摘要:
In accordance with this invention, an RPE cell membrane associated protein which has a molecular weight of about 32 kd, as determined by SDS-PAGE, has now been discovered. This protein, referred to an "p32," forms an oligomeric protein complex with the previously characterized p63 protein, a component of the membrane receptor for RBP. A nucleic acid molecule which codes for the p32 protein has also been isolated and sequence analysis shows that the p32 protein belongs to the family of short chain alcohol dehydrogenases, and exhibits 11-cis retinol dehydrogenase activity, the enzyme which catalyzes conversion of 11-cis-retinol into 11-cis retinaldehyde.
摘要:
An arrangement in a mine which is capable of being neutralized, comprising detecting means (33) operative to detect a neutralization of the mine, and initiator means (3) adapted to initiate detonation of a spotter charge (5) incorporated in the mine in response to the detection of a neutralization, and a spotter (1) which is arranged to be propelled from the mine by said detonator charge to the surface of the ground, in order to disclose the location of the mine. A penetrator (4), which is intended to drive a pathway through the ground to facilitate passage of the spotter (1), is arranged forwardly of the spotter in the mine, as seen in its direction of travel. The spotter (1) is capable of forwardly driving the penetrator (4) during a first phase of the spotter firing sequence; and the arrangement further includes a separating device (9) which is intended to separate the spotter from the penetrator during a second phase of the firing sequence.
摘要:
A user interface of a wireless user terminal provides a forecast of a future rate discount that may apply at a future time and/or at a possible future location of the wireless user terminal. The forecast may be displayed as a map and/or as textual or graphical information, and may be provided in response to a user request, in response to receipt of a message from the wireless network and/or automatically at a given time. Related systems, methods and devices are described.
摘要:
A telescopic shaft for vehicles comprising an inner shaft axially movable in an outer shaft. The telescopic shaft comprises at least two rows of balls with at least one ball per row between the inner shaft and the outer shaft. A row of balls is arranged on at least one ball race arranged against the inner shaft. The ball race is wedge shaped on its against the inner shaft facing surface. The telescopic shaft comprises a prestress mechanism which pushes the ball race along a wedge unit axially in relation to and radially in the direction against the outer shaft. whereby the telescopic shaft is prestressed. The prestress mechanism is arranged to release the prestress when the alteration in length of the telescopic shaft exceeds a predetermined length.
摘要:
Methods for inhibiting angiogenesis comprising administering tissue-plasminogen activator (tPA) inhibitors, and pharmaceutical compositions suitable for the methods comprising the tPA inhibitors. Also provided are methods for stimulating angiogenesis comprising administering tPA to a patient in need thereof, and pharmaceutical compositions comprising an effective amount of tPA for the methods of stimulation. The present invention discloses that tPA is a specific PDGF-C activating protease, and that the CUB-domains in PDGF-CC directly interact with the protease, are required for efficient proteolysis, and released CUB-domains are tPA inhibitors. Preferably, the method and compositions of the present invention are used for simultaneously stimulating, or simultaneously inhibiting, thrombolysis and angiogenesis.
摘要:
PDGF-D, a new member of the PDGF/VEGF family of growth factors, as well as the nucleotide sequence encoding it, methods for producing it, antibodies and other antagonists to it, transfected and transformed host cells expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications, including methods for stimulating growth of a connective tissue or healing a wound in a mammal, which methods comprise administering to the mammal an effective amount of PDGF-D polypeptides or polynucleotides encoding the PDGF-D polypeptides.
摘要:
A method for modulating vasculogenesis or arteriogenesis or angiogenesis, especially for treating heart and limb ischemia, using the core domain protein of PDGF-C, a new member of the PDGF/VEGF family of growth factors, or a homodimer or a heterodimer comprising the core domain. Also disclosed are pharmaceutical compositions comprising the core protein, nucleotide sequences encoding the protein, and uses thereof in medical and diagnostic applications.
摘要:
Method for inhibiting tumor cell formation or tumor cell growth, the method comprising administering to a patient in need thereof an antagonist to VEGF-B. Preferably, the antagonist is an anti-VEGF-B antibody, an antisense molecule, an RNAi molecule, a molecule for forming a triplex nucleic acid molecule with a VEGF-B encoding polynucleotide. Also disclosed are pharmaceutical compositions comprising the same.
摘要:
Angiogenesis is stimulated by introducing two replication-deficient adenovirus vectors to the endothelial cells or proximate to the endothelial cells of an organism. The first vector encodes VEGF-B167 or a fragment or conservative substitution thereof, the second vector encodes VEGF-A or VEGF-C, or fragments or conservative substitutions thereof.
摘要:
A tube heat exchanger intended to be used for the production of carbon black, includes a cylindrical closed chamber having a plurality of tubes which extend through the entire, essentially cylindrically shaped chamber. Upper end of the tubes are attached to an upper end wall, preferably by welding, and hang down to a tube plate. The tube plate equipped with compensating devices to enable thermally induced expansions and contractions of the tubes to occur.