Arrangement in a mine which is capable of being neutralized
    12.
    发明授权
    Arrangement in a mine which is capable of being neutralized 失效
    能够被中和的矿山安排

    公开(公告)号:US4711179A

    公开(公告)日:1987-12-08

    申请号:US916970

    申请日:1986-10-17

    IPC分类号: F42B23/24

    CPC分类号: F42B23/24

    摘要: An arrangement in a mine which is capable of being neutralized, comprising detecting means (33) operative to detect a neutralization of the mine, and initiator means (3) adapted to initiate detonation of a spotter charge (5) incorporated in the mine in response to the detection of a neutralization, and a spotter (1) which is arranged to be propelled from the mine by said detonator charge to the surface of the ground, in order to disclose the location of the mine. A penetrator (4), which is intended to drive a pathway through the ground to facilitate passage of the spotter (1), is arranged forwardly of the spotter in the mine, as seen in its direction of travel. The spotter (1) is capable of forwardly driving the penetrator (4) during a first phase of the spotter firing sequence; and the arrangement further includes a separating device (9) which is intended to separate the spotter from the penetrator during a second phase of the firing sequence.

    摘要翻译: PCT No.PCT / SE85 / 00489 Sec。 371日期1986年10月17日第 102(e)日期1986年10月17日PCT提交1985年11月27日PCT公布。 出版物WO86 / 03827 日期:1986年7月3日。在能够被中和的矿井中的布置,包括检测装置(33),用于检测矿井的中和;以及启动装置(3),其适于引发检测器装药的爆震 ),以及响应于中和的检测而被并入矿井的装置(1),并且设置为由所述雷管装置将其从矿井推进到地面的点样器(1),以便公开矿井的位置。 用于驱动通过地面以便于通过点样器(1)的通道的穿透器(4)被布置在矿中的检查器的前方,如其行进方向所示。 识别器(1)能够在点样器点火顺序的第一阶段期间向前驱动穿透器(4); 并且所述装置还包括分离装置(9),其用于在所述点火顺序的第二阶段期间将所述识别器与所述穿透器分离。

    Telescopic shaft
    14.
    发明授权
    Telescopic shaft 有权
    伸缩轴

    公开(公告)号:US08197348B2

    公开(公告)日:2012-06-12

    申请号:US12601702

    申请日:2008-05-28

    IPC分类号: F16C3/035

    摘要: A telescopic shaft for vehicles comprising an inner shaft axially movable in an outer shaft. The telescopic shaft comprises at least two rows of balls with at least one ball per row between the inner shaft and the outer shaft. A row of balls is arranged on at least one ball race arranged against the inner shaft. The ball race is wedge shaped on its against the inner shaft facing surface. The telescopic shaft comprises a prestress mechanism which pushes the ball race along a wedge unit axially in relation to and radially in the direction against the outer shaft. whereby the telescopic shaft is prestressed. The prestress mechanism is arranged to release the prestress when the alteration in length of the telescopic shaft exceeds a predetermined length.

    摘要翻译: 一种用于车辆的伸缩轴,包括可在外轴中可轴向移动的内轴。 伸缩轴包括至少两排球,每列在内轴和外轴之间具有至少一个球。 一排滚珠布置在抵靠内轴布置的至少一个滚珠滚道上。 球座在其相对于面向内轴的表面上是楔形的。 伸缩轴包括预应力机构,该预应力机构沿着楔形单元推动球座,该楔形单元相对于外轴线相对于径向并沿径向向外推动。 由此伸缩轴被预应力。 预应力机构布置成当伸缩轴的长度变化超过预定长度时释放预应力。

    Methods and compositions for PDGF-C activation and inhibition
    15.
    发明申请
    Methods and compositions for PDGF-C activation and inhibition 审中-公开
    用于PDGF-C活化和抑制的方法和组合物

    公开(公告)号:US20090047284A1

    公开(公告)日:2009-02-19

    申请号:US11985984

    申请日:2007-11-19

    摘要: Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.

    摘要翻译: 抑制血管发生的方法包括施用组织纤溶酶原激活剂(tPA)抑制剂和适用于包含tPA抑制剂的方法的药物组合物。 还提供了用于刺激血管生成的方法,其包括向有需要的患者施用tPA,以及包含用于刺激方法的有效量的tPA的药物组合物。 本发明公开了tPA是特异性PDGF-C活化蛋白酶,PDGF-CC中的CUB结构域与蛋白酶直接相互作用,是有效的蛋白水解所必需的,而释放的CUB结构域是tPA抑制剂。 优选地,本发明的方法和组合物用于同时刺激或同时抑制溶栓和血管发生。

    Antibodies to PDGF-D
    16.
    发明授权
    Antibodies to PDGF-D 失效
    PDGF-D抗体

    公开(公告)号:US07408040B2

    公开(公告)日:2008-08-05

    申请号:US11140284

    申请日:2005-05-31

    IPC分类号: C07K16/00

    摘要: PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.

    摘要翻译: PDGF-D,PDGF / VEGF家族生长因子的新成员,以及编码它的核苷酸序列,其生产方法,抗体和其它拮抗剂,转染和转化的表达它的宿主细胞,含有它的药物组合物 以及其在医学和诊断应用中的应用,包括刺激结缔组织生长或愈合哺乳动物伤口的方法,该方法包括向哺乳动物施用有效量的PDGF-D多肽或编码PDGF-D多肽的多核苷酸 。

    Composition and method for modulating vasculogenesis for angiogenesis
    17.
    发明申请
    Composition and method for modulating vasculogenesis for angiogenesis 审中-公开
    用于血管生成调节血管生成的组合物和方法

    公开(公告)号:US20070172423A1

    公开(公告)日:2007-07-26

    申请号:US11605607

    申请日:2006-11-29

    摘要: A method for modulating vasculogenesis or arteriogenesis or angiogenesis, especially for treating heart and limb ischemia, using the core domain protein of PDGF-C, a new member of the PDGF/VEGF family of growth factors, or a homodimer or a heterodimer comprising the core domain. Also disclosed are pharmaceutical compositions comprising the core protein, nucleotide sequences encoding the protein, and uses thereof in medical and diagnostic applications.

    摘要翻译: 使用PDGF-C的核心结构域蛋白,PDGF / VEGF生长因子家族的新成员或同型二聚体或异二聚体调节血管发生或动脉发生或血管发生,特别是用于治疗心脏和肢体缺血的方法,所述方法包括核心 域。 还公开了包含核心蛋白质,编码蛋白质的核苷酸序列及其在医学和诊断应用中的用途的药物组合物。

    Method for inhibiting tumor formation and growth
    18.
    发明申请
    Method for inhibiting tumor formation and growth 审中-公开
    抑制肿瘤形成和生长的方法

    公开(公告)号:US20050214280A1

    公开(公告)日:2005-09-29

    申请号:US11068888

    申请日:2005-03-02

    申请人: Xuri Li Ulf Eriksson

    发明人: Xuri Li Ulf Eriksson

    摘要: Method for inhibiting tumor cell formation or tumor cell growth, the method comprising administering to a patient in need thereof an antagonist to VEGF-B. Preferably, the antagonist is an anti-VEGF-B antibody, an antisense molecule, an RNAi molecule, a molecule for forming a triplex nucleic acid molecule with a VEGF-B encoding polynucleotide. Also disclosed are pharmaceutical compositions comprising the same.

    摘要翻译: 用于抑制肿瘤细胞形成或肿瘤细胞生长的方法,所述方法包括向有需要的患者施用VEGF-B的拮抗剂。 优选地,拮抗剂是抗VEGF-B抗体,反义分子,RNAi分子,用于形成具有VEGF-B编码多核苷酸的三重核酸分子的分子。 还公开了包含其的药物组合物。