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公开(公告)号：US07595153B2
公开(公告)日：2009-09-29
申请号：US11980203
申请日：2007-10-30
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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公开(公告)号：US07582419B2
公开(公告)日：2009-09-01
申请号：US11978930
申请日：2007-10-30
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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公开(公告)号：US07267939B2
公开(公告)日：2007-09-11
申请号：US11283233
申请日：2005-11-18
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译： 本发明涉及使用电子转移方法的核重组能量λ检测分析物的新方法和组合物。
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公开(公告)号：US06291188B1
公开(公告)日：2001-09-18
申请号：US09639311
申请日：2000-08-15
申请人： Thomas J. Meade , Jon F. Kayyem
发明人： Thomas J. Meade , Jon F. Kayyem
IPC分类号： C12Q168
CPC分类号： C12Q1/6818 , B82Y30/00 , C07H21/00 , C07H23/00 , C12Q1/6825 , C12Q2563/137 , C12Q2563/113 , C12Q2565/607 , C12Q2565/101 , C12Q2565/1015 , C12Q2565/401
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
摘要翻译： 本发明提供了用氧化还原活性部分如过渡金属配合物选择性共价修饰核酸。 电子供体和电子受体部分在预定位置与核酸的核糖 - 磷酸骨架共价结合。 所得的复合物表示一系列新的衍生物，其是能够以非常快的速率在非常大的距离上转移电子的双分子模板。 这些复合物具有独特的结构特征，可以使用全新的生物传感器和光敏探针。
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公开(公告)号：US06180352B2
公开(公告)日：2001-01-30
申请号：US09459191
申请日：1999-12-10
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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16.发明授权Synthesis of aromatic heterocyclic polymers from a biosynthetically prepared precursor 失效从生物合成制备的前体合成芳族杂环聚合物
公开(公告)号：US5340913A
公开(公告)日：1994-08-23
申请号：US34924
申请日：1993-03-19
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： C08G73/22 , C08G63/6852 , C12P7/42
摘要： 2,4-Polybenzoxazoles are synthesized from a biosynthetically prepared AB monomer. The biosynthetically produced precursor, 2,3-dihydro-3-hydroxyanthranilic acid (DHAA), is chemically transformed to the AB monomer, 3-hydroxyanthranilic acid (HAA). This AB monomer is used to prepare said polybenzoxazoles.
摘要翻译： 2,4-二苯并恶唑由生物合成制备的AB单体合成。 生物合成产生的2,3-二氢-3-羟基邻氨基苯甲酸（DHAA）的前体被化学转化为AB单体3-羟基邻氨基苯甲酸（HAA）。 该AB单体用于制备所述聚苯并恶唑。
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17.发明申请公开(公告)号：US20120269730A1
公开(公告)日：2012-10-25
申请号：US13388629
申请日：2010-08-09
申请人： Chad A. Mirkin , Thomas J. Meade , Ying Song , Xiaoyang Xu
发明人： Chad A. Mirkin , Thomas J. Meade , Ying Song , Xiaoyang Xu
CPC分类号： A61K49/128 , A61K49/0002 , A61K49/1881
摘要： The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.
摘要翻译： 本发明涉及用官能化纳米颗粒细胞内递送造影剂的组合物和方法。
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公开(公告)号：US20120012472A1
公开(公告)日：2012-01-19
申请号：US13187142
申请日：2011-07-20
申请人： Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
发明人： Michael Ahrens , Paul A. Bertin , Harry B. Gray , Thomas J. Meade
CPC分类号： G01N27/327 , C07F15/002 , C12Q1/003 , G01N33/54353 , G01N33/5438 , Y10T29/49117 , Y10T29/49204
摘要： The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
摘要翻译： 本发明涉及可用于合成标记蛋白质，核酸和用于电极修饰的二取代联吡啶锇络合物的新组合物。
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公开(公告)号：US07906105B1
公开(公告)日：2011-03-15
申请号：US11844088
申请日：2007-08-23
申请人： Jody L. Major , Thomas J. Meade
发明人： Jody L. Major , Thomas J. Meade
IPC分类号： A61B5/055 , C07D225/00
CPC分类号： C07D257/02
摘要： The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II) (e.g., resulting in a brighter image).
摘要翻译： 本发明涉及用于磁共振成像（MRI）的造影剂。 特别地，本发明涉及在锌（II）存在下活化的MRI造影剂（例如，产生更亮的图像）。
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公开(公告)号：US20090269284A1
公开(公告)日：2009-10-29
申请号：US12210829
申请日：2008-09-15
申请人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译： 本发明一般涉及多模式磁共振成像（MRI）造影剂。 特别地，本发明提供了构造成操纵周围水质子旋转的纵向（T1）和横向（T2）弛豫时间的MRI造影剂。
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