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    ALLELE EDITING AND APPLICATIONS THEREOF
    11.
    发明公开
    ALLELE EDITING AND APPLICATIONS THEREOF 审中-公开

    公开(公告)号：US20230193320A1

    公开(公告)日：2023-06-22

    申请号：US17948313

    申请日：2022-09-20

    Applicant: UNIVERSITÄT BASEL

    Inventor： Mara KORNETE ,  Lukas JEKER

    IPC: C12N15/90 ,  C12N15/10 ,  A61P35/00 ,  A61K35/17 ,  A61K35/28 ,  C12N5/0783 ,  C12N5/0789

    CPC classification number: C12N15/902 ,  C12N15/102 ,  A61P35/00 ,  A61K35/17 ,  A61K35/28 ,  C12N5/0636 ,  C12N5/0647

    Abstract: The invention relates to a method to determine a homology directed repair (HDR) event within a eukaryotic cell, wherein the cell expresses a first isoform of a surface protein, which is different from a second isoform of said surface protein with regard to an amino acid marker. The method comprises the steps of inducing a DNA double strand break, providing a HDR template DNA construct comprising the amino acid marker corresponding to the second isoform of the surface protein and subsequently determining the expression of the first or second isoform of said surface protein on said cell, wherein expression of the second isoform indicates a successful HDR event. The invention also relates to a method for editing a genomic location of interest within a eukaryotic cell, and to a method of selectively depleting or enriching an edited cell in a composition of non-edited and edited cells.

    Medical endodevice
    12.
    发明授权
    Medical endodevice 有权

    公开(公告)号：US11617495B2

    公开(公告)日：2023-04-04

    申请号：US16624990

    申请日：2018-06-25

    Applicant: UNIVERSITÄT BASEL

    Inventor： Manuela Eugster ,  Patrick Weber ,  Georg Rauter

    IPC: A61B18/24 ,  A61B34/30 ,  A61B1/00 ,  A61B34/20 ,  A61B18/00

    Abstract: A medical endodevice for an intervention inside a human or animal body includes an elongated liaising structure having a distal end arrangeable inside a body of the human or animal being and a proximal end arrangeable outside the body while the distal end is inside the body. The endodevice has an intervention tool arranged to manipulate a target tissue inside the human or animal body. The intervention tool is arranged at the distal end of the liaising structure. The endodevice further includes a positioning unit having a moving formation arranged to dislocate the intervention tool relative to the target tissue, and an anchoring formation arranged to fix the moving formation to a fixing tissue inside the human or animal body such that the target tissue is positioned in a workspace of the intervention tool.

    TRI-SEGMENTED PICHINDE VIRUSES AS VACCINE VECTORS
    14.
    发明申请
    TRI-SEGMENTED PICHINDE VIRUSES AS VACCINE VECTORS 有权

    公开(公告)号：US20220289797A1

    公开(公告)日：2022-09-15

    申请号：US17751319

    申请日：2022-05-23

    Applicant: Hookipa Biotech GmbH ,  Universität Basel

    Inventor： Weldi Bonilla ,  Daniel David Pinschewer ,  Klaus Orlinger

    IPC: C07K14/005 ,  C12N15/86

    Abstract: The present application relates to Pichinde viruses with rearrangements of their open reading frames (“ORF”) in their genomes. In particular. described herein is a modified Pichinde virus genomic segment, wherein the Pichinde virus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented Pichinde virus particles comprising one L segment and two S segments or two L segments and one S segment. The Pichinde virus, described herein may be suitable for vaccines md/or treatment of diseases and/or for the use in immunotherapies.

    SMALL-MOLECULE ORGANIC DYES
    17.
    发明申请
    SMALL-MOLECULE ORGANIC DYES 审中-公开

    公开(公告)号：US20200255667A1

    公开(公告)日：2020-08-13

    申请号：US16643173

    申请日：2018-08-28

    Applicant: UNIVERSITÄT BASEL

    Inventor： Christof Sparr ,  Christian Fischer

    IPC: C09B15/00 ,  C07D219/06 ,  C07D311/86 ,  C09B11/24

    Abstract: The present invention relates to compounds of formula (A), wherein Z is NR10 or O. These compounds represent novel acridinium and xanthylium salts having an unprecedented substituted heterocyclic core. They are useful as fluorescent dyes or precursors thereof in different applications including various imaging and sensing techniques, and, in particular, as photosensitizers and hereby preferably as photocatalysts. The present invention further relates to processes for preparing the inventive compounds via 1,5-organodimetallic reagents from double directed ortho-metalation reactions or combined halogen-metal exchange/directed ortho-metalation reactions.

    CONTROLLING A SURGICAL INTERVENTION TO A BONE
    18.
    发明申请
    CONTROLLING A SURGICAL INTERVENTION TO A BONE 审中-公开

    公开(公告)号：US20190388155A1

    公开(公告)日：2019-12-26

    申请号：US16563280

    申请日：2019-09-06

    Applicant: Universität Basel ,  Universitätsspital Basel

    Inventor： Philippe Cattin ,  Gregory Jost ,  Jonas Walti

    IPC: A61B34/10 ,  A61B34/20 ,  G05B15/02

    Abstract: A method of controlling a surgical intervention to a bone comprises obtaining a three-dimensional image or multiplanar reconstruction of the bone, defining a position and an axis of intervention on the three-dimensional image or multiplanar reconstruction of the bone, and controlling an orientation of an intervention instrument equipped with an orientation sensor during the surgical intervention by evaluating a signal provided by the orientation sensor. The method further comprises referencing the intervention instrument with respect to the bone before the surgical intervention by arranging the intervention instrument in relation to an anatomic landmark and rotating the orientation sensor into a predefined position. The method allows for efficiently achieving correct orientation and position of the intervention instrument in bone surgical intervention. Furthermore, the method provides an efficient real-time control at comparably low efforts. Still further, with the method radiation exposure to the operational staff as well as patients can be reduced.

    METHOD FOR PROVIDING SUB-ELEMENTS OF A MULTIPART IMPLANT OR A MULTIPART OSTEOSYNTHESIS
    20.
    发明申请
    METHOD FOR PROVIDING SUB-ELEMENTS OF A MULTIPART IMPLANT OR A MULTIPART OSTEOSYNTHESIS 审中-公开

    公开(公告)号：US20190380836A1

    公开(公告)日：2019-12-19

    申请号：US16083627

    申请日：2017-03-10

    Applicant: UNIVERSITÄT BASEL VIZEREKTORAT FORSCHUNG

    Inventor： Stefan STÜBINGER ,  Timo ZILLIG

    IPC: A61F2/28 ,  A61F2/30

    Abstract: A method for providing sub-elements of a multipart implant or a multi-part osteosynthesis prior to introducing same into a human and/or animal body, involves: A) detecting data of a patient for whom the implant and/or the osteosynthesis is intended; B) generating a model using the detected data; C) generating manufacture specifications for at least two or more sub-elements which can be combined so as to form an implant and/or an osteosynthesis on the basis of the generated model, said manufacture specifications comprising C1) a dimensioning of the sub-elements; and D) manufacturing the sub-elements on the basis of the manufacture specifications. The sub-elements can be assembled together so as to form an implant or an steosynthesis.

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