公开(公告)号：US20220213143A1

公开(公告)日：2022-07-07

申请号：US17703111

申请日：2022-03-24

Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY ,  UNIVERSITY OF SOUTH AUSTRALIA ,  THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF ,  MONASH UNIVERSITY

Inventor： Stavros SELEMIDIS ,  Doug A. BROOKS ,  John O'LEARY

IPC: C07K7/06 ,  A61P37/00 ,  A61P31/00 ,  A61P29/00 ,  A61P35/00 ,  C07K14/705

Abstract: The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.

公开(公告)号：US20220154292A1

公开(公告)日：2022-05-19

申请号：US17579355

申请日：2022-01-19

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Doug Brooks ,  Emma PARKINSON-LAWRENCE ,  Ian R.D. JOHNSON ,  Lisa BUTLER

IPC: C12Q1/6886 ,  G01N33/574 ,  C07K16/30

Abstract: Methods for detecting a prostate cancer in a subject comprise detecting a marker selected from an endosomal associated marker and/or a lysosomal associated marker from the subject.

公开(公告)号：US11000634B2

公开(公告)日：2021-05-11

申请号：US16085965

申请日：2017-03-17

Applicant: AUSHEALTH CORPORATE PTY LTD ,  UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Eli Moore ,  Glen Leon Benveniste ,  Claudine Sharon Bonder ,  Nicolas Hans Voelcker

IPC: A61L31/10 ,  C09D171/08 ,  A61L33/00 ,  C09D171/02 ,  C08G65/22 ,  A61L31/06

Abstract: The present disclosure relates to medical devices using coated polymers, methods for reducing platelet attachment and/or fouling associated with medical devices, and methods for coating polymers. Certain embodiments of the present disclosure provide a medical device comprising one or more polymeric materials coated with a hyperbranched polyglycerol.

公开(公告)号：US10752884B2

公开(公告)日：2020-08-25

申请号：US15538465

申请日：2015-12-22

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Yanchuang Han ,  Xin-Fu Zhou ,  WooKyung Kim ,  JunYong Yang ,  JiHee Kim

IPC: C12N5/071

Abstract: The disclosure relates to a method of producing induced beta cells from urine-derived cells, the method comprising providing urine-derived cells; inducing the urine-derived cells by culturing said urine-derived cells in a primary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a first period of time to obtain induced endoderm cells; inducing the induced endoderm cells by culturing said induced endoderm cells in a secondary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a second period of time to obtain induced pancreatic precursor cells; and inducing the induced pancreatic precursor cells by culturing said pancreatic precursor cells in a tertiary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a third period of time to obtain induced beta cells.

公开(公告)号：US10479785B2

公开(公告)日：2019-11-19

申请号：US15749652

申请日：2016-08-04

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Shudong Wang ,  Solomon Tadesse Zeleke ,  Mingfeng Yu

IPC: C07D417/14 ,  A61P35/02

Abstract: A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain, central nervous system, colorectal cancer and leukaemias. The inhibitors have the general structure I:

公开(公告)号：US10463626B2

公开(公告)日：2019-11-05

申请号：US15556913

申请日：2016-03-11

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Clive Allan Prestidge ,  Paul Matthew Joyce

IPC: A61K9/50 ,  A61K31/495

Abstract: A dry composition, comprising three-dimensional porous microparticles, wherein the microparticles comprise: (i) an active substance (eg a poorly water soluble drug), (ii) polymeric nanoparticles such as those composed of a biocompatible and/or biodegradable polymer (eg a PLGA polymer) (iii) lipid droplets (eg droplets of a medium chain triglyceride (MCT)), (iv) a nanoparticle stabilizing agent such as PVA or DMAB, and optionally, (v) a cryoprotectant (eg mannitol); wherein said active substance is carried by said nanoparticles and/or lipid droplets. The composition of the present invention may be formulated into, for example, a medicament for the treatment and/or prevention of various diseases or disorders (eg human or veterinary therapeutics). The average diameter of the individual microparticles of the composition, may be in the order of 2.5-3.5 μm which are particularly suitable for administration to the lung.

公开(公告)号：US20190282999A1

公开(公告)日：2019-09-19

申请号：US16094544

申请日：2017-04-20

Applicant: FLINDERS UNIVERSITY OF SOUTH AUSTRALIA

Inventor： JUSTIN MARK CHALKER ,  MAX JOHN HALDANE WORTHINGTON

IPC: B01J20/26 ,  B01D53/02 ,  B01J20/34 ,  B09C1/08 ,  C08G75/16

Abstract: A polymeric polysulfide is disclosed. The polymeric polysulfide is formed by reacting a fatty acid composition comprising at least one unsaturated fatty acid or derivative thereof with sulfur, at a weight ratio between 9:1 and 1:9, under inverse vulcanisation conditions to produce a polymeric polysulfide wherein at least 50% of the fatty acids or derivatives thereof in the fatty acid composition are unsaturated.

公开(公告)号：US10321450B2

公开(公告)日：2019-06-11

申请号：US15534424

申请日：2015-12-09

Applicant: University of South Australia

Inventor： David Victor Lawrie Haley ,  William George Cowley ,  John Lawrence Buetefuer ,  Alexander James Grant ,  Gottfried Lechner ,  Andre Pollok ,  Robert George McKilliam ,  Ingmar Rudiger Land ,  Marc Pierre Denis Lavenant ,  Ying Chen

IPC: H04L5/00 ,  H04L25/02 ,  H04L25/03 ,  H04L27/26 ,  H04W72/04

Abstract: Methods and apparatus for communication between terminals and an access node in a multiuser multicarrier communications network are described. The access node may be a satellite access node. Terminals are configured to perform initial estimation and tracking of channel offsets and to estimate channel offsets for future packets to be transmitted by the terminal. In some embodiments the channel offsets comprise mobility related channel offsets due to the relative movement between the access node and the plurality of terminals. Transmissions from the terminals to the access node are pre-compensated for the channel offsets, so that the aggregate signal received by the access node occupies a bandwidth greater or equal to the maximum signal bandwidth of any individual terminal. Terminal transmissions may overlap in frequency and time on the ground, but arrive orthogonally at the access node.

公开(公告)号：US10196606B2

公开(公告)日：2019-02-05

申请号：US14364200

申请日：2012-12-13

Applicant: FLINDERS UNIVERSITY OF SOUTH AUSTRALIA

Inventor： Xin-Fu Zhou ,  Yanchuang Han

IPC: C12N5/0797 ,  C12N5/079 ,  C12N5/0793 ,  G01N33/50

Abstract: The present invention provides a method of producing a multipotent stem cell, said method comprising culturing at least one fibroblast cell in the presence of an effective amount of at least one small molecule reprogramming factor(s) that induces the cell to de-differentiate into a multipotent stem cell, wherein the method excludes the use of reprogramming factor(s) that are not small molecules. The small molecule reprogramming factor(s) may include a G9a HMTase inhibitor(s) and/or a MEK inhibitor(s) optionally in combination with other small molecule reprogramming factor(s). The invention also includes methods of differentiating the multipotent stem cells, cells produced by the methods, assays using the cells and kits for use in the methods.

公开(公告)号：US20180227042A1

公开(公告)日：2018-08-09

申请号：US15877246

申请日：2018-01-22

Applicant: UNIVERSITY OF SOUTH AUSTRALIA

Inventor： David Victor Lawrie Haley ,  John Lawrence Buetefuer ,  Alexander James Grant ,  William George Cowley ,  Gottfried Lechner ,  Ingmar Rudiger Land ,  Robert George McKilliam ,  Andre Pollok ,  Linda Mary Davis ,  Ricky Rocco Luppino ,  Sorin Adrian Barbulescu

IPC: H04B7/185 ,  H04B7/212 ,  H04W40/20

CPC classification number: H04B7/18513 ,  H04B7/185 ,  H04B7/212 ,  H04W40/20 ,  Y02D70/00 ,  Y02D70/164 ,  Y02D70/38 ,  Y02D70/446

Abstract: A communication system is disclosed. In an embodiment, the communication system includes a user node for receiving data from a remote application program, the data including message data for communication to a central application program operatively associated with the remote application program; plurality of geographically distributed gateway nodes; one or more access nodes for receiving the message data from the user node via a first communications interface, and communicating the message data via a second communications interface to one or more of the plurality of geographically distributed gateway nodes; and a hub for communicating with the one or more of the plurality of geographically distributed gateway nodes to receive the message data for communication to the central application.