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公开(公告)号：US20240252553A1
公开(公告)日：2024-08-01
申请号：US18578856
申请日：2022-07-12
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Bahareh BEHKAM , Eric LEAMAN
Abstract: Cancer is a significant cause of mortality and morbidity worldwide. One of the principal impediments to the broad success of conventional chemotherapy is poor delivery to and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as collagen. Described herein are engineered Salmonella Typhimurium (S. Typhimurium) bacteria and uses thereof. In some embodiments, the engineered S. Typhimurium bacteria comprises an exogenous collagenase. Also described in exemplary embodiments herein methods of using the engineered S. Typhimurium bacteria, such as part of a,cancer therapy.
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12.发明公开公开(公告)号：US20240240036A1
公开(公告)日：2024-07-18
申请号：US18559525
申请日：2022-05-07
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Ranga PITCHUMANI , Ryan STODDARD
CPC classification number: C09D5/1681 , C23F1/18
Abstract: Solid-infused surfaces and articles having solid-infused surfaces are provided. The solid-infused surface includes (a) a substrate with a roughened surface having multi-scale surface roughness and a plurality of substrate asperities, and (b) a low surface-energy polymer coating a portion of the roughened surface forming the solid-infused surface having a fraction of the substrate asperities exposed on the solid-infused surface. The surfaces can be useful, in particular, for promoting condensation heat transfer performance. The articles and surfaces can include electronic components, optical components, or even pipes and other conduits for transporting certain fluids. Methods of making and methods of using the solid-infused surfaces are also provided.
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公开(公告)号：US20240238237A1
公开(公告)日：2024-07-18
申请号：US18289409
申请日：2022-05-04
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Deborah J. Good
IPC: A61K31/201 , A61P1/14 , A61P3/04 , A61P5/24
CPC classification number: A61K31/201 , A61P1/14 , A61P3/04 , A61P5/24
Abstract: Described in certain example embodiments herein are methods of and compositions for treating a Snordl l6 deficiency disease or symptom thereof with conjugated linoleic acid (CLA) or a formulation thereof. In some embodiments, the Snordl l6 deficiency disease is Prader-Willi Syndrome. Described in certain example embodiments herein are methods of and compositions for treating Nhlh2 associated hypogonadism with CLA or a formulation thereof.
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公开(公告)号：US20240207041A1
公开(公告)日：2024-06-27
申请号：US18555383
申请日：2022-05-04
Inventor： Demitria POULOS , Logan N. DICKINSON , Skye CARLSON , Zachary KOZAR , Jennifer S. WAYNE , Vincent WANG , John R. CLEMENTS
IPC: A61F2/08
CPC classification number: A61F2/0811 , A61F2002/0835 , A61F2002/0852 , A61F2002/0882 , A61F2220/0033 , A61F2220/0075
Abstract: Various aspects of an implant for plantar plate repair and a surgical method of plantar plate repair using the implant are described. In one example, the implant includes a female component and a male component. The female component includes an open barrel having an outer surface and an inner surface, a flange cap at one end of the open barrel, and a recessed tiedown bar that extends between openings through the flange cap. The openings through the flange cap extending into the open barrel of the female component. The male impant includes an open barrel portion, a pair of fingers extending from one end of the open barrel portion, and a flange cap at another end of the open barrel portion. The male implant also includes an opening through the flange cap, extending into the open barrel portion of the male implant.
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公开(公告)号：US20240204652A1
公开(公告)日：2024-06-20
申请号：US18068144
申请日：2022-12-19
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Adhistira Madhyasta Naradhipa , Qiang Li
CPC classification number: H02M1/14 , H02M3/1584
Abstract: Aspects of a transient control scheme for a multiphase power converter are described. In one example, a power converter system includes a multiphase power converter that includes a plurality of converter phases, with each converter phase comprising a switching transistor and an inductor coupled between an input power source and a load. The power converter system also includes a controller configured to distribute an on-time signal to each converter phase during operation of the multiphase power converter. The controller includes circuitry configured to enable an on-time signal phase overlap between non-subsequent phases of the multiphase power converter when a load current increase is detected during a transient state of the multiphase power converter. The on-time signal phase overlap refers to a simultaneous on-state of two or more switching transistors of the non-subsequent phases during a duration of time within the transient state.
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Patent Agency Ranking
公开(公告)号：US12015215B2
公开(公告)日：2024-06-18
申请号：US17607513
申请日：2020-07-08
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Ali Hosseini-Fahraji , Majid Manteghi
Abstract: Coaxial collinear antenna examples are described. An example coaxial collinear antenna includes a first segment and a second segment of a coaxial cable. The second segment includes a second inner conductor and a second outer conductor. The first inner conductor of the first segment is coupled to the second outer conductor of the second segment. The first outer conductor of the first segment is coupled to the second inner conductor of the second segment. Further, a first wire mesh is attached to the first outer conductor of the first segment, and a second wire mesh is attached to the second outer conductor of the second segment. Additionally, the coaxial collinear antenna includes an end-fed port that is situated at a distal end of the coaxial collinear antenna.
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17.发明公开公开(公告)号：US20240173063A1
公开(公告)日：2024-05-30
申请号：US18528051
申请日：2023-12-04
Inventor： Robert Neal, II , Rafael V. Davalos
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B34/10 , C12N13/00 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00666 , A61B2018/00672 , A61B2018/00678 , A61B2018/00767 , A61B2018/00875 , A61B2018/1425 , A61B2034/104
Abstract: A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.
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公开(公告)号：US11983210B2
公开(公告)日：2024-05-14
申请号：US17343560
申请日：2021-06-09
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Edward A. Fox , Saurabh Chakravarty , Satvik Chekuri , Maanav Mehrotra , Aarohi Sumant
IPC: G06F16/34 , G06F16/35 , G06F40/216 , G06F40/35 , G06N3/08
CPC classification number: G06F16/345 , G06F16/35 , G06F40/216 , G06F40/35 , G06N3/08
Abstract: Described herein are systems and methods to enable generation of high-quality summaries of documents that have questions and answers. To help summarize such documents, parsing methods are disclosed that account for different document formats. Question-answer groups are transformed into declarative sentences. Sentence correction can be applied to the declarative sentences. Candidate summary sentences are identified from the declarative sentences, and a subset of the candidate summary sentences are selected for inclusion in a summary. Aspects, segmentation, and augmentation can help with generation and tailoring of summaries.
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公开(公告)号：US20240143348A1
公开(公告)日：2024-05-02
申请号：US18264675
申请日：2022-02-08
Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
Inventor： Ran JIN , Xiaoyu CHEN , Nathan LAU
CPC classification number: G06F9/451 , G02B27/0093 , G06F17/16
Abstract: Adapting user interface designs for specific tasks performed by different users is a challenging yet important problem. Automatically adapting visualization designs to users and contexts (e.g., tasks, display devices, environments, etc.) can theoretically improve human-computer interaction to acquire insights from complex datasets. However, effectiveness of any specific visualization is moderated by individual differences in knowledge, skills, and abilities for different contexts. A modeling framework called Personalized Recommender System for Information visualization Methods via Extended matrix completion (PRIME) is described for recommending the optimal visualization designs for individual users in different contexts.
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公开(公告)号：US11968765B2
公开(公告)日：2024-04-23
申请号：US16657472
申请日：2019-10-18
Inventor： Jeremiah Kopiness , Andrew Amrhein , Jong-Woo Kim , Moonhyun Lee , Jih-Sheng Lai
CPC classification number: H05B6/062 , H02M1/0009 , H02M7/53871 , H03L5/00 , H05B6/1209 , H02M7/4815 , Y02B70/10
Abstract: The present disclosure describes devices and methods for improving the power efficiency and control of an induction heating system. In particular, the induction heating system includes a series resonant bridge inverter circuit and a control circuit. The inverter circuit includes one or more induction coils that are structured to inductively couple to the cookware to heat the cookware and a current sensor structured to sense a coil current signal across the one or more inductor coils. In particular, the current sensor is structured to generate a positive sensed voltage signal corresponding to a positive portion of the coil current signal and a negative sensed voltage signal corresponding to a negative portion of the coil current. The control signal is structured to control switching of a first and a second set of switches based on the positive and negative sensed voltage signals.
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