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公开(公告)号：US09248218B2
公开(公告)日：2016-02-02
申请号：US14530595
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma
IPC: A61L31/14 , A61L31/06 , C08G63/08 , C08G63/90 , A61F2/89 , C08L67/04 , C09J167/04 , A61K9/20 , C09D167/04 , A61K9/16
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal. Methods include making a poly(L-lactide) material for a stent with uniformly distributed L-lactide monomer through control of polymerization conditions during PLLA synthesis, control of post-processing conditions, or both.
Abstract translation: 公开了由聚（L-丙交酯）和低浓度的L-丙交酯单体制备可生物降解的聚合物支架的方法。 调节L-丙交酯的浓度以提供适合于包括冠状动脉，外周和鼻部在内的不同治疗应用的降解行为。 方法包括通过控制PLLA合成期间的聚合条件，后处理条件的控制或两者来制备具有均匀分布的L-丙交酯单体的支架的聚（L-丙交酯）材料。
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公开(公告)号：US20180008438A1
公开(公告)日：2018-01-11
申请号：US15688486
申请日：2017-08-28
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC: A61F2/915 , B29C71/02 , C08G63/08 , A61L31/14 , A61L31/06 , B29L31/00 , B29C35/08 , B29C35/04 , B29K67/00
CPC classification number: A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2230/0069 , A61L31/06 , A61L31/14 , A61L31/148 , B29C71/0009 , B29C71/02 , B29C2035/046 , B29C2035/048 , B29C2035/0811 , B29C2035/0822 , B29C2035/0855 , B29C2035/0861 , B29C2071/022 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08G63/08 , C08L67/04
Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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公开(公告)号：US09844612B2
公开(公告)日：2017-12-19
申请号：US15597962
申请日：2017-05-17
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , James Oberhauser
IPC: A61L31/14 , A61L31/06 , C08G63/08 , C08G63/90 , A61F2/89 , A61F2/82 , C08L67/04 , A61F2/30 , C09J167/04 , A61K9/20 , C09D167/04 , A61K9/16 , A61F2/958 , B29L31/00 , B29C47/00 , B29K67/00
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
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14.发明申请公开(公告)号：US20170319363A1
公开(公告)日：2017-11-09
申请号：US15661925
申请日：2017-07-27
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Xiao Ma , Mary Beth Kossuth , James P. Oberhauser , Stephen D. Pacetti , Manish Gada
CPC classification number: A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
Abstract: Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
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公开(公告)号：US09795497B2
公开(公告)日：2017-10-24
申请号：US14859170
申请日：2015-09-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Rommel Lumauig , Stephen D. Pacetti , Ni Ding , Joel Harrington , Xiao Ma , James P. Oberhauser , Jill McCoy , Chad J. Abunassar , Senthil Eswaran , Diem Ta
IPC: A61F2/82 , A61F2/91 , A61F2/915 , C08G63/08 , B29C71/02 , A61L31/06 , A61L31/14 , B29K67/00 , B29L31/00 , B29C35/04 , B29C35/08
CPC classification number: A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2210/0004 , A61F2230/0069 , A61L31/06 , A61L31/14 , A61L31/148 , B29C71/0009 , B29C71/02 , B29C2035/046 , B29C2035/048 , B29C2035/0811 , B29C2035/0822 , B29C2035/0855 , B29C2035/0861 , B29C2071/022 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , C08G63/08 , C08L67/04
Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.
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Patent Agency Ranking
16.发明申请METHOD OF TREATING WITH POLY(L-LACTIDE) STENT WITH TUNABLE DEGRADATION RATE 审中-公开用具有可降解速率的聚（L-柠檬酸）电极处理的方法公开(公告)号：US20160101222A1
公开(公告)日：2016-04-14
申请号：US14970890
申请日：2015-12-16
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
Abstract translation: 公开了用聚（L-丙交酯）和低浓度的L-丙交酯单体用可生物降解的聚合物支架进行处理的方法。 调节L-丙交酯的浓度以提供适合于包括冠状动脉，外周和鼻部在内的不同治疗应用的降解行为。
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17.发明申请Additives To Increase Degradation Rate Of A Biodegradable Scaffolding And Methods Of Forming Same 审中-公开增加可生物降解脚手架降解的添加剂及其形成方法公开(公告)号：US20150328373A1
公开(公告)日：2015-11-19
申请号：US14281811
申请日：2014-05-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Xiao Ma
CPC classification number: A61L31/10 , A61L31/06 , A61L31/14 , A61L31/141 , A61L31/148 , A61L2300/802 , A61L2400/18 , A61L2420/02 , A61L2420/06 , B05D1/18 , B05D2254/00 , C08L67/04
Abstract: Methods of making biodegradable polymeric devices, such as stents, with one or more modifications to alter the degradation rate, and the biodegradable polymeric devices are described. Modifications include blending of two polymers, one with a different degradation rate, inclusion of additives to alter the degradation rate, and the use of polymers of a high polydispersity.
Abstract translation: 描述了制造具有改变降解速率的一个或多个修饰物的可生物降解的聚合物装置（例如支架）和可生物降解的聚合物装置的方法。 修饰包括混合两种聚合物，一种具有不同的降解速率，包含添加剂以改变降解速率，以及使用高分散度的聚合物。
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公开(公告)号：US20150057744A1
公开(公告)日：2015-02-26
申请号：US14530595
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal. Methods include making a poly(L-lactide) material for a stent with uniformly distributed L-lactide monomer through control of polymerization conditions during PLLA synthesis, control of post-processing conditions, or both.
Abstract translation: 公开了由聚（L-丙交酯）和低浓度的L-丙交酯单体制备可生物降解的聚合物支架的方法。 调节L-丙交酯的浓度以提供适合于包括冠状动脉，外周和鼻部在内的不同治疗应用的降解行为。 方法包括通过控制PLLA合成期间的聚合条件，后处理条件的控制或两者来制备具有均匀分布的L-丙交酯单体的支架的聚（L-丙交酯）材料。
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公开(公告)号：US10703050B2
公开(公告)日：2020-07-07
申请号：US15828253
申请日：2017-11-30
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Rommel Lumauig
Abstract: A medical device includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen. A variable diameter sheath with a central portion that prevents expansion of the stent when the balloon is pressurized and larger diameter ends is disposed over the crimped stent-balloon assembly. The balloon is pressurized and the larger diameter ends of the sheath allow the balloon beyond the ends of the stent to expand. The balloon is then depressurized.
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公开(公告)号：US09855705B2
公开(公告)日：2018-01-02
申请号：US14692615
申请日：2015-04-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Rommel Lumauig
CPC classification number: B29C65/567 , A61F2/915 , A61F2/958 , A61F2002/9522 , Y10T29/49925
Abstract: A medical device includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen. A variable diameter sheath with a central portion that prevents expansion of the stent when the balloon is pressurized and larger diameter ends is disposed over the crimped stent-balloon assembly. The balloon is pressurized and the larger diameter ends of the sheath allow the balloon beyond the ends of the stent to expand. The balloon is then depressurized.
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