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    Process for the production of a solid phase matrix coated with an immunologically active substance
    2.
    发明授权
    Process for the production of a solid phase matrix coated with an immunologically active substance 失效
    制备涂有免疫活性物质的固相基质的方法

    公开(公告)号：US5316784A

    公开(公告)日：1994-05-31

    申请号：US994487

    申请日：1992-12-21

    申请人： Eberhard Maurer ,  Rolf Deeg

    发明人： Eberhard Maurer ,  Rolf Deeg

    IPC分类号： G01N33/543 ,  B05D3/06 ,  G01N33/53

    CPC分类号： G01N33/54353

    摘要： To produce a solid phase coated with an immunologically active substance, a carrier material is absorptively coated with a mixture of an immunologically active substance and a compound which contains at least two functional groups which can be photoactivated and at least one moiety which interacts with the carrier material and the immunologically active substance and it is subsequently irradiated for the cross-linkage.

    摘要翻译： 为了产生涂覆有免疫活性物质的固相，用免疫活性物质和含有至少两个可被光活化的官能团和至少一个与载体相互作用的官能团的化合物的混合物吸收载体材料 材料和免疫活性物质，随后将其照射用于交联。

    Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor
    5.
    发明授权
    Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor 失效
    用于测定免疫学可检测物质及其合适的反应容器的方法

    公开(公告)号：US5362624A

    公开(公告)日：1994-11-08

    申请号：US925300

    申请日：1992-08-05

    申请人： Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg ,  Thomas Geiger ,  Wolf D. Engel

    发明人： Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg ,  Thomas Geiger ,  Wolf D. Engel

    IPC分类号： G01N33/531 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574 ,  G01N33/58 ,  C01N33/576 ,  C01N33/547

    CPC分类号： G01N33/57473 ,  G01N33/531 ,  G01N33/54366 ,  G01N33/56988 ,  G01N33/58 ,  Y10S435/82 ,  Y10S436/811

    摘要： For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inner surface of which streptavidin or avidin is bound in such an amount that 0.1 to 2.5 .mu.g are present per ml reaction volume.A suitable reaction vessel for this has optically transparent wall areas which face one another and has avidin or streptavidin coated walls which are at least partially within the inner wall region intended as a receptacle for liquid, wherein the inner space of the container intended as a receptacle for liquid and the respective streptavidin or avidin content of the coating are so matched that 0.1 to 2.5 .mu.g streptavidin or avidin are present per ml reaction volume.

    摘要翻译： 为了通过使用其上结合有免疫活性的反应组分的固相来测定基于非均相免疫测定的免疫学可检测物质，使用反应容器作为其内表面上的固相，其中链霉亲和素或抗生物素蛋白为 结合量为每ml反应体积存在0.1至2.5μg。 合适的反应容器具有相互面对的光学透明壁区域，并且具有至少部分位于旨在作为液体容器的内壁区域内的抗生物素蛋白或链霉抗生物素蛋白包被的壁，其中容器的内部空间用作容器 对于液体，并且涂层的各自的链霉抗生物素蛋白或抗生物素蛋白含量如此匹配，每ml反应体积存在0.1至2.5μg链霉亲和素或抗生物素蛋白。

    Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor
    6.
    发明授权
    Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor 失效
    用于测定免疫学可检测物质及其合适的反应容器的方法

    公开(公告)号：US5776702A

    公开(公告)日：1998-07-07

    申请号：US271855

    申请日：1994-07-07

    申请人： Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg

    发明人： Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg

    IPC分类号： G01N33/531 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574 ,  G01N33/58 ,  G01N33/547

    CPC分类号： G01N33/57473 ,  G01N33/531 ,  G01N33/54366 ,  G01N33/56988 ,  G01N33/58 ,  Y10S435/82 ,  Y10S436/811

    摘要： For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inner surface of which streptavidin or avidin is bound in such an amount that 0.1 to 2.5 .mu.g are present per ml reaction volume. A suitable reaction vessel for this has optically transparent wall areas which face one another and has avidin or streptavidin coated walls which are at least partially within the inner wall region intended as a receptacle for liquid, wherein the inner space of the container intended as a receptacle for liquid and the respective streptavidin or avidin content of the coating are so matched that 0.1 to 2.5 .mu.g streptavidin or avidin are present per ml reaction volume.

    摘要翻译： 为了通过使用其上结合有免疫活性的反应组分的固相来测定基于非均相免疫测定的免疫学可检测物质，使用反应容器作为其内表面上的固相，其中链霉亲和素或抗生物素蛋白为 结合量为每ml反应体积存在0.1至2.5μg。 合适的反应容器具有相互面对的光学透明壁区域，并且具有至少部分位于旨在作为液体容器的内壁区域内的抗生物素蛋白或链霉抗生物素蛋白包被的壁，其中容器的内部空间用作容器 对于液体，并且涂层的各自的链霉抗生物素蛋白或抗生物素蛋白含量如此匹配，每ml反应体积存在0.1至2.5μg链霉亲和素或抗生物素蛋白。

    Process and reagent for the determination of an antibody
    7.
    再颁专利
    Process and reagent for the determination of an antibody 失效

    公开(公告)号：USRE34312E

    公开(公告)日：1993-07-13

    申请号：US796545

    申请日：1991-11-21

    申请人： Thomas Geiger ,  Wolf D. Engel ,  Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg

    发明人： Thomas Geiger ,  Wolf D. Engel ,  Urban Schmitt ,  Eberhard Maurer ,  Wolfgang Rudinger ,  Rolf Deeg

    IPC分类号： G01N33/543 ,  G01N33/576 ,  G01N33/68

    CPC分类号： G01N33/6854 ,  G01N33/5764 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S436/827

    摘要： The present invention provides a process for the determination of an antibody by incubation with three different reagents R.sub.1, R.sub.2 and R.sub.3, of which R.sub. and R.sub.3 are present in liquid phase and are bindable with the antibody, R.sub.2 is present bound to a solid phase and is bindable with R.sub.1 and R.sub.3 carries a label, separation of the solid phase from the liquid phase and measurement of the label in the solid phase, wherein as R.sub.1 there is used a conjugate of a substance specifically recognized by the antibody to be determined and a reaction component of a specific binding system, as R.sub.3 there is used a conjugate of a substance specifically recognized by the antibody to be determined and a label and as R.sub.2 there used the other binding component of the specific binding system. The present invention also provides a composition for the determination of an antibody, wherein it contains two different soluble reagents R.sub.1 and R.sub.3 specifically bindable with the antibody, of which R.sub.1 carries a reaction component of a specific binding system and R.sub.3 carries a label and also a receptor R.sub.2 which is present in solid phase and is bindable with the receptor R.sub.1, the insoluble receptor R.sub.2 and the soluble receptor R.sub.1 being present physically separated from one another.