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公开(公告)号：US07797050B2
公开(公告)日：2010-09-14
申请号：US12691392
申请日：2010-01-21
申请人： Imad Libbus , Anthony V. Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人： Imad Libbus , Anthony V. Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号： A61N1/00
CPC分类号： A61N1/36185 , A61N1/3611
摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.
摘要翻译： 各种方面涉及可植入装置。 各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和 与脉冲发生器。 所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。 用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。 各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。 本文提供了其它方面和实施例。
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公开(公告)号：US07797041B2
公开(公告)日：2010-09-14
申请号：US11548359
申请日：2006-10-11
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译： 神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。 外部神经刺激仪提供神经刺激来调节患者的心血管功能。 在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。
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公开(公告)号：US20090204173A1
公开(公告)日：2009-08-13
申请号：US12264836
申请日：2008-11-04
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/36171 , A61N1/3787
摘要： Multi-frequency neural treatments and associated systems and methods are disclosed. A method in accordance with a particular embodiment includes at least reducing patient pain by applying a first electrical signal to a first target location of the patient's spinal cord region at a frequency in a first frequency range of up to about 1,500 Hz, and applying a second electrical signal to a second target location of the patient's spinal cord region at a frequency in a second frequency range of from about 2,500 Hz to about 100,000 Hz.
摘要翻译： 公开了多频神经治疗及相关系统和方法。 根据特定实施例的方法包括至少通过以高达约1500Hz的第一频率范围的频率将第一电信号施加到患者脊髓区域的第一目标位置来减少患者疼痛，并且施加第二电信号 电信号以约2,500Hz至约100,000Hz的第二频率范围内的患者脊髓区域的第二目标位置。
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公开(公告)号：US20080319513A1
公开(公告)日：2008-12-25
申请号：US11767901
申请日：2007-06-25
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0816 , A61B5/4035 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.
摘要翻译： 系统实施例包括至少一个呼吸传感器，神经刺激治疗传递模块和控制器。 呼吸传感器适用于监测患者的呼吸。 神经刺激治疗递送模块适于产生用于刺激患者的自主神经靶标用于慢性神经刺激治疗的神经刺激信号。 控制器适于接收来自指示患者呼吸的至少一个呼吸传感器的呼吸信号，并且适于使用使用呼吸信号导出的呼吸变异性测量来控制神经刺激治疗递送模块。
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公开(公告)号：US20080228194A1
公开(公告)日：2008-09-18
申请号：US11685476
申请日：2007-03-13
IPC分类号： A61N1/02
CPC分类号： A61N1/0556 , A61B17/3468
摘要： An apparatus for performing a minimally-invasive surgical procedure in the vagus nerve region includes a cannula, an endoscopic dissection tool and a cradle assembly slideably disposed in a cannula lumen. The cradle assembly includes a C-ring, an electrode cuff disposed over an exterior surface of the C-ring, and a deployment device. The electrode cuff is adapted to wrap around the target nerve region or nerve branch to be stimulated when deployed from the C-ring using the deployment device. A method of performing a minimally invasive surgical procedure is also described.
摘要翻译： 用于在迷走神经区域中执行微创外科手术的装置包括套管，内窥镜解剖工具和可滑动地设置在套管腔中的支架组件。 支架组件包括C形环，设置在C形环的外表面上的电极套，以及展开装置。 当使用展开装置从C形环展开时，电极套套适于围绕目标神经区域或神经分支进行包围。 还描述了执行微创外科手术的方法。
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16.发明授权Apparatus and method for delivering a neurostimulator into the pterygopalatine fossa 有权将神经刺激器输送到翼腭窝的装置和方法公开(公告)号：US09456836B2
公开(公告)日：2016-10-04
申请号：US13476224
申请日：2012-05-21
IPC分类号： A61N1/05 , A61B17/24 , A61B17/34 , A61N1/36 , A61B17/02 , A61B17/3211 , A61B17/32 , A61N1/375
CPC分类号： A61B17/24 , A61B17/02 , A61B17/3211 , A61B17/3468 , A61B2017/320052 , A61N1/0526 , A61N1/0546 , A61N1/0548 , A61N1/36 , A61N1/3605 , A61N1/36057 , A61N1/375
摘要： One aspect of the present disclosure includes a neurostimulator delivery apparatus. The apparatus includes a handle portion, an elongate shaft extending from the handle portion, and a distal deployment portion. The distal deployment portion is configured to releasably mate with a neurostimulator. The neurostimulator is sized and configured for implantation into a craniofacial region of a subject.
摘要翻译： 本公开的一个方面包括神经刺激器输送装置。 该装置包括手柄部分，从把手部分延伸的细长轴和远端展开部分。 远侧展开部分构造成可释放地与神经刺激器配合。 神经刺激器的尺寸和构造适于植入受试者的颅面区域。
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公开(公告)号：US08630704B2
公开(公告)日：2014-01-14
申请号：US11767901
申请日：2007-06-25
IPC分类号： A61N1/08
CPC分类号： A61N1/36139 , A61B5/0816 , A61B5/4035 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： A system embodiment comprises at least one respiration sensor, a neural stimulation therapy delivery module, and a controller. The respiration sensor is adapted for use in monitoring respiration of the patient. The neural stimulation therapy delivery module is adapted to generate a neural stimulation signal for use in stimulating the autonomic neural target of the patient for the chronic neural stimulation therapy. The controller is adapted to receive a respiration signal from the at least one respiration sensor indicative of the patient's respiration, and adapted to control the neural stimulation therapy delivery module using a respiratory variability measurement derived using the respiration signal.
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公开(公告)号：US08571687B2
公开(公告)日：2013-10-29
申请号：US12869593
申请日：2010-08-26
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译： 神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。 外部神经刺激仪提供神经刺激来调节患者的心血管功能。 在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用位于身体上的表面刺激电极大致超过刺激目标。
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公开(公告)号：US08560072B2
公开(公告)日：2013-10-15
申请号：US13596595
申请日：2012-08-28
申请人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/18
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译： 提供了一种用于呼吸神经控制的系统，装置和方法。 本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。 根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。 该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。 在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。 本文提供了其它方面和实施例。
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公开(公告)号：US08554323B2
公开(公告)日：2013-10-08
申请号：US13363198
申请日：2012-01-31
申请人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/365
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。
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