公开(公告)号：US5324643A

公开(公告)日：1994-06-28

申请号：US739718

申请日：1991-07-29

Applicant: Wilson Greatbatch ,  John C. Sanford

Inventor： Wilson Greatbatch ,  John C. Sanford

IPC: A61K48/00 ,  C07K14/15 ,  C07K14/155 ,  C12N15/113 ,  C12N15/867 ,  C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  C12N5/10

CPC classification number: C12N15/1131 ,  C07K14/005 ,  C12N15/1132 ,  C12N15/86 ,  A61K48/00 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2740/15022 ,  C12N2740/16043

Abstract: In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or homologous, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting retroviral replication and/or interfering with assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using cells upon which resistance to infection has been conferred.

Abstract translation: 根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。 所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，所述多核苷酸指导宿主细胞内的RNA，所述RNA是a）与取决于靶区域互补或同源的RNA与一个或多个核酸序列内的核酸序列 逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，有效地抑制逆转录病毒复制和/或干扰组装成病毒颗粒。 还公开了使用其上赋予抗感染性的细胞的治疗方法。

公开(公告)号：US4385439A

公开(公告)日：1983-05-31

申请号：US161058

申请日：1980-06-19

Applicant: Ralph T. Mead ,  Frank W. Rudolph ,  Norbert W. Frenz, Jr. ,  Wilson Greatbatch

Inventor： Ralph T. Mead ,  Frank W. Rudolph ,  Norbert W. Frenz, Jr. ,  Wilson Greatbatch

IPC: H01M2/06 ,  H01M6/18 ,  H01M2/36

CPC classification number: H01M2/065 ,  H01M6/182 ,  Y10T29/49108 ,  Y10T29/4911

Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The anode operative surface is provided with a coating of an organic electron donor material. The anode conductor is enclosed within the combination of an insulator element within the casing, an isolator element between the insulator and the conductor, and a ferrule having one end within the insulator and the other end extending from the casing. During assembly, the cathode material is introduced in heated form and a filling element is employed which serves to keep the edge of the casing open end clean to facilitate subsequent welding of a lid to the casing.

Abstract translation: 一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极 与壳体和锂元素。 阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。 阳极工作表面设置有有机电子给体材料的涂层。 阳极导体封装在壳体内的绝缘体元件，绝缘体和导体之间的绝缘元件以及绝缘体内的一端和从壳体延伸的另一端的套圈之间。 在组装期间，阴极材料以加热形式引入，并且使用填充元件，其用于保持壳体的边缘开口端清洁以便于将盖子随后焊接到壳体。

公开(公告)号：US4313438A

公开(公告)日：1982-02-02

申请号：US167752

申请日：1980-07-14

Applicant: Wilson Greatbatch

Inventor： Wilson Greatbatch

IPC: A61B17/58 ,  A61F2/28 ,  A61N1/08 ,  A61N1/20 ,  A61N1/32 ,  A61N1/372 ,  A61N1/30

CPC classification number: A61B17/58 ,  A61N1/08 ,  A61N1/205 ,  A61N1/326 ,  A61N1/372 ,  A61F2002/2821

Abstract: A method and apparatus for providing germicidal and healing treatment of tissue such as bone wherein an electrode of silver or like material is applied to a living tissue site to be healed, initially a direct voltage is applied to the electrode of a polarity driving the electrode as an anode to release silver ions to create a germicidal environment at the site, and thereafter a direct voltage of opposite polarity is applied to the electrode driving it as a cathode to stimulate healing of the tissue at the site. The apparatus is implanted in the body of a patient, and in one embodiment a battery is connected through a switch to the electrode and a reference electrode, the switch initially connecting the electrode as an anode and thereafter changeable by an external operator such as a magnet to connect the electrode as a cathode. In another embodiment, another electrode and an element cooperate with the treating electrode to form a galvanic couple with the treating electrode to create a germicidal environment and a predetermined time thereafter the arrangement changes to a biogalvanic couple with body fluid to cause healing of the tissue. In either embodiment a wave shaping circuit can be operatively associated with the treating electrode to facilitate external monitoring of the apparatus when implanted.

公开(公告)号：US4157720A

公开(公告)日：1979-06-12

申请号：US833920

申请日：1977-09-16

Applicant: Wilson Greatbatch

Inventor： Wilson Greatbatch

IPC: A61N1/375 ,  A61N1/04

CPC classification number: A61N1/375 ,  A61N1/3756

Abstract: A cardiac pacemaker including a pulse generator and an electrical source such as a battery completely enveloped in a small size housing. An electrode operatively connected to the pulse generator has a helically-shaped portion extending outwardly from the housing in fixed relation thereto. The housing is of sufficiently small size to permit the pacemaker to be implanted in conjunction with a limited thoracotomy by turning the housing to rotatively insert the electrode into the heart tissue of the patient, i.e. into the myocardium. The housing can be of electrically conducting material, insulated from the electrode, and a portion of the housing can serve as an indifferent electrode.

Abstract translation: 一种心脏起搏器，包括脉冲发生器和电源，例如完全包围在小尺寸壳体中的电池。 可操作地连接到脉冲发生器的电极具有螺旋状部分，其从壳体以固定关系向外延伸。 外壳的尺寸足够小以通过转动外壳将电极转移到患者的心脏组织，即心肌中，使起搏器能够与有限的开胸手术一起植入。 壳体可以是导电材料，与电极绝缘，并且壳体的一部分可以用作无关电极。

公开(公告)号：US4105833A

公开(公告)日：1978-08-08

申请号：US722653

申请日：1976-09-16

Applicant: Wilson Greatbatch ,  Ralph T. Mead ,  Robert L. McLean ,  Frank W. Rudolph ,  Norbert W. Frenz

Inventor： Wilson Greatbatch ,  Ralph T. Mead ,  Robert L. McLean ,  Frank W. Rudolph ,  Norbert W. Frenz

IPC: H01M2/06 ,  H01M4/60 ,  H01M6/18 ,  H01M4/36

CPC classification number: H01M6/182 ,  H01M2/065 ,  H01M4/60 ,  H01M6/18

Abstract: A lithium-bromine cell comprising a casing which can be of electrically conducting material and containing a lithium anode element from which a sealed conductor extends through the casing. A filling element which can be of electrically conducting material and which has a passage therethrough is fixed to the sealed casing with one end of the passage in communication with the interior of the casing and the other end externally exposed. Bromine is introduced through the passage to the interior of the casing into operative relationship with the lithium anode whereupon the passage is closed to complete the cell. The electrically conducting casing serves as a cathode current collector in operative contact with the bromine cathode, and after closing of the passage the electrically conducting filling element serves as an electrical terminal for the cell. An electrical potential difference exists between the terminal and the anode conductor during operation of the cell.

Abstract translation: 一种锂 - 溴电池，其包括可以是导电材料并且包含锂阳极元件的壳体，密封导体从该锂阳极元件穿过壳体。 可以是导电材料并且具有穿过其的通道的填充元件被固定到密封壳体，通道的一端与壳体的内部连通，另一端从外部暴露。 通过通向壳体内部的通道将溴引入与锂阳极的操作关系，由此通道封闭以完成电池。 导电壳体用作与溴阴极有效接触的阴极集电器，并且在通路关闭之后，导电填充元件用作电池的电端子。 在电池工作期间，端子和阳极导体之间​​存在电位差。

公开(公告)号：US4058889A

公开(公告)日：1977-11-22

申请号：US708362

申请日：1976-07-26

Applicant: Wilson Greatbatch ,  Ralph T. Mead ,  Robert L. McLean ,  Frank W. Rudolph ,  Norbert W. Frenz

Inventor： Wilson Greatbatch ,  Ralph T. Mead ,  Robert L. McLean ,  Frank W. Rudolph ,  Norbert W. Frenz

IPC: H01M2/06 ,  H01M4/60 ,  H01M6/18 ,  H01M6/00

CPC classification number: H01M6/182 ,  H01M2/06 ,  H01M4/60 ,  Y10T29/49115

Abstract: A solid electrolyte primary cell comprising a lithium anode, a bromine cathode and a lithium bromide electrolyte. A solid lithium element operatively contacts the cathode material, and one form of cathode material is a charge transfer complex of an organic donor component material and bromine. The organic donor component material can be poly-2-vinyl pyridine. Another cathode material is liquid bromine. The surface of the lithium anode element which operatively contacts the cathode material can be provided with a coating of an organic electron donor component material. When the lithium anode operatively contacts the bromine cathode, a solid lithium bromide electrolyte begins to form at the interface and an electrical potential difference exists between conductors operatively connected to the anode and cathode.

Abstract translation: 一种固体电解质原电池，其包含锂阳极，溴阴极和溴化锂电解质。 固体锂元素可操作地接触阴极材料，并且一种形式的阴极材料是有机供体组分材料和溴的电荷转移络合物。 有机供体组分材料可以是聚-2-乙烯基吡啶。 另一种阴极材料是液态溴。 可操作地接触阴极材料的锂阳极元件的表面可以提供有机电子给体组分材料的涂层。 当锂阳极可操作地接触溴阴极时，固体溴化锂电解质开始在界面处形成，并且在可操作地连接到阳极和阴极的导体之间存在电势差。

公开(公告)号：US3981744A

公开(公告)日：1976-09-21

申请号：US513127

申请日：1974-10-08

Applicant: Wilson Greatbatch ,  Ralph T. Mead

Inventor： Wilson Greatbatch ,  Ralph T. Mead

IPC: H01M2/00 ,  H01M6/18 ,  H01M4/36

CPC classification number: H01M2/00 ,  H01M6/182 ,  Y10T29/4911 ,  Y10T29/49114

Abstract: An enclosure for a lithium-iodine cell including a first casing containing the cell components and a second casing containing the first casing. The first casing is disposed so that the lid thereof is adjacent the bottom of the second casing. Both casings are of a material which is non-reactive with iodine such as epoxy material. The first casing is encapsulated in a polyester material for electrical insulation and sealing against iodine migration. The second casing is placed in an hermetically sealed outer casing of metal, the second casing being spaced from the lid of the outer casing.

Abstract translation: 一种用于锂碘电池的外壳，包括容纳电池组件的第一壳体和包含第一壳体的第二壳体。 第一壳体被设置成使其盖子邻近第二壳体的底部。 两种壳体都是与碘不反应的材料，例如环氧树脂材料。 第一套被封装在聚酯材料中，用于电绝缘和密封以防碘迁移。 第二壳体放置在密封的金属外壳中，第二壳体与外壳的盖隔开。

公开(公告)号：US08059779B2

公开(公告)日：2011-11-15

申请号：US10998188

申请日：2004-11-27

Applicant: Wilson Greatbatch

Inventor： Wilson Greatbatch

IPC: G21B1/02

CPC classification number: G21B1/00 ,  Y02E30/10

Abstract: An improved 3He nuclear reactor with provision for direct electric conversion of a relativistic proton stream into useable electric power at a voltage level compatible with the national power grid (one million V DC). Various embodiments include multiple collector cages for extracting relativistic protons of various energy levels, diverter wires for deflecting high-energy proton streams to either side of lower energy cages to avoid unwanted impact. Other embodiments include arrangements for dividing multi-megavolt voltages down to a useable one megavolt level compatible with the national power grid. Further embodiments comprise guiding the proton stream by the cusps of magnetron cavities to permit conversion of the relativistic proton energies into microwave power. A proposal is also made for harvesting 3He from the Moon to supply earth-bound and space-bound reactors. A solution to the problem of charging a potential well-forming anode in an electrostatic fusion reactor without electrical arcing is further disclosed.

Abstract translation: 一个改进的3He核反应堆，提供相对论质子流直接电转换为与国家电网（一百万V DC）兼容的电压电平的可用电力。 各种实施例包括用于提取各种能级的相对论质子的多个收集器笼，用于将高能质子流偏转到较低能量笼的任一侧的分流线，以避免不必要的冲击。 其他实施例包括将多兆伏特电压分解为与国家电网兼容的可用的一兆瓦级的布置。 另外的实施例包括通过磁控管腔的尖端引导质子流，以允许相对论质子能量转换成微波功率。 还提出了从月球收获3He以提供地球和空间有限的反应堆的建议。 进一步公开了在没有电弧放电的静电聚变反应器中对潜在的成井阳极进行充电的问题的解决方案。

公开(公告)号：US20060129192A1

公开(公告)日：2006-06-15

申请号：US11274926

申请日：2005-11-15

Applicant: Wilson Greatbatch ,  Jeffrey Deal ,  Glenn Thomas

Inventor： Wilson Greatbatch ,  Jeffrey Deal ,  Glenn Thomas

IPC: A61N1/39

CPC classification number: A61N1/378 ,  A61N1/375 ,  A61N1/3956

Abstract: A high energy battery power source suitable for use in an implantable medical device includes an input, an output, and two or more battery modules each comprising two or more battery cells. The battery cells are of relatively low voltage and permanently configured within each battery module in an electrically parallel arrangement in order to provide a desired current discharge level needed to achieve high-energy output. A switching system configures the battery modules between a first configuration wherein the battery modules are electrically connected in parallel to each other and to the input in order to receive charging energy at the relatively low voltage, and a second configuration wherein the battery modules are electrically connected in series to each other in order to provide to the output a relatively high voltage corresponding to the number of battery modules at a current level corresponding to the number of battery cells in a single battery module. An alternate embodiment permanently connects the battery modules in series so that no switching system is need for discharging and charging. A technique that provides for the control of discharge voltages on a pulse-to-pulse basis is also disclosed.

Abstract translation: 适用于可植入医疗装置的高能量电池电源包括输入端，输出端和两个或更多个电池模块，每个电池模块包括两个或多个电池单元。 电池单元具有相对低的电压并且以电并联的方式永久地配置在每个电池模块内，以便提供实现高能量输出所需的期望的电流放电水平。 交换系统将电池模块配置在第一配置之间，其中电池模块彼此并联电连接到输入端，以便在相对低的电压下接收充电能量;以及第二配置，其中电池模块电连接 彼此串联，以向输出提供对应于在单个电池模块中与电池单元的数量相对应的当前电平的电池模块的数量的相对高的电压。 一个替代实施例将串联的电池模块永久连接，使得不需要用于放电和充电的开关系统。 还公开了一种提供脉冲对脉冲的放电电压控制的技术。

公开(公告)号：US06778856B2

公开(公告)日：2004-08-17

申请号：US10077897

申请日：2002-02-19

Applicant: Patrick R. Connelly ,  Stuart G. MacDonald ,  Wilson Greatbatch ,  Victor Miller

Inventor： Patrick R. Connelly ,  Stuart G. MacDonald ,  Wilson Greatbatch ,  Victor Miller

IPC: A61N1362

CPC classification number: G01R33/285 ,  A61N1/056 ,  A61N1/086 ,  A61N1/3718 ,  A61N1/375 ,  G01R33/288

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.