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    Systems for immunoassay tests
    11.
    发明授权
    Systems for immunoassay tests 有权
    免疫测定系统

    公开(公告)号：US08753574B2

    公开(公告)日：2014-06-17

    申请号：US13936047

    申请日：2013-07-05

    Applicant: Access Medical Systems, Ltd.

    Inventor： Hong Tan ,  Ming Xia ,  Yushan Tan ,  Jun Chen ,  Erhua Cao ,  Genqian Li ,  Robert F. Zuk

    IPC: G01N33/53

    CPC classification number: B01L3/52 ,  B01L3/502 ,  B01L3/527 ,  B01L2300/042 ,  B01L2300/045 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54366 ,  G01N35/026 ,  G01N2035/0436

    Abstract: This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules; (b) a sample well to receive a sample; (c) one or more reagent wells; (d) a plurality of wash wells each containing a first aqueous solution; and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution; wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed. The present invention also relates to an apparatus for loading and releasing a probe. The apparatus comprises a push pin and a groove to load and transfer the probe to a plurality of locations, such as different wells in the above-mentioned cartridge, to conduct the immunoassay test.

    Abstract translation: 本发明涉及用于免疫测定试验的药筒。 所述筒包括（a）包括探针和帽的探针孔，所述盖处于闭合位置以将所述探针包围在探针中，其中所述探针具有涂覆有分析物结合分子的底部尖端; （b）样品孔以接收样品; （c）一个或多个试剂孔; （d）多个洗涤孔，每个洗涤孔含有第一水溶液; 和（e）具有透光底部的测量井，所述测量井含有第二水溶液; 其中样品阱，试剂阱，测量井和洗涤井的开口被密封。 本发明还涉及一种用于装载和释放探针的装置。 该装置包括推针和凹槽，以将探针加载并转移到多个位置，例如上述药筒中的不同的孔，以进行免疫测定。

    OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER
    15.
    发明申请
    OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER 审中-公开
    使用薄膜干涉仪的生物分子光学传感器

    公开(公告)号：US20150204795A1

    公开(公告)日：2015-07-23

    申请号：US14604584

    申请日：2015-01-23

    Applicant: ACCESS MEDICAL SYSTEMS, LTD.

    Inventor： Hong Tan ,  Yushan Tan ,  Erhua Cao ,  Ming Xia ,  Robert F. Zuk

    IPC: G01N21/77 ,  G02B6/30 ,  G01J3/45 ,  G02B6/26

    CPC classification number: G01N21/7703 ,  G01J3/45 ,  G01N21/45 ,  G01N21/648 ,  G01N21/8507 ,  G01N2021/7779 ,  G01N2201/062 ,  G01N2201/08 ,  G02B6/262 ,  G02B6/30

    Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.

    Abstract translation: 本发明涉及一种用于基于薄膜光谱干涉检测样品中的分析物的组件。 组件包括波导，光耦合到波导的单片基板，以及直接结合到整体式基板的感测侧的薄膜层。 单片基板的折射率高于薄膜层的透明材料的折射率。 当样品中的分析物分子结合到涂覆在薄膜层上的分析物结合分子时，从第一反射表面和第二反射表面反射到波导中的光之间的光谱干涉变化。

    OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER
    16.
    发明申请
    OPTICAL SENSOR OF BIO-MOLECULES USING THIN-FILM INTERFEROMETER 有权
    使用薄膜干涉仪的生物分子光学传感器

    公开(公告)号：US20140093432A1

    公开(公告)日：2014-04-03

    申请号：US14095120

    申请日：2013-12-03

    Applicant: ACCESS MEDICAL SYSTEMS, LTD.

    Inventor： Hong Tan ,  Yushan Tan ,  Erhua Cao ,  Min Xia ,  Robert F. Zuk

    IPC: G01N21/45

    CPC classification number: G01N21/7703 ,  G01J3/45 ,  G01N21/45 ,  G01N21/648 ,  G01N21/8507 ,  G01N2021/7779 ,  G01N2201/062 ,  G01N2201/08 ,  G02B6/262 ,  G02B6/30

    Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.

    Abstract translation: 本发明涉及一种用于基于薄膜光谱干涉检测样品中的分析物的组件。 组件包括波导，光耦合到波导的单片基板，以及直接结合到整体式基板的感测侧的薄膜层。 单片基板的折射率高于薄膜层的透明材料的折射率。 当样品中的分析物分子结合到涂覆在薄膜层上的分析物结合分子时，从第一反射表面和第二反射表面反射到波导中的光之间的光谱干涉变化。

    Detection system for high sensitivity fluorescent assays
    17.
    发明授权
    Detection system for high sensitivity fluorescent assays 有权
    用于高灵敏度荧光测定的检测系统

    公开(公告)号：US08492139B2

    公开(公告)日：2013-07-23

    申请号：US13659576

    申请日：2012-10-24

    Applicant: Access Medical Systems, Ltd.

    Inventor： Hong Tan ,  Robert F. Zuk ,  Yushan Tan ,  Erhua Cao ,  Min Xia ,  Jun Chen

    IPC: C12M1/34 ,  G01N33/544

    CPC classification number: G01N33/54366 ,  C08B37/006 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2201/06113

    Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.

    Abstract translation: 本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。 该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。 本发明还涉及使用具有小表面积（@ 5mm）和具有多个结合分子和多个荧光标记的高分子量聚合物（> = 1 MD）的探针尖端来检测液体样品中的分析物的方法。 通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。 本发明进一步涉及包含具有多个结合分子和多个荧光标记的交联FICOLL®分子的荧光标记组合物。

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