公开(公告)号：US20180099951A1

公开(公告)日：2018-04-12

申请号：US15573272

申请日：2016-05-10

Applicant: Abide Therapeutics, Inc.

Inventor： Jacqueline Lorayne BLANKMAN ,  Jason Robert CLAPPER ,  R. Alan B. EZEKOWITZ ,  Iain Peter FRASER ,  Cheryl A. GRICE ,  Todd K. JONES ,  Gary Paul O'NEILL ,  Archie Wayne THURSTON, Jr. ,  Channing Rodney BEALS

IPC: C07D403/10 ,  A61P29/00

CPC classification number: C07D403/10 ,  A61K31/495 ,  A61P29/00 ,  C07D295/205

Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.

公开(公告)号：US20170190669A1

公开(公告)日：2017-07-06

申请号：US15312998

申请日：2015-05-20

Applicant: ABIDE THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Dale L. BOGER ,  Katerina OTRUBOVA ,  Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES

IPC: C07D231/14 ,  C07D491/107 ,  C07D403/12 ,  C07D417/12 ,  C07D405/12 ,  C07D401/12

CPC classification number: C07D231/14 ,  C07D231/12 ,  C07D231/16 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D491/10 ,  C07D491/107

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of one or more of MAGL, ABHD6, and FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain, solid tumors and/or obesity.

公开(公告)号：US20170183353A1

公开(公告)日：2017-06-29

申请号：US15313012

申请日：2015-05-20

Applicant: ABIDE THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Benjamin F. CRAVATT ,  Armand B. COGNETTA ,  Jonathan J. HULCE ,  Micah J. NIPHAKIS ,  Todd K. JONES ,  Cheryl A. GRICE

IPC: C07D487/04 ,  C12Q1/34

CPC classification number: C07D487/04 ,  C12Q1/34

Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.

公开(公告)号：US20170073320A1

公开(公告)日：2017-03-16

申请号：US15272313

申请日：2016-09-21

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Micah J. NIPHAKIS ,  Jae Won CHANG ,  Kenneth M. LUM ,  Benjamin F. CRAVATT

IPC: C07D295/205 ,  C07D307/79 ,  C07D215/46 ,  C07D295/26 ,  C07D263/32 ,  C07D231/56 ,  C07D213/38 ,  C07D413/10 ,  C07D403/10 ,  C07D401/10 ,  C07D231/12 ,  C07D207/14 ,  C07D231/16 ,  C07D491/107 ,  C07D471/10 ,  C07D205/04 ,  C07D471/04 ,  C07D487/04 ,  C07D317/58

CPC classification number: C07D295/205 ,  C07C271/10 ,  C07C271/12 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D213/38 ,  C07D213/40 ,  C07D213/55 ,  C07D215/42 ,  C07D215/46 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D295/26 ,  C07D307/79 ,  C07D317/46 ,  C07D317/58 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/14 ,  C07D407/06 ,  C07D413/06 ,  C07D413/10 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107

Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.

Abstract translation: 本公开提供了可以是MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药物的用途，其制备方法和包含公开的化合物作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法，其中患者患有诸如疼痛，实体瘤癌症和/或肥胖的适应症，其包括施用所公开的化合物或组合物。

公开(公告)号：US20190352273A1

公开(公告)日：2019-11-21

申请号：US16412212

申请日：2019-05-14

Applicant: Abide Therapeutics, Inc.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D295/185 ,  C07D305/08 ,  C07D263/32 ,  C07D241/12 ,  C07D213/55

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180282288A1

公开(公告)日：2018-10-04

申请号：US15764231

申请日：2016-09-29

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Micah NIPHAKIS ,  Todd K. JONES

IPC: C07D233/80

CPC classification number: C07D233/80 ,  C07D233/86

Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions of said inhibitors, and methods of their use for the treatment of disease.

公开(公告)号：US20180134675A1

公开(公告)日：2018-05-17

申请号：US15814318

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Donald L. HERTZOG ,  Daniel J. BUZARD ,  Nicole S. WHITE

IPC: C07D295/205 ,  C07B59/00

CPC classification number: C07D295/205 ,  C07B59/002 ,  C07B2200/05

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20160272602A1

公开(公告)日：2016-09-22

申请号：US15072229

申请日：2016-03-16

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Olivia D. WEBER ,  Dong-Hui WANG

IPC: C07D295/205 ,  C07D207/08 ,  C07D295/26 ,  C07D211/38 ,  C07D211/58 ,  C07D207/14 ,  C07D211/14 ,  C07D498/08 ,  C07D211/62 ,  C07D403/04 ,  C07D401/04 ,  C07D417/04 ,  C07D487/04 ,  C07D471/10 ,  C07D265/30 ,  C07D207/16 ,  C07D207/12

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

Abstract translation: 本文提供了哌嗪氨基甲酸酯和包含所述化合物的药物组合物。 主题化合物和组合物可用作MAGL和/或ABHD6的调节剂。 此外，本发明化合物和组合物可用于治疗疼痛。

公开(公告)号：US20160137649A1

公开(公告)日：2016-05-19

申请号：US14902324

申请日：2014-07-01

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Todd K. JONES ,  Justin S. CISAR ,  Cheryl A. GRICE ,  Dong-Hui WANG ,  Olivia D. WEBER

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.

Abstract translation: 本发明提供了吡咯并吡咯氨基甲酸酯和相关的有机化合物，含有这些化合物的组合物，医疗试剂盒和使用这些化合物和组合物治疗医学病症的方法，例如实体瘤，肥胖症，唐氏综合症，阿尔茨海默病或疼痛， 在病人身上 八氢吡咯并吡咯氨基甲酸酯可以衍生自六氟异丙醇，N，N-二琥珀酰亚胺等。 还描述了在MAGL，FAAH和ABHD6测定中氨基甲酸酯的活性。