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公开(公告)号：US20190119200A1
公开(公告)日：2019-04-25
申请号：US16091919
申请日：2017-04-06
申请人： AbbVie Inc.
发明人： Lawrence A. Black , William H. Bunnelle , Da Chen , Bruce Clapham , David A. Degoey , Xiangjun Deng , Liqiang Fu , Lisa A. Hazelwood , Linglong Kong , Qingyu Lang , Chih-Hung Lee , Mingfeng Li , Greta L. Lundgaard , Meena V. Patel , Ruihong Tao , Lin Zhang , Qingwei Zhang , Qiangang Zheng , Wei Zhu
IPC分类号： C07C235/34 , C07D213/69 , C07D321/10 , C07D307/86 , C07D317/46 , C07D333/24 , C07C323/52 , C07F9/38 , C07C313/04 , C07D209/20 , C07C311/32 , C07D305/06 , C07D213/71 , C07C311/51 , C07D239/72 , C07D239/52 , C07D257/06 , C07D215/50 , C07D217/26 , C07D498/04 , C07D307/33
摘要： Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
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公开(公告)号：US20200345727A1
公开(公告)日：2020-11-05
申请号：US16761390
申请日：2018-11-02
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K45/06 , C07D261/18 , C07D263/34 , C07D241/20 , A61K31/421 , A61K31/42 , A61K31/437 , C07D471/04 , C07D487/04 , C07D333/38 , C07D307/68 , A61K31/381 , A61K31/519 , A61K31/341 , A61K31/415 , A61K31/426 , A61K31/425 , C07D275/03 , C07D277/56 , C07D231/14 , C07D495/04 , A61K31/4985 , C07D237/20 , C07D413/04 , C07D285/06 , C07D317/46 , A61K31/36 , A61K31/4245 , A61K31/422 , A61K31/4196 , C07D249/10 , C07D217/26 , A61K31/472 , A61K31/196 , C07C233/62 , C07D401/04 , A61K31/4427 , A61K31/5355
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20160058894A1
公开(公告)日：2016-03-03
申请号：US14857637
申请日：2015-09-17
发明人： Lawrence A. Black , Berthold Behl , Jill Wetter
IPC分类号： A61K51/04 , C07D417/14 , C07D401/14 , C07D471/04 , C07D413/14
CPC分类号： A61K51/0455 , A61K51/0459 , A61K51/0465 , C07B59/002 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) are disclosed Compounds of formula (I) are useful in treating conditions and disorders prevented by or ameliorated by PDE10A ligands. Radiolabeled compounds of formula (I) are also useful as diagnostic tools as PDE10A positron emission tomography ligands. Also disclosed are pharmaceutical compositions comprising compound of formula (I), methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：US20220363678A1
公开(公告)日：2022-11-17
申请号：US17103003
申请日：2020-11-24
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC分类号： C07D471/04 , C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C235/22 , C07C311/13 , C07D237/14 , C07C311/24 , C07C317/22 , C07D237/16 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210269399A1
公开(公告)日：2021-09-02
申请号：US17038179
申请日：2020-09-30
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC分类号： C07D213/42 , C07D231/12 , C07D237/08 , C07D239/34 , C07D241/12 , C07D471/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D209/14 , C07C235/22 , C07D213/40 , C07D213/64 , C07D307/52 , C07D271/07 , A61K31/18 , A61K31/197 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C311/16 , C07C323/09 , C07D213/89 , C07D235/00 , C07D271/10 , C07D307/36 , C07D333/20
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US10913727B2
公开(公告)日：2021-02-09
申请号：US16098679
申请日：2017-05-05
发明人： Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC分类号： C07D307/82 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D277/32 , C07D213/57 , C07D307/56 , C07C233/74 , C07D213/54 , C07C235/54 , C07C233/79 , C07C255/41 , C07C255/57 , C07C235/14
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190142806A1
公开(公告)日：2019-05-16
申请号：US16098950
申请日：2017-05-05
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US09790203B2
公开(公告)日：2017-10-17
申请号：US14087680
申请日：2013-11-22
发明人： Hervé Geneste , Sean Colm Turner , Michael Ochse , Karla Drescher , Lawrence A. Black , Katja Jantos
IPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
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公开(公告)号：US20130343993A1
公开(公告)日：2013-12-26
申请号：US13723436
申请日：2012-12-21
申请人： AbbVie Inc.
发明人： Lawrence A. Black
IPC分类号： A61K51/04 , C07B59/00 , C07D401/14
CPC分类号： A61K51/0455 , C07B59/002 , C07D401/14
摘要： Compounds of formula (I) are disclosed Compounds of formula (I) are useful in treating conditions and disorders prevented by or ameliorated by 5-HT6 receptor ligands. Radiolabeled compounds of formula (I) are also useful as diagnostic tools as 5-HT6 positron emission tomography ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 公开了式（I）的化合物式（I）的化合物可用于治疗5-HT 6受体配体预防或改善的病症和病症。 式（I）的放射性标记化合物也可用作5-HT6正电子发射断层摄影配体的诊断工具。 还公开了包含式（I）化合物，使用这些化合物和组合物的方法以及制备式（I）范围内的化合物的方法的药物组合物。
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