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公开(公告)号：US09610034B2
公开(公告)日：2017-04-04
申请号：US14936577
申请日：2015-11-09
IPC分类号： A61B5/1495 , A61N1/08 , A61B5/1486 , A61B5/1473 , A61B5/145 , H04B1/707 , A61B5/07 , A61B5/00 , H04L1/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/0022 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/6849 , A61B5/7405 , A61B5/742 , A61B5/743 , A61B5/7445 , A61B2560/0252 , A61B2560/0412 , A61B2560/063 , A61N1/08 , H04B1/707 , H04L1/0071
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US09291592B2
公开(公告)日：2016-03-22
申请号：US14281642
申请日：2014-05-19
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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公开(公告)号：US20160058341A1
公开(公告)日：2016-03-03
申请号：US14936577
申请日：2015-11-09
IPC分类号： A61B5/1495 , A61B5/1486 , A61B5/00 , A61B5/145
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/0022 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/6849 , A61B5/7405 , A61B5/742 , A61B5/743 , A61B5/7445 , A61B2560/0252 , A61B2560/0412 , A61B2560/063 , A61N1/08 , H04B1/707 , H04L1/0071
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
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公开(公告)号：US20140251829A1
公开(公告)日：2014-09-11
申请号：US14281642
申请日：2014-05-19
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译： 描述了利用不可浸出或可扩散的氧化还原介体的传感器。 传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。 传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。 本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。 通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。
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公开(公告)号：US09316609B2
公开(公告)日：2016-04-19
申请号：US14281647
申请日：2014-05-19
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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公开(公告)号：US20140251830A1
公开(公告)日：2014-09-11
申请号：US14281647
申请日：2014-05-19
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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公开(公告)号：US20140251828A1
公开(公告)日：2014-09-11
申请号：US14281640
申请日：2014-05-19
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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公开(公告)号：US20140251827A1
公开(公告)日：2014-09-11
申请号：US14281405
申请日：2014-05-19
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
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公开(公告)号：US20210128031A1
公开(公告)日：2021-05-06
申请号：US17145655
申请日：2021-01-11
发明人： Jeffery V. Funderburk , Duane O. Yamasaki , Brian VanHiel , Stephen J. Flynn , Bradley D. Keleman
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte, such as blood glucose. An inserter having a retractable introducer is provided for subcutaneously implanting the sensor in a predictable and reliable fashion.
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公开(公告)号：US10973443B2
公开(公告)日：2021-04-13
申请号：US15963828
申请日：2018-04-26
IPC分类号： A61B5/145 , A61B5/00 , G16H10/40 , G16H50/30 , G16H50/00 , A61B5/1473 , A61B17/34 , A61N1/05 , G16H10/60
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte, such as blood glucose. An inserter having a retractable introducer is provided for subcutaneously implanting the sensor in a predictable and reliable fashion.
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