公开(公告)号：US20190062427A1

公开(公告)日：2019-02-28

申请号：US15772010

申请日：2016-10-28

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Kate MONROE ,  Seung-Joo LEE

IPC: C07K16/28 ,  A61P29/00 ,  A61P35/00 ,  A61P25/00 ,  A61P31/04 ,  A61K39/395 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20180160661A1

公开(公告)日：2018-06-14

申请号：US15836089

申请日：2017-12-08

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Seung-Joo LEE

IPC: A01K67/027 ,  C12N15/85

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/07 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  C07K14/7056 ,  C07K14/70596 ,  C12N15/8509

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US20240279341A1

公开(公告)日：2024-08-22

申请号：US18570865

申请日：2022-06-15

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Tarangsri NIVITCHANYONG ,  Wei-Hsien HO ,  Wei LI ,  Marina K. ROELL ,  Spencer LIANG

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/40

CPC classification number: C07K16/2827 ,  A61P35/00 ,  C07K16/40 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include bispecific antibodies, e.g., monoclonal antibodies, that specifically bind a MerTK polypeptide (e.g., a mammalian MerTK or human MerTK) and a PDL1 polypeptide (e.g. a mammalian PDL1 polypeptide or human PDL1 polypeptide), and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20190040130A1

公开(公告)日：2019-02-07

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina SCHWABE ,  Eric BROWN ,  Philip KONG ,  IIaria TASSI ,  Seung-Joo LEE ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Nels P. NIELSON

IPC: C07K16/28 ,  A61P25/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190002560A1

公开(公告)日：2019-01-03

申请号：US15735947

申请日：2016-06-11

Applicant: ALECTOR LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20240294650A1

公开(公告)日：2024-09-05

申请号：US17995189

申请日：2021-03-30

Applicant: Alector LLC

Inventor： Michael KURNELLAS ,  Santiago Viveros SALAZAR ,  Marina ROELL ,  Angie Grace YEE ,  Seung-Joo LEE ,  Tina SCHWABE ,  Maxime CHAPON ,  William Francis ESTACIO ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  G01N33/573

CPC classification number: C07K16/2863 ,  G01N33/573 ,  C07K2317/33 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/9121

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g. a mammalian MerTK or human MerTK, and use of such compositions in preventing, reducing risk, or treating a disease or disorder an individual in need thereof.

公开(公告)号：US20240287204A1

公开(公告)日：2024-08-29

申请号：US18392569

申请日：2023-12-21

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Spencer Liang ,  Angie YEE ,  Marina ROELL ,  Arnon ROSENTHAL

IPC: C07K16/40 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20240279358A1

公开(公告)日：2024-08-22

申请号：US18570888

申请日：2022-06-15

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Tarangsri NIVITCHANYONG ,  Wei-Hsien HO ,  Wei LI ,  Marina K. ROELL ,  Spencer LIANG

IPC: C07K16/40 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/53 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include monovalent antibodies, e.g., monoclonal monovalent antibodies that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK polypeptide or human MerTK polypeptide, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20220251190A1

公开(公告)日：2022-08-11

申请号：US17459835

申请日：2021-08-27

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Francesca AVOGADRI-CONNORS ,  Seung-Joo LEE ,  William MONTEITH ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C12N15/85

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210261685A1

公开(公告)日：2021-08-26

申请号：US17118921

申请日：2020-12-11

Applicant: Alector LLC

Inventor： Seung-Joo LEE ,  Spencer LIANG ,  Angie YEE ,  Marina ROELL ,  Arnon ROSENTHAL

IPC: C07K16/40 ,  C07K16/28 ,  A61P35/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.