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公开(公告)号：US20170106012A1
公开(公告)日：2017-04-20
申请号：US15336407
申请日：2016-10-27
Applicant: Agency for Science, Technology and Research
Inventor： Simon McKenzie Cool , Victor Nurcombe , Christian Dombrowski
IPC: A61K31/727 , A61L27/54 , A61L27/20 , A61K35/28 , A61K38/18
CPC classification number: A61K31/727 , A61K9/0024 , A61K31/726 , A61K35/28 , A61K38/1875 , A61L27/20 , A61L27/54 , C08B37/0075
Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
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公开(公告)号：US20160115251A1
公开(公告)日：2016-04-28
申请号：US14891564
申请日：2013-05-16
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Victor Nurcombe , Simon Cool
IPC: C08B37/00 , A61K38/18 , C12N5/0775 , A61K9/00 , A61L27/20 , A61K31/737 , A61K35/28
CPC classification number: C08B37/0075 , A61K9/0019 , A61K31/737 , A61K35/28 , A61K38/1825 , A61L27/20 , A61L2430/02 , C08B37/0078 , C12N5/0662 , C12N5/0663 , C12N2501/115 , C12N2501/91
Abstract: A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells whilst maintaining their pluripotency/multipotency.
Abstract translation: 公开了一类新型的结构和功能相关的分离的硫酸肝素。 已经发现新型的硫酸乙酰肝素结合FGF2并增强干细胞的增殖，同时保持它们的多能性/多能性。
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公开(公告)号：US11806362B2
公开(公告)日：2023-11-07
申请号：US17728503
申请日：2022-04-25
Applicant: Agency for Science, Technology and Research
IPC: A61K31/727
CPC classification number: A61K31/727
Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
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公开(公告)号：US20220347205A1
公开(公告)日：2022-11-03
申请号：US17728503
申请日：2022-04-25
Applicant: Agency for Science, Technology and Research
IPC: A61K31/727
Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
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公开(公告)号：US20210161945A1
公开(公告)日：2021-06-03
申请号：US16770721
申请日：2018-12-11
Applicant: Agency for Science, Technology and Research
Inventor： Raymond Alexander Alfred Smith , Simon McKenzie Cool , Victor Nurcombe
IPC: A61K31/727
Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
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Patent Agency Ranking
公开(公告)号：US10723813B2
公开(公告)日：2020-07-28
申请号：US15542123
申请日：2016-01-08
Applicant: Agency for Science, Technology and Research
Inventor： Simon Cool , Victor Nurcombe
Abstract: Affinity purification of platelet-derived growth factor-binding heparan sulphate from porcine mucosa (HS6) is disclosed. Also disclosed is the use of HS6 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
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公开(公告)号：US20180360916A1
公开(公告)日：2018-12-20
申请号：US16020463
申请日：2018-06-27
Applicant: Agency for Science, Technology and Research
Inventor： Simon McKenzie Cool , Victor Nurcombe , Christian Dombrowski
IPC: A61K38/18 , A61K31/727 , B01D15/38 , A61K31/737 , C07K14/51 , A61L27/38 , A61L27/26 , A61K35/28 , A61L27/54 , C08B37/00
Abstract: The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
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公开(公告)号：US20170043053A1
公开(公告)日：2017-02-16
申请号：US15307407
申请日：2015-04-30
Applicant: Agency for Science, Technology and Research
Inventor： Simon Cool , Victor Nurcombe , Jonathan Lee
IPC: A61L27/20 , A61L27/38 , A61L27/52 , A01N1/02 , C07K14/495 , A61K8/73 , A61L27/34 , C12N5/0775 , C08B37/00 , A61L27/54
Abstract: A heparan sulphate that binds TGPβ1 is disclosed.
Abstract translation: 公开了结合TGPβ1的硫酸乙酰肝素。
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公开(公告)号：US11806368B2
公开(公告)日：2023-11-07
申请号：US16875486
申请日：2020-05-15
Applicant: Agency for Science, Technology and Research
Inventor： Lawrence Stanton , Padmapriya Sathiyanathan , Simon Cool , Victor Nurcombe , Rebekah M. Samsonraj
IPC: A61K35/28 , C12Q1/6881 , A61K35/545 , C12N5/0775
CPC classification number: A61K35/28 , A61K35/545 , C12N5/0662 , C12N5/0663 , C12Q1/6881 , C12Y205/01018 , C12Q2600/158
Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
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公开(公告)号：US10471091B2
公开(公告)日：2019-11-12
申请号：US15527972
申请日：2015-11-19
Applicant: Agency for Science, Technology and Research
Inventor： Simon Cool , Victor Nurcombe
Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is the use of HS8 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
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