公开(公告)号：US07504424B2

公开(公告)日：2009-03-17

申请号：US11333663

申请日：2006-01-17

Applicant: Wensheng Yu ,  Ling Tong ,  Lei Chen ,  Joseph A. Kozlowski ,  Brian J. Lavey ,  Neng-Yang Shih ,  Vincent S. Madison ,  Guowei Zhou ,  Peter Orth ,  Zhuyan Guo ,  Michael K. C. Wong ,  De-Yi Yang ,  Seong Heon Kim ,  Bandarpalle B. Shankar ,  M. Arshad Siddiqui ,  Kristin E. Rosner ,  Chaoyang Dai ,  Umar Faruk Mansoor ,  Janeta Popovici-Muller ,  Vinay M. Girijavallabhan ,  Dansu Li

Inventor： Wensheng Yu ,  Ling Tong ,  Lei Chen ,  Joseph A. Kozlowski ,  Brian J. Lavey ,  Neng-Yang Shih ,  Vincent S. Madison ,  Guowei Zhou ,  Peter Orth ,  Zhuyan Guo ,  Michael K. C. Wong ,  De-Yi Yang ,  Seong Heon Kim ,  Bandarpalle B. Shankar ,  M. Arshad Siddiqui ,  Kristin E. Rosner ,  Chaoyang Dai ,  Umar Faruk Mansoor ,  Janeta Popovici-Muller ,  Vinay M. Girijavallabhan ,  Dansu Li

IPC: A61K31/416 ,  A61K31/428 ,  C07D209/04 ,  C07D231/08 ,  C07D275/04 ,  C07D417/14 ,  C07D513/12

CPC classification number: C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症 其中。

公开(公告)号：US20070265299A1

公开(公告)日：2007-11-15

申请号：US11653798

申请日：2007-01-16

Applicant: Brian Lavey ,  Joseph Kozlowski ,  Guowei Zhou ,  Ling Tong ,  Wensheng Yu ,  Michael Wong ,  Bandarpalle Shankar ,  Neng-Yang Shih ,  M. Siddiqui ,  Kristin Rosner ,  Chaoyang Dai ,  Janeta Popovici-Muller ,  Vinay Girijavallabhan ,  Dansu Li ,  Aneta Micula ,  Seong-Heon Kim ,  De-Yi Yang ,  Razia Rizvi

Inventor： Brian Lavey ,  Joseph Kozlowski ,  Guowei Zhou ,  Ling Tong ,  Wensheng Yu ,  Michael Wong ,  Bandarpalle Shankar ,  Neng-Yang Shih ,  M. Siddiqui ,  Kristin Rosner ,  Chaoyang Dai ,  Janeta Popovici-Muller ,  Vinay Girijavallabhan ,  Dansu Li ,  Aneta Micula ,  Seong-Heon Kim ,  De-Yi Yang ,  Razia Rizvi

IPC: A61K31/44 ,  A61K31/4152 ,  A61K31/4412 ,  A61K31/4709 ,  A61K35/00 ,  A61P11/00 ,  A61P11/08 ,  A61P17/06 ,  A61P3/14 ,  A61P37/00 ,  A61P37/08 ,  A61P9/00 ,  A61P9/10 ,  C07D215/06 ,  C07D233/02 ,  C07D401/06 ,  C07D471/02

CPC classification number: C07D403/14 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00

Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPS, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMPS，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症 。

公开(公告)号：US20070219218A1

公开(公告)日：2007-09-20

申请号：US11653676

申请日：2007-01-16

Applicant: Wensheng Yu ,  Ling Tong ,  Lei Chen ,  Joseph Kozlowski ,  Brian Lavey ,  Neng-Yang Shih ,  Vincent Madison ,  Guowei Zhou ,  Peter Orth ,  Zhuyan Guo ,  Michael Wong ,  De-Yi Yang ,  Seong Kim ,  Bandarpalle Shankar ,  M. Siddiqui ,  Kristin Rosner ,  Chaoyang Dai ,  Janeta Popovici-Muller ,  Vinay Girijavallabhan ,  Dansu Li ,  Razia Rizvi ,  Aneta Micula ,  Robert Feltz

Inventor： Wensheng Yu ,  Ling Tong ,  Lei Chen ,  Joseph Kozlowski ,  Brian Lavey ,  Neng-Yang Shih ,  Vincent Madison ,  Guowei Zhou ,  Peter Orth ,  Zhuyan Guo ,  Michael Wong ,  De-Yi Yang ,  Seong Kim ,  Bandarpalle Shankar ,  M. Siddiqui ,  Kristin Rosner ,  Chaoyang Dai ,  Janeta Popovici-Muller ,  Vinay Girijavallabhan ,  Dansu Li ,  Razia Rizvi ,  Aneta Micula ,  Robert Feltz

IPC: A61K31/497 ,  A61K31/506 ,  A61K31/4709 ,  A61K31/4741 ,  A61K31/4745 ,  A61K31/4178 ,  C07D403/14 ,  C07D491/02 ,  C07D471/02

CPC classification number: C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04

Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症 其中。

公开(公告)号：US20060205797A1

公开(公告)日：2006-09-14

申请号：US11180863

申请日：2005-07-13

Applicant: Wensheng Yu ,  Ling Tong ,  Lei Chen ,  Joseph Kozlowski ,  Brian Lavey ,  Neng-Yang Shih ,  Vincent Madison ,  Guowei Zhou ,  Peter Orth ,  Zhuyan Guo ,  Michael Wong ,  De-Yi Yang ,  Seong Kim ,  Bandarpalle Shankar

Inventor： Wensheng Yu ,  Ling Tong ,  Lei Chen ,  Joseph Kozlowski ,  Brian Lavey ,  Neng-Yang Shih ,  Vincent Madison ,  Guowei Zhou ,  Peter Orth ,  Zhuyan Guo ,  Michael Wong ,  De-Yi Yang ,  Seong Kim ,  Bandarpalle Shankar

IPC: A61K31/425 ,  A61K31/4178 ,  C07D417/02 ,  C07D403/02

CPC classification number: C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF—combinations thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-组合介导的疾病或病症。

公开(公告)号：US20220089585A1

公开(公告)日：2022-03-24

申请号：US17422642

申请日：2020-01-10

Applicant: Dane James CLAUSEN ,  Joseph A. KOZLOWSKI ,  Jian LIU ,  Scott E. WOLKENBERG ,  Wensheng YU ,  Merck Sharp & Dohme Corp.

Inventor： Dane James Clausen ,  Joseph A. Kozlowski ,  Jian Liu ,  Scott E. Wolkenberg ,  Wengsheng Yu

IPC: C07D413/14 ,  C07D413/12 ,  A61K45/06 ,  A61K31/422 ,  A61K31/4709 ,  C07D417/14 ,  A61P31/18

Abstract: The present invention relates to Compounds of Formula I and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, X and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.

公开(公告)号：US10927086B2

公开(公告)日：2021-02-23

申请号：US16483957

申请日：2018-02-19

Applicant: Merck Sharp & Dohme Corp. ,  Kun Liu ,  Dane Clausen ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Joseph Kozlowski ,  Derun Li ,  Qinglin Pu ,  Wensheng Yu ,  Hongjun Zhang

Inventor： Kun Liu ,  Dane Clausen ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Joseph Kozlowski ,  Derun Li ,  Qinglin Pu ,  Wensheng Yu ,  Hongjun Zhang

IPC: C07D271/08 ,  C07D413/12

Abstract: Compounds of Formula I, or a pharmaceutically acceptable salt, solvate or hydrate thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US08859529B2

公开(公告)日：2014-10-14

申请号：US13120728

申请日：2009-09-22

Applicant: Bandarpalle B. Shankar ,  Seong Heon Kim ,  Wensheng Yu ,  Ling Tong ,  Michael K. C. Wong ,  Brian J. Lavey ,  Joseph A. Kozlowski ,  Lei Chen ,  Razia K. Rizvi ,  Aneta Maria Kosinski ,  De-Yi Yang ,  Guowei Zhou ,  Kristen E. Rosner ,  Luke Fire ,  Judson E. Richard ,  Dansu Li

Inventor： Bandarpalle B. Shankar ,  Seong Heon Kim ,  Wensheng Yu ,  Ling Tong ,  Michael K. C. Wong ,  Brian J. Lavey ,  Joseph A. Kozlowski ,  Lei Chen ,  Razia K. Rizvi ,  Aneta Maria Kosinski ,  De-Yi Yang ,  Guowei Zhou ,  Kristen E. Rosner ,  Luke Fire ,  Judson E. Richard ,  Dansu Li

IPC: C07D205/06 ,  C07D413/14 ,  C07D239/02 ,  C07D401/14 ,  C07F9/02 ,  C07D491/04 ,  C07D471/02 ,  C07D233/54 ,  C07D403/14 ,  A61K31/675 ,  A61K31/397 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/505 ,  A61K31/4427 ,  A61K31/4155 ,  C07D405/14 ,  C07D403/06 ,  C07D491/048

CPC classification number: C07D403/14 ,  C07D403/06 ,  C07D405/14 ,  C07D491/048

Abstract: This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

Abstract translation: 本发明涉及本文所述的式（I）化合物或其药学上可接受的盐，溶剂化物或酯，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-或介导的疾病或病症 其组合。

公开(公告)号：US20140206681A1

公开(公告)日：2014-07-24

申请号：US14160587

申请日：2014-01-22

Applicant: RONALD M. KIM ,  Jian Liu ,  Xiaolei Gao ,  Sobhana Babu Boga ,  Deodialsingh Guiadeen ,  Joseph A. Kozlowski ,  Wensheng Yu ,  Rajan Anand ,  Younong Yu ,  Oleg B. Selyutin ,  Ying-Duo Gao ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Hongjian Wang

Inventor： RONALD M. KIM ,  Jian Liu ,  Xiaolei Gao ,  Sobhana Babu Boga ,  Deodialsingh Guiadeen ,  Joseph A. Kozlowski ,  Wensheng Yu ,  Rajan Anand ,  Younong Yu ,  Oleg B. Selyutin ,  Ying-Duo Gao ,  Hao Wu ,  Shilan Liu ,  Chundao Yang ,  Hongjian Wang

IPC: C07D471/04 ,  A61K31/4985 ,  A61K31/506 ,  C07D487/04 ,  A61K31/5383 ,  A61K31/519 ,  A61K31/5365 ,  A61K45/06 ,  C07D498/04 ,  C07D455/02

CPC classification number: C07D491/048 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61K45/06 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00 ,  Y02A50/411 ,  Y02A50/463

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

Abstract translation: 本发明提供了根据式I的Bruton's酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。 特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

公开(公告)号：US08450355B2

公开(公告)日：2013-05-28

申请号：US13120730

申请日：2009-09-22

Applicant: Michael K. C. Wong ,  Wensheng Yu ,  Ling Tong ,  Brian J. Lavey ,  Bandarpalle B. Shankar ,  Joseph A. Kozlowski ,  Seong Heon Kim ,  Guowei Zhou ,  De-Yi Yang ,  Razia K. Rizvi ,  Lei Chen ,  Aneta Maria Kosinzki ,  Kristin E. Rosner ,  Luke Fire ,  Judson E. Richard ,  Dansu Li

Inventor： Michael K. C. Wong ,  Wensheng Yu ,  Ling Tong ,  Brian J. Lavey ,  Bandarpalle B. Shankar ,  Joseph A. Kozlowski ,  Seong Heon Kim ,  Guowei Zhou ,  De-Yi Yang ,  Razia K. Rizvi ,  Lei Chen ,  Aneta Maria Kosinzki ,  Kristin E. Rosner ,  Luke Fire ,  Judson E. Richard ,  Dansu Li

IPC: A61K31/4166 ,  A61K31/4178 ,  C07D233/02

CPC classification number: C07D405/14 ,  C07D403/06 ,  C07D403/14 ,  C07D491/048

Abstract: This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α combinations thereof.

Abstract translation: 本发明涉及如本文定义的式（I） - （IX）：或其药学上可接受的盐，溶剂合物或酯的化合物，其可用于治疗由MMP，ADAM，TACE介导的疾病或病症 ，聚集蛋白聚糖酶，其TNF-α组合。

公开(公告)号：US20120015926A1

公开(公告)日：2012-01-19

申请号：US13127953

申请日：2009-11-09

Applicant: Ling Tong ,  Brian J. Lavey ,  Bandarpalle B. Shankar ,  Seong Heon Kim ,  Wensheng Yu ,  Joseph A. Kozlowski ,  Michael K.C. Wong ,  Lei Chen ,  Guowei Zhou ,  Razia K. Rizvi ,  Robert Feltz ,  Aneta Maria Kosinski ,  De-Yi Yang ,  Chaoyang Dai ,  Luke Fire ,  Vinay Girijavallabhan ,  Dansu Li ,  Janeta Popovici-Muller ,  Judson E. Richard ,  Kristen E. Rosner ,  M. Arshad Siddiqui ,  Liping Yang

Inventor： Ling Tong ,  Brian J. Lavey ,  Bandarpalle B. Shankar ,  Seong Heon Kim ,  Wensheng Yu ,  Joseph A. Kozlowski ,  Michael K.C. Wong ,  Lei Chen ,  Guowei Zhou ,  Razia K. Rizvi ,  Robert Feltz ,  Aneta Maria Kosinski ,  De-Yi Yang ,  Chaoyang Dai ,  Luke Fire ,  Vinay Girijavallabhan ,  Dansu Li ,  Janeta Popovici-Muller ,  Judson E. Richard ,  Kristen E. Rosner ,  M. Arshad Siddiqui ,  Liping Yang

IPC: A61K31/4178 ,  C07D403/14 ,  C07D513/04 ,  C07D487/04 ,  C07D419/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/4355 ,  A61K31/429 ,  A61K31/519 ,  A61K31/427 ,  A61K31/433 ,  A61K31/506 ,  A61K31/496 ,  A61K31/5377 ,  A61P27/06 ,  A61P11/00 ,  A61P17/00 ,  A61P17/06 ,  A61P31/18 ,  A61P3/10 ,  A61P25/00 ,  A61P19/02 ,  A61P1/00 ,  A61P35/00 ,  C07D491/048

CPC classification number: C07D498/04 ,  C07D513/00 ,  C07D519/00

Abstract: This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

Abstract translation: 本发明涉及式（I）的化合物：（化学式应该插在这里，它以纸的形式出现）（I）或其药学上可接受的盐，其可用于治疗疾病或病症介导 通过MMP，ADAM，TACE，聚蛋白聚糖蛋白聚糖酶，TNF-或其组合。