公开(公告)号：US11766519B2

公开(公告)日：2023-09-26

申请号：US16961762

申请日：2019-01-17

Applicant: AMGEN INC.

Inventor： Sudeshna Dutta Ray ,  Scott R. Gibson ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Robert Allen Dees ,  Jonathan Dean Johnson ,  Antonio S. Murcia

IPC: A61M5/315 ,  A61M5/20

CPC classification number: A61M5/31511 ,  A61M5/2033 ,  A61M5/31583

Abstract: A flexible plunger rod, drug delivery mechanism, drug delivery device, and methods are described that utilize the flexible plunger rod perform drug delivery operations. In embodiments, the flexible plunger rod can be stored in a curved configuration to thereby reduce a footprint of the drug delivery mechanism and device.

公开(公告)号：US11660435B2

公开(公告)日：2023-05-30

申请号：US17642345

申请日：2020-10-05

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Heejin Lee

IPC: A61M31/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/20

CPC classification number: A61M31/00 ,  A61M5/1407 ,  A61M5/14248 ,  A61M5/2053 ,  A61M5/2066

Abstract: The devices, assemblies, and methods described herein utilize photoacoustic principals to create a jet of fluid using a ultrasonic resonance member and a pulsed laser light beam. The ultrasonic resonance member is a treated substrate having an liquid interface surface in contact with a fluid. When a pulsed laser light beam is applied to the treated substrate, pressure is generated via induced ultrasonic waves to urge the fluid into a jet stream.

公开(公告)号：US20220387702A1

公开(公告)日：2022-12-08

申请号：US17770331

申请日：2020-10-23

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Mehran Mojarrad ,  Paul D. Faucher

IPC: A61M5/142 ,  A61M5/168

Abstract: A drug delivery device is provided that includes a housing, a fluid displacement assembly at least partially supported by and/or surrounded by the housing, and a drive component at least partially supported by and/or surrounded by the housing. The fluid displacement assembly includes a ring tube portion. The drive component includes an eccentric component having a contact surface configured to directly or indirectly apply a compression force to a compression patch of the ring tube portion such that when the eccentric component rotates about an axis, the contact surface moves along generally circular path and drives the medicament through the fluid displacement assembly. The compression force between the contact surface and the ring tube portion is preferably substantially constant throughout a complete revolution about the axis by the eccentric component.

公开(公告)号：US20220249778A1

公开(公告)日：2022-08-11

申请号：US17627008

申请日：2020-07-16

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Ali Nekouzadeh ,  Sheldon B. Moberg ,  Scott R. Gibson ,  Paul Daniel Faucher

IPC: A61M5/31 ,  A61M5/145 ,  A61M5/162 ,  A61M5/20 ,  A61M5/24

Abstract: A drug delivery device includes a housing releasably coupled with a patient, a container disposed in the housing, a plunger disposed in the container, an activation mechanism, and a seal member. The container includes a wall with an interior surface. The plunger includes an interior surface and is moveably disposed in the container. The interior surfaces of the wall and the plunger define a reservoir adapted to contain a drug. The activation mechanism is adapted to release a drive fluid for moving the plunger through the container to expel the drug therefrom. The seal member is moveably disposed in the container and is adapted to inhibit ingress of the drive fluid into the reservoir.

公开(公告)号：US20210228811A1

公开(公告)日：2021-07-29

申请号：US17264157

申请日：2019-09-17

Applicant: AMGEN INC.

Inventor： Sudeshna Dutta Ray ,  Scott Robert Gibson ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Andrew James Carlson ,  Lee Gordon Macklem ,  Mikhail Tikh

IPC: A61M5/315 ,  A61M5/142 ,  A61M5/145

Abstract: Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.

公开(公告)号：US20190275241A1

公开(公告)日：2019-09-12

申请号：US16297408

申请日：2019-03-08

Applicant: AMGEN INC.

Inventor： Lawrence S. Ring ,  Tohid Pirbodaghi ,  Samin Akbari ,  Daniel Eduardo Groszmann ,  Mehran Mojarrad ,  Mark Gordon ,  Mikhail Tikh ,  Jimmie L. Ward ,  Scott R. Gibson ,  Sheldon B. Moberg ,  Joshua Tamsky ,  Paul Faucher

IPC: A61M5/168 ,  A61M5/158 ,  A61M39/24

Abstract: A drug delivery device includes a housing defining a shell and an inner volume, a container, a drive mechanism, a needle assembly, a fluid flow connection, and a backflow prevention mechanism. The container has an inner volume to contain a medicament to be administered to a user. The drive mechanism is at least partially disposed within the housing and exerts a force to urge the medicament out the container. The fluid flow connection is coupled to the container and the needle assembly and allows the medicament to flow from the container to the needle assembly to be administered. The backflow prevention mechanism is associated with at least one of the container, the fluid flow connection, or the needle assembly and includes at least one flow restrictor to restrict a fluid from flowing from the needle assembly to the container.

公开(公告)号：US12070582B2

公开(公告)日：2024-08-27

申请号：US17094176

申请日：2020-11-10

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Ali Nekouzadeh ,  Susan McConnell Montalvo ,  Scott R. Gibson ,  Sheldon B. Moberg ,  Joshua Tamsky ,  Paul D. Faucher

IPC: A61M5/315

CPC classification number: A61M5/31513 ,  A61M2005/3152

Abstract: Drug delivery devices are configured to include a gas-driven piston assembly having a flexible pushrod, a non-linear guide include a non-linear guide pathway at least partially surrounding the flexible pushrod, a cylinder at least partially surrounding the flexible pushrod, and a piston movable within the cylinder in response to the pressurized gas entering the cylinder. Some arrangements include a roller pushrod guide system and/or a gear pushrod guide system.

公开(公告)号：US20240091440A1

公开(公告)日：2024-03-21

申请号：US17767469

申请日：2020-10-16

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Mehran Mojarrad ,  Paul D. Faucher ,  Antonio S. Murcia ,  Alan D. Payne ,  Sheldon Moberg ,  Olivia Li

IPC: A61M5/172 ,  A61M5/142 ,  A61M39/10

CPC classification number: A61M5/1723 ,  A61M5/14244 ,  A61M39/10 ,  A61M2205/3331

Abstract: A drug delivery device for delivering a medicament includes a housing, a pump, drive component, an inlet fluid path, an outlet fluid path, an inlet pressure sensor, an outlet pressure sensor, and a controller. The pump is coupled with the housing. The drive component is for driving the pump. The inlet fluid path is configured to deliver medicament to the pump. The outlet fluid path is configured to receive medicament from the pump. The inlet pressure sensor is positioned along the inlet fluid path and configured to measure inlet fluid pressure. The outlet pressure sensor is positioned along the outlet fluid path and configured to measure outlet fluid pressure. The controller is workingly coupled with the inlet pressure sensor, the outlet pressure sensor, and the drive component, wherein the controller is configured to adjust at least one parameter of the drive component based on input information received from the inlet pressure sensor and/or the outlet pressure sensor.

公开(公告)号：US20240066215A1

公开(公告)日：2024-02-29

申请号：US17767471

申请日：2020-10-14

Applicant: AMGEN INC.

Inventor： Scott R. Gibson ,  Mehran Mojarrad ,  Paul Daniel Faucher ,  Steven Edward Gorski ,  Nicholas D.M. Prsha ,  Eduardo Ho ,  Rafi Muhammad Sufi

IPC: A61M5/145 ,  A61M5/172

CPC classification number: A61M5/145 ,  A61M5/1723

Abstract: A drug delivery device for delivering a medicament includes a pump first housing, a pump second housing, an inlet fluid path, and an outlet fluid path. The pump first housing is at least partially supporting and/or surrounding a fluid displacement assembly. The pump second housing is at least partially supporting and/or surrounding a drive component for driving the fluid displacement assembly. The inlet fluid path is configured to deliver medicament to the fluid displacement assembly. The outlet fluid path is configured to receive medicament from the fluid displacement assembly. The pump first housing and the pump second housing are removably coupled with each other.

公开(公告)号：US20220331204A1

公开(公告)日：2022-10-20

申请号：US17763681

申请日：2020-10-16

Applicant: AMGEN INC.

Inventor： Mehran Mojarrad ,  Scott R. Gibson ,  Xiaotong Li

IPC: A61J1/20 ,  A61M39/16 ,  A61M39/22

Abstract: Drug reconstitution systems and related methods are disclosed herein. A drug reconstitution system may include a first component in a first container in a storage state and a second component in a second container in a storage state. The first component may be selected from a group of a drug product, a diluent, a saline solution, and an IV stabilizing solution (“IVSS”). The second component may be selected from a group of the drug product, the diluent, the saline solution, and the IVSS. The first component may be different than the second component. At least one fluid path may be configured to at least selectively fluidly connect the first container and the second container. An urging assembly may be configured to selectively urge at least a portion of the first component from the first container and into contact with the second component.