-
公开(公告)号：US20060204516A1
公开(公告)日：2006-09-14
申请号：US11376572
申请日：2006-03-16
申请人： Yvonne Paterson , Christian Peters , George Gunn
发明人： Yvonne Paterson , Christian Peters , George Gunn
IPC分类号： A61K39/00 , C12P21/04 , C07K14/705
CPC分类号： A61K39/0011 , A61K39/0208 , A61K39/12 , A61K39/385 , A61K2039/57 , A61K2039/6068 , C07K14/195 , C07K2319/00 , C07K2319/35 , C12N2710/20034 , Y10S435/81
摘要： The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria vaccine strains for enhancing the immunogenicity of an antigen.
-
公开(公告)号：US20060135457A1
公开(公告)日：2006-06-22
申请号：US11203408
申请日：2005-08-15
申请人： Yvonne Paterson , Thorsten Verch
发明人： Yvonne Paterson , Thorsten Verch
IPC分类号： A61K48/00
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/55544 , C07K2319/55 , C12N15/52 , C12N15/70 , C12N15/85 , C12N2820/10 , C12N2830/00 , C12N2830/55
摘要： The present invention provides DNA vaccines comprising an antibiotic resistance gene-free plasmid, methods of generating same, and methods for treating a disease agent, comprising same.
摘要翻译： 本发明提供了包含抗生素抗性基因的质粒的DNA疫苗，其生产方法和包含其的治疗疾病的方法。
-
公开(公告)号：US06565852B1
公开(公告)日：2003-05-20
申请号：US09535212
申请日：2000-03-27
申请人： Yvonne Paterson
发明人： Yvonne Paterson
IPC分类号： A61K3902
CPC分类号： C07K14/005 , A61K39/00 , C07K14/34 , C07K14/705 , C07K2319/00 , C12N2760/16022 , C12N2760/16122
摘要： Methods and vaccines for inducing an immune response to a tumor associated antigen in a host are provided wherein the vaccine contains either a fusion protein of the tumor associated antigen fused to a truncated form of listeriolysin or a recombinant form of Listeria monocytogenes which grows and spreads and is capable of expressing the tumor associated antigen alone or as a listeriolysin fusion protein. Methods of suppressing formation of tumors and inhibiting growth of tumors in a host via administration of these vaccines are also provided.
摘要翻译： 提供了用于诱导宿主中与肿瘤相关抗原的免疫应答的方法和疫苗，其中所述疫苗含有与截短形式的李斯特里血因素融合的肿瘤相关抗原的融合蛋白或生长和扩散的重组形式的单核细胞增生利斯特氏酵母 能够单独表达肿瘤相关抗原或作为李斯特里菌素融合蛋白。 还提供了通过施用这些疫苗抑制肿瘤形成和抑制宿主中肿瘤生长的方法。
-
14.发明授权Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response 失效活的重组单核细胞增多性李斯特菌和细胞毒性T细胞应答的产生
公开(公告)号：US5830702A
公开(公告)日：1998-11-03
申请号：US366477
申请日：1994-12-30
申请人： Daniel A. Portnoy , Yvonne Paterson
发明人： Daniel A. Portnoy , Yvonne Paterson
IPC分类号： A61K39/145 , C07K14/11 , C07K14/30 , C12N15/90 , C07H21/04 , A61K39/00 , C12N15/63 , C12P21/06
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , C07K14/30 , C12N15/90 , A61K2039/522 , A61K2039/523 , A61K2039/6068 , C07K2319/00 , C12N2760/16022 , C12N2760/16034 , C12N2760/16134 , Y10S435/822
摘要： Vaccines comprising an attenuated strain of Listeria spp. expressing a selected foreign antigen and methods of eliciting protective immunity by administering an effective amount of the vaccine are provided. The vaccines of the present invention are designed specifically to elicit strong cell-mediated immunity, and are particularly useful for protection in infections which can apparently persist and spread in the presence of neutralizing antibodies invoked by humoral immunity.
摘要翻译： 包含减毒李斯特氏菌菌株的疫苗 提供选择的外源抗原，并提供通过施用有效量的疫苗引起保护性免疫的方法。 本发明的疫苗被专门设计用于引发强的细胞介导的免疫，并且特别可用于在通过体液免疫引起的中和抗体存在下明显持续并扩散的感染中的保护。
-
15.发明授权Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals 有权使用利斯特氏菌疫苗载体逆转疫苗在寄生虫感染个体中的反应性公开(公告)号：US09226958B2
公开(公告)日：2016-01-05
申请号：US13876810
申请日：2011-10-03
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0003 , A61K39/12 , A61K2039/523 , A61K2039/54 , A61K2039/577 , C12N2710/20034 , C12N2740/16034 , Y02A50/41 , Y02A50/412 , Y02A50/423
摘要： This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
摘要翻译： 本发明涉及使用利斯特氏菌疫苗载体在具有持续性Th2免疫应答谱的受试者中诱导Th1免疫应答的方法。
-
16.发明授权Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors 有权用于预防HER2 / NEU过表达肿瘤的逃避突变的组合物和方法公开(公告)号：US09084747B2
公开(公告)日：2015-07-21
申请号：US12945386
申请日：2010-11-12
申请人： Vafa Shahabi , Anu Wallecha , Paulo C. Maciag , Yvonne Paterson , Matthew Seavey
发明人： Vafa Shahabi , Anu Wallecha , Paulo C. Maciag , Yvonne Paterson , Matthew Seavey
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523
摘要： This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant and several sub-dominant epitopes of the antigen.
摘要翻译： 本发明提供用于治疗和接种针对Her2 / neu抗原表达肿瘤并针对抗原的显性和几个次优势表位诱导免疫应答的组合物和方法。
-
公开(公告)号：US08771702B2
公开(公告)日：2014-07-08
申请号：US12213696
申请日：2008-06-23
CPC分类号： C07K14/705 , A61K39/00 , A61K39/0011 , A61K39/0208 , A61K39/385 , A61K2039/53 , A61K2039/55522 , C07K14/195 , C07K16/00 , C07K2317/56 , C07K2319/40 , C12N9/52
摘要： The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
摘要翻译： 本发明提供了包含突变的李斯特溶菌素O（LLO）蛋白或其片段的重组蛋白或肽，其包含胆固醇结合结构域或其部分的取代或内部缺失，包含其的融合蛋白或肽，编码它们的核苷酸分子， 和包含或编码相同的疫苗载体。 本发明还提供了利用本发明的重组蛋白质，肽，核苷酸分子和疫苗载体诱导针对目的肽的免疫应答的方法。
-
公开(公告)号：US20120177678A1
公开(公告)日：2012-07-12
申请号：US13314583
申请日：2011-12-08
申请人： Yvonne PATERSON , John Rothman
发明人： Yvonne PATERSON , John Rothman
CPC分类号： A61K39/0011 , A61K39/00 , A61K39/12 , A61K2039/523 , A61K2039/53 , A61K2039/585 , A61K2039/6068 , C07K14/195 , C07K14/70503 , C07K2319/00 , C12N2710/20034
摘要： The present invention provides methods of treating, protecting against, and inducing an immune response against cervical dysplasia and cancer, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and an E7 and/or E6 antigen. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.
摘要翻译： 本发明提供了治疗，保护和诱导针对宫颈发育不良和癌症的免疫应答的方法，包括向受试者施用包含融合肽的重组利斯特氏菌菌株的步骤，所述融合肽包含LLO片段和E7和/或 E6抗原。 本发明还提供在人受试者中诱导抗E7 CTL应答并治疗HPV介导的疾病，病症和症状的方法，包括施用重组利斯特氏菌属菌株。
-
公开(公告)号：US20120114685A1
公开(公告)日：2012-05-10
申请号：US13254607
申请日：2010-03-04
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/522 , A61K2039/523 , A61K2039/53 , A61K2039/57 , A61K2039/585 , A61K2039/6037 , A61K2039/6068 , C07K14/195 , C07K14/4748 , C07K14/71 , C07K2319/55 , C12N15/74
摘要： The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
摘要翻译： 本发明提供了包含血管生成因子的重组利斯特氏菌菌株，其包含与包含PEST样序列的多肽有效连接的血管生成因子，编码该重组核酸分子的重组多肽，相关疫苗以及利用其的免疫原性和治疗方法。
-
公开(公告)号：US08114414B2
公开(公告)日：2012-02-14
申请号：US11715497
申请日：2007-03-08
申请人： Yvonne Paterson , John Rothman
发明人： Yvonne Paterson , John Rothman
IPC分类号： A61K39/02
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/195 , C07K14/70503 , C07K16/00 , C07K16/1285 , C07K16/4208 , C07K2317/622 , C07K2319/00
摘要： The present invention provides methods of treating, protecting against, and inducing an immune response against cervical cancer, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and an E7 and/or E6 antigen. The present invention also provides methods for inducing an anti-E7 response in a human subject and treating HPV-mediated diseases, disorders, and symptoms comprising administration of the recombinant Listeria strain.
摘要翻译： 本发明提供了治疗，保护和诱导针对子宫颈癌的免疫应答的方法，包括向受试者施用包含融合肽的重组利斯特氏菌菌株的步骤，所述融合肽包含LLO片段和E7和/或E6抗原 。 本发明还提供在人受试者中诱导抗E7应答并治疗HPV介导的疾病，病症和症状的方法，包括施用重组利斯特氏菌属菌株。
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.037 秒)
