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公开(公告)号：US11149254B2
公开(公告)日：2021-10-19
申请号：US13506369
申请日：2012-04-13
申请人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/768 , C07K16/22
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
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公开(公告)号：US08586022B2
公开(公告)日：2013-11-19
申请号：US11981976
申请日：2007-10-31
CPC分类号： A61K49/0013 , A61K38/1841 , A61K38/39 , A61K49/0047 , A61K49/0097 , A61K49/1896 , C07K14/495 , C07K14/78 , C07K2319/55 , C07K2319/60 , C07K2319/61 , C12N2710/24132 , C12Q1/02 , C12Q1/66 , Y02A50/472
摘要： Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
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13.发明申请公开(公告)号：US20120308484A1
公开(公告)日：2012-12-06
申请号：US13506369
申请日：2012-04-13
申请人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Nanhai G. Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/04 , G01N21/64 , G01N21/76 , G01N24/00 , A61K49/04 , G01N23/00 , A61K35/76 , A61P35/00 , A61K39/395 , A61K49/06 , C12Q1/70 , G01N23/22
CPC分类号： C12N7/00 , A61K35/768 , C07K16/22 , C07K2317/622 , C12N2710/24121 , C12N2710/24132 , C12N2710/24143
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
摘要翻译： 提供了痘苗病毒的克隆菌株。 还提供鉴定和分离来自病毒制剂的减毒和溶瘤克隆菌株的方法。 还提供了克隆株的修饰重组形式。 克隆菌株和病毒制剂可用于诊断和治疗方法，特别是用于治疗和诊断或监测治疗增殖性疾病，包括肿瘤性疾病，例如但不限于实体瘤和血液癌。
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公开(公告)号：US08221769B2
公开(公告)日：2012-07-17
申请号：US12589694
申请日：2009-10-26
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K39/385 , A61K39/12
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以导致其中积聚的细胞的泄漏的细胞膜，导致产生对蛋白质和其他细胞产物具有反应性的抗体，并且还允许开发促进增殖的组织，特别是肿瘤，以产生选定的蛋白质等 产品。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US08021662B2
公开(公告)日：2011-09-20
申请号：US11796027
申请日：2007-04-25
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/395 , A61K39/12 , A61K39/275 , C12P21/00 , C12Q1/66 , A61K39/285
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Methods for production of tumor-specific antibodies are provided. The methods employ microorganisms that are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products.
摘要翻译： 提供了生产肿瘤特异性抗体的方法。 与其他组织，细胞和器官相比，这些方法使用设计成在免疫缺陷组织和细胞中积累的微生物，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有较低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。
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公开(公告)号：US20100008946A1
公开(公告)日：2010-01-14
申请号：US12462074
申请日：2009-07-28
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
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17.发明申请公开(公告)号：US20090155287A1
公开(公告)日：2009-06-18
申请号：US12080766
申请日：2008-04-04
申请人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
发明人： Nanhai Chen , Alexa Frentzen , Aladar A. Szalay , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/76 , A61K39/395 , A61K39/00 , A61P35/04
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要翻译： 提供了修饰的病毒和用于制备修饰的病毒的方法。 提供含有病毒的疫苗。 病毒可以用于治疗诸如增殖性和炎性疾病（包括癌症）的疾病的方法，以及作为抗肿瘤和/或抗血管生成剂。 病毒也可用于诊断方法。
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公开(公告)号：US20090117049A1
公开(公告)日：2009-05-07
申请号：US11982102
申请日：2007-10-31
IPC分类号： A61K49/00
CPC分类号： A61K49/0013 , A61K38/1841 , A61K38/39 , A61K49/0047 , A61K49/0097 , A61K49/1896 , C07K14/495 , C07K14/78 , C07K2319/55 , C07K2319/60 , C07K2319/61 , C12N2710/24132 , C12Q1/02 , C12Q1/66
摘要： Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
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公开(公告)号：US20130129614A9
公开(公告)日：2013-05-23
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
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公开(公告)号：US07588771B2
公开(公告)日：2009-09-15
申请号：US11238025
申请日：2005-09-27
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K39/385 , A61K39/12 , A61K39/20
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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