活性的反应组分的固相来测定基于非均相免疫测定的免疫学可检测物质，使用反应容器作为其内表面上的固相，其中链霉亲和素或抗生物素蛋白为 结合量为每ml反应体积存在0.1至2.5μg。 合适的反应容器具有相互面对的光学透明壁区域，并且具有至少部分位于旨在作为液体容器的内壁区域内的抗生物素蛋白或链霉抗生物素蛋白包被的壁，其中容器的内部空间用作容器 对于液体，并且涂层的各自的链霉抗生物素蛋白或抗生物素蛋白含量如此匹配，每ml反应体积存在0.1至2.5μg链霉亲和素或抗生物素蛋白。