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    AUTONOMOUS ROBOTIC SYSTEM FOR BIOCHEMICAL TESTING IN HEALTHCARE ENVIRONMENTS
    2.
    发明公开
    AUTONOMOUS ROBOTIC SYSTEM FOR BIOCHEMICAL TESTING IN HEALTHCARE ENVIRONMENTS 审中-公开

    公开(公告)号：US20240278235A1

    公开(公告)日：2024-08-22

    申请号：US18652649

    申请日：2024-05-01

    Applicant: ACCESS MEDICAL SYSTEMS, LTD.

    Inventor： Hong Tan

    IPC: B01L3/00 ,  G01N35/04 ,  G16H50/20

    CPC classification number: B01L3/5025 ,  G16H50/20 ,  G01N2035/0429

    Abstract: Introduced here are diagnostic systems that are able to autonomously move to a desired location within a healthcare environment. As such, a diagnostic system may allow an operator to conduct a biochemical test on site. A diagnostic system may include (i) a cartridge in which a patient sample can be deposited, (ii) a robotic cart in which the cartridge can be inserted for analysis, and (iii) a control platform that is responsible for managing movement of the robotic cart throughout its physical environment. In addition to having the components needed to analyze the sample deposited into the cartridge, the robotic cart could also include storage for “used” or “unused” cartridges. Thus, the robotic cart may not only be able to perform analysis of the sample on site, but the robotic cart may also be able to transport all of the supplies needed to obtain the sample to the operator.

    Detection system for high sensitivity fluorescent assays
    4.
    发明授权
    Detection system for high sensitivity fluorescent assays 有权

    公开(公告)号：US10379116B2

    公开(公告)日：2019-08-13

    申请号：US15256319

    申请日：2016-09-02

    Applicant: Access Medical Systems, LTD.

    Inventor： Hong Tan ,  Robert F. Zuk ,  Yushan Tan ,  Erhua Cao ,  Min Xia ,  Jun Chen

    IPC: G01N33/543 ,  G01N21/64 ,  C08B37/00

    Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≤5 mm) and a high molecular weight polymer (≥1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.

    Systems for immunoassay tests
    5.
    发明授权
    Systems for immunoassay tests 有权
    免疫测定系统

    公开(公告)号：US09468926B2

    公开(公告)日：2016-10-18

    申请号：US14301228

    申请日：2014-06-10

    Applicant: Access Medical Systems, LTD.

    Inventor： Hong Tan ,  Ming Xia ,  Yushan Tan ,  Jun Chen ,  Erhua Cao ,  Genqian Li ,  Robert F. Zuk

    IPC: B65G47/90 ,  B01L3/00 ,  G01N33/543 ,  G01N35/04 ,  G01N35/02

    CPC classification number: B01L3/52 ,  B01L3/502 ,  B01L3/527 ,  B01L2300/042 ,  B01L2300/045 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54366 ,  G01N35/026 ,  G01N2035/0436

    Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

    Abstract translation: 本发明涉及进行免疫测定试验的装置。 所述装置包括：槽单元，具有沿着垂直方向具有沿着垂直方向保持探针的杆状部分的垂直方向的槽;以及推动销，其构造成沿水平方向移动，所述推动销能够驻留在 第一职位和第二职位。 当推销位于第一位置时，推针的尖端能够将探针的杆状部分压靠在凹槽上。 当推销位于第二位置时，推针的尖端与槽之间的距离大于探针的棒状部分的直径。

    Luminescent polymer cyclic amplification
    6.
    发明授权
    Luminescent polymer cyclic amplification 有权
    发光聚合物循环扩增

    公开(公告)号：US09435794B2

    公开(公告)日：2016-09-06

    申请号：US14165381

    申请日：2014-01-27

    Applicant: Access Medical Systems, LTD.

    Inventor： Robert F. Zuk ,  Hong Tan

    IPC: G01N33/53 ,  G01N33/533 ,  G01N33/543

    CPC classification number: G01N33/54393 ,  G01N21/76 ,  G01N27/3277 ,  G01N33/5306 ,  G01N33/533 ,  G01N33/5438 ,  G01N33/553 ,  G01N2021/757

    Abstract: The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise.

    Abstract translation: 本发明涉及一种用于以高灵敏度检测液体样品中的分析物的发光免疫测定方法。 本发明提供了以下独特的组合：（i）使用具有小的感测表面积的探针来结合分析物分子，（ii）使用与多个结合分子共轭的高分子量支化聚合物和多个发光标记，以及（iii） 将具有免疫复合物的探针形成回试剂容器和扩增容器1-10次，并重复与试剂和扩增聚合物的反应，以提高检测水平的灵敏度。 对于每个循环，发光信号在噪声上显着增加。

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