公开(公告)号：US20230203478A1

公开(公告)日：2023-06-29

申请号：US18178367

申请日：2023-03-03

Applicant: 10x Genomics, Inc.

Inventor： Hanyoup Kim ,  David Sukovich ,  Layla Katiraee ,  Augusto Manuel Tentori

IPC: C12N15/10

CPC classification number: C12N15/1065

Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.

公开(公告)号：US11680260B2

公开(公告)日：2023-06-20

申请号：US17976422

申请日：2022-10-28

Applicant: 10x Genomics, Inc.

Inventor： Hanyoup Kim ,  David Sukovich ,  Layla Katiraee ,  Augusto Manuel Tentori ,  Lauren Gutgesell ,  Janine Hensel ,  Seayar Mohabbat

IPC: C12Q1/6837 ,  C12N15/10

CPC classification number: C12N15/1065

Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.

公开(公告)号：US11624086B2

公开(公告)日：2023-04-11

申请号：US17541818

申请日：2021-12-03

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  Layla Katiraee ,  Kristen Pham

IPC: C12Q1/6818 ,  C12N5/00 ,  C12Q1/6804 ,  C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6876 ,  G01N33/50 ,  G01N33/543

Abstract: Provided herein are methods for simultaneous spatio-temporal measurement of gene expression and cellular activity.

公开(公告)号：US11332790B2

公开(公告)日：2022-05-17

申请号：US17220529

申请日：2021-04-01

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/6811 ,  C12Q1/25 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20220090175A1

公开(公告)日：2022-03-24

申请号：US17541818

申请日：2021-12-03

Applicant: 10x Genomics, Inc.

Inventor： Cedric Uytingco ,  Layla Katiraee ,  Kristen Pham

IPC: C12Q1/6818 ,  C12Q1/6876 ,  C12N5/00 ,  G01N33/50

Abstract: Provided herein are methods for simultaneous spatio-temporal measurement of gene expression and cellular activity.

公开(公告)号：US12241060B2

公开(公告)日：2025-03-04

申请号：US18178367

申请日：2023-03-03

Applicant: 10x Genomics, Inc.

Inventor： Hanyoup Kim ,  David Sukovich ,  Layla Katiraee ,  Augusto Manuel Tentori

IPC: C12Q1/6804 ,  C12N15/10

Abstract: Provided herein are methods for capturing a connected probe and/or a capture handle sequence to a capture domain of a capture probe.

公开(公告)号：US20250019749A1

公开(公告)日：2025-01-16

申请号：US18788820

申请日：2024-07-30

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Michael Schnall-Levin ,  Christina Galonska ,  Marlon Stoeckius

IPC: C12Q1/6837 ,  C12Q1/6806 ,  C12Q1/6876

Abstract: Provided herein are methods of identifying a methylation status of an analyte in a biological sample. Also provided herein are methods that combine identifying the methylation status with spatial technology to identify the location of a methylation status in a biological sample.

公开(公告)号：US20240263218A1

公开(公告)日：2024-08-08

申请号：US18578634

申请日：2022-07-12

Applicant: 10x Genomics, Inc.

Inventor： Layla Katiraee ,  Erik Leonard Henrik Borgstrom ,  Patrick Roelli ,  Tingsheng Yu Drennon

IPC: C12Q1/6837

CPC classification number: C12Q1/6837

Abstract: Provided herein are methods for selective silencing of one or more probes used in templated ligation, or RNA-templated ligation. In some embodiments, the selective silencing is achieved using one or more blocker oligonucleotides.

公开(公告)号：US11981965B2

公开(公告)日：2024-05-14

申请号：US18100133

申请日：2023-01-23

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

CPC classification number: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.

公开(公告)号：US20240124933A1

公开(公告)日：2024-04-18

申请号：US18483280

申请日：2023-10-09

Applicant: 10x Genomics, Inc.

Inventor： James Michael Chell ,  Marlon Stoeckius ,  Jonathan Alles ,  Caroline Julie Gallant ,  Christina Galonska ,  Felice Alessio Bava ,  Layla Katiraee

IPC: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

CPC classification number: C12Q1/6876 ,  C12Q1/25 ,  C12Q1/6811 ,  C12Q1/6816 ,  C12Q1/6841 ,  C12Q1/6851

Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.