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    Biodegradable vascular device with buffering agent
    11.
    发明申请
    Biodegradable vascular device with buffering agent 有权
    具缓冲剂的可生物降解血管装置

    公开(公告)号：US20050278015A1

    公开(公告)日：2005-12-15

    申请号：US10856459

    申请日：2004-05-28

    申请人： Vipul Bhupendra Dave ,  George Landau ,  Premal Patel

    发明人： Vipul Bhupendra Dave ,  George Landau ,  Premal Patel

    IPC分类号： A61L27/00 ,  A61F2/24 ,  A61F2/84 ,  A61L27/44 ,  A61L27/48 ,  A61L31/00 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61F2/06

    CPC分类号： A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/604

    摘要： A vascular or cardiovascular medical device for placement at a site in a patient's body and for controlling pH levels at the site in the patient's body includes one or more structural components made of a biodegradable and/or bioabsorbable material, or alternatively, a coating thereon made of a biodegradable and/or bioabsorbable material. A buffering agent is provided on or in the biodegradable and/or bioabsorbable material and the buffering agent is dispersed from the biodegradable and/or bioabsorbable material in response to hydrolysis of the biodegradable and/or bioabsorbable material. Additionally, the vascular or cardiovascular medical device can include a drug that is included with the biodegradable and/or bioabsorbable material. The vascular or cardiovascular medical device can also be a stent or a valve.

    摘要翻译： 用于放置在患者体内的位置并用于控制患者体内的位置处的pH水平的血管或心血管医疗装置包括由可生物降解和/或生物可吸收材料制成的一个或多个结构组分，或者替代地，其上形成的涂层 的可生物降解和/或生物可吸收材料。 在可生物降解和/或生物可吸收材料上或其中提供缓冲剂，并且响应于可生物降解和/或生物可吸收材料的水解，缓冲剂从可生物降解和/或生物可吸收材料分散。 另外，血管或心血管医疗装置可以包括可生物降解和/或生物可吸收材料所包含的药物。 血管或心血管医疗装置也可以是支架或阀。

    Balloon expandable bioabsorbable drug eluting flexible stent
    12.
    发明授权
    Balloon expandable bioabsorbable drug eluting flexible stent 有权
    球囊可扩张生物可吸收药物洗脱柔性支架

    公开(公告)号：US09320837B2

    公开(公告)日：2016-04-26

    申请号：US11747699

    申请日：2007-05-11

    申请人： Robert Burgermeister ,  David Overaker ,  Vipul Bhupendra Dave ,  Joseph H. Contiliano ,  Qiang Zhang

    发明人： Robert Burgermeister ,  David Overaker ,  Vipul Bhupendra Dave ,  Joseph H. Contiliano ,  Qiang Zhang

    IPC分类号： A61F2/915 ,  A61L31/16 ,  A61F2/91 ,  A61L31/18

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2230/0058 ,  A61F2250/0067 ,  A61F2250/0098 ,  A61L31/18 ,  A61L2300/416 ,  A61L2300/606

    摘要： A biocompatible material may be configured into any number of implantable medical devices including intraluminal stents. Polymeric materials may be utilized to fabricate any of these devices, including stents. The stents may be balloon expandable or self-expanding. The polymeric materials may include additives such as drugs or other bioactive agents as well as radiopaque agents. By preferential mechanical deformation of the polymer, the polymer chains may be oriented to achieve certain desirable performance characteristics. The stent has a plurality of hoop components interconnected by at least one flexible connector. The hoop components are formed as a continuous series of alternating substantially longitudinally oriented strut members and connector junction struts, whereas the longitudinal strut is connected to the connector junction strut by alternating substantially circumferentially oriented arc members.

    摘要翻译： 生物相容性材料可以配置成任何数量的可植入医疗装置，包括腔内支架。 可以使用聚合材料来制造包括支架在内的任何这些装置。 支架可以是球囊扩张或自扩张。 聚合物材料可以包括添加剂如药物或其他生物活性剂以及不透射线剂。 通过聚合物的优先机械变形，聚合物链可以被取向以获得某些所需的性能特征。 支架具有通过至少一个柔性连接器互连的多个箍部件。 环形部件形成为连续的一系列交替的基本纵向取向的支柱构件和连接器连接支柱，而纵向支柱通过交替的大致圆周取向的弧形构件连接到连接器连杆支柱。

    CEA SYSTEM AND METHOD FOR DELIVERING A SELF-EXPANDING STENT
    14.
    发明申请
    CEA SYSTEM AND METHOD FOR DELIVERING A SELF-EXPANDING STENT 审中-公开
    CEA系统和用于传送自扩展的方法

    公开(公告)号：US20090024202A1

    公开(公告)日：2009-01-22

    申请号：US12243686

    申请日：2008-10-01

    申请人： Vipul Bhupendra DAVE ,  Diana Margarita Sanchez

    发明人： Vipul Bhupendra DAVE ,  Diana Margarita Sanchez

    IPC分类号： A61F2/06 ,  A61B19/00

    CPC分类号： F16K1/2263 ,  Y10T137/0491 ,  Y10T137/0525 ,  Y10T137/6052

    摘要： Self-expanding stent delivery systems and methods having an introducer that receives a delivery catheter. The delivery catheter includes an outer body, an inner body and a stent loaded onto a stent bed within the inner body. The outer body receives the inner body with the stent loaded on the stent bed thereof. The outer body helps constrain the stent in its undeployed state in the stent bed until the stent is deployed by retraction of the outer body of the delivery catheter when the stent is identified as positioned across an intended treatment site. At least one anchoring mechanism provided on the inner body helps maintain the undeployed loaded stent appropriately in the stent bed during deployment. The at least one anchoring mechanism can include radiopaque material to increase fluoroscopic visualization of the stent during deployment, and the self-expanding stent can be a bio-absorbable material including drugs or other bio-active agents incorporated therein or provided thereon. The at least one anchoring mechanism can instead comprise a set of at least two bumpers between which the stent is loaded until deployed by retraction of the outer body of the delivery catheter when the stent has been appropriately positioned across an intended treatment site. After deployment of the stent at the intended treatment site, removal of the inner body and outer body of the delivery catheter and of the introducer occurs. Reliable and accurate emplacement of the stent across an intended treatment site is rendered more likely as a result.

    摘要翻译： 自扩张支架输送系统和方法具有接收递送导管的导引器。 输送导管包括外体，内体和支撑在内体内的支架床上的支架。 外体接收内体，其中支架装载在其支架床上。 外部身体有助于将支架限制在支架床中的未部署状态，直到当支架被识别为穿过预期治疗部位定位时，支架通过收回输送导管的外部体而展开。 设置在内体上的至少一个锚固机构有助于在展开期间在支架床中适当地维持未部署的加载支架。 所述至少一个锚定机构可以包括不透射线材料，以在展开期间增加支架的荧光透视可视化，并且自扩张支架可以是生物可吸收材料，其包括并入其中或在其上提供的药物或其它生物活性剂。 所述至少一个锚固机构可以替代地包括一组至少两个缓冲器，在支架已经被适当地定位在预期的治疗部位的位置之前，支架被装载直到通过收缩输送导管的外部主体而被展开。 在预定的治疗部位展开支架之后，发生输送导管的内部主体和外部主体以及导引器的移除。 结果，更有可能在预期治疗部位的可靠和准确的支架置入。

    Methods of making bioabsorbable drug delivery devices comprised of solvent cast films
    15.
    发明申请
    Methods of making bioabsorbable drug delivery devices comprised of solvent cast films 审中-公开
    制造由溶剂流延膜组成的生物可吸收药物递送装置的方法

    公开(公告)号：US20070160672A1

    公开(公告)日：2007-07-12

    申请号：US11327637

    申请日：2006-01-06

    申请人： Vipul Bhupendra Dave

    发明人： Vipul Bhupendra Dave

    IPC分类号： A61K9/14

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L67/04

    摘要： A bioabsorbable drug delivery device and various methods of making the same. The devices are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes the steps of preparing a solution of at least one bioabsorbable polymer with a solvent and pouring the solution into a mold. The solvent is then evaporated in a nitrogen environment and the solution is converted into a film. The film is then removed from the mold and residual solvent is removed from the film. The film is then cut into strips and stored in an inert environment.

    摘要翻译： 生物吸收性药物输送装置及其制造方法。 该装置优选由使用低温制造方法的生物可吸收材料形成，由此将药物或其它生物活性剂掺入到装置中或装置上，并且在加工过程中药物或其它试剂的降解最小化。 该方法包括以下步骤：用溶剂制备至少一种生物可吸收聚合物的溶液并将溶液倒入模具中。 然后将溶剂在氮气环境中蒸发并将溶液转化成膜。 然后将膜从模具中取出，并从膜中除去残留的溶剂。 然后将膜切成条状并储存在惰性环境中。

    Self-expanding stent delivery system
    16.
    发明申请
    Self-expanding stent delivery system 审中-公开
    自扩张支架输送系统

    公开(公告)号：US20070142892A1

    公开(公告)日：2007-06-21

    申请号：US11304256

    申请日：2005-12-15

    申请人： Vipul Bhupendra Dave ,  Diana Margarita Sanchez

    发明人： Vipul Bhupendra Dave ,  Diana Margarita Sanchez

    IPC分类号： A61F2/06

    CPC分类号： A61F2/95 ,  A61F2002/9665

    摘要： Self-expanding stent delivery systems and methods having an introducer that receives a delivery catheter. The delivery catheter includes an outer body, an inner body and a stent loaded onto a stent bed within the inner body. The outer body receives the inner body with the stent loaded on the stent bed thereof. The outer body helps constrain the stent in its undeployed state in the stent bed until the stent is deployed by retraction of the outer body of the delivery catheter when the stent is identified as positioned across an intended treatment site. At least one anchoring mechanism provided on the inner body helps maintain the undeployed loaded stent appropriately in the stent bed during deployment. The at least one anchoring mechanism can include radiopaque material to increase fluoroscopic visualization of the stent during deployment, and the self-expanding stent can be a bio-absorbable material including drugs or other bio-active agents incorporated therein or provided thereon. The at least one anchoring mechanism can instead comprise a set of at least two bumpers between which the stent is loaded until deployed by retraction of the outer body of the delivery catheter when the stent has been appropriately positioned across an intended treatment site. After deployment of the stent at the intended treatment site, removal of the inner body and outer body of the delivery catheter and of the introducer occurs. Reliable and accurate emplacement of the stent across an intended treatment site is rendered more likely as a result.

    摘要翻译： 自扩张支架输送系统和方法具有接收递送导管的导引器。 输送导管包括外体，内体和支撑在内体内的支架床上的支架。 外体接收内体，其中支架装载在其支架床上。 外部身体有助于将支架限制在支架床中的未部署状态，直到当支架被识别为穿过预期治疗部位定位时，支架通过收回输送导管的外部体而展开。 设置在内体上的至少一个锚固机构有助于在展开期间在支架床中适当地维持未部署的加载支架。 所述至少一个锚定机构可以包括不透射线材料，以在展开期间增加支架的荧光透视可视化，并且自扩张支架可以是生物可吸收材料，其包括并入其中或在其上提供的药物或其它生物活性剂。 所述至少一个锚固机构可以替代地包括一组至少两个缓冲器，在支架已经被适当地定位在预期的治疗部位的位置之前，支架被装载直到通过收缩输送导管的外部主体而被展开。 在预定的治疗部位展开支架之后，发生输送导管的内部主体和外部主体以及导引器的移除。 结果，更有可能在预期治疗部位的可靠和准确的支架置入。

    Monofilament tape
    18.
    发明授权
    Monofilament tape 有权
    单丝带

    公开(公告)号：US06742528B2

    公开(公告)日：2004-06-01

    申请号：US10287204

    申请日：2002-11-04

    申请人： Vipul Bhupendra Dave

    发明人： Vipul Bhupendra Dave

    IPC分类号： A61C1500

    CPC分类号： A61C15/041 ,  D01F8/06 ,  D01F8/12 ,  D01F8/14

    摘要： A bicomponent monofilament tape wherein the tape is made from the fusion of the sheaths of at least about 60 bicomponent core-sheath fibers and the bonding of the fused sheaths to the core fibers is disclosed. A process for preparing a bicomponent monofilament tape by providing at least about 60 bicomponent core-sheath fibers; fusing the sheaths; and bonding the fused sheaths to the core fibers is also disclosed.

    摘要翻译： 公开了一种双组分单丝带，其中胶带由至少约60个双组分芯鞘纤维的护套熔合和熔融护套与芯纤维的结合制成。 通过提供至少约60个双组分芯鞘纤维制备双组分单丝带的方法; 融合护套; 并且还公开了将熔融护套粘合到芯纤维上。

    Vascular closure device
    20.
    发明授权
    Vascular closure device 有权
    血管闭合装置

    公开(公告)号：US08876860B2

    公开(公告)日：2014-11-04

    申请号：US12405087

    申请日：2009-03-16

    申请人： Vipul Bhupendra Dave ,  Chao-Chin Chen ,  Thomas Palermo

    发明人： Vipul Bhupendra Dave ,  Chao-Chin Chen ,  Thomas Palermo

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B2017/00654

    摘要： The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment.

    摘要翻译： 本发明提供一种多孔结构，其非常有效地密封穿刺部位，具有最佳的孔隙率，吸收能力和完美的解剖适合性。 插头密度和其他纤维性能/几何（总旦数，长丝数等）提供了一种有效的结构，允许在展开期间瞬间吸收血液。 使用吸收液体的塞子的最终尺寸提供了解剖学配合，并在部署后几分钟内密封穿刺部位。