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公开(公告)号：US20130343992A1
公开(公告)日：2013-12-26
申请号：US13723406
申请日：2012-12-21
申请人： AbbVie Inc.
发明人： Lawrence A. Black
IPC分类号： A61K51/04 , C07B59/00 , C07D401/14 , C07D417/14 , C07D471/04 , C07D413/14
CPC分类号： A61K51/0455 , A61K51/0459 , A61K51/0465 , C07B59/002 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) are disclosed Compounds of formula (I) are useful in treating conditions and disorders prevented by or ameliorated by PDE10A ligands. Radiolabeled compounds of formula (I) are also useful as diagnostic tools as PDE10A positron emission tomography ligands. Also disclosed are pharmaceutical compositions comprising compound of formula (I), methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 公开了式（I）的化合物式（I）的化合物可用于治疗由PDE10A配体预防或改善的病症和病症。 式（I）的放射性标记化合物也可用作PDE10A正电子发射断层摄影配体的诊断工具。 还公开了包含式（I）化合物，使用这些化合物和组合物的方法以及制备式（I）范围内的化合物的方法的药物组合物。
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公开(公告)号：US20220106281A1
公开(公告)日：2022-04-07
申请号：US17108416
申请日：2020-12-01
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC分类号： C07D307/82 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D277/32 , C07D213/57 , C07D307/56 , C07C233/74 , C07D213/54 , C07C235/54 , C07C233/79 , C07C255/41 , C07C255/57 , C07C235/14
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190194135A1
公开(公告)日：2019-06-27
申请号：US16098946
申请日：2017-05-05
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC分类号： C07D213/42 , C07D261/08 , C07D231/12 , C07D241/12 , C07D213/89 , C07D271/10 , C07D307/36 , C07D277/28 , C07D471/04 , C07D333/20 , C07D209/14 , A61K31/44 , A61K31/42 , A61K31/415 , A61K31/4965 , A61K31/4245 , A61K31/341 , A61K31/426 , A61K31/4439 , A61K31/381 , A61K31/4045 , C07D263/32 , A61K31/421 , C07D235/00 , A61K31/417 , C07D239/34 , A61K31/505 , C07D237/08 , A61K31/50 , C07C235/22 , A61K31/197 , C07C311/16 , A61K31/18 , C07C323/09
CPC分类号： C07D213/42 , A61K31/18 , A61K31/197 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C235/22 , C07C311/16 , C07C323/09 , C07C2602/38 , C07C2602/40 , C07C2602/42 , C07C2602/44 , C07C2603/90 , C07D209/14 , C07D213/40 , C07D213/64 , C07D213/89 , C07D231/12 , C07D235/00 , C07D237/08 , C07D239/34 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/07 , C07D271/10 , C07D277/28 , C07D307/36 , C07D307/52 , C07D333/20 , C07D471/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190135772A1
公开(公告)日：2019-05-09
申请号：US16098679
申请日：2017-05-05
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC分类号： C07D307/82 , C07D307/56 , C07D277/32 , C07D261/08 , C07D241/44 , C07D241/12 , C07D237/10 , C07D231/14 , C07D213/74 , C07D213/57
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US09138494B2
公开(公告)日：2015-09-22
申请号：US13723406
申请日：2012-12-21
申请人： AbbVie Inc.
发明人： Lawrence A. Black , Berthold Behl , Jill Wetter
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , C07D471/04 , C07D413/14 , C07D401/14 , C07D417/14 , C07B59/00
CPC分类号： A61K51/0455 , A61K51/0459 , A61K51/0465 , C07B59/002 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) are disclosed Compounds of formula (I) are useful in treating conditions and disorders prevented by or ameliorated by PDE10A ligands. Radiolabeled compounds of formula (I) are also useful as diagnostic tools as PDE10A positron emission tomography ligands. Also disclosed are pharmaceutical compositions comprising compound of formula (I), methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 公开了式（I）的化合物式（I）的化合物可用于治疗由PDE10A配体预防或改善的病症和病症。 式（I）的放射性标记化合物也可用作PDE10A正电子发射断层摄影配体的诊断工具。 还公开了包含式（I）化合物，使用这些化合物和组合物的方法以及制备式（I）范围内的化合物的方法的药物组合物。
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公开(公告)号：US20140120036A1
公开(公告)日：2014-05-01
申请号：US13723422
申请日：2012-12-21
申请人： AbbVie Inc.
发明人： Lawrence A. Black
IPC分类号： A61K51/04 , C07D295/112
CPC分类号： A61K51/0459 , C07B59/00 , C07D295/096 , C07D295/112
摘要： Compounds of formula (I) are disclosed Compounds of formula (I) are useful in treating conditions and disorders prevented by or ameliorated by 5-HT6 receptor ligands. Radiolabeled compounds of formula (I) are also useful as diagnostic tools as 5-HT6 positron emission tomography ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I), methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 公开了式（I）的化合物式（I）的化合物可用于治疗5-HT 6受体配体预防或改善的病症和病症。 式（I）的放射性标记化合物也可用作5-HT6正电子发射断层摄影配体的诊断工具。 还公开了包含式（I）化合物，使用这些化合物和组合物的方法以及制备式（I）范围内的化合物的方法的药物组合物。
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公开(公告)号：US20240307382A1
公开(公告)日：2024-09-19
申请号：US18330185
申请日：2023-06-06
发明人： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
CPC分类号： A61K31/4965 , A61K31/196 , A61K31/341 , A61K31/36 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/437 , A61K31/4427 , A61K31/472 , A61K31/4985 , A61K31/519 , A61K31/5355 , A61K45/06 , C07C233/62 , C07D217/26 , C07D231/14 , C07D237/20 , C07D241/20 , C07D249/10 , C07D261/18 , C07D263/34 , C07D275/03 , C07D277/56 , C07D285/06 , C07D307/68 , C07D317/46 , C07D333/38 , C07D401/04 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240166652A1
公开(公告)日：2024-05-23
申请号：US18324901
申请日：2023-05-26
发明人： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei Zhang , SeungWon Chung , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Brian S. Brown , Kathleen J. Murauski
IPC分类号： C07D487/04 , C07C235/22 , C07D213/30 , C07D213/643 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/20 , C07D271/07 , C07D271/113
CPC分类号： C07D487/04 , C07C235/22 , C07D213/30 , C07D213/643 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/20 , C07D271/07 , C07D271/113
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210113532A1
公开(公告)日：2021-04-22
申请号：US16885766
申请日：2020-05-28
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC分类号： A61K31/42 , C07D271/10 , C07D471/04 , C07D271/06 , C07D401/12 , C07D233/64 , C07D413/12 , A61P3/08 , A61P25/28 , A61P9/00 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190144440A1
公开(公告)日：2019-05-16
申请号：US16098675
申请日：2017-05-05
发明人： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC分类号： C07D471/04 , A61P25/28 , C07D213/30 , C07D213/64 , C07D213/66 , C07D213/73 , C07D231/56 , C07D241/18 , C07D261/08 , C07D271/113 , C07D261/20 , C07D317/64 , C07D401/04 , C07D405/08
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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