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11.发明授权Tube expansion processes for semicrystalline polymers to maximize fracture toughness 有权用于半结晶聚合物的管膨胀过程以使断裂韧性最大化公开(公告)号：US09278477B2
公开(公告)日：2016-03-08
申请号：US14480484
申请日：2014-09-08
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , James P. Oberhauser , Thierry Glauser , David Wrolstad , Yunbing Wang
CPC classification number: B29C61/04 , B29C35/045 , B29C35/0805 , B29C71/0063 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29K2067/046 , B29K2105/258 , B29K2995/004 , B29K2995/006 , B29K2995/0089 , B29L2031/7534
Abstract: Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.
Abstract translation: 公开了制造具有改进的断裂韧性的聚合物支架的方法，包括聚合物管的径向膨胀和从膨胀管制造支架。 聚合物管设置在模具内并且可以用辐射加热。 加热管在模具内径向扩张。
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12.发明申请CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开控制用于熔融加工的可生物降解聚合物的水分和塑化公开(公告)号：US20150375437A1
公开(公告)日：2015-12-31
申请号：US14852135
申请日：2015-09-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
IPC: B29C47/00
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/0066 , B29C47/0869 , B29C47/0893 , B29C47/0894 , B29C47/1018 , B29C47/1027 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92333 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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公开(公告)号：US20140046006A1
公开(公告)日：2014-02-13
申请号：US13941374
申请日：2013-07-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , David C. Gale , Bin Huang , Mikael O. Trollsas , Thierry Glauser , Florian Ludwig
IPC: C08L67/04
Abstract: Implantable medical devices fabricated from branched polymers are disclosed.
Abstract translation: 公开了由支化聚合物制造的可植入医疗器械。
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14.发明申请Methods of treatment of polymeric coatings for control of agent release rates 审中-公开处理聚合物涂层以控制药剂释放速率的方法公开(公告)号：US20140004250A1
公开(公告)日：2014-01-02
申请号：US13953656
申请日：2013-07-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC: A61L31/10
CPC classification number: A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。
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公开(公告)号：US08591934B2
公开(公告)日：2013-11-26
申请号：US13677115
申请日：2012-11-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Faiyaz Ahmed Hossainy , Thierry Glauser , Mikael O. Trollsas
IPC: A61F2/00
CPC classification number: A61K47/32 , A61F2/82 , A61K45/06 , A61K47/65 , A61K47/6957 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L33/26
Abstract: An implantable device including a conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.
Abstract translation: 提供了包括由丙烯酰胺类共聚物和生物活性剂形成的共轭物的可植入装置。
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Patent Agency Ranking
公开(公告)号：US20150328375A1
公开(公告)日：2015-11-19
申请号：US14664554
申请日：2015-03-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Thierry Glauser , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy , Ni Ding
CPC classification number: A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L33/0011 , A61L33/08 , A61L2300/40 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2400/18 , C08L33/14
Abstract: A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.
Abstract translation: 包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含其上的包含聚合物和任选的生物活性剂的涂层的DES，以及使用该装置的方法 提供了人类疾病的治疗。
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公开(公告)号：US20150157658A1
公开(公告)日：2015-06-11
申请号：US14622131
申请日：2015-02-13
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Thierry Glauser , Stephen D. Pacetti , Paul M. Consigny
CPC classification number: A61K33/00 , A61K45/06 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/606
Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
Abstract translation: 提供了具有能够催化体内产生一氧化氮的催化剂的医疗装置和使用该装置治疗血管状态的方法。
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18.发明申请COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 审中-公开包含乳酸聚合物的可植入装置的涂料及其制造方法公开(公告)号：US20140377325A1
公开(公告)日：2014-12-25
申请号：US14476623
申请日：2014-09-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
CPC classification number: A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。
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19.发明授权Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices 有权用可植入医疗器械的结晶或部分结晶药物形成涂层的方法公开(公告)号：US08753709B2
公开(公告)日：2014-06-17
申请号：US13722644
申请日：2012-12-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Faiyaz Ahmed Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
CPC classification number: B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
Abstract: Methods for making coatings on an implantable device, such as a drug-eluting stent. The coatings comprise a polymer and a drug in a crystalline or partially crystalline form. In addition, implantable devices produced by the methods and methods of using the coated implantable devices are described.
Abstract translation: 在可植入装置（例如药物洗脱支架）上制备涂层的方法。 涂层包含聚合物和结晶或部分结晶形式的药物。 此外，描述了通过使用涂覆的可植入装置的方法和方法制造的可植入装置。
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公开(公告)号：US20140128959A1
公开(公告)日：2014-05-08
申请号：US13998195
申请日：2013-10-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian , Anthony J. Abbate , Klaus Kleine , Stephen Schaible , Jonathan P. Durcan , Thierry Glauser , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth , Yunbing Wang , Daniel Castro , David Wrolstad
IPC: A61F2/82
CPC classification number: A61F2/915 , A61F2002/91533 , A61F2002/91566 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/04 , B29C49/14 , B29C49/4823 , B29C55/24 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , C08L67/04
Abstract: Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
Abstract translation: 公开了制造具有增强的断裂韧性的支架的支架和方法。
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